Prospective, multi-site study of patient outcomes after implementation of the TREWS machine learning-based early warning system for sepsis Research Published on 2022-07-212022-10-05 Journal: Nature Medicine [Category] 임상, [키워드] absolute reduction adjusted Adjusting Analysis Antibiotic therapy association benefit clinical evaluation cohort study confidence interval early treatment examined FIVE high risk hospitals identify implementation IMPROVE improvement in-hospital mortality rate Interaction machine mortality rate Organ failure outcome outcomes Patient Prospective reduce reduced reduction Sepsis sepsis patient severity System Treatment [DOI] 10.1038/s41591-022-01894-0 [Article Type] Research
Intravenous IgM-enriched immunoglobulins in critical COVID-19: a multicentre propensity-weighted cohort study중요한 COVID-19에서 정맥내 IgM이 풍부한 면역글로불린: 다기관 성향 가중 코호트 연구Multicenter Study Published on 2022-07-072022-09-12 Journal: Critical Care [Category] COVID19(2023년), SARS, 진단, [키워드] 30-Day mortality acute respiratory distress addition applied Characteristics clinical clinically Cohort cohort study Complication concerning confidence interval controls coronavirus disease COVID-19 COVID-19 patients Cox regression models Critical Critically ill Critically ill patient daily dose dose early administration Effect Efficacy high mortality ICU ICU Patients Immunoglobulin immunoglobulin M immunoglobulins Inflammatory intravenous laboratory-confirmed Lung injury mechanical ventilation mechanically ventilated Mortality multicentre overcome Patient Primary outcome randomization randomized clinical trials retrospective SARS-CoV-2 selection bia statistical significance statistically statistically significant difference subgroup analysis subgroups survival treated Treatment treatment regimen two group was performed Weighting with COVID-19 [DOI] 10.1186/s13054-022-04059-0 PMC 바로가기 [Article Type] Multicenter Study
COVID-19 disease severity in persons infected with the Omicron variant compared with the Delta variant in Qatar카타르의 델타 변이와 비교한 오미크론 변이에 감염된 사람의 COVID-19 질병 심각도Article Published on 2022-07-062022-09-11 Journal: Journal of Global Health [Category] COVID19(2023년), SARS, 변종, [키워드] 95% CI Admission booster confidence interval Control COVID-19 COVID-19 disease severity death Delta delta variant disease disease severity excluded Factor hospital individual Infection intensive care intensive care unit less management mechanical ventilation Mild moderate offer omicron Omicron variant positive rates of admission SARS-COV-2 infection SARS-CoV-2 virus severity Severity of disease significantly lower the disease the SARS-CoV-2 virus understanding vaccination variant variants [DOI] 10.7189/jogh.12.05032 PMC 바로가기 [Article Type] Article
A prospective study of the association between SARS-CoV-2 infection and COVID-19 vaccination with changes in usual menstrual cycle characteristicsResearch article Published on 2022-07-012022-10-05 Journal: American journal of obstetrics and gynecology [Category] 진단, [키워드] 95% confidence interval addition Adenovirus-vectored vaccine age association baseline calculated Canada changes in Characteristics clinical trials conducted confidence interval COVID-19 pandemic COVID-19 vaccination COVID-19 vaccine current Factors Follow-up follow-up time Future Health higher risk history Impact investigated mechanisms median median age menstrual menstrual cycle change menstrual cycle length menstrual health messenger multinomial logistic regression objective Odds ratio positive Prospective Study questionnaire reported Result RNA SARS-COV-2 infection SARS-CoV-2 test Sociodemographic Stress systemically the median the United State vaccination Vaccine were used women [DOI] 10.1016/j.ajog.2022.07.003 [Article Type] Research article
Factors associated with mortality, length of hospital stay and diagnosis of COVID-19: Data from a field hospital사망률, 입원 기간 및 COVID-19 진단과 관련된 요인: 야전 병원 데이터Article Published on 2022-07-012022-09-11 Journal: Journal of infection and public health [Category] COVID19(2023년), SARS, 진단, 치료기술, [키워드] 95 % confidence intervals addition age association Brazil caused change Characteristics characterized Clinical course conducted confidence interval COVID-19 COVID-19 pandemic cross-sectional cross-sectional study death diabetes Diabetes Mellitus diagnosed diagnosing Diagnosis diagnostic outcome died Effect evaluated Factor Factors greater highlight hospital Hospital stay Hospitalization hypertension majority male Mortality multivariable logistic regression multivariable logistic regression model negative test obese Odds ratio Odds ratios outcome pandemic of COVID-19 Patient Patient care Phylogenetic positive positive result pulmonary impairment Rapid test Risk factors RT-qPCR sample collection the disease Treatment variable virus virus detection [DOI] 10.1016/j.jiph.2022.06.010 PMC 바로가기 [Article Type] Article
