Clinical use – Page 5 – Communicable Diseases Research

Cardiovascular Magnetic Resonance for Patients With COVID-19

COVID-19 환자를 위한 심혈관 자기 공명

Review

Published on 2022-04-012022-09-11
Journal: JACC. Cardiovascular imaging [Category] COVID19(2023년), SARS, 진단, 치료기술,

A Modified Fibronectin Type III Domain-Conjugated, Long-Acting Pan-Coronavirus Fusion Inhibitor with Extended Half-Life

반감기가 연장된 변형된 피브로넥틴 유형 III 도메인 접합, 지속성 범 코로나바이러스 융합 억제제

Article

Published on 2022-03-222022-09-11
Journal: Viruses [Category] Coronavirus, SARS, 변종, 치료제,

Impact of Sars-CoV-2 pandemic on the Veneto Region multitissue bank activity

Article

Published on 2022-03-022022-10-31
Journal: Cell and tissue banking [Category] COVID-19, COVID19(2023년), MERS, SARS,

An infectious SARS-CoV-2 B.1.1.529 Omicron virus escapes neutralization by therapeutic monoclonal antibodies

감염성 SARS-CoV-2 B.1.1.529 Omicron 바이러스는 치료용 단일 클론 항체에 의한 중화를 피합니다

Article

Published on 2022-03-012022-09-11
Journal: Nature Medicine [Category] Fulltext, SARS, 변종, 진단,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 affected anti-receptor-binding domain antibody AstraZeneca B.1.1.529 Biotechnology Celltrion Clinical use Combination concerning coronavirus decrease Efficacy Lilly LY-CoV555 mAb mAbs monoclonal antibody Mutation neutralization neutralize Neutralizing activity omicron parent reduced Regeneron REGN10933 REGN10987 respiratory S309 SARS-CoV-2 severe acute respiratory syndrome Coronavirus Sotrovimab Spike protein tested the antibody the spike protein therapeutic TMPRSS2 TMPRSS2 cells variant Vero Vero-hACE2-TMPRSS2 cells Vir virus
[DOI] 10.1038/s41591-021-01678-y PMC 바로가기 [Article Type] Article

A Hybrid Soluble gp130/Spike-Nanobody Fusion Protein Simultaneously Blocks Interleukin-6 trans-Signaling and Cellular Infection with SARS-CoV-2

하이브리드 가용성 gp130/스파이크-나노바디 융합 단백질은 SARS-CoV-2로 인터루킨-6 트랜스-시그널링 및 세포 감염을 동시에 차단합니다

Article

Published on 2022-02-232022-09-12
Journal: Journal of Virology [Category] MERS, 진단,

[키워드] acute respiratory syndrome addition age anti-inflammatory therapies antibody Antiviral approved assays bind block Cell Clinical use Comorbidities complexes Concentration coronavirus coronavirus disease COVID-19 cytokine receptor Cytokine storm diabetes disease pathology effective fused fusing fusion Glucocorticoid treatment high affinity higher risk hybrid hyperinflammation IL-6 IL-6 receptor IL-6R Immunocompromised patient individual induce infected individuals infected patients Infection inhibitor inhibitors intensive care interleukin-6 life-threatening Lung disease Mild monoclonal antibody monoclonal antibody treatment Multiorgan nanobody pandemic Patient patients Phosphorylation Prevent proliferation Protein RBD Receptor binding domain SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 vaccine severe COVID-19 sgp130 shown Signaling sIL-6R soluble IL-6R Spike protein STAT3 Symptoms symptoms of COVID-19 the SARS-CoV-2 the spike protein therapeutic options therapy trans-signaling trans-signaling. treat Vero cells viral cell viral infection virus-induced hyperinflammation
[DOI] 10.1128/JVI.01622-21 PMC 바로가기 [Article Type] Article

Ocular Complications Following Vaccination for COVID-19: A One-Year Retrospective

Review

Published on 2022-02-212022-10-28
Journal: Vaccines [Category] COVID-19,

Emerging Insights on Caspases in COVID-19 Pathogenesis, Sequelae, and Directed Therapies

