An integrated in silico immuno-genetic analytical platform provides insights into COVID-19 serological and vaccine targetsDatabase Published on 2021-01-072022-10-31 Journal: Genome Medicine [Category] COVID-19, [키워드] activity Analysis appear COVID COVID-19 cross-reactivity D614G diagnostic epitope Epitopes Human-coronavirus Immuno-informatics in silico Mutation Nsp12 nucleocapsid protein platform Post-vaccine Protein provide resource SARS-CoV-2 SARS-CoV-2 mutation SARS-CoV-2 spike sequence serological serological tool serology spike Surveillance target targets Vaccine [DOI] 10.1186/s13073-020-00822-6 PMC 바로가기 [Article Type] Database
Neutralization assay with SARS-CoV-1 and SARS-CoV-2 spike pseudotyped murine leukemia virionsSARS-CoV-1 및 SARS-CoV-2 스파이크 유사형 쥐 백혈병 비리온을 사용한 중화 분석Methodology Published on 2021-01-042022-09-01 Journal: Virology Journal [Category] 진단, 치료기술, [키워드] Abbott antibody Antibody test antibody tests binding candidate vaccine capsid circumvent comparison Comparisons composed Concordance condition coronavirus COVID-19 detectable Euroimmun expressed firefly luciferase Genome IgG IgG test immunogenicity infected patient infected patients Influenza influenza infection Laboratory leukemia level 2 level 3 luciferase measure MLV murine Murine leukemia virus neutralization Neutralization assay neutralization titer neutralization titers Neutralizing Neutralizing activity Neutralizing antibodies neutralizing antibody neutralizing titers offer Particle Patient patients hospitalized plasma Prognostic factor promise pseudotyped Pseudotyped virus pseudovirion pseudovirions pseudovirus pseudoviruses R 2 ranged Receptor binding domain Replication replication-competent SARS-CoV-2 required Result SARS SARS-CoV-1 SARS-CoV-2 SARS-CoV-2 IgG SARS-CoV-2 spike SARS-CoV-2 spike glycoprotein serum serum sample serum samples Siemen Siemens spike spike glycoprotein tested titers Viral diseases virion virus viruses [DOI] 10.1186/s12985-020-01472-1 PMC 바로가기 [Article Type] Methodology
Development of potent and effective synthetic SARS-CoV-2 neutralizing nanobodies강력하고 효과적인 합성 SARS-CoV-2 중화 나노바디 개발Article Published on 2021-01-012022-09-12 Journal: mAbs [Category] 진단, [키워드] acute respiratory syndrome affected angiotensin-converting enzyme 2 antibody binding candidate cellular receptor characterized coronavirus coronavirus disease COVID-19 COVID-19 pandemic described development domain effective evaluated humanized in vivo nanobody neutralize Neutralizing neutralizing antibody Outbreaks phage display Prevent prophylactically respiratory virus responsible SARS-CoV-2 SARS-CoV-2 pandemic SARS-CoV-2 spike the SARS-CoV-2 therapeutic therapeutic intervention toolkit viral infection virus wildtype [DOI] 10.1080/19420862.2021.1958663 PMC 바로가기 [Article Type] Article
Drug repurposing for identification of potential inhibitors against SARS-CoV-2 spike receptor-binding domain: An in silico approachSARS-CoV-2 스파이크 수용체 결합 도메인에 대한 잠재적 억제제 식별을 위한 약물 용도 변경: 실리코 접근법Article Published on 2021-01-012022-09-24 Journal: The Indian journal of medical research [Category] 신약개발, [키워드] analysed Analysis angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 antiviral activity antiviral drug antiviral drugs approach AutoDock binding energy carried caused chalcone clinical investigation computational tool coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 therapeutics crystal structure daclatasvir docking dolutegravir domain drug Drug repurposing drug-target interaction drugs effective enzaplatovir enzyme Favipiravir Grazoprevir highest binding affinity in silico in silico Approach Infection information inhibitor Laboratory molecular molecular docking molecular docking analysis molecular dynamics predicted presatovir present Protein RBD RBD of SARS-CoV-2 reactivity Receptor-binding domain Remdesivir reported S protein SARS-CoV-2 SARS-CoV-2 S protein SARS-CoV-2 spike Simeprevir simeprevir. therapeutic efficacy tideglusib was performed [DOI] 10.4103/ijmr.IJMR_1132_20 PMC 바로가기 [Article Type] Article
Lack of Serologic Evidence of Infection Among Health Care Personnel and Other Contacts of First 2 Confirmed Patients With COVID-19 in Illinois, 20202020년 일리노이주에서 처음 2명의 COVID-19 확인된 환자의 의료 종사자 및 기타 접촉자 간의 감염에 대한 혈청학적 증거 부족Article Published on 2021-01-012022-09-11 Journal: Public health reports (Washington, D.C. : 1974) [Category] SARS, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 antibodies antibody Antibody testing Asymptomatic Atypical Care Characteristics collected collected data Community condition Confirmed Contact Contact tracing coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 determine Dilution dilutions eligible enrolled enzyme-linked immunosorbent enzyme-linked immunosorbent assay Epidemiology Evidence evidence of exposure to Follow-up Health Health care Infection initial Interaction medium Other participant Patient Personal protective equipment PPE provided question questionnaire reported respiratory risk SARS-CoV-2 SARS-CoV-2 antibodies SARS-CoV-2 antibody testing SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV-2 spike secondary transmission Seroconversion serologic serologic testing serology serum severe acute respiratory syndrome Coronavirus specimen symptom onset tested Transmission Transmission dynamics virus with COVID-19 [DOI] 10.1177/0033354920966064 PMC 바로가기 [Article Type] Article
