Integrative metabolomic and proteomic signatures define clinical outcomes in severe COVID-19Research article Published on 2022-06-172022-10-05 Journal: iScience [Category] 바이오마커, 임상, [키워드] Analysis Biological sciences Clinical finding Clinical outcome clinical outcomes collagen Concordance controls Coronavirus disease-19 COVID-19 COVID-19 disease severity COVID-19 patient cross talk disease global healthcare Hospitalized human metabolism immune modulation independent datasets Interaction Medicine metabolism metabolite metabolomic metabolomics molecular morbidity morbidity and mortality Mortality nucleotide outcome measure pandemic pathogenic performed Physiology predict predictive power Protein proteomic serum severe COVID-19 severe disease vascular homeostasis [DOI] 10.1016/j.isci.2022.104612 [Article Type] Research article
Clinical evaluation of the Diagnostic Analyzer for Selective Hybridization (DASH): A point-of-care PCR test for rapid detection of SARS-CoV-2 infectionDASH(Diagnostic Analyzer for Selective Hybridization) 임상 평가: SARS-CoV-2 감염의 신속한 검출을 위한 현장 진료 PCR 검사Article Published on 2022-06-162022-09-11 Journal: PLoS ONE [Category] COVID19(2023년), SARS, 치료기술, [키워드] analyzed Analyzer Antigen calculated Cepheid clinical clinical setting collected Concordance conducted correlated COVID-19 COVID-19 symptoms COVID-19 vaccine cross-sectional cross-sectional study DASH dose doses enrolled evaluated female gold gold standard hybridization information Laboratory median age mRNA nasal swab negative and positive Negative predictive value participant PCR PCR test performed POC point-of-care positive Positive predictive value Predictive Predictive value provided SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 PCR sensitivity specificity speed Swab symptomatic symptoms of COVID-19 vaccination was tested without symptom [DOI] 10.1371/journal.pone.0270060 PMC 바로가기 [Article Type] Article
Proficiency testing for SARS-CoV-2 in assuring the quality and overall performance in viral RNA detection in clinical and public health laboratories임상 및 공중 보건 실험실에서 바이러스 RNA 검출의 품질 및 전반적인 성능을 보장하기 위한 SARS-CoV-2에 대한 숙련도 테스트Article Published on 2022-06-012022-09-11 Journal: Pathology [Category] COVID19(2023년), SARS, 치료기술, [키워드] Accuracy acute respiratory syndrome acute respiratory syndrome coronavirus assays assist Australasia change choice college Concordance confidence coronavirus demonstrated diagnostic testing early stage early stages FIVE Genes house improvement in viral Inconclusive increase in initial Laboratory medium New nucleic acid offered pandemic participant Pathologists positive produced proficiency testing Program progressed protocol protocols provided public health Quality Quality assurance Result RNA SARS-CoV-2 selected severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 shown specimen specimens Viral detection Viral load viral loads [DOI] 10.1016/j.pathol.2022.01.006 PMC 바로가기 [Article Type] Article
Multisystem screening reveals SARS-CoV-2 in neurons of the myenteric plexus and in megakaryocytes다중 시스템 스크리닝은 myenteric plexus의 뉴런과 거핵 세포에서 SARS-CoV-2를 나타냅니다Article Published on 2022-06-012022-09-11 Journal: The Journal of pathology [Category] COVID19(2023년), SARS, 치료법, [키워드] ACE2 expression affected Analysis average biopsy Bone marrow causative agent Cell cellular tropism Chain Reaction clinical symptom Clinical symptoms Complete complications of COVID-19 Concordance controls COVID-19 cytoplasmic death digestive disease enteric nervous system entry receptor exceeded followed by gastrointestinal tract Great Britain histological immunohistochemistry increasingly Ireland journal megakaryocytes monoclonal antibody Multiorgan myenteric plexus nervous system Neuron neurons nucleocapsid protein organ pandemic parkinson s disease Parkinson's Disease pathological pathology Patient patients PCR swab performed Platelet polymerase chain polymerase chain reaction Respiratory illness reveal SARS-CoV-2 Society Son staining symptom onset the SARS-CoV-2 thrombotic Thrombotic events Thrombus thrombus formation time of death tissue tracheal tropism tropism of SARS-CoV-2 Ventilation widespread [DOI] 10.1002/path.5878 PMC 바로가기 [Article Type] Article
