Atypical response to bacterial coinfection and persistent neutrophilic bronchoalveolar inflammation distinguish critical COVID-19 from influenza박테리아 동시 감염 및 지속적인 호중구 기관지 폐포 염증에 대한 비정형 반응은 인플루엔자와 중요한 COVID-19를 구별합니다Research Article Published on 2022-01-112022-09-12 Journal: JCI Insight [Category] 진단, 치료기술, [키워드] activating Antibiotic treatment Bacterial bacterial coinfections BAL BAL fluid blood sample bronchoalveolar Bronchoalveolar lavage CCL7 chemokine chemokines chemotactic factor circulating Cohort collected comparable Concentration coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient Critical Critically ill critically ill COVID-19 patients CXCL1 CXCL11 CXCL12 CXCL8 cytokine Cytokines decrease effector cell elafin elevated fluids G-CSF highlighting IL-1 β IL-17A IL-1ra Immunological response immunology Inflammation Influenza Invasive mechanical ventilation leukocyte lung Lungs Lymphocytes mechanically ventilated patient mechanically ventilated patients metalloproteinase Monocytes neutrophil neutrophilic Neutrophils NK cell NK cells parameter pathophysiology patients with COVID-19 patients with influenza Protease inhibitor protease inhibitors proteolytic activity severe coronavirus disease Tissue Inhibitor TNF- α Treatment Viral pneumonia [DOI] 10.1172/jci.insight.155055 PMC 바로가기 [Article Type] Research Article
Long non-coding RNAs (lncRNAs) NEAT1 and MALAT1 are differentially expressed in severe COVID-19 patients: An integrated single-cell analysis긴 비 코딩 RNA (LNCRNA) NEAT1 및 MALAT1은 심각한 COVID-19 환자에서 차등 적으로 발현됩니다. 통합 된 단일 세포 분석Research Article Published on 2022-01-102022-09-10 Journal: PLoS ONE [Category] 유전자 메커니즘, 치료기술, 치료제, [키워드] Analysis analyzed Apoptosis applied BAL Bronchoalveolar lavage Cell cell population cell stress cell types cellular stress response component coronavirus disease Coronavirus disease 2019 COVID-19 damage diagnostic differentially expressed differentiator disease severity dysregulation focus foster hallmark immune dysregulation immunomodulatory Inflammation Inflammatory involved lncRNA Long long non-coding RNA MALAT1 measure Mild mononuclear cell mononuclear cells NEAT1 non-coding RNA Patient PBMCs Peripheral blood Peripheral blood mononuclear cells pro-inflammatory function pro-inflammatory functions Regulation sequenced severe COVID-19 Severe patient severity single-cell single-cell RNA-seq dataset single-cell transcriptomic analysis stress response target targets therapy with COVID-19 [DOI] 10.1371/journal.pone.0261242 PMC 바로가기 [Article Type] Research Article
Pulmonary aspergillosis and cryptococcosis as a complication of COVID-19Case Report Published on 2022-01-062022-10-29 Journal: Medical Mycology Case Reports [Category] COVID-19, [키워드] Aspergillus Bronchoalveolar lavage CAPA Comorbidities Comorbidity complicate complication of COVID-19 Corticosteroid COVID-19 Critical Cryptococcus Culture Cyclophosphamide diagnosed dose Fungal infection High-dose hospital hypoxic respiratory failure immunosuppressants Infection morbidity and mortality Patient pulmonary aspergillosis SARS-CoV-2 Secondary infection transferred Treatment worsening [DOI] 10.1016/j.mmcr.2022.01.003 PMC 바로가기 [Article Type] Case Report
The prevalence of early‐ and late‐onset bacterial, viral, and fungal respiratory superinfections in invasively ventilated COVID‐19 patientsResearch Article Published on 2022-01-042022-10-04 Journal: Journal of medical virology [Category] COVID19(2023년), MERS, SARS, 치료기술, [키워드] Aspergillus fumigatus Bacteria Bacterial Bronchoalveolar lavage chronic obstructive Cohort coronavirus disease Coronavirus disease 2019 correlation COVID‐19 COVID‐19 patient Day develop Diabetes Mellitus fungal fungal pathogen herpes simplex Infection intensive care intubation invasive ventilation invasively ventilated patient investigated Klebsiella Klebsiella pneumoniae mechanical ventilation obesity pathogen Pathogens Patient Pneumonia Prevalence prevalent Probability Pseudomonas aeruginosa pulmonary disease respiratory coinfections respiratory virus severe acute respiratory syndrome coronavirus 2 significantly higher tested Ventilated virus [DOI] 10.1002/jmv.27548 PMC 바로가기 [Article Type] Research Article
Cytopathological Findings in Bronchoalveolar Lavage from Patients with COVID-19Article Published on 2022-01-012022-11-15 Journal: Acta cytologica [Category] 진단, [키워드] addition addressed alveolar Analysis Atypical BAL bronchial cell Bronchoalveolar lavage Cell cellular change changes Characteristics clearance clinically collected COVID-19 cytopathic Cytopathic effect Cytopathological finding. cytoplasmic described evaluated finding increase in Inflammatory information lavage leukocyte lymphocyte Macrophage macrophages malignancy molecular multinucleated giant cell multinucleated giant cells Nasopharyngeal swab neutrophilic nuclear nuclear chromatin nuclei pathological change pathological changes patients patients with COVID-19 Peripheral blood pneumocyte Pneumonia reactive reported Research respiratory tract suspected patient virus with COVID-19 [DOI] 10.1159/000525339 PMC 바로가기
