compassionate use – Page 5 – Communicable Diseases Research

Compassionate Use of Tocilizumab for Treatment of SARS-CoV-2 Pneumonia

SARS-CoV-2 폐렴 치료를 위한 토실리주맙의 자비로운 사용

Article

Published on 2020-12-152022-09-11
Journal: Clinical Infectious Diseases: An Official Publicat [Category] MERS, SARS, 신약개발, 진단, 치료기술,

COVID: Its compassionate use

COVID: 자비로운 사용

Editorial

Published on 2020-12-012022-09-11
Journal: Journal of vascular nursing : official publication [Category] MERS, SARS, 신약개발,

[키워드] compassionate use
[DOI] 10.1016/j.jvn.2020.11.001 PMC 바로가기 [Article Type] Editorial

Repurposing Anti-Cancer Drugs for COVID-19 Treatment

COVID-19 치료를 위한 항암제의 용도 변경

Review

Published on 2020-11-182022-08-31
Journal: Drug design, development and therapy [Category] 신약개발, 임상, 치료제,

[키워드] adverse event adverse events allergy anti-cancer drugs benefit Cancer catastrophic caused Cell cell division center clinical trials compassionate use coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 de novo died drug Drug development Drug discovery drug-repurposing. effective drug effective drugs Efficacy effort FDA focus food Food and Drug Administration globe hospitalized COVID-19 patients Host Infectious disease Infectious diseases Inflammation inhibiting Johns Hopkins Johns Hopkins University life microenvironment modulating NIAID Novel coronavirus novel coronavirus disease novel vaccines pandemic present promise randomized study Remdesivir repurposing scarcity shown tested the disease Therapies Treatment Vaccine Vaccines
[DOI] 10.2147/DDDT.S282252 PMC 바로가기 [Article Type] Review

Can hyperbaric oxygen safely serve as an anti-inflammatory treatment for COVID-19?

고압산소가 COVID-19의 항염증 치료제로 안전하게 사용될 수 있습니까?

Article

Published on 2020-11-012022-09-11
Journal: Medical Hypotheses [Category] 비임상,

[키워드] activate acute respiratory distress acute respiratory distress syndrome Affect Anecdote anti-inflammatory treatment ARDS attenuation breath Can Case report change chemokines Clinical practice compassionate use consequence COVID-19 CT-scan cytokine Cytokines evaluated HBO Hypothesis hypoxia Inflammatory inflammatory cascade inflammatory condition inflammatory conditions Inflammatory response innate immune response innate immune system lung Mild symptom mild symptoms Organ failure oxygen Patient Pneumonitis Prevent Prospective clinical trial pulmonary CT randomized clinical trial reduce reduce mortality respiratory distress safe and reduce SARS-CoV-2 syndrome Tolerance treat Viral
[DOI] 10.1016/j.mehy.2020.110224 PMC 바로가기 [Article Type] Article

Endothelial injury and thrombotic microangiopathy in COVID-19: Treatment with the lectin-pathway inhibitor narsoplimab

COVID-19의 내피 손상 및 혈전성 미세혈관병증: 렉틴 경로 억제제 나르소플리맙으로 치료

Article

Published on 2020-11-012022-09-11
Journal: Immunobiology [Category] SARS, 진단, 치료법,

[키워드] activate Activation acute respiratory distress acute respiratory distress syndrome acute respiratory syndrome Adverse drug reaction Adverse drug reactions anticoagulant effects ARDS Arterial thrombosis Autopsies baseline bind C-reactive protein C-reactive protein (CRP circulating compassionate use complement Complement activation complications Continuous Positive Airway Pressure control group Coronavirus-2 COVID-19 COVID-19 patient CPAP CRP during treatment effective Endothelial cell endothelial cell damage endothelial damage endothelial injury enzyme human immunoglobulin IgG4 IL-6 IL-8 Immunoglobulin Inflammation inhibit inhibitor Injury interleukin interleukin-6 interleukin-8 intubation Lactate lactate dehydrogenase LDH lectin lectin pathway life-threatening Lung injury mannan MASP-2 monoclonal antibody Mortality Narsoplimab nucleocapsid protein pathogenic Patient positive airway pressure reducing reduction reported respiratory respiratory distress Respiratory distress syndrome resulting retrospective SARS-CoV-2 Serine serine protease serum Serum IL-6 Serum level serum levels Severe acute respiratory syndrome severe acute respiratory syndrome-associated coronavirus-2 significantly higher survived sustained syndrome thrombosis thrombotic thrombotic event Thrombotic events thrombotic risk treat Treatment treatment for COVID-19 was used were assessed were used
[DOI] 10.1016/j.imbio.2020.152001 PMC 바로가기 [Article Type] Article

