Endothelial function provides early prognostic information in patients with COVID-19: A cohort study내피 기능은 COVID-19 환자의 조기 예후 정보를 제공합니다: 코호트 연구Observational Study Published on 2021-08-012022-09-11 Journal: Respiratory medicine [Category] SARS, 바이오마커, 임상, 치료기술, [키워드] Analysis assessment assessments blood flow cardiovascular risk Characteristics clinical clinical evaluation cohort study COVID-19 COVID-19 group cutoff point death deaths deficiency detect diagnosed diagnosed with COVID-19 diffuse intravascular coagulation discharge endothelial Endothelial dysfunction endothelial function Endothelium evaluated Flow-mediated dilation (FMD) greater Hospital stay Hospitalization Hospitalized hospitalized patient information intravascular coagulation Mortality non-COVID-19 group observational study occurred Patient patients without COVID-19 performed phenotype predict Probability prognostic prospective observational study prothrombotic provide reduction in remained significantly Vascular vascular dysfunction [DOI] 10.1016/j.rmed.2021.106469 PMC 바로가기 [Article Type] Observational Study
COVID-19 and its effects on endothelium in HIV-positive patients in sub-Saharan Africa: Cardiometabolic risk, thrombosis and vascular function (ENDOCOVID STUDY)Observational Study Published on 2021-07-312022-10-04 Journal: BMC Infectious Diseases [Category] SARS, 임상, [키워드] Admission affected Alter analyses Antiretroviral therapy ART assessments biochemical Biomarker Blood brachial cardiovascular cardiovascular disease cardiovascular risk cardiovascular risk factor cardiovascular risk factors carotid carried change Co-infection Coagulation correlation country Course COVID-19 COVID-19 patient CVD discharge Effect endothelial Endothelial dysfunction endothelial function Endothelium evaluate health system HIV HIV infection HIV-infection HIV-negative Human immunodeficiency virus Impact Infection Interaction modulate Non-communicable disease Patient phenotype PLHIV Registered Research risk role SSA sub-Saharan Africa supplementary material the disease therapy thrombosis Treatment Vascular Vascular endothelial function Vascular function vessel with COVID-19 with HIV [DOI] 10.1186/s12879-021-06426-8 PMC 바로가기 [Article Type] Observational Study
Immune cell profiling in atherosclerosis: role in research and precision medicine Reviews Published on 2021-07-152022-10-05 Journal: Nature reviews. Cardiology [Category] 신약개발, [키워드] alteration Atherosclerosis atherosclerotic atherosclerotic plaque cardiovascular disease cardiovascular event cardiovascular risk Cell cellular cellular and molecular clinical trial CRISPR Cytometry data-driven early phase epitope experimental models group Human identify immune immunotherapies Immunotherapy Inflammation involved mouse model Myocardial infarction Patient patient population patients Precision randomized clinical trial reduce Research review Sequencing single-cell Single-cell RNA sequencing Stage These data Transcriptome translation treat treated patients [DOI] 10.1038/s41569-021-00589-2 [Article Type] Reviews
Impact of clinical and subclinical coronary artery disease as assessed by coronary artery calcium in COVID-19코로나19에서 관상동맥 칼슘으로 평가한 임상 및 무증상 관상동맥 질환의 영향Multicenter Study Published on 2021-07-012022-09-11 Journal: Atherosclerosis [Category] SARS, 치료기술, [키워드] 95% CI 95% confidence interval 95%CI active cancer adjusted hazard ratio Agatston score age association Atherosclerosis C-reactive protein CAD calcium Calcium score cardiovascular cardiovascular risk cardiovascular risk factors cerebrovascular accident Chest computed tomography Clinical outcome clinical outcomes Clinical practice Composite Computed tomography Coronary artery Coronary artery calcifications Coronary artery disease coronary atherosclerosis COVID-19 COVID-19 disease COVID-19 patient disease Endpoint evaluate event had no hemoglobin Hospital mortality hospitalized COVID-19 patient hospitalized COVID-19 patients hospitalized patient hospitalized patients hospitals Impact in-hospital mortality increase in Increasing independent independent of independent predictor independent predictors Italian LDH lung male median age Mortality multicenter Myocardial infarction outcome Patient Peripheral artery disease positive patient predictor primary endpoint prognostic retrospective Risk assessment risk factor SARS-CoV 2 secondary endpoint stratified three groups with COVID-19 [DOI] 10.1016/j.atherosclerosis.2021.03.041 PMC 바로가기 [Article Type] Multicenter Study
Peripheral Artery Disease and Abdominal Aortic Aneurysm: The Forgotten Diseases in COVID-19 Pandemic. Results from an Observational Study on Real-World ManagementObservational Study Published on 2021-06-292022-10-04 Journal: Medicina [Category] MERS, SARS, 임상, [키워드] Abdominal aortic aneurysm analyzed aortic aneurysm Artery benefit cardiovascular risk COVID-19 COVID-19 pandemic disease drug Follow-up High-risk patients higher risk impacted LDL limitations Lipid lipid profile low-density management material Modification Mortality objective offer Patient patients peripheral Peripheral artery disease profile reducing required Result risk risk reduction Surveillance survival targets the mean therapeutic target therapy treated unit were recorded [DOI] 10.3390/medicina57070672 PMC 바로가기 [Article Type] Observational Study
