CD8+ T cell – Page 5 – Communicable Diseases Research

Immune-Mediated Mechanisms in Patients Testing Positive for SARS-CoV-2: Protocol for a Multianalysis Study

Protocol

Published on 2022-01-252022-10-29
Journal: JMIR Research Protocols [Category] COVID-19,

Neutralizing-antibody-independent SARS-CoV-2 control correlated with intranasal-vaccine-induced CD8 + T cell responses

비강내 백신 유도 CD8 + T 세포 반응과 상관관계가 있는 중화 항체 비의존적 SARS-CoV-2 대조군

Article

Published on 2022-01-192022-09-11
Journal: Cell Reports Medicine [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료법,

[키워드] absence acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Antigen antigen-specific neutralizing antibodies appearance CD8 CD8+ CD8+ T cell Containment contribute controls coronavirus coronavirus disease Coronavirus disease 2019 correlated COVID-19 cynomolgus macaques effective Effective vaccines Efficacy expressing highlighting intranasal macaque NAb NAbs Nasopharyngeal swab nasopharyngeal swabs Neutralizing antibodies neutralizing antibody nine pandemic reduced respiratory S variant SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus significantly specific neutralizing antibodies T cell T cell response T cell responses vaccination Vaccine variant variants Viral viral control Viral load Viral vector virus viruses
[DOI] 10.1016/j.xcrm.2022.100520 PMC 바로가기 [Article Type] Article

Selection and T-cell antigenicity of synthetic long peptides derived from SARS-CoV-2

Animal

Published on 2022-01-112022-10-30
Journal: The Journal of General Virology [Category] COVID-19,

Immune Response to SARS-CoV-2 Vaccine in 2 Men

2명의 남성에서 SARS-CoV-2 백신에 대한 면역 반응

Article

Published on 2022-01-012022-09-12
Journal: International archives of allergy and immunology [Category] MERS, SARS, 진단,

[키워드] Analysis B cells B-cell Breg carried CD4 CD4+ CD8 CD8 T-cell CD8+ CD8+ T cell CD8+ T cells Cell cells COVID-19 dose evaluated flow cytometry follicular cell follicular helper T cells healthy subject IgG antibody immunological increase in induce lack lymphocyte magnitude memory memory B cells memory T cells monoclonal antibody naïve performed Pfizer plasmablasts receiving Regulatory regulatory lymphocytes response SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2-specific CD8 T cells subject subjects subset Support T cell TCM TEM TEMRA Total transitional B cells Treg Trial vaccination Vaccine Vaccines virus zone
[DOI] 10.1159/000520046 PMC 바로가기 [Article Type] Article

T cell counts and IL-6 concentration in blood of North African COVID-19 patients are two independent prognostic factors for severe disease and death

북아프리카 COVID-19 환자의 혈액 내 T 세포 수와 IL-6 농도는 심각한 질병 및 사망에 대한 두 가지 독립적인 예후 인자입니다

Article

Published on 2022-01-012022-09-11
Journal: Journal of leukocyte biology [Category] 바이오마커,

[키워드] 95% confidence interval acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition African Analysis B cells Blood CD4+ T cells CD8+ T cell CD8+ T cells characteristic clinician Concentration coronavirus coronavirus disease Coronavirus disease 2019 correlated COVID-19 COVID-19 patient COVID-19 patients cutoff value cytokine cytokine level cytokine levels Cytokines death death group develop disease flow cytometry healthy control healthy controls help high risk IL-10 IL-6 immune parameter immune system independent investigated lymphocyte Lymphocyte subset Lymphocyte subsets Lymphocytes Mild Mortality multivariate logistic regression multivariate logistic regression analysis natural killer cell Natural killer cells North outcome parameter pathology Patient patients percentage percentages performed Peripheral blood peripheral blood lymphocyte predict Prognosis Prognostic factor receiver operating characteristic respiratory risk ROC ROC curves SARS-CoV2 severe acute respiratory syndrome Coronavirus severe cases severe disease severity severity of illness significant difference significant differences significantly higher statistical difference statistical differences subset survival T cell T cells Th17 Th2 the disease the patient threshold Total two group two groups
[DOI] 10.1002/JLB.4COVA1020-703R PMC 바로가기 [Article Type] Article

A promiscuous T cell epitope-based HIV vaccine providing redundant population coverage of the HLA class II elicits broad, polyfunctional T cell responses in nonhuman primates

