Impact of cancer and cardiovascular disease on in-hospital outcomes of COVID-19 patients: results from the american heart association COVID-19 cardiovascular disease registryResearch Published on 2021-08-102022-10-31 Journal: Cardio-oncology [Category] COVID-19, [키워드] 95% confidence interval adjusted adjusted odds ratio Admission age analyzed appear association average BMI body mass index Cancer cancer patient Cancer patients Cancer therapy cardiovascular disease Chemotherapy COVID-19 CVD demographics demonstrated died distribution enrolled evaluate the effect heart history hospital Hospitalized hospitalized COVID-19 patients Impact implication In-hospital In-hospital death in-hospital mortality increased mortality logistic regression model malignancy Mortality outcome Patient patients Primary outcome registry Result risk factor Risk factors severe disease significant interaction significantly smoking statistically survival symptomatic adult tested thromboembolic disease Vaccine while with COVID-19 [DOI] 10.1186/s40959-021-00113-y PMC 바로가기 [Article Type] Research
Unsupervised machine learning reveals key immune cell subsets in COVID-19, rhinovirus infection, and cancer therapyResearch Article Published on 2021-08-052022-10-31 Journal: eLife [Category] COVID-19, MERS, SARS, [키워드] Algorithm Analysis Cancer therapy CD4+ cell CD4+ T cell Cell cells changes in Chemotherapy clinical response comparable Complete COVID-19 COVID-19 patient Cytometry Disease progression emerging disease example homogeneous hotspot Human identify immune Immune cell immune changes Immune monitoring immune system immunology individual donor Infection inhibitor knowledge leukemia machine learning magnitude Melanoma MHCII Other Patient phenotype Post-infection provided reagent repeated reveal rhinovirus SARS-CoV-2 infections Single Cell subset Systems biology therapy trajectory virus virus-specific T cell [DOI] 10.7554/eLife.64653 PMC 바로가기 [Article Type] Research Article
Quantifying nanodiamonds biodistribution in whole cells with correlative iono-nanoscopyArticle Published on 2021-08-022022-10-04 Journal: Nature Communications [Category] 바이오마커, [키워드] Alpha approach benefit biodistribution Cancer therapy Cell clinical study Effect Effects example experiments Fluorescence imaging fluorescent Imaging techniques Interaction ions mechanism Microscopy Nanoparticles Particle Particles probes quantification Research resulting ultrastructure unique [DOI] 10.1038/s41467-021-25004-9 PMC 바로가기 [Article Type] Article
Real time remote symptom monitoring during chemotherapy for cancer: European multicentre randomised controlled trial (eSMART)암에 대한 화학 요법 중 실시간 원격 증상 모니터링 : 유럽 멀티 센터 무작위 대조 시험 (ESMART)Research Published on 2021-07-212022-08-09 Journal: The BMJ [Category] 임상, [키워드] 95% confidence interval across all cycle adjuvant chemotherapy Anxiety arising assessment ASyMS blended model blended models Breast cancer Cancer cancer centre Cancer therapy Care care needs CASE-Cancer Chemotherapy Clinical effect Cohen’s effect size Colorectal cancer communication Control COVID-19 pandemic cycle daily living domain domains Effect eSMART European evaluate evaluator FACT-G FIVE Functional assessment General global distress index Greece Health Hodgkin’s disease indicated intervention group Ireland life mean difference mean score mean scores Memorial monitoring system multicentre Neutropenic Neutropenic event Neutropenic events non-Hodgkin’s lymphoma non-metastatic breast cancer Norway not significantly different objective Other outcome outcome measure pandemic parallel group participant Patient Patient care patients’ symptom experiences physical Physical symptom physical symptoms positive pre-chemotherapy treatment Primary outcome psychological symptom psychological symptoms Quality of life questionnaire randomised randomised controlled trial receiving reduction in reductions in remained remote remote monitoring Remote monitoring systems remote symptom repeated measures reported Result Safety SCNS-SF34 secondary Secondary outcomes Self-efficacy setting Sexuality Side effect Side effects Significant significant reductions squares absolute mean STAI STAI-R standard care stratified Support supportive care survey symptom burden System work limitation work limitations [DOI] 10.1136/bmj.n1647 PMC 바로가기 [Article Type] Research