Concordance of SARS-CoV-2 RNA in Aerosols From a Nurses Station and in Nurses and Patients During a Hospital Ward Outbreak병원 병동 발병 중 간호사 스테이션과 간호사 및 환자의 에어로졸에서 SARS-CoV-2 RNA의 일치Article Published on 2022-06-012022-09-11 Journal: JAMA Network Open [Category] COVID19(2023년), SARS, 치료기술, [키워드] aerosol Aerosols Affair Care Chain Reaction cohort study collected Concordance conducted Contact tracing contributed COVID-19 COVID-19 outbreak Department detect finding fraction fragment genome sequence genomic genomic sequence Health Health care Health care system hospital Hospital wards masking nosocomial Nosocomial outbreaks Nurse outbreak outcome Particle Patient polymerase chain reaction positive positive RT-PCR Primary outcome reduce reducing representing reverse transcriptase reverse transcriptase-polymerase chain reaction risk RT-PCR Sample SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 RNA sequence identity sequenced similarity Station Surveillance Transmission Ventilation veteran ward were used [DOI] 10.1001/jamanetworkopen.2022.16176 PMC 바로가기 [Article Type] Article
Concordance in RT-PCR detection of SARS-CoV-2 between samples preserved in viral and bacterial transport medium바이러스 및 박테리아 수송 배지에 보존된 샘플 간의 SARS-CoV-2 RT-PCR 검출 일치Article Published on 2022-06-012022-09-11 Journal: Journal of virological methods [Category] COVID19(2023년), SARS, 치료기술, 치료제, [키워드] All participants analyzed Bacteria Bacterial calculated collected Community Concordance Ct values cycle threshold determine Diagnostic method Glucose Glycerin in viral independent independent of longitudinal cohort study medium nasal nasal swab nasal swabs nasopharyngeal Nasopharyngeal swab NP swab NP swabs ORF1 ORF1ab participant Pathogens preserved real time respiratory pathogen respiratory symptoms RT-PCR RT-PCR detection Sample SARS-CoV-2 SARS-CoV-2 detection SARS-CoV-2 infections skim milk specimen statistically Swab swabs targets Transport Transport media transport medium tryptone Viral transport medium VTM was used while [DOI] 10.1016/j.jviromet.2022.114522 PMC 바로가기 [Article Type] Article
Evaluation of Neutralizing Antibodies against SARS-CoV-2 Variants after Infection and Vaccination Using a Multiplexed Surrogate Virus Neutralization Test다중 대리 바이러스 중화 테스트를 사용한 감염 및 예방 접종 후 SARS-CoV-2 변이체에 대한 중화 항체 평가Article Published on 2022-05-182022-09-11 Journal: Clinical Chemistry [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] ACE2 angiotensin angiotensin converting enzyme Angiotensin converting enzyme-2 antibody Antibody neutralization antibody neutralization activity Antibody therapeutics approach B.1.1.7 B.1.351 binding Cohort cohorts Concordance COVID-19 COVID-19 pandemic COVID-19 patient Decline demonstrated determine diagnostics Effectiveness evaluated Evolution immune response inception individual inhibit measure Moderna mRNA vaccines mutated neutralization neutralization activity neutralization test neutralizing capacity Pfizer-BioNTech plaque reduction neutralization Plaque reduction neutralization test post infection PRNT Protective provide question reduced required SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants SARS-CoV-2 virus serum significantly Spike protein surrogate surrogate virus neutralization test sVNT Test Trimeric spike protein vaccinated individual vaccination Vaccine variants virus virus neutralization test wild type [DOI] 10.1093/clinchem/hvab283 PMC 바로가기 [Article Type] Article
