Predictive factors of clinical outcomes in patients with COVID-19 treated with tocilizumab: A monocentric retrospective analysis토실리주맙 치료를 받은 코로나19 환자의 임상 결과 예측 요인: 단일 중심적 후향적 분석Research Article Published on 2022-01-262022-09-12 Journal: PLoS ONE [Category] SARS, 진단, [키워드] Analysis angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme inhibitors association benefit C-reactive protein Characteristics checked Clinical improvement Clinical outcome clinical phenotype clinical phenotypes clinical status clinical variables clinically consecutive patient COVID-19 COVID-19 pneumonia COVID19 patient COVID19 patients defined Descriptive statistics enrolled Evaluating Factor Fisher Follow-up Guidance Hospitalized hypertension identify inhibitors Logistic multivariable model Multivariate analysis null model objective Observational cohort study observational study Ordinal Scale outcome outcomes PaO Patient patients with COVID-19 Pneumonia predictor quantitative variables radiological respiratory rate response to treatment Result retrospective Retrospective analysis selected serological Severe COVID-19 pneumonia significantly status the WHO Tocilizumab treated Treatment was recorded WHO ordinal scale [DOI] 10.1371/journal.pone.0262908 PMC 바로가기 [Article Type] Research Article
Effects of Prone Positioning on Respiratory Mechanics and Oxygenation in Critically Ill Patients With COVID-19 Requiring Venovenous Extracorporeal Membrane OxygenationMedicine Published on 2022-01-172022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] acute respiratory distress acute respiratory distress syndrome (ARDS) alveolar recruitment analyzed ARDS change changes in Compliance condition conditions Continuous data COVID-19 driving Effect evaluated Evolution Extracorporeal extracorporeal membrane oxygenation Ill increase in Mechanical power Mechanics Oxygenation oxygenation index PaO parameter parameters Patient patients patients with COVID-19 performed positioning positive end-expiratory pressure (PEEP) prone prone positioning prone positioning (PP) quartile quartiles remains uncertain respiratory Respiratory mechanics Responder severe ARDS significantly significantly higher significantly increased syndrome venovenous extracorporeal membrane oxygenation VV-ECMO [DOI] 10.3389/fmed.2021.810393 PMC 바로가기 [Article Type] Medicine
Cytokine Hemoadsorption as Rescue Therapy for Critically Ill Patients With SARS-CoV-2 Pneumonia With Severe Respiratory Failure and HypercytokinemiaMedicine Published on 2022-01-102022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] “cytokine storm” acute respiratory distress syndrome (ARDS) All the patient analyzed benefit Berlin C-reactive protein Case series clinical response clinically coronavirus 2019 disease COVID-19 Critically ill patient cytokine cytokine removal D-dimer death dysregulated Europe evaluate failure ferritin Germany hemoadsorption high risk hypercytokinemia ICU identifying IL-6 Ill improvement in-hospital mortality inflammatory biomarkers Inflammatory response intensive care interleukin-6 Invasive mechanical ventilation organ dysfunction Oxygenation PaO pathophysiology Patient plasma Prone position prone positioning reduction in rescue respiratory Respiratory failure Retrospective study SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 pneumonia severe respiratory failure significant difference single center SOFA score Therapies therapy Treatment with COVID-19 [DOI] 10.3389/fmed.2021.779038 PMC 바로가기 [Article Type] Medicine
First and second waves among hospitalised patients with COVID-19 with severe pneumonia: a comparison of 28-day mortality over the 1-year pandemic in a tertiary university hospital in Italy중증 폐렴으로 입원한 COVID-19 환자의 1차 및 2차 유행: 이탈리아의 한 대학병원의 1년 대유행 동안 28일 사망률 비교Observational Study Published on 2022-01-032022-09-11 Journal: BMJ Open [Category] SARS, 변종, 임상, [키워드] 28-day mortality 95% CI 95% CIs age all-cause mortality Analysis circulating cohort study Comorbidity contributed COVID-19 COVID-19 pneumonia Cox regression model death duration of symptom epidemic wave Epidemiology European Factor First wave hospital Hospital admission hospitalised patient Hospitalised patients identify IQR Italy Kaplan-Meier Kaplan-Meier curve log-rank test median median age Modena mortality rate multivariable Cox regression multivariable Cox regression model Observational cohort study pandemic PaO Patient predictor reduced respiratory infections risk of death second wave sensitivity analysis Severe COVID-19 pneumonia severe pneumonia shown Standard suggested survival survival analysis university university hospital variant was performed Wave Waves were used with COVID-19 women [DOI] 10.1136/bmjopen-2021-054069 PMC 바로가기 [Article Type] Observational Study
Sildenafil for treating patients with COVID-19 and perfusion mismatch: a pilot randomized trialRandomized Controlled Trial Published on 2022-01-032022-10-04 Journal: Critical Care [Category] 임상, [키워드] 1:1 abnormality Admission Affect blood gas analysis characterized Computed tomography conducted control group COVID-19 COVID-19 patient Efficacy eligible adult enrolled evaluate Follow-up group hospital Hospital stay Hospitalized hypoperfusion ICU IMV Infection Inpatient intensive care unit intention-to-treat basis intervention group Invasive mechanical ventilation IQR Length of stay lung lung parenchyma mechanical ventilation median median age mortality rates non-invasive ventilation outcome Oxygenation PaO parameter parameters participant Patient patients with COVID-19 performed Placebo placebo-controlled trial Randomized randomized trial Registration Regulation repeated-measures ANOVA required Result SARS-CoV-2 secondary Seven significant difference significantly shorter Sildenafil statistically significant difference Subtraction CT angiography supplementary material the placebo group therapeutic treating COVID-19 Treatment Ventilation–perfusion ratio ventilatory support was performed were excluded [DOI] 10.1186/s13054-021-03885-y PMC 바로가기 [Article Type] Randomized Controlled Trial
