The Extracts of Polygonum cuspidatum Root and Rhizome Block the Entry of SARS-CoV-2 Wild-Type and Omicron Pseudotyped Viruses via Inhibition of the S-Protein and 3CL ProteasePolygonum cuspidatum 뿌리 및 뿌리 줄기 추출물은 S-단백질 및 3CL 프로테아제의 억제를 통해 SARS-CoV-2 야생형 및 오미크론 의사형 바이러스의 진입을 차단합니다Article Published on 2022-06-132022-09-11 Journal: Molecules [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] 3CL ACE2 angiotensin Angiotensin-converting enzyme Anti-viral block blocked caused Chinese Compound contagious COVID-19 develop disease effective Efficacy Ethanol Extract fibroblast fibroblasts gallic acid herbal medicine Infection inhibit inhibition Interaction omicron Omicron variant pandemic pharmacological treatment phytochemical Polygoni Cuspidati Rhizoma et Radix Polygonum Protease activity Pseudotyped virus pseudovirus pseudovirus entry Radix receptor responsible resulting rhizome root S-protein SARS-CoV-2 SARS-CoV-2 pseudotyped virus SARS-CoV-2 virus shown Spike protein tested the SARS-CoV-2 the SARS-CoV-2 virus the spike protein Traditional Chinese medicine Treatment Vaccines water wild-type zebrafish zebrafish larvae. [DOI] 10.3390/molecules27123806 PMC 바로가기 [Article Type] Article
Baricitinib in hospitalised patients with COVID-19: A meta-analysis of randomised controlled trialsResearch article Published on 2022-06-032022-10-05 Journal: EClinicalMedicine [Category] 임상, [키워드] 28-day mortality 95% CI Analysis Anti-inflammatory Anti-viral Baricitinib COVID COVID19 database death Dexamethasone discharge disease duration of hospitalisation ECMO Efficacy finding funding hospitalised patient improved mortality IMV inhibitor Invasive mechanical ventilation Jak Janus kinase Janus kinase inhibitors Meta-analysis outcome patients patients with COVID-19 performed positive pressure ventilation progression PROSPERO database random-effects model randomised controlled trial RCT reduce mortality reduced Registered Respiratory failure searched severe disease shown Standard of care Standard therapy statistically significant statistically significant reduction Tocilizumab Treatment with COVID-19 [DOI] 10.1016/j.eclinm.2022.101489 [Article Type] Research article
Anti-inflammatory response of cardamom extract and prediction of therapeutic window in COVID-19 patients by assessing inflammatory markers using RT-PCRRT-PCR을 사용한 염증 마커를 평가함으로써 COVID-19 환자에서 카 다몬 추출물의 항 염증 반응 및 치료 창의 예측Article Published on 2022-06-012022-08-31 Journal: Inflammopharmacology [Category] COVID19(2023년), MERS, SARS, 진단, 치료제, [키워드] addition alternative Anti-inflammatory anti-inflammatory action anti-inflammatory response Anti-viral association attending physician Awareness breathlessness can not Cardamom Clinical improvement Clinical practice clinician control group cough Course COVID-19 COVID-19 patient COVID-19 patients COVID-19 symptom COVID-19 symptoms CRP Ct values cycle threshold cytokine Cytokine storm dawn Diagnostic method diagnostic test diagnostic tests disease Disease progression dosage dose effective elevated end point enrolled Fever FORTE gene expression profile hospital IL-10 IL-6 India indicate Inflammation Inflammatory marker inflammatory markers inflammatory parameter intake Intervention lack LDH majority material molecular diagnostics morbidity morbidity and mortality multiplex negativity normalized onset of symptom outcome parameter Patient patients PCR test performed popularity potentiality predict Prednisolone prevalent Prognosis protein level provide reason for reducing reported RT-PCR RT-PCR analysis RT-PCR assay RT-PCR test SARS-CoV-2 SARS-CoV-2 RT-PCR SARS-CoV-2 RT-PCR test serum Serum IL-6 sore throat Standard of care standard treatment Steroids Symptom Tablet tested the cytokine storm the patient therapeutic window time TNF- α Treatment treatment arm treatment group were given worsening [DOI] 10.1007/s10787-022-00951-x PMC 바로가기 [Article Type] Article