Diagnostic concordance between BioFire® FilmArray® Pneumonia Panel and culture in patients with COVID-19 pneumonia admitted to intensive care units: the experience of the third wave in eight hospitals in ColombiaBioFire® FilmArray® Pneumonia 패널과 중환자실에 입원한 COVID-19 폐렴 환자의 배양 사이의 진단 일치: 콜롬비아의 8개 병원에서 3차 유행의 경험Article Published on 2022-05-092022-09-11 Journal: Critical Care [Category] COVID19(2023년), SARS, 치료기술, [키워드] analyzed antibiotic Antibiotics Antimicrobial therapy Bacteria Bacterial coinfection bacterial coinfections bacterial pneumonia Bronchoalveolar lavage C-reactive protein Care changes in Coinfection Concordance COVID-19 Culture cultures defined diagnostic diagnostic testing dose eight Enterobacter FilmArray greater hospital Hospitalized ICU identify infected with SARS-CoV-2 Inflammatory response intensive care intensive care units intubation Klebsiella pneumoniae leukocytes management mechanical ventilation Medellín, Colombia microorganism microorganisms Negative predictive value no significant difference no significant differences NPV on mechanical ventilation overall concordance Panel pathogen Pathogens Patient patients with COVID-19 patients with SARS-CoV-2 Pneumonia pneumoniae positive Positive predictive value PPV Predictive value procalcitonin processed Prospective Study respiratory pathogen serum sample serum samples specificity Staphylococcus aureus stratified Streptococcus Streptococcus agalactiae [DOI] 10.1186/s13054-022-04006-z PMC 바로가기 [Article Type] Article
Predicting Direct-Specimen SARS-CoV-2 Assay Performance Using Residual Patient Samples잔류 환자 샘플을 사용하여 직접 표본 SARS-CoV-2 분석 성능 예측Article Published on 2022-05-042022-09-11 Journal: The journal of applied laboratory medicine [Category] COVID19(2023년), SARS, 치료기술, 치료제, [키워드] Abbott adjusted applied assays Asymptomatic Concordance conducted COVID-19 cycle threshold dependent on diagnostic sensitivity DiaSorin Direct distribution doubling emergency services in viral Infectious disease Laboratory laboratory methods and tools Logistic regression nasal nasopharyngeal nasopharyngeal sample nasopharyngeal specimen PCR cycle performance point-of-care point-of-care testing systems. Population predict predicted presenting residual Sample SARS-CoV-2 specimen specimens symptomatic symptomatic and asymptomatic Transport media Viral load viral loads viral transport media VTM was used [DOI] 10.1093/jalm/jfab159 PMC 바로가기 [Article Type] Article
Rapid identification of SARS-CoV-2 in the point-of-care using digital PCR-based Dr. PCR™ Di20K COVID-19 Detection Kit without viral RNA extraction바이러스 RNA 추출 없이 디지털 PCR 기반 Dr. PCR™ Di20K COVID-19 Detection Kit를 사용하여 현장 진료에서 SARS-CoV-2의 신속한 식별Article Published on 2022-05-012022-09-11 Journal: Genes & genomics [Category] COVID19(2023년), SARS, 치료기술, [키워드] 2019-nCoV addition assessment biosafety Concordance Contamination COVID-19 cross-over detection Diagnosis diagnostic diagnostic sensitivity diagnostic test diagnostic tests dPCR evaluate evaluated Kappa coefficient limitation pandemic performed POCT point-of-care point-of-care testing pre-diagnosis previous study qRT-PCR Rapid reliability reported RNA extraction SARS-CoV-2 sensitivity Sensitivity and specificity Space specificity specimen Spread the WHO viral RNA extraction was measured were measured [DOI] 10.1007/s13258-022-01242-z PMC 바로가기 [Article Type] Article