Morphogenetic (Mucin Expression) as Well as Potential Anti-Corona Viral Activity of the Marine Secondary Metabolite Polyphosphate on A549 CellsA549 세포에 대한 해양 2차 대사산물 폴리포스페이트의 형태유전학적(뮤신 발현) 및 잠재적인 항-코로나 바이러스 활성Article Published on 2020-12-142022-09-10 Journal: Marine Drugs [Category] MERS, SARS, 바이오마커, [키워드] A549 A549 cell ACE2 receptor activity addition adenylate kinase ADK alkaline phosphatase ALP alveolar antiviral response ATP attachment Bacteria binding block Blood Blood platelets Bronchial epithelium Cell cell growth cells cellular collagen coronavirus coronavirus SARS-CoV-2 epithelial Express expression Extracellular extracellular ATP growth human alveolar cells hydrogel immunostaining in vitro in vivo Inhaled inhibiting Innate immunity involved metabolic energy MUC1 MUC5AC mucin mucins nasopharynx nontoxic pathogen Pathogens phosphatase physiological Platelets Polymer polyp polyphosphate Potential protective effect Proteins RBD Receptor binding domain reduction in released SARS-CoV-2 spike protein secondary secreted significantly increased stimulated strength the cells These cells Viral viral RBD virus well [DOI] 10.3390/md18120639 PMC 바로가기 [Article Type] Article
Vascular Disease and Thrombosis in SARS-CoV-2-Infected Rhesus MacaquesSARS-CoV-2에 감염된 붉은털 원숭이의 혈관 질환 및 혈전증Case Reports Published on 2020-11-252022-09-11 Journal: Cell [Category] MERS, SARS, 유전자 메커니즘, 진단, [키워드] Analysis Bronchoalveolar lavage C-reactive protein clinical Clinical features Coagulation collagen complement COVID-19 COVID-19 pandemic Critical endothelial feature Human IFNα IL-1 IL-6 IL-8 include infected with SARS-CoV-2 Inflammation Inflammatory Interaction lead lung Lungs macaque macaques Macrophage molecular morbidity and mortality MX1 NF-κB pathway performed Peripheral blood Platelet platelet activation potential therapeutic target potential therapeutic targets proinflammatory proteomic rhesus macaque rhesus macaques SARS-CoV-2 SARS-CoV-2 pathogenesis serum thrombosis TNFα transcriptomic Transcriptomic analyses upregulation Vascular vascular disease vascular thrombosis vWF [DOI] 10.1016/j.cell.2020.10.005 PMC 바로가기 [Article Type] Case Reports
Clinical, Serological, and Histopathological Similarities Between Severe COVID-19 and Acute Exacerbation of Connective Tissue Disease-Associated Interstitial Lung Disease (CTD-ILD)Immunology Published on 2020-10-022022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS, [키워드] Activation acute exacerbation acute respiratory distress Analysis ARDS autoantibodies autoantibody Autoimmune Autoimmunity clinical Clinical course collagen Computed tomography connective tissue connective tissue disease coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients detection determine died disease ENA enrolled exacerbating Exacerbation feature fibroblast FIVE heterogeneous High-resolution histopathological finding Histopathology immunoblot immunofluorescence intensive care treatment Interstitial lung disease interstitial thickening investigated Laboratory testing mechanism objective Occurrence overlapping pathophysiology Patient Pneumonia positive predict Respiratory failure Result SARS-CoV-2 SARS-COV-2 infection serological severe complication severe COVID-19 significantly similarity syndrome the disease Therapeutic strategies tissue sample understanding was performed [DOI] 10.3389/fimmu.2020.587517 PMC 바로가기 [Article Type] Immunology
Management of an ophthalmology department during COVID-19 pandemic in Milan, ItalyOriginal Research Articles Published on 2020-09-222022-10-31 Journal: European Journal of Ophthalmology [Category] COVID-19, SARS, [키워드] access activity Analysis Care center China clinical collagen Complete Containment Corneal corneal cross linking COVID-19 COVID-19 pandemic Cross linking Department electronic medical record evaluated healthcare providers identify infected patients intravitreal injection Intravitreal injections introduced involved Italy keratoconus lockdown management measure minor surgery ophthalmology pathology Patient Patient care patients performed problems reached recall reduce reducing reported symptom risk spreading surgical telephonic triage Viral transmission [DOI] 10.1177/1120672120960334 PMC 바로가기 [Article Type] Original Research Articles
