CP: Microbiology – Page 5 – Communicable Diseases Research

Delta spike P681R mutation enhances SARS-CoV-2 fitness over Alpha variant

델타 스파이크 P681R 돌연변이는 알파 변종보다 SARS-CoV-2 적합성을 향상시킵니다.

Article

Published on 2022-05-172022-09-11
Journal: Cell Reports [Category] COVID19(2023년), SARS, 변종,

Inter-domain communication in SARS-CoV-2 spike proteins controls protease-triggered cell entry

SARS-CoV-2 스파이크 단백질의 도메인 간 통신은 프로테아제에 의해 유발된 세포 진입을 제어합니다

Article

Published on 2022-05-032022-09-11
Journal: Cell Reports [Category] COVID19(2023년), SARS, 변종,

[키워드] adaptive addition antibody Antibody neutralization cell entry changes changes in cleavage Control coronavirus CP: Microbiology domain driving facilitate fusion activation hypersensitive identify Infection Inter-domain mechanism membrane membrane fusion Microbiology Mutagenesis neutralization NTD NTDs Particle proteolysis proteolytic activation provide recognize restriction SARS-CoV-2 SARS-CoV-2 evolution SARS-CoV-2 spike protein SARS-CoV-2 virus SARS-CoV-2 virus particle selective Spike protein Spike proteins subsequent Transmission Variability variant variants variants of concern Variation virus virus entry Virus evolution Virus neutralization virus particles virus variation VoC
[DOI] 10.1016/j.celrep.2022.110786 PMC 바로가기 [Article Type] Article

SARS-CoV-2 variants C.1.2 and B.1.621 (Mu) partially evade neutralization by antibodies elicited upon infection or vaccination

SARS-CoV-2 변이체 C.1.2 및 B.1.621(Mu)은 감염 또는 백신 접종 시 유도된 항체에 의한 중화를 부분적으로 회피합니다.

Article

Published on 2022-05-032022-09-11
Journal: Cell Reports [Category] COVID19(2023년), MERS, SARS, 변종, 진단,

Structures of Omicron spike complexes and implications for neutralizing antibody development

Omicron 스파이크 복합체의 구조 및 중화 항체 개발에 대한 의미

Article

Published on 2022-05-032022-09-11
Journal: Cell Reports [Category] COVID19(2023년), MERS, SARS, 변종, 진단,

[키워드] ACE2 antibodies antibody Antibody binding Antibody structure binding biochemical complexes country CP: Immunology CP: Microbiology cryo Cryo-electron microscopy cryo-EM cryo-EM structures Delta dominant drugs electron microscopy Evidence explain Fab immune immune evasion immunology implication information interactions lead Microbiology Mutation mutations neutralization Neutralization antibody neutralization assays neutralizing antibody omicron provide required responsible SARS-CoV-2 spike spike mutation spike mutations Structure structures the SARS-CoV-2 therapeutic therapeutic antibodies Vaccine variant wild-type
[DOI] 10.1016/j.celrep.2022.110770 PMC 바로가기 [Article Type] Article

Systems analysis shows a role of cytophilic antibodies in shaping innate tolerance to malaria

Article

Published on 2022-04-192024-08-28
Journal: Cell Reports [Category] 말라리아,

[키워드] antibodies CP: Immunology CP: Microbiology Gamma delta T cells Innate immunity malaria Monocytes omics data Plasmodium falciparum systems immunology Tolerance

Humanized mice reveal a macrophage-enriched gene signature defining human lung tissue protection during SARS-CoV-2 infection

인간화 마우스는 SARS-CoV-2 감염 동안 인간 폐 조직 보호를 정의하는 대식세포가 풍부한 유전자 서명을 나타냅니다

Article

Published on 2022-04-192022-09-11
Journal: Cell Reports [Category] COVID19(2023년), SARS, 유전자 메커니즘, 진단,

[키워드] Antiviral antiviral responses cellular and molecular Clinical outcome composed COVID-19 CP: Immunology CP: Microbiology differentiation driven by fetal gene signature highlight histopathological Histopathology Human human immune response human immune responses to SARS-CoV-2 Human immune system human lung human lung tissue humanized humanized mice identify immune mechanism immune responses immunological mechanism immunology Infection knowledge lack lung Lung protection lung tissue Macrophage Macrophage infiltration Macrophage response macrophage responses macrophage responses to SARS-CoV-2 mice Microbiology mouse model Mouse models mouse models of SARS-CoV-2 pathway Phenotypes platform pulmonary immune responses. SARS-COV-2 infection severe inflammation signaling pathway tissue type I interferon upregulation
[DOI] 10.1016/j.celrep.2022.110714 PMC 바로가기 [Article Type] Article

mRNA vaccination in octogenarians 15 and 20 months after recovery from COVID-19 elicits robust immune and antibody responses that include Omicron

COVID-19에서 회복된 후 15개월 및 20개월 후 80세 여성에서 mRNA 백신 접종은 Omicron을 포함한 강력한 면역 및 항체 반응을 이끌어냅니다

Article

Published on 2022-04-122022-09-11
Journal: Cell Reports [Category] COVID19(2023년), MERS, SARS, 변종, 진단,

[키워드] ACE2 Activation acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 angiotensin angiotensin-converting enzyme 2 antibody Antibody binding antibody levels Antibody Response Antibody responses BNT162b2 BNT162b2 mRNA BNT162b2 mRNA vaccine BNT162b2 vaccine boost Cohort coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 CP: Microbiology cytokine doses elicit Genetic heavy chain high-risk population IgG IGHV IGHV clones immune Immune transcriptome Immunoglobulin Immunoglobulin G include individual Infection interferon Microbiology mRNA vaccination mRNA vaccine naïve individuals naive versus COVID-19-recovered individuals neutralization Neutralizing antibodies neutralizing antibody octogenarian. of BNT162b2 omicron PBMC receiving respiratory response RNA sequencing RNA-Seq robust SARS-CoV-2 SARS-CoV-2 spike-specific single dose sustained transcript Transcriptome vaccination Vaccine vaccine dose vulnerable population
[DOI] 10.1016/j.celrep.2022.110680 PMC 바로가기 [Article Type] Article

Cross-species tropism and antigenic landscapes of circulating SARS-CoV-2 variants

순환하는 SARS-CoV-2 변이체의 종간 친화성 및 항원 지형

Article

Published on 2022-03-222022-09-11
Journal: Cell Reports [Category] MERS, SARS, 변종, 진단,

[키워드] ACE2 ACE2 ortholog ACE2 orthologs ACE2 receptor activities activity acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Affect Alter Amino acid amino acids antigenic Cell change circulating SARS-CoV-2 variant circulating SARS-CoV-2 variants circulating variant coronavirus CP: Immunology CP: Microbiology cross-species tropism cumulative driver expressing ferret Forecasting host tropism humans immunology Infection investigated less Microbiology mouse mutant Mutation mutations neutralization neutralization resistance Neutralizing antibodies omicron parameter positive correlation Prevalence RBD RBD mutation RBD mutations respiratory SARS-CoV-2 SARS-CoV-2 variants severe acute respiratory syndrome Coronavirus spike receptor-binding domain susceptible variant variants variants of concern variants of interest Viral viral infectivity VOCs VOIs
[DOI] 10.1016/j.celrep.2022.110558 PMC 바로가기 [Article Type] Article