molecular mechanism – Page 49 – Communicable Diseases Research

Functional IL6R 358Ala Allele Impairs Classical IL-6 Receptor Signaling and Influences Risk of Diverse Inflammatory Diseases

기능성 IL6R 358Ala 대립유전자는 전통적인 IL-6 수용체 신호 전달을 손상시키고 다양한 염증성 질환의 위험에 영향을 미칩니다

Research Article

Published on 2013-04-042022-09-06
Journal: PLoS Genetics [Category] Communicable Disease,

Plasma cell disorders in HIV-infected patients: epidemiology and molecular mechanisms

Review

Published on 2013-02-042024-09-02
Journal: Biomarker Research [Category] 대상포진,

[키워드] AIDS Epidemiology gammopathy hematopoietic stem cell transplantation HIV molecular mechanism Multiple myeloma outcome Treatment
[DOI] 10.1186/2050-7771-1-8 PMC 바로가기 [Article Type] Review

Starvation, Together with the SOS Response, Mediates High Biofilm-Specific Tolerance to the Fluoroquinolone Ofloxacin

기아는 SOS 반응과 함께 Fluoroquinolone Ofloxacin에 대한 높은 생물막 특정 내성을 매개합니다

Research Article

Published on 2013-01-032022-09-06
Journal: PLoS Genetics [Category] Communicable Disease,

[키워드] a minor age Amino acid amino acids antibiotic Antibiotic resistance Antibiotics Author Bacteria Bacterial biofilm carbon carbon source Community Concentration Critical demonstrated dependent on Escherichia coli exhibited functional greater growth hallmark heterogeneity heterogeneous Hypothesis identify infections influence lead leucine Medical devices microenvironment minor molecular mechanism molecular mechanisms multicellular Mutagenesis mutant mutants ofloxacin organism physiological physiological state planktonic random response significantly SOS SOS response starvation Stress stress response subpopulation subpopulations Support systemic infections Tolerance transposon
[DOI] 10.1371/journal.pgen.1003144 PMC 바로가기 [Article Type] Research Article

A Mechanism of Gene Amplification Driven by Small DNA Fragments

작은 DNA 조각에 의한 유전자 증폭 메커니즘

Research Article

Published on 2012-12-132022-09-06
Journal: PLoS Genetics [Category] Communicable Disease,

[키워드] amplification amplified amplify annealing Author Cancer cancer cell Cancer cells capture cause Cell chromosomal chromosomal DNA chromosomal region contribute copy number degenerative dependent on detected disorders DNA DNA amplification DNA fragment driving duplication Efficiency elevated event events expression Extracellular Factor favor found fragment Frequency gene amplification Genetic variation genomic homology Human increase independent independent of initiated involved loci mechanism molecular molecular mechanism molecular mechanisms nucleotide nucleotides occur oligonucleotide Organisms Patients with cancer polymorphism Rad1 Rad51 Rad52 regions S. cerevisiae Saccharomyces cerevisiae serum single-stranded stimulate Trigger triggered Variation yeast
[DOI] 10.1371/journal.pgen.1003119 PMC 바로가기 [Article Type] Research Article

The GATA Transcription Factor egl-27 Delays Aging by Promoting Stress Resistance in Caenorhabditis elegans

GATA 전사 인자 egl-27은 꼬마선충의 스트레스 저항성을 촉진하여 노화를 지연시킵니다

Research Article

Published on 2012-12-132022-09-06
Journal: PLoS Genetics [Category] Communicable Disease,

[키워드] accumulated activated Affect age aging aging process alteration animals Author Caenorhabditis Caenorhabditis elegan Caenorhabditis elegans conserved daf-16 Delay Effect elegan expression Factor Factors found FoxO GATA GATA transcription factor Gene Genes heat stress identify IGF-1 impair IMPROVE increase inhibited insulin Intersection involved limit Longevity molecular mechanism molecular mechanisms mutant overexpression oxidative stress pathway Pathways promote Promoting PROTECT protective response protective responses receptor reduced required resistance response Signaling significantly Stress stress response stress responses suppresse survival target transcription factor wild-type worm worms
[DOI] 10.1371/journal.pgen.1003108 PMC 바로가기 [Article Type] Research Article

A Genome-Wide Association Scan on the Levels of Markers of Inflammation in Sardinians Reveals Associations That Underpin Its Complex Regulation

사르데냐인의 염증 표지자 수준에 대한 게놈 전체의 연관성 스캔은 복잡한 조절을 뒷받침하는 연관성을 보여줍니다

Research Article

Published on 2012-01-262022-09-06
Journal: PLoS Genetics [Category] Communicable Disease,