Intranasal exposure of African green monkeys to SARS-CoV-2 results in acute phase pneumonia with shedding and lung injury still present in the early convalescence phaseShort Report Published on 2020-08-182022-10-28 Journal: Virology Journal [Category] COVID-19, MERS, [키워드] absence acute phase acute respiratory syndrome African green monkey AGM AGMs alveolar animal models circulating coagulation dysfunction collagen coronavirus COVID-19 detectable euthanized evidence of evidenced fibrinogen increases in interstitial pneumonia intranasal lung Lung injury Lung pathology MAD mucosal nasal swab nonhuman primate Pneumonia rectal swab reported Respiratory disease robust SARS-CoV-2 SARS-CoV-2 replication SARS-CoV-2 RNA supported virus virus replication were infected [DOI] 10.1186/s12985-020-01396-w PMC 바로가기 [Article Type] Short Report
A Five-Ingredient Nutritional Supplement and Home-Based Resistance Exercise Improve Lean Mass and Strength in Free-Living Elderly5가지 성분의 영양 보조제 및 가정 기반 저항 운동으로 자유 생활 노인의 제지방 및 근력 향상Article Published on 2020-08-102022-08-13 Journal: Nutrients [Category] 임상, [키워드] age anabolic Analysis body fat casein collagen Combination complement conditions COVID-19 creatine cross-sectional area desensitization double-blind trial Effect effective Efficacy elderly examined exercise fat fatty acids fiber greater grip IMPROVE indicated individual lean mass leg press lower physical activity levels mass men MIS multi-ingredient supplement muscle fiber muscle loss muscle mass old age Older omega-3 Omega-3 fatty acids physical activity levels Placebo placebo-controlled post intervention PROTECT Protein quadricep Randomized randomized clinical trial resistance resistance exercise Safe sarcopenia sarcopenic significantly significantly increased Stand strength sunflower oil therapy Type Vitamin D whey [DOI] 10.3390/nu12082391 PMC 바로가기 [Article Type] Article
E-cigarette-induced pulmonary inflammation and dysregulated repair are mediated by nAChR α7 receptor: role of nAChR α7 in SARS-CoV-2 Covid-19 ACE2 receptor regulationResearch Published on 2020-06-182022-10-28 Journal: Respiratory Research [Category] COVID-19, [키워드] ACE2 receptor affected BALF cellular collagen collected conducted determine dysregulated Dysregulated repair E-cig exposure ECM Effect Electronic cigarette Extracellular matrix female glycol Health induce Inflammation Inflammatory Inflammatory response less lung epithelial Lung inflammation lung tissue Macrophage male matrix metalloproteinase mechanism mice MMP12 MMP2 Mmp8 MMP9 mRNA transcript nAChRα7 occur phenotype pro-inflammatory cytokine Protein Proteins pulmonary inflammation receptor reduced Regulation Research SARS-CoV-2 significantly T-lymphocyte The United States Toxicity was increased wild-type [DOI] 10.1186/s12931-020-01396-y PMC 바로가기 [Article Type] Research
Potential Novel Strategies for the Treatment of Dental Pulp-Derived Pain: Pharmacological Approaches and BeyondReview Published on 2019-09-182024-09-02 Journal: Frontiers in Pharmacology [Category] 대상포진, [키워드] collagen Dental caries dentin dentistry Endodontics Pain Pharmacology regenerative medicine [DOI] 10.3389/fphar.2019.01068 PMC 바로가기 [Article Type] Review
A GBF1-Dependent Mechanism for Environmentally Responsive Regulation of ER-Golgi TransportArticle Published on 2019-06-032023-08-30 Journal: Developmental cell [Category] E형 간염, [키워드] AMPK anterograde trafficking collagen endothelial cells GBF1 Golgi Hemostasis organelle size secretion von Willebrand factor [DOI] 10.1016/j.devcel.2019.04.006 PMC 바로가기 [Article Type] Article
γ-Herpes virus-68, but not Pseudomonas aeruginosa or influenza A (H1N1), exacerbates established murine lung fibrosisArticle Published on 2014-08-012023-06-25 Journal: American journal of physiology. Lung cellular and [Category] 신종인플루엔자, [키워드] Bacteria collagen fibrosis lung virus [DOI] 10.1152/ajplung.00300.2013 PMC 바로가기