Antibody and T cell responses to COVID-19 vaccination in patients receiving anticancer therapies항암치료를 받는 환자의 코로나19 백신접종에 대한 항체 및 T세포 반응Article Published on 2022-06-012022-09-11 Journal: Journal for immunotherapy of cancer [Category] COVID19(2023년), MERS, SARS, 바이오마커, 변종, 진단, 치료기술, 치료제, [키워드] active treatment adrenal crisis Adrenal insufficiency Affect Anti-CD20 antibodies Anti-CD20 antibody Anti-viral antibodies antibody antibody formation Antibody titer Antibody titers Anticancer therapy B cells B-cell B.1.617.2 blockade Cancer CD4 CD8 Cell cellular Chemoimmunotherapy Chemotherapy Corticosteroids COVID-19 COVID-19 infection COVID-19 infections COVID-19 vaccination COVID-19 vaccinations COVID-19 vaccine trials cross-reactive cytokine detectable develop dose doses effector cells Endocrine expressed follicular generate healthy donor healthy donors helper cells Humoral response hypoadrenalism Hypothesis IgG antibody titer immune Immunocompromised immunogenic immunogenicity immunogenicity, vaccine Immunotherapy intracellular cytokine staining Lymphocytes mRNA vaccine Multiple myeloma Myeloma n=36 no differences oncology patients Participants Patient Patients with cancer PD-1 peptide peptides Phase 3 profile Prophylactic RBD reactivity receiving Receptor binding domain Safe seronegative seronegative patient Side effect solid tumors spike Spike protein steroid Steroids Stress symptomatic T cell T cell response T cell responses T cells T follicular helper cells T-lymphocytes targeted therapy the SARS-CoV-2 therapy Treatment treatment groups tumors Two patient two patients vaccination Vaccinations Vaccine variant spike was measured were assessed were excluded wild-type WT spike [DOI] 10.1136/jitc-2022-004766 PMC 바로가기 [Article Type] Article
Early Th2 inflammation in the upper respiratory mucosa as a predictor of severe COVID-19 and modulation by early treatment with inhaled corticosteroids: a mechanistic analysis중증 COVID-19의 예측인자로서 상부 호흡기 점막의 초기 Th2 염증 및 흡입 코르티코스테로이드 조기 치료에 의한 조절: 기계론적 분석Clinical Trial Published on 2022-06-012022-09-11 Journal: The Lancet. Respiratory Medicine [Category] COVID19(2023년), SARS, 바이오마커, 신약개발, 임상, 치료법, 치료제, [키워드] 1:1 adaptive airway Analysis Anti-viral antipyretics assigned AstraZeneca Biomarker Blood blood sample Blood samples Budesonide CCL17 chemokine clinical benefit clinical symptom clinical trial clinically Cohort collected Concentration Corticosteroid Course COVID-19 COVID-19 disease COVID-19 disease course Data collection decrease deteriorate dose early treatment Efficacy elevated enzyme eosinophil epithelial epithelial lining Evolution experimental analysis healthy controls healthy individuals IL-33 immunoassay individual Inflammation Inflammatory Inflammatory mediators Inflammatory response Inhaled inhaled budesonide inhaled corticosteroid initial interferon interferon response interleukin Intervention investigated Ligand marker mechanism Meso Scale Discovery modulated modulation mucosa mucosal nasal Nasal sample nasal samples Necrosis negative control nose Observational data open label outcomes over Oxford parallel group participant Patient patients with SARS-CoV-2 Phase 2 Primary outcome Proteins randomisation randomised Randomly receive recruited reducing Registered respiratory tract SARS-COV-2 infection severe COVID-19 severe COVID-19 disease shown systemic inflammation T-cell Response Th2 the SARS-CoV-2 Treatment Trial tumour necrosis factor tumour necrosis factor-α twice a day University of Oxford upper respiratory usual care usual care group was collected were assessed were used Whole blood with COVID-19 [DOI] 10.1016/S2213-2600(22)00002-9 PMC 바로가기 [Article Type] Clinical Trial
