In Silico Analysis of the Effects of Omicron Spike Amino Acid Changes on the Interactions with Human Proteins인간 단백질과의 상호 작용에 대한 오미크론 스파이크 아미노산 변화의 효과에 대한 실리코 분석Article Published on 2022-07-282022-09-11 Journal: Molecules [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] 3D structure acid adopted affected Amino acid amino acid change amino acid changes among others Analysis antibodies antibody applied approach can be used change characterized complexes comprehensive analysis detectability Effect Epidemiology Human Interaction Mutation omicron other variants predict predicted Protein protein variants protein–protein interactions resolved SARS-CoV-2 SARS-CoV-2 spike protein SARS-CoV-2 variant selected spike spike glycoprotein Spike protein Transmissibility [DOI] 10.3390/molecules27154827 PMC 바로가기 [Article Type] Article
A Hybrid Epidemic Model to Explore Stochasticity in COVID-19 DynamicsCOVID-19 역학에서 확률을 탐색하기 위한 하이브리드 전염병 모델Article Published on 2022-07-202022-09-11 Journal: Bulletin of Mathematical Biology [Category] COVID19(2023년), SARS, 치료기술, [키워드] adopted approaches Canada Clinical data confirmed case contributed COVID-19 COVID-19 outbreak COVID-19 pandemic death death rates determine differential equation disease disease transmission Dynamics e parameters Environmental variability Face masks hybrid Impact initiated Measures Model outbreak parameter Parameter estimation Probability public health Public health intervention Public health interventions reducing severity of COVID-19 shown silent Silent spreader social distancing Stage stochastic Stochastic models. subpopulations Symptom symptomatic Transmission transmission rate transmission rates USA Variability virus [DOI] 10.1007/s11538-022-01030-6 PMC 바로가기 [Article Type] Article
Applying the RE-AIM framework to evaluate a holistic caregiver-centric hospital-to-home programme: a feasibility study on Carer MattersArticle Published on 2022-07-192022-10-05 Journal: BMC health services research [Category] 임상, [키워드] addressed adopted adoption affecting Applying approach Care Caregiver caregiver burden Caregiver stress Caregiving clinician collected Community condition conducted Course courses disease ecosystem effective emotional enrolled evaluate family feasibility Feasibility study highlight hospital implementation Implementation science initial involved Isolation knowledge maintenance majority matter Nurses Older pandemic Person Person-centered care. Perspective Prolonged provided qualitative data Quantitative data recipients recruitment reduced reported resource resources screened Singapore Stress Support was collected were given [DOI] 10.1186/s12913-022-08317-3 PMC 바로가기 [Article Type] Article
Novel Engineered SARS-CoV-2 HR1 Trimer Exhibits Improved Potency and Broad-Spectrum Activity against SARS-CoV-2 and Its Variants신규 설계된 SARS-CoV-2 HR1 삼량체, SARS-CoV-2 및 그 변이체에 대해 향상된 효능 및 광범위한 활성을 나타냄Article Published on 2022-07-132022-09-11 Journal: Journal of Virology [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] activities activity adopted affinity antibodies binding affinity C terminus caused cell-cell fusion develop domain effective Effectiveness foldon foundation fusing fusion fusion inhibitor global public health HR1 HR1 domain Improved increased the risk information inhibit inhibit SARS-CoV-2 inhibitor inhibitors inhibitory inhibitory activity limit MERS MERS-CoV MERS-CoV pseudoviruses motif much higher Multiple NAbs Neutralizing antibodies neutralizing antibody novel pandemic of COVID-19 peptide Peptide inhibitor Peptide Inhibitors peptides potency provide pseudoviruses reported S protein SARS-CoV SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant SARS-CoV-2 variants shown significantly Spread the S protein the SARS-CoV-2 theory treating SARS-CoV-2 infection trimer trimeric Vaccine variants viral infection viral S protein viral variant Viral variants VOCs [DOI] 10.1128/jvi.00681-22 PMC 바로가기 [Article Type] Article
The Cellular Characterization of SARS-CoV-2 Spike Protein in Virus-Infected Cells Using the Receptor Binding Domain Binding Specific Human Monoclonal Antibodies수용체 결합 도메인 결합 특이적 인간 단일클론 항체를 사용하여 바이러스에 감염된 세포에서 SARS-CoV-2 스파이크 단백질의 세포 특성화Article Published on 2022-07-132022-09-11 Journal: Journal of Virology [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] adopted antibody appearance appears attachment B cell B cells biological properties biological property can be used Cell cell-to-cell transmission characterization conformation conformational change convalescent COVID-19 patient convalescent COVID-19 patients convalescent patient convalescent patient serum Convalescent patients cytoplasmic demonstrated early stage early stages electron microscopy epitope Epitopes Evidence exhibited FIVE focus furin future therapeutic Golgi complex host cell Human human monoclonal antibodies Human monoclonal antibody immunofluorescence microscopy immunological indicated infected cells infected with SARS-CoV-2 Infection Interaction isolate isolates Microscopy mitigate MONITOR monoclonal new virus occur offer Protein provided RBD reagent Receptor binding domain receptor binding domain (RBD) recognize required S protein S protein cleavage S protein RBD SARS- CoV-2 SARS-CoV-2 SARS-CoV-2 clinical isolates SARS-CoV-2 spike SARS-CoV-2-infected cell SARS-CoV-2-infected cells Singapore Specific spike staining the RBD the S protein therapeutic These data Transmission Vaccine variant virus infection virus particles virus-infected cell virus-infected cells was used were used while [DOI] 10.1128/jvi.00455-22 PMC 바로가기 [Article Type] Article