[키워드] ABO gene AIRE APOC-I approach association associations Author autosomal C-reactive protein CADM3 CCR2 Cohort common disease complex conducted CR1 CRP CRP gene damaged cells DARC detect different different diseases Effects erythrocyte sedimentation erythrocyte sedimentation rate ESR Evidence Factor found functional Gene genetic determinant genetic determinants Genetic variant genetic variants genome-wide association scan Genome-wide association scans genome-wide significant genotyped GWAS HBB Health help High-sensitivity C-reactive protein highlight HNF1A hsCRP ICOSLG identifying IL-6 IL-6R gene ImmunoChip implicated IMPROVE included independent individual individuals Inflammation inflammation erythrocyte sedimentation rate Inflammatory biomarker interleukin interleukin-6 knowledge large cohort led to Level loci MCP-1 mechanism MetaboChip custom arrays molecular mechanism molecular mechanisms monocyte monocyte chemotactic protein-1 novel organism performed power pro-inflammatory molecule pro-inflammatory molecules Protective Protein provided QTLs Quantitative quantitative traits receptor Regulation replicated robust rs113459440 rs11829037 rs1205 rs12075 rs12567990 rs17141006 rs225918 rs3026968 rs3093077 rs3845624 rs4129267 rs4420638 rs4910472 rs657152 Sardinia Sardinian sedimentation rate selected SNP SPPL3 TMEM57 UCN119B UNC119B variant X chromosome SNP
[DOI] 10.1371/journal.pgen.1002480 PMC 바로가기 [Article Type] Research Article

Coronavirus Gene 7 Counteracts Host Defenses and Modulates Virus Virulence

Research Article

Published on 2011-06-092022-10-29
Journal: PLoS Pathogens [Category] Coronavirus, MERS,

[키워드] absence accelerated accessory gene acquisition Activation Analysis Antiviral antiviral response Apoptosis assay association Author benefit binding caspase catalytic caused Cell cellular RNA clinical disease compared conserved coronavirus CoV cultures Cytopathic effect Defense Degradation Deleterious demonstrated eIF2α ENCODE eukaryotic translation evade Evolution expression Genome growth Host host antiviral response host cell hydrophobic immune response indicated Infected infected cells Infection Innate inoculation Interaction led to mechanism modify modulation molecular mechanism motif mutant mutant virus Newborn observation parental pathology Pathways persistence Phosphorylation promoted Protein protein phosphatase 1 provided pull-down reducing required RNA degradation RNA viruses RNase selective sequence subunit suggested survival TGEV tissue translational transmissible gastroenteritis virus Viral RNA virulence virus virus infection
[DOI] 10.1371/journal.ppat.1002090 PMC 바로가기 [Article Type] Research Article

A Decline in p38 MAPK Signaling Underlies Immunosenescence in Caenorhabditis elegans

Caenorhabditis elegans에서 p38 MAPK 신호 전달의 감소는 면역 노화의 기초가 됩니다

Research Article

Published on 2011-05-192022-09-06
Journal: PLoS Genetics [Category] Communicable Disease,

[키워드] addressed age aging amplify Author Bacteria Bacterial Bacterial infection Caenorhabditis Caenorhabditis elegan Caenorhabditis elegans change conserved cycle death Decline declines Defense defined Deterioration elegan examined exhibit Genetic Host host defense human pathogen humans immune function immunosenescence impair implicated increase in Infection innate immune Innate immunity intestinal intestinal tissue involved leads MAPK mice mitogen mitogen-activated protein kinase molecular basis molecular mechanism motion pathogen pathway phenomenon PMK-1 proliferation promote Protein protein kinase Pseudomonas aeruginosa regulate signaling pathway susceptibility tissue damage turn
[DOI] 10.1371/journal.pgen.1002082 PMC 바로가기 [Article Type] Research Article

Interactions of SARS Coronavirus Nucleocapsid Protein with the host cell proteasome subunit p42

Research

Published on 2010-05-172022-10-28
Journal: Virology Journal [Category] Coronavirus,

SARS-CoV Pathogenesis Is Regulated by a STAT1 Dependent but a Type I, II and III Interferon Receptor Independent Mechanism

Research Article

Published on 2010-04-082022-10-29
Journal: PLoS Pathogens [Category] Coronavirus, MERS,

[키워드] acute lung injury acute respiratory syndrome affecting alveolar inflammation ARDS Author BALB/c mice caused cell proliferation clinical disease coronavirus death demonstrated Dependent died Diffuse alveolar damage ENhance Epidemic evaluated highly pathogenic I, II independent Infected Infection innate immune innate immune response Innate immunity interferon interferon signaling knockout mice lack liver Lung disease Lung injury Lung pathology MA15 mechanism mice molecular mechanism Mortality Mouse models other tissue outcomes Pathogenesis Pathways Post-infection PROTECT Protein pulmonary fibrosis pulmonary lesion question receptor regulated respiratory respiratory virus SARS Coronavirus SARS pathogenesis SARS-CoV SARS-CoV infection severe severe disease Signaling spleen Stat1 the epidemic Type type I type III interferon viral pathogenesis virus virus pathogenesis virus titer Virus-host interaction viruses weight loss wildtype
[DOI] 10.1371/journal.ppat.1000849 PMC 바로가기 [Article Type] Research Article