Enumerating asymptomatic COVID-19 cases and estimating SARS-CoV-2 fecal shedding rates via wastewater-based epidemiologyResearch article Published on 2021-12-012022-10-05 Journal: The Science of the total environment [Category] SARS, 유전자 메커니즘, [키워드] Antigen Asymptomatic Asymptomatic COVID-19 averaged can be used clinical clinical testing collected COVID-19 COVID-19 symptom Critical defined determine Dormitories Epidemiology events examined expression fecal Fecal shedding Genome indicated infected individual MONITOR nasopharyngeal swab sample PCR test positive predict Prevalence processed public health prevention Public health response reduction reported SARS-CoV-2 SARS-CoV-2 infected individual SARS-COV-2 infection SARS-CoV-2 RNA SARS-CoV-2 transmission Symptom symptomatic case triggered university viral shedding Virus concentrations Wastewater-based epidemiology [DOI] 10.1016/j.scitotenv.2021.149794 [Article Type] Research article
Seroprevalence of Antibodies to SARS-CoV-2 in Guangdong Province, China between March to June 2020Article Published on 2021-11-182022-10-28 Journal: Pathogens [Category] COVID-19, [키워드] age antibody China clinical testing conducted Coronavirus disease 2019 COVID-19 COVID-19 case cross-sectional determine enzyme Epidemics Guangdong hidden immunoassay neutralization titer population immunity positive pseudovirus Pseudovirus neutralization assay resulting S-protein SARS-CoV-2 SARS-CoV-2 antibody SARS-CoV-2 IgG Seroprevalence Serosurvey serum sample South submitted tested Wuhan [DOI] 10.3390/pathogens10111505 PMC 바로가기 [Article Type] Article
Safety and Immunogenicity Analysis of a Newcastle Disease Virus (NDV-HXP-S) Expressing the Spike Protein of SARS-CoV-2 in Sprague Dawley RatsSprague Dawley 쥐에서 SARS-CoV-2의 스파이크 단백질을 발현하는 뉴캐슬병 바이러스(NDV-HXP-S)의 안전성 및 면역원성 분석Immunology Published on 2021-11-182022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 변종, 진단, 치료기술, [키워드] (Alpha) (Beta acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Administered administration Alpha animal model Antibody titer Antibody titers approach B.1.1.7 B.1.351 B.1.617.2 Beta boost Brazil clinical clinical testing coronavirus country COVID-19 elicited expand expressing followed by Histopathology Immunity immunogenicity immunogenicity analysis induce intramuscularly intranasally Local mucosal Neutralizing activity newcastle disease virus performed Post-mortem pre-fusion RAT rat model reactogenicity regimen Region respiratory robust Safety SARS-CoV-2 SARS-CoV-2 spike protein SARS-CoV-2 vaccine second serum antibodies serum antibody severe acute respiratory syndrome Coronavirus Spike protein Spread systemic reactions tested the Spike the spike protein the United State the vaccine Toxicity United States vaccination vaccination rate Vaccine vaccine administration variants of concern VOCs were assessed wild type [DOI] 10.3389/fimmu.2021.791764 PMC 바로가기 [Article Type] Immunology
Changes in Severe Acute Respiratory Syndrome Coronavirus 2 Seroprevalence Over Time in 10 Sites in the United States, March-August, 20202020년 3월-8월 미국 10개 사이트에서 시간 경과에 따른 중증 급성 호흡기 증후군 코로나바이러스 2 혈청 유병률의 변화Article Published on 2021-11-162022-09-11 Journal: Clinical Infectious Diseases: An Official Publicat [Category] MERS, SARS, 진단, 치료기술, [키워드] absence acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adjusted age and sex anti-SARS-CoV-2 antibody antibody Antibody Response bootstrap change changes in clinical testing complement confidence Confidence intervals coronavirus coronavirus 2 COVID-19 cumulative cumulative incidence decrease decreases detectable estimate Estimated Evidence evidence of incidence infected with SARS-CoV-2 Infection interval Laboratory majority monitoring New York over performed population level Prevalence reached remained repeated reported respiratory SARS-CoV-2 SARS-COV-2 infection serologic testing serology Seroprevalence serum severe acute respiratory syndrome Coronavirus significant decrease significant increases in Site South statistically significant the United State The United States time United States Utah Washington [DOI] 10.1093/cid/ciab185 PMC 바로가기 [Article Type] Article
491. Persistence of SARS-CoV-2 Iinfection in Immunocompromised ChildrenPoster Abstracts Published on 2021-11-042022-10-29 Journal: Open Forum Infectious Diseases [Category] COVID-19, [키워드] 2019-nCoV 24 hour age Asymptomatic CDC center Chi-square children Clinical characteristics clinical testing Cohort Comorbidity conducted consecutive negative test consultant Control Ct value cycle threshold defined diagnose DiaSorin evaluated Factor figure Fisher had more hospital Immunocompromised immunocompromising condition immunodeficiency Immunosuppressive treatment Implications inclusion criteria infection control initial IQR Kaplan-Meier curve Latinx log-rank test lymphopenia male median median time moderate MOST negative test no difference no significant difference outcomes Panel Patient PCR pediatric persistence Pfizer platform plot polymerase chain reaction positive Positive test potential transmission Primary outcome Result retrospective cohort study risk RT-PCR Samuel SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 PCR test SARS-CoV-2 PCR testing SARS-CoV-2 viral SAS shown specific diagnoses subsequent symptomatic temporal dynamics tested timeline unique Viral load viral loads viral persistence were used Wilcoxon test [DOI] 10.1093/ofid/ofab466.690 PMC 바로가기 [Article Type] Poster Abstracts
