Detection of Antibody Responses Against SARS-CoV-2 in Plasma and Saliva From Vaccinated and Infected Individuals백신 접종 및 감염된 개인의 혈장 및 타액에서 SARS-CoV-2에 대한 항체 반응 검출Immunology Published on 2021-12-202022-09-11 Journal: Frontiers in Immunology [Category] SARS, 변종, 진단, 치료기술, 치료제, [키워드] (alpha (Beta activate activity ADCP Against Alpha antibody isotypes Antibody-dependent cellular phagocytosis antiviral activities B.1.1.7 B.1.351 B.1.617.2 Blood comparable complement complement fixation convalescent Convalescent patients correlated correlation COVID-19 Critical D614G detection elicited examined function greater group Host immune response IgG1 IgG1 response IgG3 IgM individual induce infected individuals Infection initial mucosal neutralization neutralization titers plasma Prevalence respiratory respiratory virus response Saliva SARS-CoV-2 SARS-CoV-2 antigen SARS-CoV-2 antigens SARS-CoV-2 spike significantly significantly lower Spike-specific antibody strain tested the SARS-CoV-2 the vaccine the vaccines total Ig vaccinated individuals vaccination virus WA1 [DOI] 10.3389/fimmu.2021.759688 PMC 바로가기 [Article Type] Immunology
The emergence of SARS-CoV-2 variants threatens to decrease the efficacy of neutralizing antibodies and vaccinesSARS-COV-2 변이체의 출현은 중화 항체 및 백신의 효능을 감소시킬 위협Review Published on 2021-12-172022-09-01 Journal: Biochemical Society Transactions [Category] SARS, 변종, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus Administered antibodies antibody convalescent patient Convalescent patients coronavirus coronavirus disease COVID-19 decrease Efficacy Infection monoclonal antibodies monoclonal antibody mutant viruses neutralize Neutralizing antibodies neutralizing antibody Novel coronavirus pandemic problem problems Prophylactic respiratory restrict SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant severe acute respiratory syndrome Coronavirus Spread the SARS-CoV-2 therapeutic therapeutic antibodies Vaccine Vaccines variant variants variants of concern variants of SARS-CoV-2 virus [DOI] 10.1042/BST20210859 PMC 바로가기 [Article Type] Review
Impact of chemotherapy and immunotherapy on the composition and function of immune cells in COVID-19 convalescent with gynecological tumors부인과 종양과 코비드 -19 회복기에서 면역 세포의 조성 및 기능에 대한 화학 요법 및 면역 요법의 영향Research Paper Published on 2021-12-152022-09-01 Journal: Aging (Albany NY) [Category] SARS, 진단, [키워드] acute infection anti-viral activity B cells cancers caused Chemotherapy clonal expansion convalescent Convalescent patients coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients CoVs effort ENhance facilitated functional phenotype healthy donor ICIs Immune cell immunological change Immunological memory Immunotherapy Impact molecular feature molecular features neutropenia NK cells pandemic Patient patients PBMC PBMCs performed Peripheral blood peripheral blood samples proportion PROTECT Reinfection resurgence SARS-CoV-2 virus single cell sequencing Single-cell RNA sequencing T and B cells T cell T cells Treatment Tumor tumors [DOI] 10.18632/aging.203739 PMC 바로가기 [Article Type] Research Paper
Endothelial dysfunction contributes to severe COVID-19 in combination with dysregulated lymphocyte responses and cytokine networks내피 기능 장애는 조절 이상 림프구 반응 및 사이토카인 네트워크와 함께 심각한 COVID-19에 기여합니다Observational Study Published on 2021-12-102022-09-10 Journal: Signal Transduction and Targeted Therapy [Category] Fulltext, SARS, 바이오마커, 임상, 진단, 치료법, [키워드] activated Activation acute disease Adaptive immunity addition analyses Analysis change Clustering Combination contribute convalescent patient Convalescent patients COVID-19 cytokine disease Disease progression driven by dysfunction dysregulated dysregulation endothelial endothelial injury endothelial integrity expansion flow cytometry granulocyte Granulocytes hallmark hallmarks Hannover ICU patient ICU Patients Immune cell immune cells immune response immune responses immune signature Infectious diseases Inflammatory Inflammatory response Injury involved life-threatening lymphocyte response lymphopenia manifestation medical school microenvironment NK cell observational study plasma protein plasma proteins plasmablast plasmablasts proteomics data regeneration SARS-COV-2 infection SARS-CoV-2-specific antibodies School Seven severe COVID-19 terminally differentiated [DOI] 10.1038/s41392-021-00819-6 PMC 바로가기 [Article Type] Observational Study