Boosting Vaccine-Elicited Respiratory Mucosal and Systemic COVID-19 Immunity in Mice With the Oral Lactobacillus plantarumNutrition Published on 2021-12-222022-10-31 Journal: Frontiers in Nutrition [Category] COVID-19, [키워드] Lactobacillus plantarum accquired immunity adjuvant administration Analysis antibody apoptotic BAL boost Bronchoalveolar lavage Combination COVID-19 COVID-19 pandemic effective Efficacy gut-lung axis immune immune response Immunity immunization inflammatory pathways interferon signaling lactobacillus memory memory immunity mucosal Neutralization antibody oral Probiotics promote promoted respiratory SARS-CoV-2 SARS-CoV-2 neutralization SARS-CoV-2 vaccination SARS-CoV-2 vaccine SARS-CoV-2-specific immune response sera spleen systemic T-cell Response unique vaccination Vaccine [DOI] 10.3389/fnut.2021.789242 PMC 바로가기 [Article Type] Nutrition
SARS-CoV-2 viral load assessment in lung transplantation폐 이식에서 SARS-CoV-2 바이러스 부하 평가Case Reports Published on 2021-12-162022-09-11 Journal: Physiological research [Category] SARS, 치료법, [키워드] Antigen Bronchoalveolar lavage complex COVID-19 COVID-19 pandemic criteria Ct value Ct values cycle threshold decision Diagnosis Donor IgA antibodies IgA antibody Laboratory lung lung transplantation medical history Nasopharyngeal swab organ Organ donor organ transplantation PCR proceed Respiratory disease SARS-CoV-2 nucleocapsid SARS-CoV-2 viral load serum solid organ Support thought transplantation viability Viral load Viral RNA [DOI] 10.33549/physiolres.934760 PMC 바로가기 [Article Type] Case Reports
A Sensitive, Portable Microfluidic Device for SARS-CoV-2 Detection from Self-Collected SalivaArticle Published on 2021-12-142022-10-30 Journal: Infectious Disease Reports [Category] COVID-19, [키워드] acute respiratory syndrome approach Bronchoalveolar lavage cartridge cDNA coronavirus demonstrated detection Detection sensitivity Device diagnostic test FDA fecal samples genomic Infection integration Internal control Isolation medical intervention Microfluidics multiplex Nasopharyngeal swab Novel coronavirus outbreak pandemic point-of-care polymerase chain primer primer set protocol Quantitative quantitative PCR reverse transcription RNA RNA isolation RNA template Saliva SARS-Co-V2 SARS-CoV-2 SARS-CoV-2 detection SARS-CoV-2 nucleic acid SARS-CoV-2 RNA SARS-CoV2 infection sensitive sensitivity Spread the patient Treatment Urine Viral RNA virus [DOI] 10.3390/idr13040097 PMC 바로가기 [Article Type] Article
Risk-focused differences in molecular processes implicated in SARS-CoV-2 infection: corollaries in DNA methylation and gene expressionSARS-CoV-2 감염과 관련된 분자 과정의 위험 중심적 차이: DNA 메틸화 및 유전자 발현의 결과Research Published on 2021-12-112022-09-11 Journal: Epigenetics & Chromatin [Category] SARS, 유전자 메커니즘, [키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition Air pollutants airway epithelia Analysis ARRB2 association Asthma autosomal Bronchoalveolar lavage CA5B candidate gene changes in chronic conditions chronic obstructive COMT conducted COPD coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 susceptibility CpG data set Diagnosis diesel exhaust DNA methylation downloaded epithelia exaggerated immune response exhibited explain Exploratory analysis exposure to Factor female Gene Expression gene expression patterns Genes GEO GPX1 Health highlight HS6ST2 immune genes imperative implicated inactivation increased risk individual Infection infections investigated involved loci lung magnitude male molecular molecular association molecular associations molecular basis molecular pattern molecular patterns mRNA expression nasal Nicotine nicotine dependence nitrogen nitrogen dioxide NLRP2 outcomes portal PRIM2 profile Repository respiratory Respiratory conditions Respiratory disease respiratory tissue Result risk risk factor Risk factors SARS-CoV-2 SARS-COV-2 infection second severe acute respiratory syndrome Coronavirus Sex Sex difference Smokers smoking suggested supplementary material susceptibility TATDN1 the disease TLE1 understanding Variation while Whole blood X-linked X-linked gene [DOI] 10.1186/s13072-021-00428-1 PMC 바로가기 [Article Type] Research
Anakinra reduces lung inflammation in experimental acute lung injuryOriginal Article Published on 2021-12-092022-10-30 Journal: Immunity, Inflammation and Disease [Category] Coronavirus, COVID19(2023년), MERS, SARS, [키워드] Abstract acute lung injury alveolar macrophage Anakinra animal model approach ARDS BAL BAL fluid blockade Bronchoalveolar lavage caused classical COVID‐19 patients COVID‐19 Day distress dysregulated Effect evaluate evaluated fluids Frequency general health status groups hallmark hypoxaemia IL‐1 IL‐1 IL‐1Ra immunomodulatory Immunotherapy IMPROVE infiltrating Inflammation Inflammatory cytokine inflammatory immune responses leukocyte Lung disease Lung inflammation lung tissue mice Mortality neutrophil nine NK cell pathogen potential treatment option Protein protein level reduce reduced Research Respiratory distress syndrome Result resulting Support syndrome therapeutic potential trauma treated Treatment variety weight loss [DOI] 10.1002/iid3.548 PMC 바로가기 [Article Type] Original Article