Host methylation predicts SARS-CoV-2 infection and clinical outcomeArticle Published on 2021-10-262022-10-04 Journal: Communications Medicine [Category] 바이오마커, 유전자 메커니즘, 진단, [키워드] Affect Analysis analyzed approach association AUC blood draw blood sample change Clinical deterioration Clinical outcome clinical testing Combination controls Coronavirus infection COVID-19 COVID-19 disease COVID-19 disease severity COVID-19 patient death determine Diagnosis Disease progression disease severity DNA methylation driven by ENhance Epigenetic Genetic genome-wide significant help hospital Hospitalization ICU admission identify immune response individual individuals Infection initial interferon signaling involved IRF7 marker methylated Methylation methylation site Modification non-infected OAS1 observé pandemic pathway Patient patients with SARS-CoV-2 Peripheral blood predict Predictive Predictive markers prognosis of patient progression provide reported Result RT-PCR SARS-CoV-2 SARS-COV-2 infection severity significantly statistical the SARS-CoV-2 uninfected viral infection viral infections [DOI] 10.1038/s43856-021-00042-y PMC 바로가기 [Article Type] Article
SARS-CoV-2 RNA detected in urban wastewater from Porto, Portugal: Method optimization and continuous 25-week monitoring포르투갈 포르토의 도시 폐수에서 SARS-CoV-2 RNA 검출: 분석법 최적화 및 25주 연속 모니터링Article Published on 2021-10-202022-09-11 Journal: The Science of the total environment [Category] SARS, 치료기술, [키워드] Analysis analyzed can be used centrifugation circulation city clinical testing collected complement Concentration continuous monitoring COVID-19 COVID-19 incidence COVID-19 pandemic develop effort eight Epidemiology evaluate first stage fraction implementation Improvements iterative Measures methodological methodology optimization organized pandemic plant Porto Portugal protocol public health quantification quantitative PCR reverse transcription Reverse transcription quantitative PCR RNA RNA extraction RT-qPCR SARS-CoV-2 SARS-CoV-2 RNA SARS-CoV-2 RNA detection selected Specific Support Surveillance the SARS-CoV-2 treated Treatment virus Virus quantification wastewater Wastewater-based epidemiology [DOI] 10.1016/j.scitotenv.2021.148467 PMC 바로가기 [Article Type] Article
Study on the Effect and Application Value of Heat-Inactivated Serum on the Detection of Thyroid Function, Tumor Markers, and Cytokines During the SARS-CoV-2 PandemicMedicine Published on 2021-10-182022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] AFP anti-nuclear antibody application blood sample CA125 CEA clinical examination clinical testing correlation CPS Cytokines detection Detection limit Effect evaluated FIVE function HCG heat inactivation Hepatitis B virus iatrogenic IL-10 IL-1β IL-6 IL-8 inactivated inactivation infections no correlation not significantly different pandemic positive positive rate Quantitative reference range regression equation SARS-CoV-2 selected serum inactivation specimen statistically statistically significant difference test indicator the SARS-CoV-2 TNF-α TSH tumor markers two group value [DOI] 10.3389/fmed.2021.742067 PMC 바로가기 [Article Type] Medicine
Moore swab performs equal to composite and outperforms grab sampling for SARS-CoV-2 monitoring in wastewaterMoore 면봉은 합성물과 동일한 성능을 발휘하고 폐수에서 SARS-CoV-2 모니터링을 위한 샘플링 샘플링보다 우수합니다.Article Published on 2021-10-102022-09-11 Journal: The Science of the total environment [Category] SARS, 치료기술, [키워드] Accuracy Analysis approach CDC clinical testing Community Composite detect Disease surveillance Epidemiology experimental design Frequency glycol Grab highest incidence Infection information Iran Local middle Moore Moore swab ORF1 ORF1ab outperform performed Polyethylene glycol positive prevalence of COVID-19 profile protocol real time Region resource RT-qPCR Sample sampling Sampling method SARS-CoV-2 simplicity Swab swabs Tehran threshold unique Viral RNA virus copy number viruses Volume wastewater-based epidemiology (WBE) [DOI] 10.1016/j.scitotenv.2021.148205 PMC 바로가기 [Article Type] Article
SARS-CoV-2 inhibition using a mucoadhesive, amphiphilic chitosan that may serve as an anti-viral nasal spray항 바이러스 비강 스프레이로서 작용할 수있는 점막 흡착성, 양친 매성 키토산을 사용한 SARS-COV-2 억제Article Published on 2021-10-082022-08-31 Journal: Scientific Reports [Category] SARS, 치료기술, 치료제, [키워드] A549 ACE-2 receptor adverse effect Anti-viral binding Biomedical materials Brain Cell clinical testing Concentration controls Coronavirus infections Course COVID-19 COVID-19 pandemic detect dose dosed effective electrostatic epithelial cells expressing Good host cells human airway human airway epithelial human airway epithelial cells hypothesise Infection inhibit injected limit log mammalian mechanism mice nares nasal nasal epithelial cell open Polymer Practice Prevent preventive intervention Prophylactic RATs reduce respiratory respiratory droplet Respiratory droplets respiratory tract Safe SARS-CoV-2 Spread spread of COVID-19 statistical significance TCID transgenic mice Vero E6 Vero E6 cell VERO E6 cells Viral viral entry viral infection Viral load virus [DOI] 10.1038/s41598-021-99404-8 PMC 바로가기 [Article Type] Article