Predicting In-hospital Mortality Using D-Dimer in COVID-19 Patients With Acute Ischemic StrokeNeurology Published on 2021-07-162022-11-01 Journal: Frontiers in Neurology [Category] COVID-19, [키워드] 95% CI Admission AIS baseline characteristics characterized clinical variables Coagulopathy conducted coronavirus Coronavirus disease 2019 COVID-19 COVID-19 patient cut-off Cutoff D-dimer D-dimer level D-dimer levels dataset disease severity electronic medical records FEU greater Hospitalized in-hospital mortality increased mortality Ischemic Mortality Older outcome Patient patients patients hospitalized peak peak D-dimer predict Record retrospective cohort study risk risk ratio RRs sensitivity specificity stroke threshold with COVID-19 [DOI] 10.3389/fneur.2021.702927 PMC 바로가기 [Article Type] Neurology
Diverse Humoral Immune Responses in Younger and Older Adult COVID-19 PatientsResearch Article Published on 2021-06-292022-10-29 Journal: mBio [Category] COVID-19, MERS, SARS, [키워드] acute respiratory syndrome age Amino acid antibody antibody reactivity Antibody Response antigenic B.1.1.7 B.1.526 B1.351 CD40 ligand chemokine clinical outcomes Clinical severity clinical variables Cohort collected coronavirus Coronaviruses correlation COVID-19 cytokine Cytokine analysis EGF elevated Endemic Endemic coronaviruses epidermal epitope Epitopes Frame group growth factor HCoV-NL63 HCoV-OC43 human coronavirus OC43 Humoral immunity IgG antibody IL-10 IL-15 in vitro transcription individual interferon IP-10 mechanically ventilated membrane MERS-CoV Microarray Middle East Mutation nucleocapsid Older Older age older patient ORF overlap overlapping P.1 Patient patients probe profiles Protein Proteins Region respiratory syndrome coronavirus response SARS-CoV SARS-CoV-2 SARS-CoV-2 antigen SARS-CoV-2 spike SARS-CoV-2 variant selected serum sample significantly significantly higher subset systemic cytokine the N protein the S1 protein translation Ventilated Viral variants [DOI] 10.1128/mBio.01229-21 PMC 바로가기 [Article Type] Research Article
Identification and Prediction of Novel Clinical Phenotypes for Intensive Care Patients With SARS-CoV-2 Pneumonia: An Observational Cohort StudyMedicine Published on 2021-06-042022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] 28-day mortality 95% CI acute respiratory distress Adult patient Analysis applied Classifier clinical clinical variables Clustering Cohort Concentration confidence interval Consensus coronavirus disease correlation COVID-19 develop disease exhibited FIVE heterogeneous hospital host response identification identify Implications inspired air intensive care patient intensive care unit lactate dehydrogenase latent class LDH Logistic logistic regression model machine learning machine learning algorithm Necrosis Neutrophil-to-lymphocyte ratio NLR novel organ dysfunction outcomes oxygen oxygen saturation Patient phenotype Phenotypes prediction Prognosis prognostic pulse SARS-CoV-2 Sepsis syndrome therapeutic TNF-α urea nitrogen variable variables with COVID-19 [DOI] 10.3389/fmed.2021.681336 PMC 바로가기 [Article Type] Medicine
Matched cohort study on the efficacy of tocilizumab in patients with COVID-19Research article Published on 2021-06-012022-10-05 Journal: One Health [Category] 유전자 메커니즘, [키워드] adjusted Admission analyzed baseline clinical benefit clinical variables Cohort cohort study confounders control patient control patients coronavirus COVID-19 discharge disease Efficacy Evidence group hospital increment inspired oxygen fraction logistic regression models lung involvement Matched Mortality no difference not significantly different observational study other treatment Patient patients patients treated patients with COVID-19 Primary outcomes Respiratory function Result risk factor SAFI SARS-CoV-2 secondary outcome Spain sub-cohort Support Tocilizumab Treatment [DOI] 10.1016/j.onehlt.2021.100214 [Article Type] Research article
Acute kidney injury: Incidence, risk factors, and outcomes in severe COVID-19 patientsResearch Article Published on 2021-05-252022-10-28 Journal: PLoS ONE [Category] COVID-19, SARS, [키워드] Acute kidney injury AKI assist azithromycin treatment biochemical Blood Brazil C-reactive protein cause cellular clinical variables COVID-19 COVID-19 patient COVID-19 patients creatinine criteria CRP defined elevated evaluated Factors help Hospital admission hospital discharge hospitalized patient Hydroxychloroquine hypertension ICU Improving incidence Inflammatory intensive care KDIGO kidney leucocytes leukocyte leukocytes management marker mechanical ventilation Medicine Monocytes multisystemic disorder Multivariate analysis Neutrophil-to-lymphocyte ratio Neutrophils NLR Older age outcome Patient performed potential risk progression protocol Result Retrospective study risk Risk factors RT-PCR severe COVID-19 severe COVID-19 patient Stage therapy Univariate analysis university variable vasoactive drug vasoactive drugs was related with COVID-19 [DOI] 10.1371/journal.pone.0251048 PMC 바로가기 [Article Type] Research Article
