News from around the RNA world: new avenues in RNA biology, biotechnology and therapeutics from the 2022 SIBBM meetingArticle Published on 2022-10-152022-11-16 Journal: Biology open [Category] 유전자 메커니즘, [키워드] Biology Biophysics cell differentiation cellular Circular circular RNAs Community COVID19 disease DNA Dogma highlighting information International involved Italian modulating Molecular biology National New Non-coding RNAs, microRNAs Pandemics Protein provided RNA RNA therapies. RNAs Rome Society Stress Therapies therapy transcript translational [DOI] 10.1242/bio.059597 PMC 바로가기
As the virus evolves, so too must we: a drug developer’s perspective : We need a new paradigm in searching for next-generation countermeasuresArticle Published on 2022-10-102022-11-15 Journal: Virology Journal [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] addition antibody Antiviral approach cellular immunity COVID19 develop drug drug resistance drugs Effect effective Evolution of SARS-CoV-2 Genetic greater HAD HDTx host-directed antiviral Host-directed therapeutics humoral immune immune evasion in sight infections offer omicron Pandemic countermeasures Perspective plasticity population immunity Quasispecies recombinant reduce risk SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 virus selective severity strain Treatment Vaccine variant variants virus [DOI] 10.1186/s12985-022-01887-y PMC 바로가기
SARS-CoV-2 humoral responses following booster BNT162b2 vaccination in patients with B-cell malignanciesArticle Published on 2022-10-012022-11-15 Journal: American journal of hematology [Category] COVID19(2023년), SARS, 진단, [키워드] active treatment B-cell malignancies B-cell malignancy BNT162b2 BNT162b2 vaccine booster booster dose Comparisons Control COVID19 disease dose elicited ENhance enrolled evaluated healthy controls high-risk population Humoral response immune response leukemia median NAb nAb response NAb titer NAbs NHL Patient patient group patients Prognostic factor proportion Protective response SARS-CoV-2 SARS-CoV-2 neutralizing antibody SARS-CoV-2 vaccination significantly significantly lower Treatment vaccination [DOI] 10.1002/ajh.26669 PMC 바로가기
Pharmacophore screening to identify natural origin compounds to target RNA-dependent RNA polymerase (RdRp) of SARS-CoV2Article Published on 2022-10-012022-11-15 Journal: Molecular diversity [Category] COVID19(2023년), SARS, 치료제, [키워드] 3CLpro Antiviral Antiviral compound binding binding affinity binding energy calculated catalytic Characteristics complex Compound Corona COVID-19 COVID19 database determine docked docking drug examined explicit solvent group HCQ Hydroxychloroquine identify inhibitor initial Interaction investigated medium molecular pharmacophore Pharmacophore screening physiological Poisson produced protease Protein RdRP RdRp protein residue RNA-dependent RNA polymerase SARS-CoV2 SARS-CoV2 inhibitor. screened Spike protein therapeutic therapy trajectory treat treated [DOI] 10.1007/s11030-021-10358-5 PMC 바로가기
Impact of SARS-CoV-2 viral load and duration of symptoms before hospital admission on the mortality of hospitalized COVID-19 patientsArticle Published on 2022-10-012022-11-15 Journal: Infection [Category] COVID19(2023년), SARS, 치료제, [키워드] Admission Analysis antivirals clinical manifestation collected COVID-19 COVID19 Ct value cycle threshold Day Days of symptoms demographic duration of symptom Efficacy evaluate Factor Factors highest Hospital admission hospitalized COVID-19 patient hospitalized patient identify Impact Inclusion laboratory parameter Mortality mortality rate Multivariate analysis Nasopharyngeal swab Patient performed positive predictor reverse transcription rRT-PCR SARS-CoV-2 viral load study population symptoms onset three group Viral load was performed [DOI] 10.1007/s15010-022-01833-8 PMC 바로가기
In silico inquest reveals the efficacy of Cannabis in the treatment of post-Covid-19 related neurodegenerationArticle Published on 2022-10-012023-07-06 Journal: Journal of biomolecular structure & dynamics [Category] COVID19(2023년), [키워드] cannabis COVID19 docking and molecular simulation post-Covid neural degeneration post-Covid symptoms. [DOI] 10.1080/07391102.2021.1905556
Optimized infection control practices augment the robust protective effect of vaccination for ESRD patients during a hemodialysis facility SARS-CoV-2 outbreakArticle Published on 2022-10-012022-11-16 Journal: American journal of infection control [Category] COVID19(2023년), SARS, 변종, [키워드] affected attack Care Cluster complications COVID19 demonstrated diagnosed diagnostic dialysis disease incidence effective Effectiveness effort Epidemiology ESRD Genomics greater help Hemodialysis Infection infection control Infection prevention Intervention measure Measures mitigate morbidity Nosocomial transmission outbreak Patient patients positive protective effect provided receiving reducing risk robust RT-PCR SARS-CoV-2 SARS-CoV-2 antigen SARS-CoV-2 genome sequence SARS-COV-2 infection specimens Support Transmission vaccination Viral epidemiology. Viral genome sequencing while [DOI] 10.1016/j.ajic.2022.06.025 PMC 바로가기
UV-C Light Completely Blocks Aerosol Transmission of Highly Contagious SARS-CoV-2 Variants WA1 and Delta in HamstersArticle Published on 2022-09-062022-11-16 Journal: Environmental science & technology [Category] SARS, 변종, [키워드] activities adhere aerosol block COVID COVID19 Delta effective Effectiveness element hamster individual investigated LIGHT measure Population Prevent prevented reduce risk SARS-CoV-2 SARS-CoV-2 transmission Spread susceptible Syrian Golden hamsters Transmission transmission of SARS-CoV-2 ultraviolet light UV-C virus WA1 wavelength [DOI] 10.1021/acs.est.2c02822 PMC 바로가기
Beyond the vaccines: a glance at the small molecule and peptide-based anti-COVID19 arsenalReview Published on 2022-09-062022-10-04 Journal: Journal of Biomedical Science [Category] SARS, 변종, 신약개발, [키워드] 3CLpro 3CLpro inhibitors accelerated ACE-2 ACE2 antibody anticipated Antiviral effect approach benefit composed Conjugates conserved Coronaviruses COVID-19 COVID-19 pandemic COVID19 drug Drug discovery effort Evidence FDA approval In-vitro inhibitor Medicinal chemistry monoclonal antibodies peptide-based peptides plethora PLPro PLpro inhibitors Predictive model Prevent Proteases Protein pursuit RdRP RdRp inhibitors Replication reported required researcher S protein SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant SARS-CoV-2 variants small molecule small molecule drug Small molecule inhibitors targets therapeutic option TMPRSS2 TMPRSS2 drug repurposing TMPRSS2 inhibitors Treatment vaccination vaccine platform Vaccines viral entry viral replication [DOI] 10.1186/s12929-022-00847-6 PMC 바로가기 [Article Type] Review
Immunology to Immunotherapeutics of SARS-CoV-2: Identification of Immunogenic Epitopes for Vaccine DevelopmentArticle Published on 2022-09-052022-11-16 Journal: Current microbiology [Category] SARS, 유전자 메커니즘, [키워드] adaptive Antigen approach candidate caused Coverage COVID19 cytokine development epitope global public health homology identification immune in silico mechanism pandemic Pathogenesis pathway peptide Protein retrieved SARS-CoV-2 SARS-CoV-2 virus Signaling spike Stage T cell Trial Vaccine vaccine candidates Vaccine development virus [DOI] 10.1007/s00284-022-03003-3 PMC 바로가기