The role of Mannose-binding lectin in leprosy: A systematic reviewarticle Published on 2021-09-302024-09-01 Journal: Infection, Genetics and Evolution [Category] 한센병, [키워드] complement system Innate immunity leprosy MBL2 polymorphism [Article Type] article
Complement levels at admission as a reflection of coronavirus disease 2019 (COVID-19) severity state코로나바이러스 질병 2019(COVID-19) 심각도 상태를 반영하여 입원 시 보완 수준Article Published on 2021-09-012022-09-11 Journal: Journal of medical virology [Category] SARS, 바이오마커, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus 2 ADAMTS13 Admission adverse outcome adverse outcomes analyzed association benefit Blood blood sample Blood samples C3a C3a/C3 Clinical improvement complement complement system confounders coronavirus coronavirus disease Coronavirus disease 2019 correlated correlation correlations Course COVID-19 COVID-19 illness COVID-19 patient COVID-19 severity disease severity displaying elevated emergency department enrolled Evidence evidence of fibrinogen highest Hyperactivation hyperinflammation Hyperinflammatory implicated infected patients inflammatory biomarkers investigated moderate organ damage over parameter Patient phenotype plasminogen predict presenting Primary outcome progression Research respiratory SARS-CoV-2 SARS-CoV-2 hyperinflammation secondary outcome severe acute respiratory syndrome Coronavirus severe COVID-19 illness severe disease severity significantly therapy thrombotic thrombotic microangiopathy tissue [DOI] 10.1002/jmv.27077 PMC 바로가기 [Article Type] Article
Medical Records-Based Genetic Studies of the Complement SystemClinical Research Published on 2021-08-012024-09-04 Journal: Journal of the American Society of Nephrology [Category] 대상포진, [키워드] Autoimmunity complement system Electronic health records Genome wide association study phenome wide association study [DOI] 10.1681/ASN.2020091371 PMC 바로가기 [Article Type] Clinical Research
Elevated Expression Levels of Lung Complement Anaphylatoxin, Neutrophil Chemoattractant Chemokine IL-8, and RANTES in MERS-CoV-Infected Patients: Predictive Biomarkers for Disease Severity and MortalityOriginal Article Published on 2021-07-072023-06-15 Journal: Journal of Clinical Immunology [Category] MERS, [키워드] chemokine complement system cytokine immunopathology lung MERS-CoV infection [DOI] 10.1007/s10875-021-01061-z PMC 바로가기 [Article Type] Original Article
Lectin Pathway Mediates Complement Activation by SARS-CoV-2 Proteins렉틴 경로는 SARS-CoV-2 단백질에 의한 보체 활성화를 매개합니다Immunology Published on 2021-07-052022-09-11 Journal: Frontiers in Immunology [Category] SARS, 바이오마커, [키워드] activate Activation acute respiratory distress acute respiratory distress syndrome addition antibody antiviral drug antiviral drugs ARDS bind block C3b cause Cell cell surface cellular clinical trials complement Complement activation Complement activation product Complement activation products complement system Corticosteroid Corticosteroids COVID-19 Critical cytokine Cytokine storm disease severity early stage early stages Efficacy endothelial injury enzyme event expressing FACS analyses FACS analysis HEK-293 cell HEK-293 cells immune system Infection inflammatory phenotype Inflammatory response inhibited inhibition inhibitor inhibitory Innate immunity lectin lectin pathway maintenance MASP-2 microangiopathy monoclonal antibody N-protein Narsoplimab Pathogenesis pathogenesis of COVID-19 pathology pathophysiological Patient progressed proinflammatory provide respiratory distress Respiratory distress syndrome robust S protein SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 S SARS-CoV-2 S protein severe COVID-19 shifting shown subsequent syndrome targeting the cell the cytokine storm therapeutic efficacy Treatment triggering [DOI] 10.3389/fimmu.2021.714511 PMC 바로가기 [Article Type] Immunology
Mass Spectrometric Analysis of Urine from COVID-19 Patients for Detection of SARS-CoV-2 Viral Antigen and to Study Host ResponseSARS-CoV-2 바이러스 항원 검출 및 숙주 반응 연구를 위한 COVID-19 환자의 소변 질량 분광 분석Article Published on 2021-07-022022-09-11 Journal: Journal of Proteome Research [Category] MERS, SARS, 진단, 치료기술, 치료법, [키워드] acute phase response Affect alteration Amino acid amino acid transporter Analysis approach body fluid body fluids Brain capture Chain Reaction complement complement system coronavirus COVID-19 COVID-19 negative COVID-19 patient COVID-19 patients Culture detect detection diagnosed Glucose immune response in urine Infection involved Kidney function kidneys liver Lungs mass mass spectrometry microbial Nasopharyngeal swab nasopharyngeal swabs NPHS2 nucleocapsid protein organ Pathogenesis pathogenesis of COVID-19 peptide peptides polymerase chain polymerase chain reaction positive Protein proteome proteomic proteomics public health Quantitative quantitative proteomic analysis Regulation renal response reverse transcriptase Reverse transcriptase polymerase chain reaction RT-PCR SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 nucleocapsid SARS-CoV-2 positive individual SARS-CoV-2 positive individuals SLC36A2 SLC5A10 sodium subset transcriptase Urine Viral Viral antigen viral antigens Viral RNA virus were used [DOI] 10.1021/acs.jproteome.1c00391 PMC 바로가기 [Article Type] Article
