Respiratory viruses involved in influenza‐like illness in a Greek pediatric population during the winter period of the years 2005–2008 † , ‡Research Article Published on 2011-08-112022-11-01 Journal: Journal of medical virology [Category] Coronavirus, [키워드] assay children clinician clinics Co‐infection collected Coronaviruses determine diagnosed distribution dominant Epidemiology Greece Inc included Influenza Influenza virus influenza viruses involved majority occurred Older parainfluenza PCR pediatric polymerase chain reaction positive protocols real time respiratory respiratory specimens respiratory syncytial virus respiratory tract infection respiratory virus respiratory viruses rhinovirus rhinoviruses Simultaneous specimen subtype tested to screen virus viruses [DOI] 10.1002/jmv.22173 PMC 바로가기 [Article Type] Research Article
Coronavirus Gene 7 Counteracts Host Defenses and Modulates Virus VirulenceResearch Article Published on 2011-06-092022-10-29 Journal: PLoS Pathogens [Category] Coronavirus, MERS, [키워드] absence accelerated accessory gene acquisition Activation Analysis Antiviral antiviral response Apoptosis assay association Author benefit binding caspase catalytic caused Cell cellular RNA clinical disease compared conserved coronavirus CoV cultures Cytopathic effect Defense Degradation Deleterious demonstrated eIF2α ENCODE eukaryotic translation evade Evolution expression Genome growth Host host antiviral response host cell hydrophobic immune response indicated Infected infected cells Infection Innate inoculation Interaction led to mechanism modify modulation molecular mechanism motif mutant mutant virus Newborn observation parental pathology Pathways persistence Phosphorylation promoted Protein protein phosphatase 1 provided pull-down reducing required RNA degradation RNA viruses RNase selective sequence subunit suggested survival TGEV tissue translational transmissible gastroenteritis virus Viral RNA virulence virus virus infection [DOI] 10.1371/journal.ppat.1002090 PMC 바로가기 [Article Type] Research Article
Crystal Structure and Functional Analysis of the SARS-Coronavirus RNA Cap 2′-O-Methyltransferase nsp10/nsp16 ComplexResearch Article Published on 2011-05-262022-10-29 Journal: PLoS Pathogens [Category] Coronavirus, [키워드] 2003 activating Activation antiviral drug assay association atomic resolution Author bind binding binding pocket CAP chromatin complex coronavirus crystal crystal structures disease enzyme etiological agent exhibit functional Genome Giant host cell identify inhibitor Innate immunity involved mechanism metabolism methyltransferase mRNA mutant non-structural protein Novel coronavirus nucleic acid performed Protein provide regulated Regulation replicate residue respiratory resulting RNA S-adenosylmethionine SAM severe Signal transduction stability Structure translation viruses [DOI] 10.1371/journal.ppat.1002059 PMC 바로가기 [Article Type] Research Article
Action Mechanisms of Lithium Chloride on Cell Infection by Transmissible Gastroenteritis CoronavirusResearch Article Published on 2011-05-062022-10-28 Journal: PLoS ONE [Category] Coronavirus, [키워드] Action added Analysis Annexin anti-apoptotic Apoptosis assay bronchitis caspase-3 Cell Cell culture cell lines concerning coronavirus Coronaviruses detected different DNA viruses dose dose-dependent manner effective epidemic diarrhea expression flow cytometry found Genes herpes simplex virus IBV immunofluorescence in vitro indicated Infection infectious inhibit inhibited inhibitory effect initial investigated late stage LiCl lithium Lithium chloride (LiCl mechanism MTT not affected nuclei plaque Post-infection Real-time PCR reported RNA virus RT-PCR staining TGEV Transcription transmissible gastroenteritis virus Treatment vaccinia virus virus [DOI] 10.1371/journal.pone.0018669 PMC 바로가기 [Article Type] Research Article
Prevalence of human coronaviruses in adults with acute respiratory tract infections in Beijing, China †Research Article Published on 2011-02-222022-11-01 Journal: Journal of medical virology [Category] Coronavirus, [키워드] addition Adult assay Beijing caused characterized China Clinical data clinical presentation clinical sample coronavirus enterovirus Epidemiology etiological agent evaluate exhibited fluctuation found HKU1 Human human coronavirus IMPROVE Inc Infection infections NL63 Other respiratory viruses parainfluenza virus Pathogenesis Patient positive Prevalence respiratory specimen respiratory tract infection Respiratory tract infections reverse transcriptase PCR rhinovirus Sequencing analysis study period virus was performed [DOI] 10.1002/jmv.21956 PMC 바로가기 [Article Type] Research Article