A case of COVID-19 Convalescent Plasma Donation in Greece: Directed donation for compassionate use in the donor’s critically ill father

그리스 COVID-19 회복기 혈장 기증 사례: 기증자의 위독한 아버지에 대한 자비로운 사용을 위한 직접 기증

Case Reports

Published on 2020-11-012022-09-11
Journal: Transfusion clinique et biologique : journal de la [Category] 신약개발, 치료제,

[키워드] compassionate use COVID-19 Critically ill Directed donation donation Donor
[DOI] 10.1016/j.tracli.2020.09.001 PMC 바로가기 [Article Type] Case Reports

Safety and efficacy of antiviral combination therapy in symptomatic patients of Covid-19 infection – a randomised controlled trial (SEV-COVID Trial): A structured summary of a study protocol for a randomized controlled trial

Letter

Published on 2020-10-202022-10-29
Journal: Trials [Category] COVID-19, MERS, SARS,

[키워드] 1:1 2019-nCoV allergic Antipyretic Antiretroviral therapy Antiviral Arm as required assigned Breastfeeding Care categories cause clinical combination therapy compassionate use cough country COVID-19 COVID-19 infection criteria death defined described discharged disease dissemination drug Efficacy element eligibility criteria enrolled enrolment Etiquette exclusion criteria exploratory female Fever Frequency H1N1 hand hygiene Hydration Hydroxychloroquine ICU Patients inclusion criteria India Infection infection with SARS-CoV-2 investigator Laboratory Loading dose Lopinavir/ritonavir Lopinavir/Ritonavir combination mechanical ventilation medication Mortality non-ICU non-invasive ventilation Non-severe case Normalisation number nutrition objective off-label organ oxygen saturation paO2/fiO2 participant Participants Patient pharmacotherapy Placebo positive Precaution progression protocol QT prolongation randomisation randomised randomised controlled trial randomization Randomized controlled trial Randomly receipt recruitment regimen Registration registry replaced required Research respiratory rate ribavirin RT-PCR Safety Sample size SARS-CoV-2 RT-PCR screened secondary secure Serious Adverse Event Severe COVID-19 Infection Severe patient severity specimen Standard standard treatment status stratified study period Study protocol supplemental oxygen Support Suppressant surgical sustained symptomatic patient Tablet tested the patient therapeutic intervention therapy time time to defervescence treated Treatment treatment arm treatment group Trial upper respiratory tract Vasopressor Ventilation ventilator wear website
[DOI] 10.1186/s13063-020-04774-5 PMC 바로가기 [Article Type] Letter

Lessons learned from early compassionate use of convalescent plasma on critically ill patients with Covid-19

Covid-19에 걸린 중환자에게 회복기 혈장을 초기에 동정적으로 사용하여 얻은 교훈

Article

Published on 2020-10-012022-09-12
Journal: Transfusion [Category] Coronavirus, SARS, 진단,

Remdesivir emergency approvals: a comparison of the U.S., Japanese, and EU systems

Review

Published on 2020-10-012023-07-06
Journal: Expert review of clinical pharmacology [Category] SARS,

[키워드] Anti-viral compassionate use Conditional marketing authorization COVID-19 Emergency use marketing authorization. Regulatory
[DOI] 10.1080/17512433.2020.1821650 [Article Type] Review

The Pipeline of Therapeutics Testing During the Emergency Phase of the COVID-19 Outbreak

Medicine

Published on 2020-09-242022-10-31
Journal: Frontiers in Medicine [Category] COVID-19,

[키워드] Affect Antiviral antivirals clinical clinical trials clinicians and researcher compassionate use condition coronavirus disease COVID-19 COVID-19 pandemic database described disease Drug development effective Efficacy effort Emergency Epidemiology European feature Healthcare system identify immunomodulators investigated management nine off-label outbreak pandemic pharmacological intervention phase Phase 3 profile provide Research Research protocol research protocols SARS-CoV-2 SARS-COV-2 infection significant effect supportive care syndrome Testing therapeutic Therapeutics Treatment union vaccination with COVID-19
[DOI] 10.3389/fmed.2020.552991 PMC 바로가기 [Article Type] Medicine