Complement Anaphylatoxins and Inflammatory Cytokines as Prognostic Markers for COVID-19 Severity and In-Hospital MortalityCOVID-19 심각도 및 병원 내 사망률에 대한 예후 마커로서 아나필라톡신 및 염증성 사이토카인 보완Immunology Published on 2021-07-012022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 바이오마커, [키워드] Activation Analysis anaphylatoxin anaphylatoxins C3a C5a changes in chemokine chemokines clinical disease clinical outcomes complement complement anaphylatoxins Complement pathway complement system complications COVID-19 COVID-19 patient COVID-19 severity Critical critical COVID-19 patient critical COVID-19 patients critical patients cytokine Cytokine storm Cytokines deaths dysregulation enrolled enzyme-linked immunosorbent enzyme-linked immunosorbent assay healthy control healthy controls highlight Hospitalization IgM antibody IgM antibody levels IL-1β IL-6 IL-8 immunopathology In-hospital in-hospital mortality infected with SARS-CoV-2 Inflammatory cytokine Inflammatory cytokines Inflammatory mediators Innate immunity Interaction interleukin investigated mediators mild cases mild COVID-19 patients mild patient mild patients Mortality Necrosis outcome Patient patients patients with COVID-19 positively correlated Potential treatment Prognosis prognostic properdin Protein RANTES SARS-COV-2 infection SARS-CoV-2 infections SARS‐CoV‐2 SARS‐CoV‐2 sera serum severe SARS Signaling significantly significantly higher survival group target Treatment strategies treatment strategy Tumor tumor necrosis tumor necrosis factor upregulated utility were measured [DOI] 10.3389/fimmu.2021.668725 PMC 바로가기 [Article Type] Immunology
Tackling COVID-19 infection through complement-targeted immunotherapy보체 표적 면역 요법을 통한 COVID-19 감염 퇴치Review Published on 2021-07-012022-09-11 Journal: British Journal of Pharmacology [Category] SARS, 변종, [키워드] Activation acute respiratory syndrome acute respiratory syndrome coronavirus 2 anaphylatoxin anaphylatoxins article Blood C3a C5a complement Complement activation complement system coronavirus coronavirus 2 COVID-19 infection COVID-19 patient Crosstalk death disease Disease progression effector molecules Endothelial cell endothelial cells function Health high mortality higher risk highly pathogenic immune system Immunotherapy Injury Innate immunity knowledge lectin lectin pathway Pathogenesis prevalent Regulation regulator gene reported resulting Serum level Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severe disease subsequent thrombotic thrombotic microangiopathy variant [DOI] 10.1111/bph.15187 PMC 바로가기 [Article Type] Review
Case Report: Adult Post-COVID-19 Multisystem Inflammatory Syndrome and Thrombotic Microangiopathy증례 보고서: 성인 포스트-COVID-19 다기관 염증 증후군 및 혈전성 미세혈관병증Case Reports Published on 2021-06-232022-09-12 Journal: Frontiers in Immunology [Category] MERS, SARS, 진단, [키워드] affected blocker Case report children complement complement system coronavirus disease COVID-19 described eculizumab Inflammatory initiated microangiopathy MIS MIS-C Multisystem inflammatory syndrome pandemic pathophysiology presentation renal renal function SARS-COV-2 infection Specific syndrome therapeutic option thrombotic thrombotic microangiopathy [DOI] 10.3389/fimmu.2021.680567 PMC 바로가기 [Article Type] Case Reports
Temporal proteomic changes induced by nicotine in human cells: A quantitative proteomics approach인간 세포에서 니코틴에 의해 유발된 시간적 단백질체 변화: 정량적 단백질체학 접근법Article Published on 2021-06-152022-09-11 Journal: Journal of proteomics [Category] SARS, 유전자 메커니즘, 치료기술, [키워드] A549 A549 cell line A549 cell lines affected alteration approach association biological processe Cancer cell line change changes in complement complement system complex compounds concerning COVID19 dataset decrease diabetes disease Diseases Effect event FAIMS heart disease host protein immune pathways implication in vitro in vivo Infection mitochondrial Nicotine Phosphorylation Protein protein-protein interactions proteome proteomes proteomic proteomics public health quantified Quantitative Real time search reported RTS SARS-CoV2 SH-SY5Y smoke smoking smoking cessation stroke susceptibility susceptibility to infection Temporal TMTpro. Tobacco Treatment type 2 diabetes Viral protein Viral proteins [DOI] 10.1016/j.jprot.2021.104244 PMC 바로가기 [Article Type] Article