CpG – Page 5 – Communicable Diseases Research

Methylation of Host Genes Associated with Coronavirus Infection from Birth to 26 Years

Article

Published on 2021-07-312022-10-31
Journal: Genes [Category] COVID-19,

Evolution of Human Memory B Cells From Childhood to Old Age

유년기에서 노년기로의 인간 기억 B 세포의 진화

Clinical Trial

Published on 2021-07-232022-09-12
Journal: Frontiers in Immunology [Category] SARS, 임상, 진단,

Laser-facilitated epicutaneous immunization of mice with SARS-CoV-2 spike protein induces antibodies inhibiting spike/ACE2 binding

SARS-CoV-2 스파이크 단백질을 사용한 마우스의 레이저 촉진 표피 면역화는 스파이크/ACE2 결합을 억제하는 항체를 유도합니다

Article

Published on 2021-07-222022-09-12
Journal: Vaccine [Category] MERS, SARS, 진단,

Biomaterials and Oxygen Join Forces to Shape the Immune Response and Boost COVID‐19 Vaccines

생체 재료 및 산소 결합 힘을 결합하여 면역 반응을 형성하고 Covid -19 백신을 향상시킵니다.

Research Article

Published on 2021-07-202022-08-31
Journal: Advanced Science [Category] SARS, 치료제,

[키워드] activate acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adaptive immune system antibody Antibody titer Antibody titers antigens approach Arm binding biomaterial boost coronavirus coronavirus disease Coronavirus disease 2019 COVID‐19 COVID‐19 CpG Critical demonstrated Diseases dose effective effective vaccine Effective vaccines Effectiveness Emerging infectious diseases Engineering force generate GM‐CSF Health Health crisis immune response immune stimulation immunization immunized immunogenicity immunological immunomodulatory immunostimulation Infectious diseases injectable cryogel lack mice Neutralizing antibodies neutralizing antibody nucleocapsid offer overcome oxygen platform preclinical studies protective antibodies Protein Protein subunit vaccines RBD receptor‐binding domain reported required respiratory response resulting robust SARS‐CoV‐2 SARS‐CoV‐2 protein second dose severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) vaccine shape Subunit vaccine subunit vaccines sustained Th1 Th2 Vaccine virus
[DOI] 10.1002/advs.202100316 PMC 바로가기 [Article Type] Research Article

The Heterogeneous Landscape and Early Evolution of Pathogen-Associated CpG Dinucleotides in SARS-CoV-2

SARS-CoV-2에서 병원체 관련 CpG 디뉴클레오티드의 이질적 풍경과 초기 진화

Discoveries

Published on 2021-06-082022-09-10
Journal: Molecular Biology and Evolution [Category] SARS, 치료법,

[키워드] 3′UTR acting acute respiratory syndrome Amino acid Antiviral antiviral protein binding pattern binding patterns circulating coding region comparable COVID-19 COVID-19 pandemic CpG CpG motifs cytoplasm dinucleotide dinucleotides distribution dual dysregulated Evolution evolution of synonymous mutations expressed Genome greater HKU1 human host immune infected cell infected cells landscape lead loci MERS motif Mutation ORF outbreak pathogen-associated molecular pathogen-associated molecular patterns pathogenic Pattern recognition pattern recognition receptor Pattern recognition receptors pressure Protein Region Replication respiratory RNA SARS-CoV-2 SARS-CoV-2 genome Sequence motifs Signaling signature ssRNA viruses statistical synonymous the SARS-CoV-2 genome transcript transversion triggering Viral viral host mimicry Zinc zinc finger antiviral protein
[DOI] 10.1093/molbev/msab036 PMC 바로가기 [Article Type] Discoveries

Evidence for Biological Age Acceleration and Telomere Shortening in COVID-19 Survivors

COVID-19 생존자의 생물학적 연령 가속 및 텔로미어 단축에 대한 증거

Hypothesis

Published on 2021-06-072022-09-10
Journal: International Journal of Molecular Sciences [Category] MERS, 바이오마커, 유전자 메커니즘,

[키워드] acceleration ACE2 ACE2 expression age age determination alteration analyzed Biological biological age characterized Cohort COVID-19 CpG cytokine death defined DeltaAge determine difficulty DIFFICULTY CONCENTRATING DNA methylation DPP-4 Dyspnea Epigenetic epigenetics fatigue fibrosis Immunosuppression increase in Inflammatory cytokine memory memory loss non-infected normality post-COVID-19 Post-COVID-19 patients PPCs pyrosequencing respiratory distress SARS-COV-2 infection Severe respiratory distress shortening sleep disorders subject survivor Survivors syndrome telomere telomeres Volunteer world population younger patient younger patients
[DOI] 10.3390/ijms22116151 PMC 바로가기 [Article Type] Hypothesis