PSGL-1 Inhibits the Incorporation of SARS-CoV and SARS-CoV-2 Spike Glycoproteins into Pseudovirions and Impairs Pseudovirus Attachment and InfectivityBrief Report Published on 2020-12-302022-10-28 Journal: Viruses [Category] COVID-19, MERS, SARS, [키워드] antiviral activities attachment bind block Cell Cell migration cellular antiviral factor coronavirus Coronavirus replication Endothelium expression glycoprotein HIV-1 Immune cell impair incorporation Infection Infectivity inflamed tissues inhibit interferon-γ L-selectin P-selectin pseudovirion pseudovirus PSGL-1 restrict SARS-CoV SARS-CoV-2 SARS-CoV-2 spike spike Surface glycoprotein target cells virus-producing cell [DOI] 10.3390/v13010046 PMC 바로가기 [Article Type] Brief Report
Comparison of Four SARS-CoV-2 Neutralization AssaysArticle Published on 2020-12-282022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] antibody binding antibody comparable competent correlated described effective ELISA focus forming assay In vitro assay induce Infection lentiviral Neutralization assay neutralization titers Neutralizing antibodies neutralizing antibody novel coronavirus SARS-CoV-2 Particle Patient produced pseudotype virus pseudotyped Replication robust S-protein SARS-CoV-2 SARS-CoV-2 neutralization SARS-CoV-2 neutralizing antibody SARS-CoV-2 spike TCID titer vaccine candidate variety vesicular stomatitis virus virus [DOI] 10.3390/vaccines9010013 PMC 바로가기 [Article Type] Article
High affinity nanobodies block SARS-CoV-2 spike receptor binding domain interaction with human angiotensin converting enzyme고친화성 나노바디는 SARS-CoV-2 스파이크 수용체 결합 도메인과 인간 안지오텐신 전환 효소의 상호작용을 차단합니다Article Published on 2020-12-222022-09-01 Journal: Scientific Reports [Category] MERS, SARS, 변종, 진단, [키워드] ACE2 angiotensin angiotensin converting enzyme angiotensin converting enzyme 2 antibody fragment approved Biochemistry block COVID-19 pandemic derivative diagnostic Drug development effective enzyme expressing form HEK293 cell HEK293 cells high affinity human ACE2 Infection inhalation Interaction lead lentivirus Medical research nanobodies nanobody nebulization potency Proteins pseudotyped Receptor binding domain responsible SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 spike protein receptor binding domain Spike protein the SARS-CoV-2 the spike protein therapeutic Treatment variant virus [DOI] 10.1038/s41598-020-79036-0 PMC 바로가기 [Article Type] Article
Rapid generation of durable B cell memory to SARS-CoV-2 spike and nucleocapsid proteins in COVID-19 and convalescenceCOVID-19 및 회복기에 SARS-CoV-2 스파이크 및 뉴클레오캡시드 단백질에 대한 내구성 B 세포 메모리의 신속한 생성Reports Published on 2020-12-222022-09-10 Journal: Science Immunology [Category] MERS, SARS, 진단, 치료법, [키워드] antibody antibody levels Antibody Response B cell memory B cells blood sample Blood samples CD27 Cell cells circulating convalescence correlated COVID-19 COVID-19 patient COVID-19 patients cytometric declining determine expressed Flow follicular functional helper T cell IgG1 IgM Immunity immunophenotype Infection long-term immune memory Longevity memory memory B cell memory B cells memory T nucleocapsid protein Nucleocapsid proteins patients Peripheral blood persistence post-symptom onset Rapid RBD RBD-specific IgG Receptor binding domain SARS-COV-2 infection SARS-CoV-2 spike serum antibodies serum antibody serum IgG significantly Spike receptor binding domain symptom onset T cell the SARS-CoV-2 vaccination while [DOI] 10.1126/sciimmunol.abf8891 PMC 바로가기 [Article Type] Reports
Evaluating SARS-CoV-2 Seroconversion Following Relieve of Confinement MeasuresMedicine Published on 2020-12-182022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] Anti-spike Asymptomatic Community diagnosed Efficiency essential worker Evaluating full-length spike protein IgA IgA and IgG IgA antibodies IgG antibodies increase in measure Measures participant pauci/asymptomatic COVID-19 prevalence Portugal positive post-confinement community setting Prevalence provide Registered SARS-CoV-2 SARS-CoV-2 ELISA SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV-2 spike SARS-CoV2 screened serological survey Seroprevalence Serosurvey spike-specific IgG subgroup University of Lisbon [DOI] 10.3389/fmed.2020.603996 PMC 바로가기 [Article Type] Medicine