SARS-CoV-2 infections in mRNA vaccinated individuals are biased for viruses encoding spike E484K and associated with reduced infectious virus loads that correlate with respiratory antiviral IgG levelsmRNA 백신을 접종한 개인의 SARS-CoV-2 감염은 스파이크 E484K를 인코딩하는 바이러스에 대해 편향되어 있으며 호흡기 항바이러스성 IgG 수준과 상관관계가 있는 감소된 감염성 바이러스 부하와 관련이 있습니다.Article Published on 2022-06-012022-09-11 Journal: Journal of Clinical Virology [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료제, [키워드] A significant reduction accompanied Alpha Alpha variant Amino acid Analysis Anti-viral Antiviral association B.1.1.7 B.1.526 BNT162b2 Breakthrough infection breakthrough infections caused Cell culture change Cohort collected COVID-19 cycle threshold dose E484K early phase ELISA examined Genome ICU admission IgG IgG level IgG levels immunization increase in Infectious virus investigated Lineage Moderna molecular Mortality mRNA mRNA-1273 PCR Pfizer-BioNTech positive positive sample Positive test predominant Protein reduce reduced required respiratory respiratory sample Respiratory samples Sample SARS-CoV-2 SARS-CoV-2 IgG antibody SARS-COV-2 infection SARS-CoV-2 positive patient sequenced Sequencing specimen specimens spike Spike protein symptomatic infection symptomatic infections upper respiratory tract vaccinated individual vaccinated individuals vaccination Vaccines variant Viral Viral load viral loads viral variant virus were used whole genome [DOI] 10.1016/j.jcv.2022.105151 PMC 바로가기 [Article Type] Article
The role of statin therapy in COVID-19Editorial Published on 2022-06-012023-07-09 Journal: Expert review of cardiovascular therapy [Category] COVID19(2023년), [키워드] Anti-viral COVID-19 SARS-CoV-2 statins therapy [DOI] 10.1080/14779072.2022.2081548 [Article Type] Editorial
Recurrent SARS-CoV-2 Infection and Impaired Immunologic Response in a Pediatric Oncologic Patient While Treated With Radiochemotherapy방사선화학요법을 받는 동안 소아 종양 환자의 재발성 SARS-CoV-2 감염 및 면역학적 반응 손상Case Reports Published on 2022-06-012022-09-12 Journal: The Pediatric Infectious Disease Journal [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] acute respiratory syndrome affected analyzed Anti-viral coronavirus IgG levels Immunologic Impaired Infection Intensive malignant disease Pediatric patient Recurrent response responses SARS-CoV-2 SARS-COV-2 infection T-cell therapy while [DOI] 10.1097/INF.0000000000003515 PMC 바로가기 [Article Type] Case Reports
Immune response in COVID-19: what is next? Reviews Published on 2022-05-172022-10-05 Journal: Cell Death and Differentiation [Category] COVID19(2023년), SARS, 바이오마커, 변종, 임상, [키워드] administration alteration Anti-viral antibody cellular immunity compared and analyzed coronavirus disease COVID-19 COVID-19 pandemic disease manifestation effective elicit global pandemic Humoral immunity immune response Immunity Impact Inflammation innate immune response medication Neutrophil extracellular traps predict public health measures Regulation SARS-COV-2 infection therapeutic strategy unique Vaccine virus mutation [DOI] 10.1038/s41418-022-01015-x [Article Type] Reviews
Molecular docking analysis reveals the functional inhibitory effect of Genistein and Quercetin on TMPRSS2: SARS-COV-2 cell entry facilitator spike protein분자 도킹 분석을 통해 TMPRSS2: SARS-COV-2 세포 진입 촉진제 스파이크 단백질에 대한 제니스테인 및 퀘르세틴의 기능적 억제 효과가 나타남Article Published on 2022-05-162022-09-11 Journal: BMC Bioinformatics [Category] COVID19(2023년), SARS, 치료제, [키워드] active site Analysis Anti-viral binding binding affinity binding free energy binding pocket Bioinformatics tools catalytic catalytic site cell entry Combination complex Compound compounds conformational coronavirus spike protein Critical docked docking docking analysis dynamic Efficacy exhibit form free energy functional Genistein host cell human cell hydrogen Hydrogen bond hydrophilic hydrophobic identify Infection inhibit inhibitory effect Innate immunity Interaction Medicines molecular docking molecular docking analysis molecular dynamic simulations molecular dynamics Molecular dynamics simulation performed Phyto compounds Prevent priming Protein proteolytic cleavage quercetin receptor ACE2 reduce residue reveal SARS-CoV-2 coronavirus SARS-COV-2 infection Schrodinger screened selected Serine serine protease Simulation Spike protein stable complex subsequent target target protein the spike protein therapeutic target TMPRSS TMPRSS2 transmembrane glycoprotein transmembrane serine protease transmembrane serine protease 2 type I type I transmembrane glycoprotein Vaccine virus weak interaction [DOI] 10.1186/s12859-022-04724-9 PMC 바로가기 [Article Type] Article