SARS-CoV-2 spike protein promotes IL-6 trans-signaling by activation of angiotensin II receptor signaling in epithelial cells
SARS-CoV-2 스파이크 단백질은 상피 세포에서 지오텐신 II 수용체 신호 전달의 활성화에 의해 IL-6 트랜스 신호 전달을 촉진합니다
Research Article
[키워드] ACE2
ACE2 expression
Activation
acute respiratory distress
acute respiratory distress syndrome
ADAM
Aggressive
angiotensin
angiotensin converting enzyme
Angiotensin converting enzyme-2
Angiotensin II
AP-1
AT1
Author
c-Fos
candesartan
Candesartan cilexetil
cascade
Cell
cell interactions
cells
Characteristics
chemokines
classical
combating
coordination
Coronavirus infection
COVID-19
COVID-19 disease
COVID-19 disease severity
culture supernatant
cytokine
cytokine response
Cytokine storm
Cytokines
disease severity
down-regulation
ectopic expression
elevated
endothelial
Endothelial cell
epithelial
epithelial cell
epithelial cells
excessive inflammatory response
expressed
expressing
expression
Extracellular
generate
Host
human epithelial cell
human epithelial cells
human liver
hyper-inflammatory response
IL-6
IL-6R
indicated
induce
inducer
Infection
Inflammatory cytokine
inhibit
inhibited
Interaction
leads
Lung epithelial cells
Lung injury
Macrophage
macrophage activation
macrophages
MAPK
MCP-1
mechanism
mediators
Monocytes
monocytes/macrophage
monocytes/macrophages
Multi-organ damage
NF-κB
observation
pathology
pathway
patient sera
Phosphorylation
primary host
pro-inflammatory
promote
promoted
promotion
protease
protein expression
pulmonary epithelial cell
receptor
receptor antagonist
receptor protein
receptor signaling
referred to
Regulatory
residue
respiratory distress
Respiratory distress syndrome
SARS Coronavirus
SARS-CoV-2
SARS-COV-2 infection
SARS-CoV-2 spike
SARS-CoV-2 spike protein
secretion
Signaling
SOCS3
soluble IL-6R
Spike protein
STAT3
suggested
syndrome
therapeutic
therapeutic intervention
tissue damage
trans
trans-signaling
transcriptional
transmembrane
vascular endothelial cell
Viral
viral infection
viral spike protein
with COVID-19
[DOI] 10.1371/journal.ppat.1009128 PMC 바로가기 [Article Type] Research Article
[DOI] 10.1371/journal.ppat.1009128 PMC 바로가기 [Article Type] Research Article