Prediction of potential inhibitors for RNA-dependent RNA polymerase of SARS-CoV-2 using comprehensive drug repurposing and molecular docking approachResearch article Published on 2020-11-012022-10-05 Journal: International journal of biological macromolecules [Category] SARS, 신약개발, [키워드] addition ADME Amino acid Analysis approach Comparative complexes Compound compounds computational approach COVID-19 drug drug candidate drug target drug-likeness effective effective drug effective inhibitor enzyme feature fidaxomicin Health hotspot inhibitor inhibitory Interaction molecular docking pandemic predict prediction prevalence of COVID-19 RdRP rifabutin Rifapentine RNA-dependent RNA polymerase SARS-CoV-2 SARS-CoV-2 replication scientist Structural analysis Toxicity Virtual screening ZINC database [DOI] 10.1016/j.ijbiomac.2020.09.098 [Article Type] Research article
Computational perspectives revealed prospective vaccine candidates from five structural proteins of novel SARS corona virus 2019 (SARS-CoV-2)Bioinformatics Published on 2020-09-292022-10-28 Journal: PeerJ [Category] COVID-19, [키워드] antigenic antigenicity antiviral drugs B cell B cell epitope B-cell binding binding interaction bioinformatics caused CD8 CD8+ T cell Cluster computational approach computational tools conformational Coverage COVID-19 directive Discovery Studio docking study effective epitope Epitopes FIVE greater identify Immune Epitope Database indicated Interaction lack linear linear B-cell epitope linear B-cell epitopes linear epitope majority membrane membrane protein nucleocapsid nucleocapsid protein Nucleocapsid proteins ORF3a ORF3a protein pandemic parameter peptide peptide epitopes peptide-based performed Perspective predicted produced required Result RNA virus robust SARS-CoV-2 Seven single-stranded positive-sense solvent structural protein Structure Surface glycoprotein T cell T cell epitope T cell epitopes T-cell epitopes target targets the Coronaviridae the spike protein Vaccine vaccine candidate vaccine candidates vaccine target virus was used were used Z score [DOI] 10.7717/peerj.9855 PMC 바로가기 [Article Type] Bioinformatics
Reverse vaccinology assisted designing of multiepitope-based subunit vaccine against SARS-CoV-2Research Article Published on 2020-09-162022-10-29 Journal: Infectious Diseases of Poverty [Category] COVID-19, SARS, [키워드] acute respiratory syndrome alleles Amino acid Antigen antigenicity B-cell epitope binding binding affinity Cell computational approach coronavirus Coronavirus disease 2019 Coverage COVID-19 COVID-19 pandemic CTL cytotoxic T lymphocyte docking downloaded effective envelope epitope Escherichia coli functions GenBank glycoprotein highly antigenic HLA HTL humans immune response Immune simulation immunogenic immunoinformatics in silico In silico cloning increased expression Infection Interaction investigated K-12 leukocyte life-threatening linkers membrane glycoprotein MEV codon Multiepitope-based subunit vaccine non-allergenic pathogenic Pneumonia Prevent Protein responsible Result SARS-CoV-2 sequence structural protein subunit suggested surface T lymphocyte the SARS-CoV-2 TLR3 Vaccine vaccine candidate [DOI] 10.1186/s40249-020-00752-w PMC 바로가기 [Article Type] Research Article
Epigenetic Regulator miRNA Pattern Differences Among SARS-CoV, SARS-CoV-2, and SARS-CoV-2 World-Wide Isolates Delineated the Mystery Behind the Epic Pathogenicity and Distinct Clinical Characteristics of Pandemic COVID-19SARS-CoV, SARS-CoV-2 및 SARS-CoV-2 전 세계 분리주 사이의 후성유전 조절자 miRNA 패턴 차이로 팬데믹 COVID-19의 서사적 병원성과 독특한 임상적 특징 뒤에 숨겨진 미스터리Genetics Published on 2020-07-102022-08-13 Journal: Frontiers in Genetics [Category] 유전자 메커니즘, [키워드] alleviate anomalies Anomaly antiviral miRNAs autophagy binding breathing complications cardiovascular diseases cellular miRNA cellular pathway clinical Comorbidities Complication computational approach Computational approaches country COVID-19 COVID-19 patients death death rates diabetes difference disease effective epigenetic modulator epigenetic regulator experiments Factors functional Gene Expression Host host antiviral miRNA host genes host immunity