Novel Functions of IFI44L as a Feedback Regulator of Host Antiviral ResponsesArticle Published on 2019-08-212023-08-30 Journal: Journal of Virology [Category] E형 간염, [키워드] antiviral responses FKBP5 IκBα phosphorylation IFI44L IKK kinase activity IKKβ kinase activity IKKε kinase activity Innate immunity interferon-induced protein IRF-3 phosphorylation signaling transduction type I and III interferon responses [DOI] 10.1128/JVI.01159-19 PMC 바로가기
Interferon Regulatory Factor 3-Mediated Signaling Limits Middle-East Respiratory Syndrome (MERS) Coronavirus Propagation in Cells from an Insectivorous BatArticle Published on 2019-02-132022-10-28 Journal: Viruses [Category] Coronavirus, [키워드] Activation Antiviral antiviral response antiviral responses antiviral signaling bat bats cause Cell cells coronavirus CoV Critical demonstrated determine develop disease Eptesicus examined Factor fatality hallmark Host Human human cell human cells Hypothesis IFNβ interferon interferon beta IRF3 less MERS MERS-CoV nuclear translocation post-translational modifications Propagation Protein regulated replicate respiratory RNA siRNA suppressed suppression syndrome tested the interferon viral double-stranded RNA virus [DOI] 10.3390/v11020152 PMC 바로가기 [Article Type] Article
Poly(ADP-Ribose) Polymerases in Host-Pathogen Interactions, Inflammation, and ImmunityReview Published on 2018-12-192023-08-30 Journal: Microbiology and molecular biology reviews : MMBR [Category] E형 간염, [키워드] ADP-ribosylation antiviral responses Autoimmunity Enzyme inhibition host-pathogen interactions Inflammation poly(ADP-ribose) poly(ADP-ribose) polymerases stress granules transcriptional regulation [DOI] 10.1128/MMBR.00038-18 PMC 바로가기 [Article Type] Review
Tolerability, pharmacokinetics and antiviral activity of rHSA/IFNα2a for the treatment of chronic hepatitis B infectionClinical Trial Published on 2017-05-012023-06-19 Journal: British Journal of Clinical Pharmacology [Category] B형 간염, [키워드] albumin-interferon antiviral responses HBV pharmacokinetics. [DOI] 10.1111/bcp.13184 PMC 바로가기 [Article Type] Clinical Trial
Middle East respiratory syndrome coronavirus ORF4b protein inhibits type I interferon production through both cytoplasmic and nuclear targetsArticle Published on 2015-12-032022-10-29 Journal: Scientific Reports [Category] Coronavirus, [키워드] abrogated Analysis Antiviral antiviral response antiviral responses antiviral signaling Asia binding contribute coronavirus country cytoplasm cytoplasmic determinant Europe evade highly pathogenic IFN IFN-α/β IFN-β IKKε inhibit Interaction interferon IRF3 IκB MAVS MDA5 mechanism MERS-CoV Middle East mitochondrial molecular interaction Mortality North nuclear nuclear localization signal nucleus ORF4b other coronavirus Pathogenesis pathogenicity Phosphorylation previous study Protein Regulatory respiratory syndrome coronavirus RIG-I shown significantly spread to subsequent suppress TANK target TBK1 the interferon therapeutic Type I IFN type I interferon virulence virus [DOI] 10.1038/srep17554 PMC 바로가기 [Article Type] Article
Coronavirus nonstructural protein 1: Common and distinct functions in the regulation of host and viral gene expressionArticle Published on 2014-11-262022-11-01 Journal: Virus research [Category] Coronavirus, [키워드] accumulating acute respiratory syndrome antiviral responses biological function common conserved coronavirus CoV CoV infection CoVs determine downregulation Evidence Factor function functional highly pathogenic Host host gene expression human coronavirus inhibit innate immune response knowledge mammalian Middle East modulate mRNA cleavage nonstructural protein 1 novel nsp1 Pathogenesis Protein provide Regulation RNA viruses SARS SARS Coronavirus syndrome translation inhibition unique Vaccine development viral gene expression Viral protein virulence [DOI] 10.1016/j.virusres.2014.11.019 PMC 바로가기 [Article Type] Article