Immunologic memory to SARS-CoV-2 in convalescent COVID-19 patients at 1 year postinfection감염 후 1년에 회복 중인 COVID-19 환자의 SARS-CoV-2에 대한 면역학적 기억Article Published on 2021-12-012022-09-12 Journal: The Journal of Allergy and Clinical Immunology [Category] SARS, 진단, [키워드] acute respiratory syndrome anti-receptor-binding domain antibody CD4 CD4(+) T-cell responses Cell cellular response convalescent COVID-19 patient convalescent patient Convalescent patients coronavirus coronavirus disease correlation COVID-19 Critical CTLA-4 cytokine dysfunction evaluate follow-up time groups humoral immune immune memory Immunologic memory increased expression marker moderate multifunctional NAb Neutralizing antibodies neutralizing antibody observé positive rate positively correlated Postinfection Prevalence produced proportion protective immunity reached recruited Reinfection SARS-CoV-2 SARS-CoV-2-specific T cell severity statistical statistical significance Support T cell T-cell TIGIT understanding vaccination were assessed with COVID-19 [DOI] 10.1016/j.jaci.2021.09.008 PMC 바로가기 [Article Type] Article
Sequential Analysis of Binding and Neutralizing Antibody in COVID-19 Convalescent Patients at 14 Months After SARS-CoV-2 InfectionSARS-CoV-2 감염 14개월 후 COVID-19 회복기 환자의 결합 및 중화 항체의 순차 분석Immunology Published on 2021-11-262022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 변종, 진단, 치료기술, 치료법, [키워드] Alpha Analysis anamnestic response Anti-nucleocapsid antibodies anti-SARS-CoV-2 antibodies anti-SARS-CoV-2 antibody anti-spike antibodies antibodies antibody antibody kinetics Antibody Response Asymptomatic Beta binding Cohort convalescent patient Convalescent patients COVID-19 cross-reactive cross-reactivity Delta delta variant detectable example Follow-up functional functional antibody response functional antibody responses Gamma half-live humans Immunity Infection information long-lasting Longevity maintain median Month neutralization nucleocapsid offer one patient pandemic Patient persistence Post-infection prevalent strain provide re-exposure Re-infection recall reduced RNA SARS-CoV-2 significantly specificity spike Spike receptor binding domain spike variants Support symptom onset symptomatic disease tested the antibody These data variant variants of concern WA1 Wuhan [DOI] 10.3389/fimmu.2021.793953 PMC 바로가기 [Article Type] Immunology
Detection of Antibodies Against the SARS-CoV-2 Spike Protein and Analysis of the Peripheral Blood Mononuclear Cell Transcriptomic Profile, 15 Years After Recovery From SARSSARS-CoV-2 스파이크 단백질에 대한 항체 검출 및 SARS 회복 15년 후의 말초혈액 단핵세포 전사체 프로파일 분석Cellular and Infection Microbiology Published on 2021-11-182022-09-11 Journal: Frontiers in Cellular and Infection Microbiology [Category] MERS, SARS, 유전자 메커니즘, 진단, 치료기술, 치료제, [키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus Against antibodies antibody binding cellular entry cellular immunity chemiluminescence chemokine clinical manifestations collected conducted convalescent patient Convalescent patients coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 cross-reactivity cytokine detection elicit epitope Epitopes exhibited expressed Genes heatmap homology immune immune cross-reactivity Immune status Immunity immunoassay in vitro inhibit interferon gamma microsphere mononuclear cell mRNA mRNAs pandemic patients with COVID-19 patients with SARS PBMC PBMCs peptide peptide epitope peripheral Peripheral blood Peripheral blood mononuclear cells Post-infection profile protein sequences Research respiratory responses SARS-CoV SARS-CoV-2 SARS-CoV-2 spike protein serum serum antibodies severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Signal transduction significantly spike Spike protein stimulated the SARS-CoV-2 transcriptomic profile was obtained were used Year [DOI] 10.3389/fcimb.2021.768993 PMC 바로가기 [Article Type] Cellular and Infection Microbiology