Research article

Published on 2022-01-012022-10-05
Journal: Vaccine [Category] 비임상,

[키워드] alleles Antigen approach BALB/c binding CD4+ CD4+ T cell CD8+ T cell cellular immunity conserved costly Coverage COVID-19 described Diseases DNA vaccine Electroporation elicit elicited ENCODE epitope Epitope-based vaccine Epitopes Evidence facilitate generate HIV HIV vaccine HLA class II HLA-DR immune response immunization immunized immunodominant immunogen in vivo Increasing induce less MHC mice multiple epitopes Multiple HLA-binding epitopes neutralizing antibody over patients peptides platform Populational vaccine response Result rhesus macaque rhesus macaques shown T cell T cell epitope T cell response transgenic Vaccine Vaccines viral disease viral infections
[DOI] 10.1016/j.vaccine.2021.11.076 [Article Type] Research article

Characterization of SARS-CoV-2-Specific Humoral and Cellular Immune Responses Induced by Inactivated COVID-19 Vaccines in a Real-World Setting

Immunology

Published on 2021-12-222022-11-01
Journal: Frontiers in Immunology [Category] COVID-19, SARS,

[키워드] acute respiratory syndrome binding domain CD4+ CD4+ T cell CD8+ T cell cellular cellular immune responses characterization characterized clinical trials Concentration concerning conditions coronavirus coronavirus disease COVID-19 COVID-19 vaccine COVID-19 vaccines COVID‐19 cytokine demonstrated detectable dose dosing interval elicited Evidence Frequency humoral humoral immune response humoral immune responses IFN-γ IgG IgG response IL-2 immune response Immunity inactivated Inactivated vaccine individual individuals induced longitudinal analysis majority male membrane neutralizing antibody nucleocapsid parameter participant peptide pool Protein raised recognizing response S-RBD SARS-CoV-2 SARS‐CoV‐2 second dose second vaccination setting significantly higher single vaccine sustained the SARS-CoV-2 TNF-α vaccination Vaccine vaccinees waned while
[DOI] 10.3389/fimmu.2021.802858 PMC 바로가기 [Article Type] Immunology

Prolonged activation of nasal immune cell populations and development of tissue-resident SARS-CoV-2-specific CD8+ T cell responses following COVID-19

Research

Published on 2021-12-222022-10-05
Journal: Nature Immunology [Category] SARS, 유전자 메커니즘, 임상, 치료법, 치료제,

Assessment of SARS-CoV-2 Immunity in Convalescent Children and Adolescents

회복기 아동 및 청소년의 SARS-CoV-2 면역 평가

Immunology

Published on 2021-12-172022-09-11
Journal: Frontiers in Immunology [Category] SARS, 진단, 치료기술, 치료제,

[키워드] activated adaptive Adolescent adolescents age assessment baseline level baseline levels CD4+ CD4+ T cell CD8+ T cell CD8+ T cells cellular children controls convalescence convalescent COVID-19 patients correlated COVID-19 Diagnosis half-life humoral Humoral immunity IgG levels immune memory response immune memory responses Immunity Immunological memory independent independent assay independent of knowledge membrane nuclear pediatric Pediatric patient Pediatric patients peptide peptides performed protective immunity quantified RBD IgG recovered patient recovered patients Reinfection response robust SARS-CoV-2 SARS-CoV-2 immunity SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV-2 RBD SARS-CoV-2 RBD IgG SARS-CoV-2 S shown specific immunity stimulated T cell T cell response T cells the SARS-CoV-2 Vaccine
[DOI] 10.3389/fimmu.2021.797919 PMC 바로가기 [Article Type] Immunology

Innate and Adaptive Immunity Imbalance With Severe COVID-19 Pneumonia in Children and Adults

Pediatrics

Published on 2021-12-152022-10-31
Journal: Frontiers in Pediatrics [Category] COVID-19,

[키워드] Abnormalities adaptive adaptive immune cells Admission Adult patient Adult patients Adults alteration analyzed CD14+ monocyte CD3+ CD4+ T cell CD8+ T cell Characteristics Chest CT children clinical complication clinical manifestation Clinical symptoms Comorbidities Control controls coronavirus disease COVID-19 COVID-19 patient COVID-19 patients Critical enrolled Frequency had more healthy Imbalance immune Immune cell immune response alteration Inflammatory response Innate Innate immune cells Laboratory laboratory abnormalities Laboratory features lymphocyte Mild much higher Patient patients pilot study Pneumonia Prevalence radiological real-time RT-PCR recruited SARS-CoV-2 severe patients significantly lower subpopulations subset survived T-lymphocyte with COVID-19
[DOI] 10.3389/fped.2021.736013 PMC 바로가기 [Article Type] Pediatrics