The Biobanque québécoise de la COVID-19 (BQC19)—A cohort to prospectively study the clinical and biological determinants of COVID-19 clinical trajectoriesBiobanque québécoise de la COVID-19(BQC19) - COVID-19 임상 궤적의 임상 및 생물학적 결정 요인을 전향적으로 연구하기 위한 코호트Research Article Published on 2021-05-192022-09-12 Journal: PLoS ONE [Category] MERS, SARS, 진단, [키워드] addition analyses anti-SARS-CoV-2 antibody approved Canada circulating Clinical data clinical variables Cohort Community coordination coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 crisis death determinant disease DNA and RNA effort global pandemic health authorities Health Organization Hospitalized immediate action include individuals Infection International limit Local magnitude management Manifestations marker metabolome mononuclear cell multiplex National Novel coronavirus novel coronavirus disease organized outbreak pandemic patients Peripheral blood Peripheral blood mononuclear cells plasma positive proteome Research researcher responses responsible SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 PCR serum Spectrum storage trajectory Transcriptome transcriptome sequencing uninfected urgency Whole blood whole genome World Health Organization [DOI] 10.1371/journal.pone.0245031 PMC 바로가기 [Article Type] Research Article
Association between Postmortem Kidney Biopsy Findings and Acute Kidney Injury from Patients with SARS-CoV-2 (COVID-19)Observational Study Published on 2021-05-082022-10-05 Journal: Clinical journal of the American Society of Nephro [Category] SARS, 임상, [키워드] 95% confidence interval acute kidney Acute kidney injury age AKI Analysis angiotensin-converting enzyme inhibitor Anti-inflammatory drugs Anticoagulant anticoagulation antivirals association biopsies biopsy blockers body mass index C-reactive protein Characteristics clinical variables Comorbidity coronavirus disease COVID-19 Deceased diabetes Diabetic diagnosis of COVID-19 evaluate evaluated finding histologic hypertension identify Injury kidney Kidney biopsy Kidney function marker medication men Mexico City Microscopy morbidity and mortality multicenter nephropathy nephrotoxic Odds ratio Participants Patient patients patients with COVID-19 performed Postmortem postmortem. Prevalence Probability receptor SARS-CoV-2 serum albumin severity significantly lower Steroids variables [DOI] 10.2215/CJN.16281020 PMC 바로가기 [Article Type] Observational Study
Time-to-Death Longitudinal Characterization of Clinical Variables and Longitudinal Prediction of Mortality in COVID-19 Patients: A Two-Center StudyMedicine Published on 2021-04-292022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] acute respiratory syndrome analyzed AUC biochemical build C-reactive protein Cell Characteristics characterization clinical clinical marker clinical variable clinical variables cohort study Coronavirus-2 COVID-19 D-dimer death demonstrated Deterioration discharge evaluated fluctuation Hospital admission Intervention lactate dehydrogenase longitudinal Lymphocytes measurement Mortality New York non-survivor Non-survivors outcome Patient performance physiological polymerase chain positive predicted prediction Predictive predictor Prevent procalcitonin progression provide receiver operating characteristics respiratory rate SARS-CoV-2 survivor Survivors Temporal Tongji Hospital trend university variable were used with COVID-19 Wuhan, China [DOI] 10.3389/fmed.2021.661940 PMC 바로가기 [Article Type] Medicine
A COVID-19 risk score combining chest CT radiomics and clinical characteristics to differentiate COVID-19 pneumonia from other viral pneumoniasResearch Paper Published on 2021-04-152022-10-28 Journal: Aging (Albany NY) [Category] COVID-19, SARS, [키워드] acute respiratory syndrome Analysis AUC value Chest CT Chest CT image Clinical characteristics clinical factor clinical variables clinically coronavirus Coronavirus disease 2019 correlation COVID-19 COVID-19 patient diagnostic feature identify implication moderate nomogram patients with COVID-19 Perspective Pneumonia Precision radiologist Radiomics risk risk score SARS-CoV-2 severe acute respiratory syndrome coronavirus 2 therapeutic Transmission Viral pneumonia viral-induced with COVID-19 [DOI] 10.18632/aging.202735 PMC 바로가기 [Article Type] Research Paper
[Clinical and pharmacological data in COVID-19 hospitalized nonagenarian patients][코로나19 입원 비노년 환자의 임상 및 약리학적 데이터]Observational Study Published on 2021-04-012022-09-11 Journal: Revista española de quimioterapia : publicación [Category] 임상, 치료제, [키워드] Analysis Azithromycin Chloroquine clinical evolution clinical feature Clinical features clinical variable clinical variables Comorbidities Comorbidity correlated COVID-19 drug English ENhance functional functional dependence Geriatrics Hospitalized Hydroxychloroquine hydroxychloroquine/chloroquine implementation Implementing leukocyte leukocytes lymphopenia material Mortality MOST Neutrophils Non-survivors nonagenarians. observational study Patient patients pharmacological Registered SARS-CoV-2 SARS-COV-2 infection significantly higher Spanish specific treatment therapeutic response therapeutic strategy Treatment variable [DOI] 10.37201/req/130.2020 PMC 바로가기 [Article Type] Observational Study