Blood DNA methylation and COVID-19 outcomes

Research

Published on 2021-05-252022-10-31
Journal: Clinical Epigenetics [Category] COVID-19, SARS,

[키워드] acute respiratory distress syndrome (ARDS) Analysis Autoimmune disorders Blood blood sample circulating collected contribute controls COVID-19 COVID-19 patient COVID-19 progression COVID-19 severity CpG disease DNA DNA methylation expression of gene Gene Expression genome-wide analysis healthy healthy individual Hospitalized Human immune response leukocyte methylated Methylation Mortality not differ Ontology outcome outcome measure outcomes pandemic Patient patients performed platform Predictive promoter region Prospective Region regulate reported Result supplementary material the SARS-CoV-2 These data viral infection
[DOI] 10.1186/s13148-021-01102-9 PMC 바로가기 [Article Type] Research

SARS-CoV-2 and other human coronavirus show genome patterns previously associated to reduced viral recognition and altered immune response

SARS-CoV-2 및 기타 인간 코로나바이러스는 이전에 감소된 바이러스 인식 및 변경된 면역 반응과 관련된 게놈 패턴을 보여줍니다

Article

Published on 2021-05-212022-09-10
Journal: Scientific Reports [Category] SARS, 치료법,

[키워드] acting affected Antiviral Asymptomatic Betacoronavirus caused China coding sequence coding sequences codon codon usage Codons contribute coronavirus CpG demonstrated develop dinucleotide dinucleotides disease severity downloaded dysregulated immune response dysregulation envelope evaluate Evidence experimental evidence feature Genome HCoVs Host human coronavirus human coronaviruses immune evasion immune response Increasing Interaction interferon investigated involved matrix Microbial genetics Mortality nucleocapsid older patients outcome pandemic Pathogenesis pathway polyprotein protein sequence reduced RNA degradation SARS-CoV SARS-CoV-2 severe pneumonia synonymous Viral viral replication Virology
[DOI] 10.1038/s41598-021-90278-4 PMC 바로가기 [Article Type] Article

Echinacea purpurea (L.) Moench treatment of monocytes promotes tonic interferon signaling, increased innate immunity gene expression and DNA repeat hypermethylated silencing of endogenous retroviral sequences

Echinacea purpurea (L.) 단핵구의 Moench 처리는 강장제 인터페론 신호 전달, 선천 면역 유전자 발현 증가 및 내인성 레트로 바이러스 서열의 DNA 반복 과메틸화 침묵을 촉진합니다

Research Article

Published on 2021-05-122022-09-10
Journal: BMC Complementary Medicine and Therapies [Category] SARS, 유전자 메커니즘, 치료제,

[키워드] Activation Analysis Antiviral change changes in characterisation chemokine chemotaxis common cold conserved CoV CpG Defense DNA DNA methylation Duration of infection Echinacea element epigenome experiment expression filgotinib Gene Expression genomic Herbal HERV HERVs IFN IFN signaling immunomodulation immunomodulatory effect induce inhibitor innate immune Innate immunity interferon interferon signaling involved janus Janus kinase kinase LTR monocyte Monocytes nuclear DNA Pathways Pattern recognition Pattern recognition receptors pharmacological promise promote Protective reduce Regulation respiratory Respiratory tract infections Result retroviral SARS-CoV-2 sequence Severe acute respiratory syndrome Signaling strain supplementary material Symptom Systems biology THP1 monocytes Transcription Transcriptome Treatment Trigger triggers Viral viral infections virus viruses
[DOI] 10.1186/s12906-021-03310-5 PMC 바로가기 [Article Type] Research Article

CpG-adjuvanted stable prefusion SARS-CoV-2 spike protein protected hamsters from SARS-CoV-2 challenge

SARS-CoV-2 공격으로부터 햄스터를 보호하는 CpG 보조 안정 예비 융합 SARS-CoV-2 스파이크 단백질

Article

Published on 2021-04-222022-09-01
Journal: Scientific Reports [Category] MERS, SARS, 진단, 치료기술,

[키워드] alum aluminum aluminum hydroxide applied average build clinical development comparable control groups COVID-19 pandemic COVID-19 vaccine CpG Detection limit Diseases dose effective vaccine global public health group hamster hydroxide IgG immunized immunogenic immunogenicity immunology imperative Infection injection intramuscularly intranasally Lung pathology lung viral load Microbiology Neutralizing antibodies neutralizing antibody Neutralizing titer pandemic prefusion produced Protective pseudovirus Rapid reduced S-2P Safe SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 spike protein significantly Support the vaccine titers Vaccine vehicle Viral virus weight loss with infection
[DOI] 10.1038/s41598-021-88283-8 PMC 바로가기 [Article Type] Article