The Antiviral Effect of the Chemical Compounds Targeting DED/EDh Motifs of the Viral Proteins on Lymphocytic Choriomeningitis Virus and SARS-CoV-2Article Published on 2021-06-242022-10-28 Journal: Viruses [Category] COVID-19, SARS, [키워드] A549 antivirals arenavirus arenaviruses cell lines Cell toxicity cells Chemical Choriomeningitis Compound compounds Concentration coronavirus Coronaviruses DED/EDh motif drug target Effect exhibited exonuclease exonuclease (ExoN) motif include indicated inhibited LCMV Lymphocytic choriomeningitis Lymphocytic choriomeningitis virus (LCMV) MERS-CoV motif motifs nsp14 pathogenic viruses performed SARS-CoV SARS-CoV-2 SARS-COV-2 infection Simulation study targeting these compound treat Vero Viral protein Viral proteins virus was used [DOI] 10.3390/v13071220 PMC 바로가기 [Article Type] Article
Drug–drug interactions between treatment specific pharmacotherapy and concomitant medication in patients with COVID-19 in the first wave in Spain스페인의 첫 번째 물결에서 COVID-19 환자의 치료 특이 적 약물 요법과 동반 약물 간의 약물 연체 상호 작용Article Published on 2021-06-142022-09-10 Journal: Scientific Reports [Category] MERS, SARS, 임상, 치료기술, 치료법, [키워드] 105 patient 105 patients Admission adverse effects analyzed binomial logistic regression carried Charlson index checked Chemical clinically cohort study Comorbidity Concomitant Concomitant medication concomitant medications conducted COVID-19 drug drug therapy drug–drug interaction drugs during admission Factor First wave hospital Hospital stay hospitalized patient hospitalized patients Hydroxychloroquine identify Infectious diseases Interaction involved Lopinavir Lopinavir/ritonavir mechanism medication Patient patients patients with COVID-19 polypharmacy Prevalence prolongation QTC prolongation resource risk factor Risk factors Ritonavir SARS-COV-2 infection severity single center Spain therapy Treatment University of Liverpool [DOI] 10.1038/s41598-021-91953-2 PMC 바로가기 [Article Type] Article
Chemical profiling of Huashi Baidu prescription, an effective anti-COVID-19 TCM formula, by UPLC-Q-TOF/MSUPLC-Q-TOF/MS에 의한 효과적인 항-COVID-19 TCM 공식인 Huashi Baidu 처방의 화학적 프로파일링Article Published on 2021-06-012022-08-31 Journal: Chinese journal of natural medicines [Category] SARS, 치료제, [키워드] 2019-nCoV alleviate anti-inflammatory effect Antiviral effect antiviral effects Baidu blood-stained sputum Cell cells characterization Characterization of chemical constituents characterized Chemical clinically Corona virus corona virus disease 2019 cough COVID-19 cytokine Cytokines defecation determine disease Effect effective ELISA enzyme enzyme-linked immunosorbent assay enzyme-linked immunosorbent assays expression level expression levels Extract guideline Huashi Baidu prescription. IL-6 in vitro Inflammatory cytokine Inflammatory cytokines inhibited knowledge lipopolysaccharide negative and positive novel Novel coronavirus Pneumonia Regulation severe corona virus disease sputum Symptoms TCM the cell TNF-α tongue treat UPLC Virus Disease were measured [DOI] 10.1016/S1875-5364(21)60046-8 PMC 바로가기 [Article Type] Article
A unique view of SARS-CoV-2 through the lens of ORF8 proteinORF8 단백질 렌즈를 통한 SARS-CoV-2의 독특한 시각Article Published on 2021-06-012022-09-11 Journal: Computers in biology and medicine [Category] SARS, 변종, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adaptive amalgamation Amino acid Analysis antiviral response bat Characteristics Chemical coronavirus down-regulation Effect highlight histocompatibility Host host immunity hosts immune immune evasion immune responses innate immune response innate immune responses interferon Major major histocompatibility complex modulate Mutation Mutational hotspots ORF8 ORF8 evolution ORF8 protein ORF8 proteins pangolin pangolin-CoV performed Perspective phylogenetics phylogenies Physicochemical properties predicted Protein sample collection SARS-CoV-2 sequence similarity severe acute respiratory syndrome Coronavirus structural property unique variant [DOI] 10.1016/j.compbiomed.2021.104380 PMC 바로가기 [Article Type] Article
Drug-utilisation profiles and COVID-19Article Published on 2021-04-262022-10-29 Journal: Scientific Reports [Category] COVID-19, MERS, SARS, [키워드] acting age and sex antihypertensive drugs association ATC B01 Campania carried category Characteristics Chemical collected Comorbidity Coronavirus disease 2019 COVID-19 COVID-19 infection COVID-19 patient database drug Effect Epidemiology generate Health policy healthcare Healthcare system highlight hypothese individual Infectious diseases information Italy medication monotherapy Mortality non-COVID-19 patient Outcomes research positive Prevalence prevalence rate profile profiles renin-angiotensin system retrospective study cohort susceptibility tested to define [DOI] 10.1038/s41598-021-88398-y PMC 바로가기 [Article Type] Article