Interleukin-6 inhibitors reduce mortality in coronavirus disease-2019: An individual patient data meta-analysis from randomized controlled trialsInterleukin-6 억제제는 코로나바이러스 질병-2019의 사망률을 감소시킵니다: 무작위 대조 시험의 개별 환자 데이터 메타 분석Meta-Analysis Published on 2022-07-012022-09-11 Journal: European journal of internal medicine [Category] 임상, [키워드] 95%CI age Analysis confidence confidence interval coronavirus COVID-19 COVID-19 patients data extraction database death discharge discharge rate Efficacy eligible hazard hazard ratio hospitalized COVID-19 patient hospitalized COVID-19 patients IL-6 IL-6 inhibitor IL-6 inhibitors individual inhibitor inhibitors Inteleukin-6 intubation Kaplan-Meier curve meta-analyses Meta-analysis outcome Patient patient data patients Randomized control trials Randomized controlled trial randomized trial randomized trials Ratio RCTs reduce reduce mortality risk risk of death significantly SOC. Standard of care synthesis systematic review the mean the MEDLINE Trial two group two groups was performed [DOI] 10.1016/j.ejim.2022.04.004 PMC 바로가기 [Article Type] Meta-Analysis
Nicotine patches in patients on mechanical ventilation for severe COVID-19: a randomized, double-blind, placebo-controlled, multicentre trialRandomized Controlled Trial Published on 2022-07-012022-10-04 Journal: Intensive care medicine [Category] COVID19(2023년), SARS, 임상, [키워드] active smoker Acute respiratory failure Administered Adverse affected artificial assessment assigned Care conducted confidence interval coronavirus disease COVID-19 Critically ill patient daily dose days alive dose double-blind Efficacy and safety event France function intensive care unit intensive care units Invasive mechanical ventilation IQR mechanical ventilation median men Mortality multicentre Nicotine Nicotinic receptor not differ Odds ratio on mechanical ventilation Organ failure Patient Placebo placebo-controlled placebo-controlled trial Pneumonia Primary outcome Randomized randomized trial Randomly receive receiving reduce renal replacement therapy secondary outcome Severe COVID-19 pneumonia significantly smoker stratified symptomatic patient the median the placebo group Trial two group two groups vasopressor support Ventilation ventilator-free day with COVID-19 [DOI] 10.1007/s00134-022-06721-1 PMC 바로가기 [Article Type] Randomized Controlled Trial
Tocilizumab effectiveness in mechanically ventilated COVID-19 patients (T-MVC-19 Study): a multicenter real-world evidence기계적으로 환기되는 COVID-19 환자에 대한 토실리주맙 효과(T-MVC-19 연구): 다기관 실제 세계 증거Multicenter Study Published on 2022-07-012022-09-12 Journal: Expert review of anti-infective therapy [Category] COVID19(2023년), SARS, 진단, [키워드] acute respiratory syndrome Admission Analysis conducted confidence interval control arm coronavirus coronavirus disease COVID-19 COVID-19 patient diagnosed effective Effectiveness Endpoint evaluate Evidence hazard hazard ratio Invasive mechanical ventilation inverse majority mechanical ventilation mechanically ventilated mechanically ventilated patient Mortality multicenter Nasopharyngeal swab on mechanical ventilation participant Patient polymerase chain propensity score matching PSM reducing mortality reduction in mortality Research design Retrospective multicenter study risk RT-PCR SARS-CoV-2 Tocilizumab treated Treatment was performed Weighting [DOI] 10.1080/14787210.2022.2046462 PMC 바로가기 [Article Type] Multicenter Study
The roles of methylprednisolone treatment in patients with COVID-19: A systematic review and meta-analysisReview article Published on 2022-07-012022-10-05 Journal: Steroids [Category] 임상, 치료법, [키워드] 95% CI benefit clinical outcomes confidence interval COVID-19 COVID-19 patient COVID-19 patients Efficacy and safety eligible evaluate glucocorticoid Glucocorticoids ICU admission less low-dose mean difference mechanical ventilation Meta-analysis Methylprednisolone Mortality observational studies Patient patients with COVID-19 randomized trial reduced reported risk searched Secondary infection secondary infections severe COVID-19 severe COVID-19 patient subgroup analysis systematic review Treatment ventilator-free day viral shedding Web of Science [DOI] 10.1016/j.steroids.2022.109022 [Article Type] Review article
Durability of BNT162b2 vaccine against hospital and emergency department admissions due to the omicron and delta variants in a large health system in the USA: a test-negative case-control study미국의 대규모 의료 시스템에서 오미크론 및 델타 변이로 인한 병원 및 응급실 입원에 대한 BNT162b2 백신의 내구성: 테스트 음성 사례-대조군 연구Article Published on 2022-07-012022-09-11 Journal: The Lancet. Respiratory Medicine [Category] COVID19(2023년), SARS, 변종, 임상, [키워드] 95% CI Acute respiratory infection adjusted adjusted analyses Admission Admissions Against analysed B.1.1.529 B.1.617.2 BNT162b2 BNT162b2 vaccine calculated case-control study caused confidence interval Confidence intervals COVD-19 COVID-19 vaccine delta variant Diagnosis dose doses Effectiveness Electronic health record Electronic health records emergency department estimate evaluate health system hospital Hospital admission less logistic regression models maintain mRNA vaccine Odds ratio Odds ratios of BNT162b2 Older omicron Omicron variant Omicron variants outcome Patient PCR Pfizer Pfizer-BioNTech receipt Registered respiratory infection SARS-CoV-2 second dose subsequent tested trend USA vaccination Vaccine variant [DOI] 10.1016/S2213-2600(22)00101-1 PMC 바로가기 [Article Type] Article