host miRNA host's miRNAs human cell IFN-I IFN-I signaling immune regulation immune-escape mechanism immune-signaling pathways implication isolate latency lead Microarray miRNA miRNA clusters miRNA-mediated interaction miRNA-microRNA miRNAs mode modulate molecular mechanism Neutralizing normalized over representation analysis Pathogenesis Pathways patients with comorbidity pattern predict predicted profile regulator RNA therapeutics RNA-Seq SARS virus SARS viruses SARS-CoV SARS-CoV and SARS-CoV-2 viral miRNAs SARS-CoV and SARS-CoV-2 viruses SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 genomes SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV-2 miRNAs SARS-CoV-2 pathogenesis SARS-CoV-2 viral SARS-CoV-2 virus SARS-infected human cell microarray signaling pathways Support symptoms of COVID-19 target targets the SARS-CoV-2 Viral viral miRNA viral miRNAs viral pathogenesis viruses [DOI] 10.3389/fgene.2020.00765 PMC 바로가기 [Article Type] Genetics
Advanced bioinformatics rapidly identifies existing therapeutics for patients with coronavirus disease-2019 (COVID-19)Research Published on 2020-06-252022-10-30 Journal: Journal of Translational Medicine [Category] COVID-19, SARS, [키워드] ACE inhibitors ACE1 ACE2 ACE2 binding acute respiratory syndrome animal model antibiotic antiviral agent applied artificial intelligence attenuate benefit binding binding affinity bioinformatics blocking virus entry caused Cell Compound computational approach Computational biology coronavirus Coronaviruses COVID-19 DCT disease-associated drug drug therapy Effect Effects emerging disease Emricasan FDA approved drug Fosamprenavir Gene Expression gene expression pattern global pandemic Glutamine glutathione highlight identify independent induce Infection Patient platform precursor Prevent protective effect Result ruxolitinib SARS-CoV SARS-CoV-2 second specificity technology therapeutic agent TMPRSS2 translation Vitamin E while [DOI] 10.1186/s12967-020-02430-9 PMC 바로가기 [Article Type] Research
Current Status of COVID-19 Therapies and Drug Repositioning ApplicationsReview Published on 2020-06-202022-10-04 Journal: iScience [Category] 신약개발, 치료제, [키워드] addition application approach approved drug clinical trial computational approach concerning coronavirus COVID-19 COVID-19 therapy current drug Drug discovery effort example facilitate Health Health Sciences highlight illness in silico indications information Medicine produced repositioning SARS-CoV-2 Spread status target treat Treatment urgency [DOI] 10.1016/j.isci.2020.101303 PMC 바로가기 [Article Type] Review
Epitope‐based peptide vaccine design and target site depiction against Middle East Respiratory Syndrome Coronavirus: an immune-informatics studyResearch Published on 2019-11-082022-10-30 Journal: Journal of Translational Medicine [Category] Coronavirus, [키워드] allele Analysis Antigen antigenic epitope antigenicity Antiviral strategies B-cell epitopes binding combating computational approach Computational approaches conserved country docking effective epitope highest highly antigenic HLA HLA-B7 allele Host identify immunogenic Infection Infection prevention Interaction isolate Isolation kidney infection leukocyte linear B-cell epitope lung MERS-CoV MHC Middle East peptide positive predicted receptors respiratory Result RNA virus S protein S protein epitope Saudi Arabia single-stranded South Korea Spike protein T cell epitope T-and B-cell epitopes T-cell epitopes Vaccine Vaccine design [DOI] 10.1186/s12967-019-2116-8 PMC 바로가기 [Article Type] Research
Phenotype Ontologies and Cross-Species Analysis for Translational Research번역 연구를 위한 표현형 온톨로지 및 교차 종 분석Review Published on 2014-04-032022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] aetiology approach approaches comparable computational approach consequence disorders DNA sequence equivalence example Genetic variation hereditary traits human genetic variation identify involved mouse Neuropsychiatric ontologies organism orthologue orthologues phenotype phenotypic resulting significantly statistical traits zebrafish [DOI] 10.1371/journal.pgen.1004268 PMC 바로가기 [Article Type] Review