Uncovering a conserved vulnerability site in SARS‐CoV‐2 by a human antibody인간 항체에 의한 SARS-CoV-2의 보존된 취약성 사이트 발견Article Published on 2021-11-172022-09-11 Journal: EMBO Molecular Medicine [Category] MERS, SARS, 변종, 진단, [키워드] Affect Alpha antibody antiviral drugs attachment B.1.1.7 B.1.351 B.1.617.2 Beta characterized concern conserved convalescent Convalescent patients COVID‐19 patient COVID‐19 cross‐reactivity cross‐active neutralizing antibody Delta Delta variants destruction of spike electron microscopy engage epitope epitope distal escape mutants functional Gamma generate hamsters host cell host cell receptor mechanism Microbiology, Virology & Host Pathogen Interaction Microscopy monoclonal antibody MOST motif mutable mutants Mutation neutralization neutralize neutralized Neutralizing antibodies neutralizing antibody P.1 predicted RBD RBM receptor‐binding domain receptor‐binding domain reduce residue residues SARS‐CoV‐2 SARS‐CoV‐2 infection SARS‐CoV‐2 spike spike Strains structural biology the RBD the Spike variants variants of concern Viral viral replication [DOI] 10.15252/emmm.202114544 PMC 바로가기 [Article Type] Article
Transcriptomic characteristics and impaired immune function of patients who retest positive for SARS-CoV-2 RNASARS-CoV-2 RNA에 대해 재검사를 받은 환자의 전사 특성 및 면역 기능 장애Article Published on 2021-10-232022-09-10 Journal: Journal of Molecular Cell Biology [Category] Coronavirus, SARS, 바이오마커, 유전자 메커니즘, [키워드] Activation acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Analysis caused CD4 CD8 CD8+ Characteristics contribute Convalescent patients coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 demonstrated differentiation discharge enrolled expression global public health Health crisis healthy control hospital ID1 IFITM10 Immune cell immune cells immune function immunological characteristics Infection inhibitor interferon low expression marker mechanism mononuclear cells natural killer cell Natural killer cells NK cells Occurrence Pathogenesis Patient patients Peripheral blood Peripheral blood mononuclear cells positive reduced respiratory RTP patients SARS-CoV-2 SARS-CoV-2 RNA severe acute respiratory syndrome Coronavirus significantly T cell T cells these cell These cells Transcriptome transcriptome sequencing transmembrane protein with COVID-19 [DOI] 10.1093/jmcb/mjab067 PMC 바로가기 [Article Type] Article
Dysregulated Immune Responses in COVID-19 Patients Correlating With Disease Severity and Invasive Oxygen Requirements질병 중증도 및 침습적 산소 요구량과 관련된 COVID-19 환자의 조절되지 않은 면역 반응Immunology Published on 2021-10-212022-09-12 Journal: Frontiers in Immunology [Category] MERS, SARS, 진단, [키워드] activated T cell addition analyzed antibody isotype cellular Community convalescent patient Convalescent patients COVID-19 COVID-19 patient eosinophils Frequency healthy controls hospital discharge immune Immune cell Immunity immunological Immunological memory information Invasive mechanical ventilation maintain mechanism moderate Monocytes nasal normal proportion outcome oxygen Oxygen therapy Pathogenesis Patient patients plasmablasts Prognosis progression Requirement Research response SARS-CoV-2 pathogenesis SARS-CoV-2-specific antibody SARS-CoV-2-specific IgG severe COVID-19 severe COVID-19 patient Severe patient subset Th1 cell the disease the WHO [DOI] 10.3389/fimmu.2021.769059 PMC 바로가기 [Article Type] Immunology