A year in pharmacology: new drugs approved by the US Food and Drug Administration in 2021약리학의 1년: 2021년 미국 식품의약국 승인 신약Review Published on 2022-08-012022-09-11 Journal: Naunyn-Schmiedeberg's Archives of Pharmacology [Category] 신약개발, 유전자 메커니즘, [키워드] aducanumab adverse effect antibody approval approvals approved Cancer cancers class contrary COVID-19 pandemic disease drug drugs Effects Evidence evidence of FDA First-in-class First-in-indication followed by food genetic alterations had no identify indication Innovation molecular mechanism New New drugs Next Next-in-class. small molecule Small molecules target Treatment US Food and Drug Administration [DOI] 10.1007/s00210-022-02250-2 PMC 바로가기 [Article Type] Review
Reverse vaccinology approach for multi-epitope centered vaccine design against delta variant of the SARS-CoV-2Article Published on 2022-08-012022-11-16 Journal: Environmental science and pollution research inter [Category] COVID19(2023년), SARS, 변종, [키워드] addition adverse effect Alpha applied approach Asia B-cell chimeric Chimeric vaccine conserved contagious COVID-19 COVID-19 infection COVID-19 outbreak CTL epitope Delta delta variant docking Efficacy effort elicit Epitopes expression faster globe highly antigenic HLA HTL humoral immune response Immune simulation impacted in silico India induce infective Multi-epitope vaccine Mutation non-allergenic other variant Protein reported reverse vaccinology SARS-CoV-2 South spike Spike protein the SARS-CoV-2 the spike protein TLR4 transmission rate USA Vaccine vaccine construct Vaccine design Vaccines variant variants of concern variants of SARS-CoV-2 was performed Wuhan, China [DOI] 10.1007/s11356-022-19979-1 PMC 바로가기
Anxiety disorders, COVID-19 fear, and vaccine hesitancyResearch article Published on 2022-08-012022-10-05 Journal: Journal of anxiety disorders [Category] 진단, [키워드] adverse effect Anxiety Anxiety Disorder anxiety disorders coronavirus COVID-19 COVID-19 vaccine development disorders Effectiveness Efficacy examined Factor greater group groups Influenza less not differ predict predictor Prevent PROTECT reducing the vaccine Vaccine Vaccine hesitancy Vaccines [DOI] 10.1016/j.janxdis.2022.102598 [Article Type] Research article
Unilateral optic neuritis after vaccination against the coronavirus disease: two case reports코로나바이러스 백신 접종 후 편측성 시신경염: 2건의 보고Case Reports Published on 2022-08-012022-09-12 Journal: Documenta ophthalmologica. Advances in ophthalmolo [Category] MERS, 진단, [키워드] adverse effect analyzed antibody Case report China clinical history coronavirus coronavirus disease country COVID-19 COVID-19 vaccination COVID-19 vaccine described Female patients first dose glycoprotein group immunization individual intravenous methylprednisolone manifestation MOG one patient Optic neuritis Patient positive pulse receiving reported second dose Sinopharm the timing therapy treated Treatment Two patient Unilateral vaccination vaccination against COVID-19 Vaccine visual acuity [DOI] 10.1007/s10633-022-09880-0 PMC 바로가기 [Article Type] Case Reports
Non-steroidal anti-inflammatory drugs in the era of the Covid-19 pandemic in the context of the human and the environmentReview article Published on 2022-08-012022-10-05 Journal: The Science of the total environment [Category] COVID19(2023년), SARS, 치료제, [키워드] adverse effect affected analysed Analysis anti-inflammatory drug Concentration conducted COVID-19 epidemic drug Effect Epidemic Google Scholar indicate Infection information item non-steroidal anti-inflammatory drug NSAIDS Organisms pandemic peer-reviewed Pollution positive PROTECT Reporting review SARS-CoV-2 SARS-COV-2 infection successive wave Symptom the epidemic Topic Toxicity Treatment virus Web WoS [DOI] 10.1016/j.scitotenv.2022.155317 [Article Type] Review article
A multidisciplinary effort to increase COVID-19 vaccination among the older adults노년층의 코로나19 예방접종 확대를 위한 다학제적 노력Article Published on 2022-08-012022-09-11 Journal: Frontiers in Public Health [Category] 변종, [키워드] addressed Adults adverse effect analyzed approach case study clinics Cluster Community COVE COVID-19 COVID-19 vaccination COVID-19 vaccine Data analysis dose effort elderly expressed facilitated healthcare worker Healthcare workers implementation information initiated Intention morbidity and mortality multidisciplinary team Older older adult Phase 1 Phase I primary care reduce reported risk of infection significantly Singapore SMS the vaccine vaccinate vaccination vaccination appointment vaccination appointments Vaccination program Vaccine Vaccine hesitancy vaccine promotion variants of concern Volunteer [DOI] 10.3389/fpubh.2022.904161 PMC 바로가기 [Article Type] Article
