BNT162b2 mRNA SARS-CoV-2 Vaccine Elicits High Avidity and Neutralizing Antibodies in Healthcare WorkersArticle Published on 2021-06-182022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] ACE2 Administered affinity anti-RBD Anti-RBD antibody antibody Antibody avidity avidity baseline binding domain BNT162b2 mRNA BNT162b2 vaccine booster characterized dose ELISA evaluate evaluated first dose full-length spike protein Health care worker health care workers IgA IgG IgM immune response immunize increase induce inhibiting inhibitory antibody Interaction Italy less maturation mRNA Neutralizing antibodies persistence produced Protective antibody RBD RBD binding SARS-CoV-2 subject subjects tested the antibody response urea Vaccine was measured worker [DOI] 10.3390/vaccines9060672 PMC 바로가기 [Article Type] Article
Comparative Antibody Responses to the Live-Attenuated and Recombinant Herpes Zoster Vaccines생백신 및 재조합 대상포진 백신에 대한 비교 항체 반응Randomized Controlled Trial Published on 2021-05-242023-06-01 Journal: Journal of Virology [Category] Fulltext, 대상포진, 두창, 수두, 홍역, [키워드] avidity herpes zoster Humoral immunity Neutralizing antibodies Vaccine [DOI] 10.1128/JVI.00240-21 PMC 바로가기 [Article Type] Randomized Controlled Trial
Rapid decline of neutralizing antibodies is associated with decay of IgM in adults recovered from mild COVID-19중화 항체의 급격한 감소는 가벼운 COVID-19에서 회복된 성인의 IgM 붕괴와 관련이 있습니다Article Published on 2021-04-202022-09-11 Journal: Cell Reports Medicine [Category] MERS, SARS, 진단, 치료법, [키워드] age anti-RBD anti-receptor-binding domain anti-S antibody Antibody avidity Antibody Response Antibody responses avidity binding Cohort COVID-19 Decline declines defined Fever Follow-up functional Gender IgA IgG IgM Immunoglobulin immunoglobulin A implication increase Infection levels of antibodies Mild mild infection mild SARS-CoV-2 infection Neutralizing antibodies neutralizing antibody Neutralizing antibody response neutralizing antibody responses observation observé participant protective immunity Protein Rapid RBD respiratory responses SARS-CoV-2 SARS-COV-2 infection symptom onset trimer Viral Viral antigen viral antigens [DOI] 10.1016/j.xcrm.2021.100253 PMC 바로가기 [Article Type] Article
Association of Age With SARS-CoV-2 Antibody ResponseSARS-CoV-2 항체 반응과 연령의 연관성Research Published on 2021-03-222022-09-12 Journal: JAMA Network Open [Category] SARS, 진단, [키워드] 95% CI acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition Adolescent adolescents and adults Adults age Analysis antibody Antibody binding Antibody Response Antibody responses Antibody test antibody test result antibody tests association avidity children Cohort collected coronavirus correlated cross-sectional cross-sectional study disease evaluated Evidence exhibited Female patients finding group groups hospital IgG IgG level IgG levels immune response Importance IQR lower risk lowest management measure median Mild symptom mild symptoms moderate negative correlation Neutralizing activity neutralizing antibody New York City not significant objective participant Patient patient population patients pediatric Pediatric patient performed Point populations positive correlation profile quantity relative fluorescence unit relative fluorescence units Relevance Respiratory disease response responses Result RFU SARS-CoV-2 SARS-CoV-2 antibody SARS-CoV-2 antibody responses SARS-CoV-2 antibody test SARS-CoV-2 antibody tests SARS-CoV-2 IgG SARS-CoV-2 viral sera Seroprevalence setting severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severe respiratory disease SNAb subset Vaccine development was performed [DOI] 10.1001/jamanetworkopen.2021.4302 PMC 바로가기 [Article Type] Research
