MicroRNAs as Potential Tools for Predicting Cancer Patients’ Susceptibility to SARS-CoV-2 Infection and Vaccination ResponseSARS-CoV-2 감염 및 백신 접종 반응에 대한 암 환자의 감수성을 예측하기 위한 잠재적 도구로서의 MicroRNAReview Published on 2022-07-232022-09-12 Journal: Cells [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] ACE2 Antiviral Biomarkers Cancer Cancer patients caused cellular processes contagious COVID-19 Defense deregulated deregulation described disease dysregulated expression genetic information global pandemic human infection immune immune response impair Infection Infectious disease key factor malignancies miR-223-3p miRNA miRNA profile miRNAs mRNA vaccine mRNAs Potential prognostic biomarker Regulation response SARS-CoV-2 SARS-CoV-2 replication Seven spike glycoproteins Spread treatment strategy Vaccine Vaccines [DOI] 10.3390/cells11152279 PMC 바로가기 [Article Type] Review
Identifying enhancers of innate immune signaling as broad-spectrum antivirals active against emerging viruses신종 바이러스에 대해 활성을 나타내는 광범위한 항바이러스제로서 타고난 면역 신호의 인핸서 식별Article Published on 2022-07-212022-09-11 Journal: Cell chemical biology [Category] COVID19(2023년), SARS, 치료제, [키워드] active against acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Antiviral antiviral activity boost broad-spectrum antiviral broad-spectrum antivirals Compound coronavirus Defense dependent on Drug screening emerging viruses enhancer Factors Gilteritinib identifying Immunity immunomodulatory molecules immunostimulatory IMPROVE increasingly Infection Innate innate immune innate immune activation Innate immunity innate response interferon interferon regulatory factor interferon regulatory factors. IRF7 IRFs Kinase inhibitor kinase inhibitors library nuclear translocation outbreak Pandemics pathogenic virus pathogenic viruses Pathogens proof proof of concept Regulatory RNA viruses SARS-CoV-2 screened severe acute respiratory syndrome Coronavirus Signaling viral infection virus [DOI] 10.1016/j.chembiol.2022.05.009 PMC 바로가기 [Article Type] Article
Chapter 12: Insight into coronaviruses and natural products-based approach for COVID-19 treatmentBook chapter Published on 2022-07-192022-10-05 Journal: Molecules [Category] 신약개발, 치료법, [키워드] Analysis Anticoronaviral natural products approach caused Contagion coronavirus Coronaviruses COVID-19 Defense disease drug effective humans include insight metabolite microbe molecular docking natural nontoxic pandemic of COVID-19 Pathogens performed plant Safe SARS-CoV-2 Secondary Metabolite shown Side effect specificity therapeutic targets Treatment [DOI] 10.1016/B978-0-323-91099-6.00005-0 [Article Type] Book chapter
Current Therapeutics for COVID-19, What We Know about the Molecular Mechanism and Efficacy of Treatments for This Novel VirusCOVID-19에 대한 현재 치료제, 이 새로운 바이러스에 대한 분자 메커니즘 및 치료 효능에 대해 우리가 알고 있는 것Review Published on 2022-07-122022-09-11 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), SARS, 치료제, [키워드] anti-viral agent anti-viral agents Antiviral approved caused clinical trial Combination coronavirus coronavirus disease coronavirus disease 19 COVID-19 COVID-19 disease COVID-19 pandemic COVID-19 therapeutics current Defense early treatment effective therapy Efficacy Epidemics Evolution globe Hospitalization immunomodulatory individual molecular mechanism molecular mechanisms monoclonal antibodies monoclonal antibody morbidity and mortality Multiple multitude novel novel SARS-CoV-2 virus pandemic performed Prevent promise Randomized controlled trial remained SARS-CoV-2 SARS-CoV-2 virus searched Severe acute respiratory syndrome severe disease shown Spread the SARS-CoV-2 virus the United State Therapeutic approach therapeutic option Therapeutics Therapies therapy Treatment Trial United States Vaccine were used [DOI] 10.3390/ijms23147702 PMC 바로가기 [Article Type] Review