Association and predictive value of biomarkers with severe outcomes in hospitalized patients with SARS-CoV-2 infectionSARS-COV-2 감염이있는 입원 환자에서 심각한 결과를 가진 바이오 마커의 연관 및 예측 가치Multicenter Study Published on 2022-01-012022-08-31 Journal: Cytokine [Category] MERS, SARS, 바이오마커, [키워드] Admission Analysis analyzed association Biomarker Biomarkers Blood urea nitrogen Chi-square chi-square tests Coagulation COVID-19 Critical care Cytokines Cytokines and inflammatory mediators D-dimer disease severity Factor frequencies Frequency Growth factors hematological hospitalized patient hyper-inflammation ICU IL-6 IMV in-hospital mortality Inflammation Inflammatory Inflammatory marker inflammatory markers Inflammatory mediators intensive care Invasive mechanical ventilation Kidney function Mann-Whitney U Mechanical mechanical ventilation Mortality multivariable logistic regression Multivariable logistic regression analysis nitrogen outcome outcomes PaO Patient patients hospitalized Platelet Platelet count predict Predictive reduced respiratory Respiratory function risk Risk factors SARS-COV-2 infection suffered the disease urea Ventilation was performed with COVID-19 [DOI] 10.1016/j.cyto.2021.155755 PMC 바로가기 [Article Type] Multicenter Study
High-flow nasal cannula versus noninvasive ventilation in patients with COVID-19: a systematic review and meta-analysisCOVID-19 환자의 고유량 비강 캐뉼러 대 비침습적 환기: 체계적인 검토 및 메타 분석Meta-Analysis Published on 2022-01-012022-09-11 Journal: Therapeutic Advances in Respiratory Disease [Category] 임상, [키워드] Biology China CNKI conducted Controlled trial coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patients database death Disc Effectiveness enrolled followed by fraction group HFNC HFNC therapy High-flow nasal cannula Hospital stay ICU IMPROVE IMV incidence Infrastructure Inhaled intensive care intensive care unit Invasive mechanical ventilation Medicine Meta-analysis nasal nasal cannula nine NIV Noninvasive ventilation Novel coronavirus novel coronavirus disease Occurrence oxygen oxygenation index pandemic PaO partial pressure Patient performed Primary outcome Randomized controlled trial RCT reduction Respiratory Support retrospective Risk of bias secondary outcome Secondary outcomes Seven significantly SinoMed statistically significant systematic review Treatment ventilator-free day Ventilator-free days vision was used Web of Science WHO [DOI] 10.1177/17534666221087847 PMC 바로가기 [Article Type] Meta-Analysis
Efficacy of the early treatment with tocilizumab-hydroxychloroquine and tocilizumab-remdesivir in severe COVID-19 Patients중증 코로나19 환자에서 토실리주맙-히드록시클로로퀸 및 토실리주맙-렘데시비르 조기 치료 효과Randomized Controlled Trial Published on 2022-01-012022-09-12 Journal: Journal of infection and public health [Category] 임상, 진단, 치료제, [키워드] Anti-inflammatory anti-inflammatory drug Antiviral both groups clinical clinical parameter cohort study Combination Complication contributed COVID 19 COVID-19 COVID19 CRP Cytokine storm dimer doses early treatment Effectiveness ferritin groups HCQ Hospitalization Hydroxychloroquine hyper inflammation ICU Infection infused interquartile range IQR laboratory investigation LDH mechanical ventilation mechanically ventilated patient median myocarditis no significant difference P/F PaO Patient PCR Randomized regimen Registered Remdesivir secondary bacterial infection severe COVID-19 significant decrease significantly TCZ Thrombotic events Tocilizumab Treatment treatment groups treatment regimen two group were assessed [DOI] 10.1016/j.jiph.2021.10.024 PMC 바로가기 [Article Type] Randomized Controlled Trial
Tocilizumab improves 28-day survival in hospitalized patients with severe COVID-19: an open label, prospective study토 실리 주맙Research Published on 2021-12-222022-09-01 Journal: Respiratory Research [Category] 진단, [키워드] 28-day mortality 95% CI Administered allocation Analysis Clinical outcome clinical outcomes consecutive patient consecutive patients COVID-19 discharge Efficacy evaluated finding FiO2 hospital discharge hospitalized patient hospitalized patients IMPROVE Mortality open open label outcome outcomes PaO PaO2/FiO2 Patient Primary outcome progression Prospective Study receiving secondary Secondary outcomes severe COVID-19 significant increase significantly higher significantly lower statistically significant difference supplementary material survival systemic inflammatory marker Tocilizumab usual care usual care alone usual care group WHO with COVID-19 [DOI] 10.1186/s12931-021-01914-6 PMC 바로가기 [Article Type] Research
Awake prone position reduces work of breathing in patients with COVID-19 ARDS supported by CPAPResearch Published on 2021-12-202022-10-28 Journal: Annals of Intensive Care [Category] COVID-19, [키워드] acute respiratory distress applied ARDS Awake prone position consecutive patient Continuous Positive Airway Pressure COVID-19 COVID-19-associated ARDS CPAP did not reduce Dyspnea enrolled evaluate the effect Gas exchange Helmet CPAP IMPROVE Inspiratory effort mechanical ventilation median minute ventilation Non-invasive Oxygenation PaO Patient patients with COVID-19 PEEP positive airway pressure presenting prone Prone position reduce reduction in respiratory Result shown Supine position supplementary material supported syndrome transpulmonary pressure Ventilation were recorded Work of breathing [DOI] 10.1186/s13613-021-00967-6 PMC 바로가기 [Article Type] Research