Improvements of Physical Activity Performance and Motivation in Adult Men through Augmented Reality Approach: A Randomized Controlled TrialRandomized Controlled Trial Published on 2022-07-092022-10-05 Journal: Journal of Environmental and Public Health [Category] 임상, [키워드] activity adopted ANOVA ART can be used change control group Controlled COVID-19 pandemic effective Efficacy enrolled group groups healthy highest IMPROVE improvement increase in Intervention intrinsic lockdown men motivation Muscle strength outcome pandemic performance physical physical activity Physical inactivity Prevalence Randomized randomly divided REALITY receiving Research Result significantly Social distancing measure suggested t -test therapy Trial was used were used [DOI] 10.1155/2022/3050424 PMC 바로가기 [Article Type] Randomized Controlled Trial
Modeling transmission of SARS-CoV-2 Omicron in China중국 SARS-CoV-2 Omicron 전파 모델링Article Published on 2022-07-012022-09-11 Journal: Nature Medicine [Category] COVID19(2023년), SARS, 변종, 치료법, 치료제, [키워드] Accessibility adopted antiviral therapies antiviral therapy calibrated China Clinical endpoints Coverage COVID-19 Critical care deaths debate Disruption Efficacy Epidemic Factor growth Growth phase Healthcare system Hospitalization hypothetical Immunity implementation individual initial intensive care modeling nonpharmaceutical intervention Nonpharmaceutical interventions omicron outbreak Patient Prevent respond SARS-CoV-2 transmission SARS-CoV-2 variant SARS-CoV-2 variants Shanghai Transmissibility transmission of SARS-CoV-2 vaccination Vaccine vaccine efficacy [DOI] 10.1038/s41591-022-01855-7 PMC 바로가기 [Article Type] Article
Prospect of acute hepatitis E virus outbreak in the context of the COVID-19 Pandemic in Africa: A contingency planShort communication Published on 2022-07-012022-10-05 Journal: Annals of Medicine and Surgery [Category] 진단, 치료제, [키워드] adopted affected Africa approach concerning Coronavirus disease-19 country COVID-19 COVID-19 pandemic Healthcare system Hepatitis hepatitis E hepatitis E virus hygiene Infection Local low-income countries Measures mitigate National outbreak SSA sub-Saharan Africa Support susceptibility transmitted Viral hepatitis Virology virus [DOI] 10.1016/j.amsu.2022.104084 [Article Type] Short communication
Receptor-Binding-Motif-Targeted Sanger Sequencing: a Quick and Cost-Effective Strategy for Molecular Surveillance of SARS-CoV-2 Variants수용체 결합 모티브 표적 생어 시퀀싱: SARS-CoV-2 변이체의 분자 감시를 위한 빠르고 비용 효율적인 전략Article Published on 2022-06-292022-09-11 Journal: Microbiology Spectrum [Category] Coronavirus, COVID19(2023년), SARS, 변종, 치료법, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adopted aligned Alpha Alpha variant B.1.1.529 B.1.1.7 B.1.617.2 causative agent changes in CLC Clinical use coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 pandemic Critical death Delta delta variant develop disease spread Genome gold gold standard Infection involved Lineage lineages modifications molecular mutate Mutation mutations nasal nasal swab nasal swabs nucleocapsid omicron Omicron variant Omicron variants pandemic prevalent Prevent public health receptor-binding motif Receptor-binding motif (RBM) resource Saliva Sanger sequencing SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants sequence sequences Sequencing severe acute respiratory syndrome Coronavirus Spike protein Spread Strategy Surveillance swab samples the disease variant variant surveillance. variants WGS whole-genome sequencing [DOI] 10.1128/spectrum.00665-22 PMC 바로가기 [Article Type] Article
Exposing and Overcoming Limitations of Clinical Laboratory Tests in COVID-19 by Adding Immunological Parameters; A Retrospective Cohort Analysis and Pilot Study면역학적 매개변수를 추가하여 COVID-19에서 임상 실험실 테스트의 한계를 노출하고 극복합니다. 후향적 코호트 분석 및 파일럿 연구Article Published on 2022-06-292022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 바이오마커, [키워드] acute phase acute phase reactants Adding adopted age Alanine alanine aminotransferase Algorithm Analysis aspartate Aspartate aminotransferase association Barcelona best Biomarker C-reactive protein category CCL2 chemokines classical clinical clinical and laboratory variables clinical laboratories clinical laboratory clinical laboratory tests Clinical management clinical parameter Clinical parameters clinical variable clinical variables Cohort collected Comorbidity conducted COVID 19 patient COVID 19 patients COVID-19 COVID-19 pandemic COVID-19 patient CXCL10 cytokine Cytokines exploratory feasible fibrinogen filtration rate First wave flow cytometry fraction glomerular filtration rate IL-1ra IL-6 immune response immunological Immunological test immunological tests IMPROVE independent Inflammation Interpretation Laboratory Laboratory test Laboratory tests limitation lymphocyte neutrophil organ organ damage outcome overcome oxygen oxygen saturation pandemic patients performed phenotype pilot study Predictive predictive power predictive risk-profile. predictor Prognosis redundancy reflected SARS-CoV-2 SARS-COV-2 infection severity statistical statistical analysis survival Test two subgroup two subgroups understanding validation cohort validation cohorts variable [DOI] 10.3389/fimmu.2022.902837 PMC 바로가기 [Article Type] Article