Molecular docking, molecular dynamics, and in vitro studies reveal the potential of angiotensin II receptor blockers to inhibit the COVID-19 main proteaseResearch Article Published on 2020-12-032022-10-04 Journal: Heliyon [Category] 신약개발, [키워드] Anti-SARS-CoV-2 Activity ARB ARBs Azilsartan binding affinity binding free energy Biological Biological sciences blocker Blood coagulation carried Chemistry clinical study Combination Compound compounds computer Computer science COVID-19 COVID-19 pandemic COVID-19 virus disease docked docking drug Drug repurposing drugs targeting effective drug Effectiveness eprosartan fibrosis in vitro In vitro studies Inflammation inhibit Irbesartan material Materials science MD MM-GBSA molecular N3 inhibitor nine olmesartan pandemic coronavirus Patient patients worldwide Physics Prevent profiles Prophylactic protease pulmonary fibrosis receptor reduce required SAR SARS-CoV-2 SARS-CoV-2 protease Science telmisartan tested Treatment valsartan vasodilatation VERO E6 cells Virtual screening was performed [DOI] 10.1016/j.heliyon.2020.e05641 PMC 바로가기 [Article Type] Research Article
Remdesivir Is Effective in Combating COVID-19 because It Is a Better Substrate than ATP for the Viral RNA-Dependent RNA PolymeraseArticle Published on 2020-11-282022-10-30 Journal: iScience [Category] COVID-19, [키워드] acute respiratory syndrome Analysis ATP Better Biochemistry Biological Biological sciences Biology caused chaperone competing complex coronavirus COVID-19 Efficiency enzyme expression Genome inhibit inhibitor inhibitors kinetic analysis mechanism Molecular biology Molecular Biology Experimental Approach polymerase polymerization provide purification RdRP replicate RNA robust SARS-CoV-2 specificity substrate the SARS-CoV-2 treated [DOI] 10.1016/j.isci.2020.101849 PMC 바로가기 [Article Type] Article
SARS-CoV-2 RNA Dependent RNA polymerase (RdRp) – A drug repurposing studyResearch article Published on 2020-07-232022-10-05 Journal: Heliyon [Category] 신약개발, [키워드] acute respiratory syndrome amino acid residue anti-viral drug approach approved binding pocket Biochemistry bioinformatics Biological sciences candidate China cisatracurium cofactor complex coronavirus COVID-19 database Dependent drug Drug repurposing effective Examorelin FDA FDA approved drug form Health include Interaction Lypressin Molecular biology molecular docking simulation Ornipressin outbreak pandemic Pharmaceutical science polymerase Polymyxin B1 RdRP RNA RNA dependent RNA polymerase RNA polymerase SARS-CoV-2 SARS-CoV-2 RNA screened sustained therapeutic options Vaccine X-ray crystallography [DOI] 10.1016/j.heliyon.2020.e04502 [Article Type] Research article
Antigenic cross-reactivity between Schistosoma mansoni and allergenic invertebrates putatively due to shared glycanic epitopesArticle Published on 2020-02-252023-08-29 Journal: Scientific Reports [Category] E형 간염, [키워드] Biological sciences mass spectrometry [DOI] 10.1038/s41598-020-59892-6 PMC 바로가기 [Article Type] Article
In Vivo F-Actin Filament Organization during Lymphocyte Transendothelial and Interstitial Migration Revealed by Intravital MicroscopyArticle Published on 2019-05-302023-08-30 Journal: iScience [Category] E형 간염, [키워드] Biological sciences Cell Biology Organizational Aspects of Cell Biology [DOI] 10.1016/j.isci.2019.05.040 PMC 바로가기 [Article Type] Article