COVID-19 발병, 후유증 및 직접 요법의 카스파제에 대한 새로운 통찰력

Review

Published on 2022-02-212022-09-11
Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 변종,

[키워드] accumulating activated acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Apoptosis apoptotic approved benefit broad spectrum caspase Caspases caused Cell cell death characterized clinical manifestation clinical manifestations Clinical use coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 current therapy cytokine cytokine release death disease disease severity downstream dysregulated effective effort Evidence expressed expression family members health emergency high risk highest highlight Hypercoagulation IL-18 IL-1β immune immune responses immunological immunological mechanism in some in vitro individual inflammasomes Inflammation inflammatory mediator Inflammatory mediators inhibitor insight Manifestations mediators multi-organ failure multiprotein complex non-immune observational studies observational study occur outcomes pathology Pathways Prevent progression pyroptosis receptor signaling respiratory risk SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus severe COVID-19 therapeutic therapeutic intervention upstream Vaccines variant
[DOI] 10.3389/fimmu.2022.842740 PMC 바로가기 [Article Type] Review

An ultrapotent RBD-targeted biparatopic nanobody neutralizes broad SARS-CoV-2 variants

Article

Published on 2022-02-092022-10-04
Journal: Signal Transduction and Targeted Therapy [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘,

[키워드] amino acid substitutions antibodies antibody B.1.1.529 B.1.1.7 B.1.351 B.1.617.1 B.1.617.2 B.1.621 Beta binding epitope Clinical use convalescent patient Delta determine domain Drug development Effectiveness experiment extension fusing Gamma highlight host adaptation human IgG1 Fc identify IMPROVE Lambda Microbiology Mutation mutations nanobody neutralization breadth neutralization potency neutralize Neutralizing activity neutralizing antibody omicron P.1 RBD RBD mutations SARS-CoV-2 SARS-CoV-2 neutralization activity SARS-CoV-2 variant spike stability tested the RBD therapeutic Transmission Vaccine variant virus
[DOI] 10.1038/s41392-022-00912-4 PMC 바로가기 [Article Type] Article

Blood GFAP as an emerging biomarker in brain and spinal cord disorders

Reviews

Published on 2022-02-032022-10-05
Journal: Nature reviews. Neurology [Category] 바이오마커,

Quantifying Neutralizing Antibodies in Patients with COVID-19 by a Two-Variable Generalized Additive Model

2변수 일반화 첨가제 모델을 통한 COVID-19 환자의 중화 항체 정량화

Research Article

Published on 2022-02-022022-09-10
Journal: mSphere [Category] COVID19(2023년), MERS, SARS, 바이오마커, 진단, 치료기술,

[키워드] “COVID-19 acute respiratory syndrome Additive Additive Model analyzed antibodies antibody Antibody binding Antibody titer Antibody titers approach binding binding affinity Biology biosafety biosafety level certification Clinical use Combination conventional virus neutralization test coronavirus correlation CoV COVID-19 detect disease domain Efficacy ELISA enzyme enzyme-linked immunosorbent enzyme-linked immunosorbent assay faster Generalized gold gold standard healthy donors Immunity Laboratory level 2 mathematics methodology Model neutralization test Neutralizing antibodies neutralizing antibody Neutralizing antibody titer neutralizing antibody titers Patient patients with COVID-19 PCR-confirmed Perspective platform predicted RBD Receptor-binding domain reflected regions risk SARS-CoV-2 SARS-CoV-2 antibodies SARS-CoV-2 antibody SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV-2 viral Serological testing serum Severe acute respiratory syndrome Severe Acute Respiratory Syndrome CoV specimens Spike protein surrogate the binding affinity the RBD time-consuming Travel two-variable generalized additive model Vaccine vaccine efficacy Viral viral spike protein virus neutralization test with COVID-19
[DOI] 10.1128/msphere.00883-21 PMC 바로가기 [Article Type] Research Article