Endocrine-Disrupting Chemicals and Infectious Diseases: From Endocrine Disruption to ImmunosuppressionReview Published on 2021-04-112022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, MERS, [키워드] adopted animal model article Cancer cardiovascular disease Chemical Clinical outcome comorbid diseases Comorbidities Comorbidity component Compound contaminant contribute contributing to coronavirus disease COVID-19 COVID-19 mortality death diabetes Disruption EDC Effects Endocrine endocrine disrupting chemicals Evidence H1N1 Health humans hypertension immune dysfunction immune system Impact include interfere kidney liver diseases Major methodology obesity occur progression public health representing risk severe disease severity significantly susceptibility virus vital role while [DOI] 10.3390/ijms22083939 PMC 바로가기 [Article Type] Review
Variables associated with COVID-19 severity: an observational study of non-paediatric confirmed cases from the general population of the Basque Country, SpainObservational Study Published on 2021-04-012022-10-04 Journal: BMJ Open [Category] 임상, [키워드] Admission affected age ageing effect Alter association associations Blood Care category Chemical chronic drug classification clinical variable confirmed case COVID-19 COVID-19 pandemic death drugs Factor General population Health Health status healthcare hospital inclusion criteria individual interfere methodology MOST nervous system organ outcome outcomes Patient positive PCR primary care Psychosis public health Public health intervention Regression Research research methods retrospective serology test severity Sex Sociodemographic Spain statistically significant statistics & Stratification suggested tree understanding variable were excluded with COVID-19 [DOI] 10.1136/bmjopen-2021-049066 PMC 바로가기 [Article Type] Observational Study
A computational drug repurposing approach in identifying the cephalosporin antibiotic and anti-hepatitis C drug derivatives for COVID-19 treatmentCOVID-19 치료를 위한 세팔로스포린 항생제 및 항 C형 간염 약물 유도체 식별을 위한 컴퓨터 약물 용도 변경 접근법Article Published on 2021-03-012022-08-31 Journal: Computers in biology and medicine [Category] MERS, SARS, 신약개발, 치료제, [키워드] active site acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 amalgam Analysis antibiotic antiviral agent Antiviral agents approach backbone atom Bacterial bacterial pneumonia Bank binding binding free energy caused Ceftaroline Ceftaroline fosamil Chemical complex Computational drug coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 Critical Cys145 database death derivative drug Drug repurposing free energy Free energy calculations Glu166 Gly143 HCV hepatitis C hepatitis C virus His41 hydrogen Hydrogen bond hydrogen bonds identify indicated indication information inhibitor inhibitors Interaction investigated M pro MD simulations molecular molecular dynamics offer pharmacokinetic Pneumonia potential energy Preclinical Testing profiles Protease inhibitor Protein repurposing residue respiratory RMSD SARS-CoV-2 SARS-CoV-2 main protease Seven severe acute respiratory syndrome Coronavirus Side effects suggested supported telaprevir Treatment Virtual screening [DOI] 10.1016/j.compbiomed.2020.104186 PMC 바로가기 [Article Type] Article
Chemical composition and pharmacological mechanism of ephedra-glycyrrhiza drug pair against coronavirus disease 2019 (COVID-19)코로나바이러스 질병 2019(COVID-19)에 대한 마황-글리시리자 약물 쌍의 화학 성분 및 약리학적 메커니즘Research Paper Published on 2021-02-282022-08-31 Journal: Aging (Albany NY) [Category] MERS, 진단, 치료제, [키워드] 3CLpro ACE2 ALB Analysis analyzed angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 antiviral effects approach blood circulation CAMP Chemical chemokine chemokine signaling pathways complex Compound coronavirus disease COVID-19 demonstrated digestive digestive system Diseases docking result Effectiveness enrichment analysis ephedra flexibility FOS glycyrrhiza high correlation IL2 immune regulation Jak-STAT molecular docking molecular dynamics Molecular dynamics simulation MPro network pharmacology organ pathway Pathway analysis Pathways pharmacological mechanism PI3K PI3K-Akt signaling Prevention and control protease PTGS2 respiratory S protein Spike protein stability Statistics target targets TCM the spike protein these compound these compounds TNF-α Traditional Chinese medicine Treatment treatment of COVID-19 [DOI] 10.18632/aging.202622 PMC 바로가기 [Article Type] Research Paper
Evaluation of serum ferritin for prediction of severity and mortality in COVID-19- A cross sectional studyCross-sectional Study Published on 2021-02-122022-10-04 Journal: Annals of Medicine and Surgery [Category] 바이오마커, [키워드] all age group all-cause mortality Analysis analyzed association Binary logistic regression category characteristic Chemical Concentration conducted Coronavirus disease 2019 COVID-19 COVID-19 cases cross Department evaluated females ferritin Final genders hospitalized patient Hypothesis identify in-patient independent Karachi Logistic regression male material medical record Medicine Mortality Non-survivors Patient positive Prognosis prognostic prognostic biomarker Result ROC analysis Science Serum ferritin severe severity significant difference SPSS Statistical Package subject survivor tested total body university utility variable was used were recorded with COVID-19 [DOI] 10.1016/j.amsu.2021.02.009 PMC 바로가기 [Article Type] Cross-sectional Study