Avidity assay to test functionality of anti-SARS-Cov-2 antibodies항-SARS-Cov-2 항체의 기능을 테스트하기 위한 결합력 분석Article Published on 2021-03-052022-09-12 Journal: Vaccine [Category] MERS, SARS, 진단, [키워드] Abstract antibody avidity Coronavirus RBD Neisseria meningitis Neutralizing antibodies SARS-CoV-2 [DOI] 10.1016/j.vaccine.2021.02.003 PMC 바로가기 [Article Type] Article
The challenge of avidity determination in SARS‐CoV‐2 serologySARS-CoV-2 혈청학에서 결합력 측정의 도전Research Article Published on 2021-02-192022-09-10 Journal: Journal of medical virology [Category] MERS, SARS, 진단, 치료법, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Antibody titer Antibody titers Antigen antigens approach avidity characterized Combination complexity Concentration coronavirus described determine differentiation domain IgG IgG response IgG responses immune response Immunoglobulin Immunoglobulin G immunoglobulin M indicate Infection kinetic late stage maturation Neutralizing antibodies nucleoprotein occur optimization positive Probability protective effect protective immunity RBD receptor‐binding domain receptor‐binding domain required respiratory SARS‐CoV‐2 SARS‐CoV‐2 seasonal coronavirus seasonal coronaviruses serological response serology severe acute respiratory syndrome Coronavirus shown Spike protein spike protein S1 suggested to define Treatment urea vaccination virus [DOI] 10.1002/jmv.26863 PMC 바로가기 [Article Type] Research Article
Neutralizing Human Antibodies against Severe Acute Respiratory Syndrome Coronavirus 2 Isolated from a Human Synthetic Fab Phage Display Library인간 합성 Fab 파지 디스플레이 라이브러리에서 분리된 중증 급성 호흡기 증후군 코로나바이러스 2에 대한 인간 항체 중화Article Published on 2021-02-152022-09-12 Journal: International Journal of Molecular Sciences [Category] MERS, 진단, [키워드] absence ACE2 activity acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 affinities angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 anti-SARS-CoV-2 Antibody therapeutics apparent affinity avidity caused Cell coronavirus coronavirus 2 COVID-19 cross-reactivity D12 develop diagnostics display domain drug target Effect Fab Fabs FIVE Human human monoclonal antibodies Human monoclonal antibody IgGs Immunoglobulin In vitro assay Interaction Isolated library mAb mAbs MERS MERS-CoV moderate monoclonal antibody neutralize neutralizing activities Neutralizing activity outbreak pandemic phage phage display Prophylactic RBD reagent receptor protein Receptor-binding domain reported Research respiratory resulting SARS-CoV spike protein SARS-CoV-2 SARS-CoV-2 spike protein severe acute respiratory syndrome Coronavirus significantly Spike protein Spread synthetic the RBD the SARS-CoV-2 therapeutic drug thermal stability treat unique Vaccine Viral viral entry virus Wuhan Wuhan, China yielding [DOI] 10.3390/ijms22041913 PMC 바로가기 [Article Type] Article
Qualitative assessment of SARS-CoV-2-specific antibody avidity by lateral flow immunochromatographic IgG/IgM antibody assayArticle Published on 2021-02-012023-06-19 Journal: Journal of medical virology [Category] Fulltext, MERS, [키워드] antibodies avidity COVID-19 SARS-CoV-2 urea dissociation. [DOI] 10.1002/jmv.26344 PMC 바로가기
The variability of the serological response to SARS-corona virus-2: Potential resolution of ambiguity through determination of avidity (functional affinity)Review Published on 2021-01-012023-06-19 Journal: Journal of medical virology [Category] MERS, SARS, [키워드] affinity avidity IgG SARS-CoV-2 serology Variability [DOI] 10.1002/jmv.26262 PMC 바로가기 [Article Type] Review
SARS-CoV-2 Antibody Avidity Responses in COVID-19 Patients and Convalescent Plasma DonorsArticle Published on 2020-12-152023-07-02 Journal: The Journal of Infectious Diseases [Category] SARS, [키워드] Anti-nucleocapsid Anti-spike avidity convalescent plasma SARS-CoV-2 [DOI] 10.1093/infdis/jiaa581 PMC 바로가기