Study on valuable metal incorporation in the Fe–Al precipitate during neutralization of LIB leach solutionArticle Published on 2021-12-022023-08-29 Journal: Scientific Reports [Category] E형 간염, [키워드] Chemical engineering Chemistry [DOI] 10.1038/s41598-021-02019-2 PMC 바로가기 [Article Type] Article
A hydrated 2,3-diaminophenazinium chloride as a promising building block against SARS-CoV-2Article Published on 2021-11-302022-10-04 Journal: Scientific Reports [Category] SARS, 치료제, [키워드] aerobic Analysis Bacteria Bacterial binding binding energy Biotechnology catalytic Cell Chemistry chloride chloride ion Cluster complex complexes Computational models Concentration contribute crystal diffusion method Drug discovery ecological Efficiency Escherichia coli exhibit function inhibition zone iron(III M pro Microbiology molecular Molecular docking study Molecular dynamics simulation non-structural protein NSP2 pathogen pathogenicity pneumoniae producing protease Remdesivir SARS-CoV-2 Secondary Metabolite strain Streptococcus pneumoniae Structural analysis Structure therapeutic viability X-ray [DOI] 10.1038/s41598-021-02280-5 PMC 바로가기 [Article Type] Article
Site-Specific Labeling of Endogenous Proteins Using CoLDR ChemistryArticle Published on 2021-11-242022-10-29 Journal: Journal of the American Chemical Society [Category] Coronavirus, SARS, [키워드] addition Affect approach binding binding pocket BTK Cell cells Chemical Chemistry CRBN Degradation demonstrated endogenous fluorescent functional inhibit interactions labeling Ligand maintain Modification MONITOR probe Protein quantification SARS-CoV-2 selective shown stability target protein variety [DOI] 10.1021/jacs.1c06167 PMC 바로가기 [Article Type] Article
Multiplexed detection of respiratory pathogens with a portable analyzer in a “raw-sample-in and answer-out” mannerArticle Published on 2021-11-232022-10-04 Journal: Microsystems & Nanoengineering [Category] 진단, [키워드] acute respiratory syndrome automatically bacterial specy caused Chemistry coronavirus Coronavirus disease 2019 COVID-19 detect diagnostic test Electrical and electronic engineering Infection isothermal amplification Klebsiella pneumoniae limit of detection morbidity and mortality N gene nucleic acid extraction ORF1ab gene performed primer set Pseudomonas aeruginosa pseudovirus public health respiratory pathogen Respiratory pathogens reverse transcription RT-LAMP SARS-CoV-2 SARS-CoV-2 pseudovirus Spread Swab swab sample the SARS-CoV-2 [DOI] 10.1038/s41378-021-00321-7 PMC 바로가기 [Article Type] Article
Theaflavin Chemistry and Its Health BenefitsReview Article Published on 2021-11-182022-10-29 Journal: Oxidative Medicine and Cellular Longevity [Category] COVID-19, [키워드] activity Anti-inflammatory anticancer antioxidant cellular and molecular Chemistry clinical study derivative Diseases Effect epidemiological gut microbiota Health Health Benefit include manuscript mechanism of action mechanisms medication modulate pharmacological Population reported significant effect TF1 TFS theaflavin [DOI] 10.1155/2021/6256618 PMC 바로가기 [Article Type] Review Article
Defining the kinetic effects of infection with influenza virus A/PR8/34 (H1N1) on sphingosine-1-phosphate signaling in mice by targeted LC/MSArticle Published on 2021-10-112023-06-08 Journal: Scientific Reports [Category] 신종인플루엔자, [키워드] Biochemistry Biomarkers Chemistry Diseases Microbiology [DOI] 10.1038/s41598-021-99765-0 PMC 바로가기 [Article Type] Article
Laboratory parameters in patients with COVID-19 on first emergency admission is different in non-survivors: albumin and lactate dehydrogenase as risk factorsArticle Published on 2021-10-012023-07-06 Journal: Journal of Clinical Pathology [Category] SARS, [키워드] blood proteins Chemistry clinical diagnostic techniques and procedures infections medical laboratory science. [DOI] 10.1136/jclinpath-2020-206865
Fluorogenic in vitro activity assay for the main protease M pro from SARS-CoV-2 and its adaptation to the identification of inhibitorsSARS-CoV-2의 주요 프로테아제 M pro에 대한 형광 체외 활성 분석 및 억제제 식별에 대한 적응Article Published on 2021-09-172022-09-11 Journal: STAR protocols [Category] SARS, 치료기술, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 bioengineering Biotechnology Biotechnology and bioengineering Chemistry clinical clinical protocol coronavirus coumarin detectable energy energy transfer Fluorescence fluorescent Health Sciences High Throughput Screening identify in silico in vitro in vitro activity inhibitor inhibitors M pro molecular dynamics Molecular dynamics simulation Molecular/Chemical Probes offered produced protease Protein Biochemistry proteolytic activity protocol resonance SARS-CoV-2 sensitivity severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 specificity substrates throughput [DOI] 10.1016/j.xpro.2021.100793 PMC 바로가기 [Article Type] Article
Identification and Engineering of Aptamers for Theranostic Application in Human Health and Disorders인간 건강 및 장애에 대한 치료학적 적용을 위한 압타머의 식별 및 엔지니어링Review Published on 2021-09-072022-09-10 Journal: International Journal of Molecular Sciences [Category] 진단, 치료제, [키워드] antibody application approach aptamer aptasensor Biomarker Care chemical properties chemical property Chemistry clearance Cost effectiveness COVID-19 demonstrated diagnostic different disease different diseases digestion disease pathology Engineering Food industry Frame fungal infections Health heterogeneity Human identification Immunotherapy In-vitro initial Lateral flow assay (LFA) ligands maintain Modification molecular Molecular biology molecular imaging Nuclease oligonucleotide physical protein level proteomics renal renal clearance sensitivity Sensitivity and specificity sensor sequence shelf life Single Cell single cell proteomics stem cell stem cells systematic evolution of ligands by exponential enrichment (SELEX) theranostic therapeutic Treatment Variation while [DOI] 10.3390/ijms22189661 PMC 바로가기 [Article Type] Review
Computer-aided screening for potential TMPRSS2 inhibitors: a combination of pharmacophore modeling, molecular docking and molecular dynamics simulation approaches잠재적인 TMPRSS2 억제제에 대한 컴퓨터 지원 스크리닝: 약전 모델링, 분자 도킹 및 분자 역학 시뮬레이션 접근법의 조합Article Published on 2021-09-012022-09-11 Journal: Journal of biomolecular structure & dynamics [Category] 치료제, [키워드] active site active sites acute respiratory syndrome ADME analyses approach approaches binding binding affinities binding affinity Chemistry Combination Compound compounds coronavirus COVID-19 docked docking scores drug drugs facilitate feature free energy homology homology modeling Host host cells host protein host proteins identify inhibit inhibitors Interaction molecular docking molecular dynamics Molecular dynamics simulation pharmacophore pharmacophore modeling proliferation residue retrieved SARS-CoV-1 and -2 Serine serine protease stability target tested these compound these compounds TMPRSS2 trajectory transmembrane serine protease virus was used Zinc ZINC database [DOI] 10.1080/07391102.2020.1792346 PMC 바로가기 [Article Type] Article