Metalloprotease-Dependent S2′-Activation Promotes Cell-Cell Fusion and Syncytiation of SARS-CoV-2Article Published on 2022-09-212022-11-16 Journal: Viruses [Category] SARS, 변종, [키워드] absence ACE2 ACE2 receptor assays benefit cell-cell fusion Combination contribute contributing to COVID-19 ectodomain Factor fusion in vitro induce inhibitor metalloproteases not reduce observation patients with COVID-19 pharmacological promote reduce SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 spike protein SARS-CoV-2 variant serine protease serine proteases significantly Spike protein syncytiation. the SARS-CoV-2 the spike protein treatment strategy [DOI] 10.3390/v14102094 PMC 바로가기
Proteomics of fibrin amyloid microclots in long COVID/post-acute sequelae of COVID-19 (PASC) shows many entrapped pro-inflammatory molecules that may also contribute to a failed fibrinolytic systemArticle Published on 2022-09-212022-11-15 Journal: Cardiovascular Diabetology [Category] 바이오마커, 유전자 메커니즘, 진단, [키워드] absence addition analysed antibodies Anxiety Biomarker C-reactive protein cardiovascular disease Chronic fatigue circulation Clinicians Cognitive impairment Cohort Comorbidities Confusion contribute controls COVID COVID patient COVID-19 Depression detect disease Dyspnoea Evidence explain Failed fibrinolysis fatigue fibrinogen fibrinolytic system granular Health healthy controls Host immune response IL-6 implication increased risk individual Inflammatory inflammatory markers insoluble Kallikrein Long Long COVID mechanism Microclots PASC pathology Patient PF4 plasma Platelet platelet factor 4 platelet hyperactivation presence of antibody prevalent Prevent pro-inflammatory molecule Protein provided questionnaire reduced reported serum CRP sick Symptom thrombosis type 2 diabetes von Willebrand factor vWF [DOI] 10.1186/s12933-022-01623-4 PMC 바로가기
SARS-CoV-2 Omicron BA.5: Evolving tropism and evasion of potent humoral responses and resistance to clinical immunotherapeutics relative to viral variants of concernArticle Published on 2022-09-182022-10-06 Journal: EBioMedicine [Category] COVID19(2023년), SARS, 변종, 진단, 치료제, [키워드] absence ACE2 acute respiratory syndrome ADK antibody BA.2 BA.5 Beta BNT162b2 breadth Breakthrough infection cell line change circulating clade Clinical effect cohorts contributed convalescent convalescent sera coronavirus COVID-19 COVID-19 hospitalisation Delta development disease severity Donor donors dose foundation Future genetic difference greater humoral Humoral response IgG in vitro isolate Lineage lineages Live virus management monitoring monoclonal antibody mortality rates nafamostat nasopharyngeal sample nasopharyngeal swabs neutralisation neutralisation assay Neutralising Antibodies neutralising antibody New observation of BNT162b2 omicron Omicron BA.1 other variant pathway peak plasma potency recorded reduced reduction reduction in Research response responses SARS-CoV-2 sensitivity significantly Sotrovimab South Spread Support supported tested Testing therapeutic Therapies TMPRSS2 TMPRSS2 inhibitor Transmission utilised vaccination Vaccine variant viral lineage viral variant [DOI] 10.1016/j.ebiom.2022.104270 PMC 바로가기 [Article Type] Article
Substantial impact of mobility restrictions on reducing COVID-19 incidence in Italy in 2020Article Published on 2022-09-172022-11-16 Journal: Journal of Travel Medicine [Category] SARS, 변종, [키워드] absence accompanied adherence Admission affected benefit Cell cell phone China communicable comparable Compliance country COVID-19 COVID-19 incidence COVID-19 pandemic death decrease effective Effects Efficacy eliminated epidemic wave Epidemiology First wave had no Health highest Hospital admissions indicated Infection infections intensive care Italy linear lockdown means of transport Mobility National new SARS-CoV-2 occurred outbreak outcomes peak. reducing reduction reduction in reductions in SARS-CoV-2 Spread study period the mean threshold Transmission dynamics Transport Travel vaccine availability viral variant [DOI] 10.1093/jtm/taac081 PMC 바로가기
Severe Acute Respiratory Syndrome Coronavirus 2 Nucleocapsid Antigen in Urine of Hospitalized Patients With Coronavirus Disease 2019Article Published on 2022-09-132022-11-15 Journal: The Journal of Infectious Diseases [Category] SARS, 진단, 치료기술, [키워드] absence Accuracy acute respiratory syndrome Admission antibodies Blood C-reactive protein Compound coronavirus coronavirus 2 coronavirus disease Course COVID-19 disease severity dissemination early phase hospitalized patient immunoassay Infection intensive care units lactate dehydrogenase lymphopenia marker nucleocapsid nucleocapsid antigen Patient patients hospitalized patients with SARS-CoV-2 plasma polymerase chain positive reflect respiratory SARS-CoV-2 SARS-CoV-2 infections SARS-CoV-2 nucleocapsid severe COVID-19 severity Severity of disease tested urinary Urine [DOI] 10.1093/infdis/jiac073 PMC 바로가기