Statins in COVID-19 TherapyReview Published on 2021-06-162022-10-29 Journal: International Review of Cell and Molecular Biology [Category] COVID-19, [키워드] antioxidant antiviral therapy atherosclerotic plaque cardiac cardiovascular disease cardiovascular risk clinical trial COVID-19 COVID-19 therapy Cytokine storm de novo drug Effect Endothelial dysfunction European group host cells Inflammatory responses pathophysiology Patient patients with COVID-19 pleiotropic Pleiotropic effects respiratory infections SARS-CoV-2 statin statins therapy thrombosis Treatment [DOI] 10.3390/life11060565 PMC 바로가기 [Article Type] Review
Altered Vascular Endothelium-Dependent Responsiveness in Frail Elderly Patients Recovering from COVID-19 Pneumonia: Preliminary EvidenceArticle Published on 2021-06-092022-10-30 Journal: Journal of Clinical Medicine [Category] COVID-19, [키워드] Altered Blood blood flow blood gas analysis cardiovascular risk changes in circulating clinical condition Coagulation Comorbidities component contrary Control COVID-19 COVID-19 infection COVID-19 patient CTRL D-dimer dietary supplement drugs elderly Elderly patient Endothelial dysfunction ESR evaluated fatigue Hospitalization Hypoxemia Impact impacted Inflammation male marker metabolism Mild moderate nitric oxide Pneumonia reduced responsiveness Sex single leg passive movement spirometry syndrome value Vascular vascular dysfunction [DOI] 10.3390/jcm10122558 PMC 바로가기 [Article Type] Article
Cardiovascular Risk Factors and the Severity of COVID-19 DiseaseCardiology Published on 2021-06-072022-10-31 Journal: Cureus [Category] COVID-19, [키워드] acute respiratory distress Admission ARDS association Cardiology cardiovascular cardiovascular risk cardiovascular risk factor Complication coronavirus disease COVID 19 COVID-19 death determinant disease EAS European examined Factor high risk highlight Hospitalized ICU ICU admission Infection intensive care logistic regression model material moderate Patient patients patients with COVID-19 responsible Result risk sar-cov 2 infection Severity markers severity of COVID-19 significantly Society syndrome the patient traditional cardiovascular risk factors university Zaid [DOI] 10.7759/cureus.15486 PMC 바로가기 [Article Type] Cardiology
Rationale and design of the pragmatic randomized trial of icosapent ethyl for high cardiovascular risk adults (MITIGATE)심혈관 위험이 높은 성인을 위한 icosapent ethyl의 실용적인 무작위 시험의 이론적 근거 및 설계(MITIGATE)Multicenter Study Published on 2021-05-012022-09-11 Journal: American heart journal [Category] 임상, [키워드] age anti-inflammatory property Antiviral approved atherosclerotic Atherosclerotic cardiovascular disease by mouth Cardiopulmonary cardiovascular disease cardiovascular risk Care clinical effectiveness clinical observation clinical observations Clinical practice clinical status clinical trial clinics co-primary endpoint co-primary endpoints cohort of patient consequence control group coronavirus disease Coronavirus disease 2019 COVID-19 downstream elevated evaluate Evidence fatty Fatty acid Follow-up Health Health care Health status hospital Icosapent icosapent ethyl Intervention laboratory-confirmed mitigate morbidity and mortality mouth omega-3 omega-3 fatty acid Open-label participant pleiotropic effect Pleiotropic effects Pragmatic Preclinical preclinical data prescription medication Prevent purified Randomized randomized trial rationale reduce reduction in respiratory infection seasonal flu statin stratified therapy triglycerides upper respiratory infection usual care viral upper respiratory infection. [DOI] 10.1016/j.ahj.2021.01.018 PMC 바로가기 [Article Type] Multicenter Study
Linking COVID-19 and Heme-Driven Pathophysiologies: A Combined Computational–Experimental ApproachCOVID-19와 헴 기반 병태생리학 연결: 결합된 전산-실험적 접근Article Published on 2021-04-272022-09-01 Journal: Biomolecules [Category] MERS, SARS, 진단, [키워드] accompanied Analysis analyzed approach Biomarker Biomarkers cardiovascular risk changes in characterized Coagulation Combined contribute COVID-19 COVID-19 infection COVID-19 infections Diagnosis disease elements experimental validation focus heme heme-binding motifs hemoglobin Hemolysis host cell increase in Inflammation inflammatory pathway inflammatory pathways Interleukins knowledge Knowledge graphs outbreak parameter pathophysiology pathway pathway networks Patient performed progression Protein Proteins proteins ACE2 respiratory respiratory tract S protein SARS-CoV-2 Superimposition therapy TMPRSS2 Trigger triggers Viral protein Viral proteins worldwide pandemic [DOI] 10.3390/biom11050644 PMC 바로가기 [Article Type] Article