Prolonged SARS-CoV-2 RNA virus shedding and lymphopenia are hallmarks of COVID-19 in cancer patients with poor prognosis장기간 SARS-CoV-2 RNA 바이러스 배출 및 림프구감소증은 예후가 불량한 암 환자에서 COVID-19의 특징입니다Article Published on 2021-07-062022-09-10 Journal: Cell Death and Differentiation [Category] SARS, 유전자 메커니즘, 임상, 치료기술, [키워드] accompanied activated acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 anti-RBD IgG antibodies association Blood Cancer cancer patient Cancer patients Cancer therapy carriers CD8 cells circulation coronavirus Coronavirus-2 correlated COVID-19 COVID-19 severity cycle threshold death Depletion DNA early phase Elevation Enterobacteriaceae Eomes exacerbate exhibited family members favor follicular granzyme granzyme B Gut hallmark higher risk IFN immature immunopathology Infection Infectious disease lymphocyte Lymphocyte count lymphopenia magnitude malignant disease mechanism Medical research metabolite metabolites Monocytes Nasopharyngeal swab nasopharyngeal swabs Neutrophils pandemic paradoxical pathway Patient PD-1 plasmablasts polyamine poor prognosis Prognostic markers Prolonged RBD IgG reduce respiratory RT-qPCR salt SARS-CoV-2 SARS-CoV-2 RNA SARS-CoV-2 RNA detection serum severe COVID-19 significant changes in T-helper cells Viral Viral RNA Viral RNA shedding virus virus–host interaction virus–host interactions worsened [DOI] 10.1038/s41418-021-00817-9 PMC 바로가기 [Article Type] Article
DHODH and cancer: promising prospects to be exploredReview Published on 2021-05-102022-10-31 Journal: Cancer & Metabolism [Category] COVID-19, [키워드] association Cancer Cancer cells Cancer metabolism Cancer therapy de novo De novo pyrimidine biosynthesis DHODH DHODH inhibitors dihydroorotate dehydrogenase disease Effect enzyme Evidence Human inhibitor mechanism Mitochondria mitochondrial multiple sclerosis pathway rheumatoid arthritis therapeutic target Therapies Treatment Tumor tumor progression [DOI] 10.1186/s40170-021-00250-z PMC 바로가기 [Article Type] Review
Downregulation of ACE2 expression by SARS-CoV-2 worsens the prognosis of KIRC and KIRP patients via metabolism and immunoregulationResearch Paper Published on 2021-05-102022-10-29 Journal: International Journal of Biological Sciences [Category] COVID-19, SARS, [키워드] Accuracy ACE2 ACE2 expression acute respiratory syndrome animal model Atla bioinformatics Cancer Cancer patients Cancer therapy Cell clinical information clinical risk coronavirus correlated correlation database diagnosing downregulated downregulation enzyme exhibit expression function Gene Expression Gene Expression Omnibus GEO high risk host cell human tissues immune immune infiltration immunoregulation involved kidney metabolic pathway metabolism not correlated overall survival overlap Patient patient survival patients Predictive Prognosis renal Renal cancer SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2-infected cell searched significantly survival Symptoms target tissue TMPRSS2 transmembrane serine protease upregulated Xena [DOI] 10.7150/ijbs.57802 PMC 바로가기 [Article Type] Research Paper
Overlap of immunotherapy-related pneumonitis and COVID-19 pneumonia: diagnostic and vaccine considerationsCommentary Published on 2021-04-302022-10-30 Journal: Journal for immunotherapy of cancer [Category] COVID-19, MERS, SARS, [키워드] Autoimmunity Cancer Cancer therapy cancers caused cellular clinically Community complex Corticosteroid COVID-19 diagnostic immune immune dysregulation Immunity Immunocompromised patient immunological Immunotherapy Intersection knowledge nuance oncologist overlap pandemic Patient Patients with cancer Pneumonia Replication risk SARS-COV-2 infection T-cell therapeutic vaccination Vaccine viability viral replication virus with COVID-19 working [DOI] 10.1136/jitc-2020-002307 PMC 바로가기 [Article Type] Commentary
Lights and Shadows on Managing Immune Checkpoint Inhibitors in Oncology during the COVID-19 EraOpinion Published on 2021-04-152022-10-31 Journal: Cancers [Category] COVID-19, [키워드] “COVID-19 addressed administration affected anticancer assumption cancer patient Cancer therapy changes in Chemotherapy clinical observation Clinical outcome clinical outcomes clinics Consequences contribute coronavirus disease COVID COVID-19 detrimental Drug safety Effect ENhance evaluate hyper-inflammatory phase Immune checkpoint inhibitor immune response immune system immuno-oncologics immunological immunomodulatory drug Immunotherapy increased risk Infection LIGHT management managing modulating Mortality pandemic Potential question raise raised Safe severe disease course shadow shown simple solid tumors Spread susceptible the patient therapeutic strategy Treatment viral infection worsening [DOI] 10.3390/cancers13081906 PMC 바로가기 [Article Type] Opinion
The Deadly Duo of COVID-19 and Cancer!Molecular Biosciences Published on 2021-04-122022-10-31 Journal: Frontiers in Molecular Biosciences [Category] COVID-19, [키워드] ACE2 added anti-cancer drugs Cancer cancer patient Cancer patients Cancer therapy Complication COVID-19 COVID-19 patient Diagnosis disease Drug repurposing effective effort enzyme Factor Health Immunity include increase in infection with COVID-19 Inflammation management molecular novel corona virus Patient Patient care severity Surgical Procedure the patient Treatment [DOI] 10.3389/fmolb.2021.643004 PMC 바로가기 [Article Type] Molecular Biosciences