Modeling the Enzymatic Mechanism of the SARS-CoV-2 RNA-Dependent RNA Polymerase by DFT/MM-MD: An Unusual Active Site Leading to High Replication RatesArticle Published on 2022-09-122022-11-15 Journal: Journal of Chemical Information and Modeling [Category] SARS, 유전자 메커니즘, 치료제, [키워드] absence Activation Antiviral assist cellular compensated computation COVID-19 diffusion duplication Efficiency Enzymes highlight histidine Inclusion infecting Infection lack leading less Lower lysine mechanism modeling nucleotide Pandemics performed polymerase polymerases Rate reactive reactivity Replication replication of SARS-CoV-2 RNA RNA genome RNA viruses RNA-dependent RNA polymerase SARS-CoV-2 genome Site subsequent the SARS-CoV-2 viral genome Viral RNA virus [DOI] 10.1021/acs.jcim.2c00802 PMC 바로가기
Intranasal administration of a single dose of MVA-based vaccine candidates against COVID-19 induced local and systemic immune responses and protects mice from a lethal SARS-CoV-2 infectionArticle Published on 2022-09-122022-11-15 Journal: Frontiers in Immunology [Category] SARS, 변종, 진단, 치료기술, [키워드] absence acute respiratory syndrome Administered administration animal model blocked bronchoalveolar C57BL/6 caused CD4 CD8 coronavirus Coronavirus disease-19 COVID-19 COVID-19 progression current demonstrated effective Efficacy elicited evaluated expressing full-length histopathological IgA antibody IgG immune responses Immunity immunogenic immunogenicity induce intramuscular intranasal intranasal delivery K18-hACE2 transgenic mice Local lung lung lesion lymph nodes mice modified vaccinia virus morbidity and mortality mucosal mucosal immune MVA nasal washe Nasal washes neutralizing antibody parental Prevent pro-inflammatory cytokine PROTECT Protective protective efficacy Protein responses Result S protein SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 transmission SARS-CoV-2 variant SARS-CoV-2 virus SARS-CoV-2-specific immune response serum single dose spleen susceptible systemic immune response systemically T-cell immune response the SARS-CoV-2 Transmission undetectable upper respiratory tract vaccination Vaccine vaccine administration vaccine candidate vaccine candidates vaccine dose virus infection [DOI] 10.3389/fimmu.2022.995235 PMC 바로가기
Efficacy and safety of COVID-19 vaccines: A network meta-analysisArticle Published on 2022-09-012022-11-16 Journal: Journal of evidence-based medicine [Category] meta-analysis, SARS, 변종, [키워드] absence B.1.351 variant clinical trial Community COVID-19 COVID-19 infection COVID-19 vaccines database effective Effectiveness Efficacy effort Human investigated Local Meta-analysis Network meta-analysis nonrandomized pandemic participant Pfizer placebo-controlled clinical trial randomized trial reported required safety profile searched Severe COVID-19 Infection Sinopharm the vaccine threshold trials V-01 vaccination Vaccine variant variants [DOI] 10.1111/jebm.12492 PMC 바로가기
Current management of infantile cataractsReview article Published on 2022-09-012022-10-05 Journal: Survey of Ophthalmology [Category] 비임상, [키워드] absence approach association base benefit Better Cataract Cataracts cause children Complication Contact country current demonstrated description effort Epidemiological study etiology Evolution eyes Guidance healthy highlight IMPROVE infancy Infant Infantile cataract less management Molecular genetics morphology nystagmus outcome outcomes patients performed Prevalence Prognostic value recent Research surgical therapy treatable visual impairment while [DOI] 10.1016/j.survophthal.2022.03.005 [Article Type] Review article
Long COVID symptoms in SARS-CoV-2-positive children aged 0-14 years and matched controls in Denmark (LongCOVIDKidsDK): a national, cross-sectional studyArticle Published on 2022-09-012022-10-04 Journal: The Lancet. Child & adolescent health [Category] COVID19(2023년), SARS, 임상, [키워드] absence acute phase age age and sex children clinically clinics conducted Control control group controls COVID cross-sectional defined Denmark Descriptive statistics develop difference emotional female foundation greater had more Health Hedge higher odd infected with SARS-CoV-2 intensity inventory IQR life Logistic regression analysis Long long-lasting male median mother National Older outcome PCR test positive Prevalence prevalent Psychological Quality Quality of life question Registered response SARS-COV-2 infection SARS-CoV-2 test sick Somatic statistically significant Symptom Symptoms were used [DOI] 10.1016/S2352-4642(22)00154-7 PMC 바로가기 [Article Type] Article