Nanoparticles in the diagnosis and treatment of vascular aging and related diseases Reviews Published on 2022-07-112022-10-05 Journal: Signal Transduction and Targeted Therapy [Category] 바이오마커, [키워드] advance adverse effect alteration cardiovascular diseases cellular cellular senescence cerebrovascular diseases chronic kidney diseases Diagnosis diagnostic disease Diseases Epigenetic events function knowledge less limitation mitochondrial dysfunction molecular Multiple nanoparticle Occurrence oxidative stress Phenotypes Prognosis structures therapeutic tissues Treatment Vascular vascular inflammation vasculature [DOI] 10.1038/s41392-022-01082-z [Article Type] Reviews
Bone Marrow-Derived Mesenchymal Stromal Cell Therapy in Severe COVID-19: Preliminary Results of a Phase I/II Clinical TrialClinical Trial Published on 2022-07-042022-10-04 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 임상, [키워드] acute respiratory distress acute respiratory distress syndrome adverse effect ARDS bone Bone marrow cells cellular cellular therapy clinical Cohort control patient control patients COVID-19 COVID-19 disease Critical D-dimer value Dexamethasone Efficacy Endocarditis evaluate extracorporeal membrane oxygenation group high mortality High-flow nasal oxygen Immune cell Immune-mediated induce Inflammation Inflammatory response intensive care intensive care unit (ICU) interval intravenous infusion invasive Invasive mechanical ventilation limit mechanical ventilation median Mesenchymal stromal cells MSC MSC-treated MSCs nasal no significant difference observation outcome oxygen Patient patients phase phenotype Randomized controlled trial Regulatory reported required requiring supplemental oxygen Result Safe SARS-CoV-2 severe COVID-19 significantly higher significantly lower Statistical tests stimulate stroke stromal cell survival syndrome therapy tissue repair treated Trial [DOI] 10.3389/fimmu.2022.932360 PMC 바로가기 [Article Type] Clinical Trial
Response to PEEP in COVID-19 ARDS patients with and without extracorporeal membrane oxygenation. A multicenter case-control computed tomography studyObservational Study Published on 2022-07-022022-10-04 Journal: Critical Care [Category] 임상, [키워드] adverse effect alveolar appear ARDS ARDS patients benefit Case-control case-control study Computed tomography conducted COVID-19 COVID-19 ARDS patient ECMO extracorporeal membrane oxygenation fraction greater logarithm lung lung collapse Lung recruitability median moderate multicenter not significantly different Patient patients PEEP PEEP. Pneumonia Recruitability recruitment required response severe ARDS severe COVID-19 patient significantly significantly higher significantly lower Total variations [DOI] 10.1186/s13054-022-04076-z PMC 바로가기 [Article Type] Observational Study
Heart-lung interactions in COVID-19: prognostic impact and usefulness of bedside echocardiography for monitoring of the right ventricle involvementCOVID-19의 심장-폐 상호작용: 우심실 침범 모니터링을 위한 병상 심장 초음파의 예후 영향 및 유용성Review Published on 2022-07-012022-09-11 Journal: Heart failure reviews [Category] COVID19(2023년), SARS, 치료기술, [키워드] addition adverse effect Afterload appear avoidance circulation Clinical deterioration contribute COVID-19 Critically ill critically ill patients dysfunction echocardiography extracorporeal membrane oxygenation facilitate heart heart failure Heart–lung interaction hemodynamic instability high mortality high risk hospitalized COVID-19 patient hospitalized COVID-19 patients hospitalized patient hospitalized patients Hypoxemia IMPROVE increase in Interaction involved limit Limited management mechanical ventilation medication optimization outcome pathophysiologic Patient patient survival patients with COVID-19 pressure overload prognostic progression pulmonary pulmonary circulation pulmonary vascular resistance Pulmonary vessel thrombosis reducing Respiratory failure right heart failure right ventricle RV dysfunction SARS-COV-2 infection severe COVID-19 small vessel the SARS-CoV-2 thrombosis thrombotic thrombotic microangiopathy tissue damage transthoracic echocardiography Treatment TTE Vascular Vascular resistance ventricular vessel widespread [DOI] 10.1007/s10741-021-10108-7 PMC 바로가기 [Article Type] Review