Detection of four human coronaviruses in respiratory infections in children: A one‐year study in ColoradoResearch Article Published on 2009-07-222022-11-01 Journal: Journal of medical virology [Category] Coronavirus, [키워드] assay assays association children CNS coronavirus death detected detection diagnostic diarrhea disease Diseases Epidemiology evaluate Evidence healthy children Hospitalized human coronavirus illness Immunocompromised patient Inc Infection Laboratory Lower Lower respiratory tract majority occurred Patient patients PCR polymerase chain positive positive patient raise respiratory respiratory infection respiratory specimen respiratory tract infection respiratory virus rhinovirus RNA RT‐PCR Seizures Seven specimen specimens submitted tested vomiting [DOI] 10.1002/jmv.21541 PMC 바로가기 [Article Type] Research Article
Antigenic characterization of severe acute respiratory syndrome-coronavirus nucleocapsid protein expressed in insect cells: The effect of phosphorylation on immunoreactivity and specificityArticle Published on 2007-05-112022-11-01 Journal: Virus research [Category] Coronavirus, [키워드] Analysis Antigen antigenic antigenicity assay baculovirus coronavirus correlation cross-reactivity determine diagnostic E. coli expressed facilitate immunoreactivity insect cell insect cells involved mAb molecular MOST N protein nucleocapsid nucleocapsid protein pathology phosphorylated Phosphorylation produced Protein protein phosphatase 1 reduced Research SARS infection SARS-CoV SARS-CoV N SARS-CoV N protein serum Severe acute respiratory syndrome specificity treated were expressed [DOI] 10.1016/j.virusres.2007.03.019 PMC 바로가기 [Article Type] Article
Inhibition of SARS-CoV replication cycle by small interference RNAs silencing specific SARS proteins, 7a/7b, 3a/3b and SArticle Published on 2007-03-012022-10-06 Journal: Antiviral Research [Category] 진단, [키워드] accessory proteins acute respiratory syndrome aspecific assay coronavirus demonstrated Efficiency eight expressing expression full-length Genome genomic indirect immunofluorescence infected cell inhibit inhibition knockdown mRNA not affected nucleocapsid protein nucleotide Open reading frame ORF ORFs progeny Protein Proteins reduction in Replication RNA SARS CoV SARS-CoV sgRNA sgRNAs siRNA siRNAs specificity tested translated Vero E6 cell viral infection Viral protein virus were infected without affecting [DOI] 10.1016/j.antiviral.2006.10.008 PMC 바로가기 [Article Type] Article
Detection and typing by molecular techniques of respiratory viruses in children hospitalized for acute respiratory infection in Rome, ItalyResearch Article Published on 2007-02-202022-11-01 Journal: Journal of medical virology [Category] Coronavirus, Fulltext, MERS, [키워드] Acute respiratory infection adopted amplified fragment approach assay Asthma Bronchiolitis bronchitis bronchopneumonia children circulation Co‐infection Department described detected detection Diagnosis enrolled Hospitalized Inc infected children Infection influenza type A involved Italy métapneumovirus molecular NL63 Novel coronavirus parainfluenza virus pathogen Patient Pneumonia positive result respiratory pathogen respiratory syncytial virus respiratory tract infection respiratory virus reverse transcription rhinovirus Rome RSV RT‐PCR sequenced the patient to define viral pathogen virus [DOI] 10.1002/jmv.20832 PMC 바로가기 [Article Type] Research Article
Time Course and Cellular Localization of SARS-CoV Nucleoprotein and RNA in Lungs from Fatal Cases of SARSResearch Article Published on 2006-02-032022-10-29 Journal: PLoS Medicine [Category] Coronavirus, MERS, [키워드] 2003 acute respiratory syndrome alveolar alveolar epithelium antiviral therapy appear assay association Autopsy Canada case cellular China Clinical course clinical disease collected compared coronavirus detected died disease etiological Evidence finding Hong Kong humans illness onset immunohistochemistry In situ Infected involved knowledge less Localization lung lung tissue Lungs Macrophage macrophages monoclonal antibody nucleoprotein outbreak Pathogenesis Patient patients with SARS pneumocyte Pulmonary pathology Region Replication RNA SARS Coronavirus SARS-CoV Seven symptom onset target the disease time Toronto Treatment viral infection virus widespread [DOI] 10.1371/journal.pmed.0030027 PMC 바로가기 [Article Type] Research Article