The significance of advanced COVID-19 diagnostic testing in pandemic control measures전염병 통제 조치에서 고급 COVID-19 진단 테스트의 중요성Review Published on 2022-07-112022-09-11 Journal: International Journal of Biological Sciences [Category] COVID19(2023년), SARS, 변종, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 advancement antibody Antigen causative agent caused combating Community condition conditions coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 outbreak Defense diagnostic diagnostic test diagnostic testing diagnostic tests disease effort evade Evolution Hospitalization measure methodology mortality rates Mutation Novel coronavirus novel coronavirus disease nuclei pandemic Pandemic conditions reduced SARS-CoV-2 Scientific community Sensitivity and specificity severe acute respiratory syndrome Coronavirus shown Transmissibility Treatment strategies treatment strategy Vaccine Viral transmission Viral variants virus [DOI] 10.7150/ijbs.72837 PMC 바로가기 [Article Type] Review
SARS-CoV-2 infection of human-induced pluripotent stem cells-derived lung lineage cells evokes inflammatory and chemosensory responses by targeting mitochondrial pathways인간 유도 만능 줄기 세포 유래 폐 계통 세포의 SARS-CoV-2 감염은 미토콘드리아 경로를 표적으로 하여 염증 및 화학 감각 반응을 유발합니다Article Published on 2022-07-012022-09-12 Journal: Journal of cellular physiology [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] activated acute respiratory syndrome addition Affect airway alveolar alveolar cells Antiviral Apoptosis caused Cell cells chemosensory chemosensory response complexes Consequences coronavirus COVID-19 COVID-19 disease COVID-19 patients Defense developmental distal dysregulation epithelial HMOX1 IL-13 IL-6 immune responses in viral in vitro Increased induced pluripotent stem cells INF-γ infected cell Inflammatory Inflammatory response Lineage lung lung epithelial Lung epithelial cells Lung injury lung tissue maturation mechanism metabolic processe mitochondrial mitochondrial damage. pathway precursor Proinflammatory cytokine proximal replicated response resulting robust ROS ROS production SARS-CoV-2 SARS-COV-2 infection spatiotemporal therapeutic drug TNF-α transcriptomics Transport upregulated upregulation [DOI] 10.1002/jcp.30755 PMC 바로가기 [Article Type] Article
Immature granulocytes: Innovative biomarker for SARS‑CoV‑2 infection미성숙 과립구: SARS‑CoV‑2 감염에 대한 혁신적인 바이오마커Article Published on 2022-07-012022-09-11 Journal: Molecular medicine reports [Category] COVID19(2023년), MERS, SARS, 바이오마커, 변종, 치료기술, [키워드] acute pancreatitis acute respiratory syndrome addition age Alpha Alpha variant Analysis antiviral immune response Bacterial bacterial and fungal infections Biomarker Biomarkers Bone marrow Cardiopulmonary cardiopulmonary bypass clinical conditions Comorbidities complications confounders coronavirus coronavirus disease Coronavirus disease 2019 COVID‐19 critical cases Defense disease severity duration of hospitalization evaluate evaluated fungal infections granulocyte Granulocytes greater Host host defense immature immature granulocytes in viral include Increased independent Infection infections infectious complication Infectious complications intubation involved Logistic regression analysis Male sex Mortality multivariate logistic regression neutrophil Neutrophils Numerous outcomes Pancreatitis Patient patients hospitalized Peripheral blood precursor precursors presence of comorbidity present prognostic biomarker reported Research respiratory severe acute respiratory syndrome Coronavirus severe and critical cases severity significantly syndrome systemic inflammatory response systemic inflammatory response syndrome variant Viral viral infections was measured [DOI] 10.3892/mmr.2022.12733 PMC 바로가기 [Article Type] Article
When cyclin-dependent kinases meet viral infections, including SARS-CoV-2사이클린 의존성 키나제가 SARS-CoV-2를 포함한 바이러스 감염을 만날 때Review Published on 2022-07-012022-09-11 Journal: Journal of medical virology [Category] COVID19(2023년), SARS, 치료제, [키워드] Antiviral CDKs Cell cell division Critical Defense demonstrated DNA DNA viruses drug target function highlight Host in viral Infection kinase kinases molecular protein kinase protein kinases recent Regulation RNA RNA viruses SARS-CoV-2 Therapeutic strategies therapeutic strategy transcriptional regulation viral infection viral infections [DOI] 10.1002/jmv.27719 PMC 바로가기 [Article Type] Review
SARS-CoV-2 Achieves Immune Escape by Destroying Mitochondrial Quality: Comprehensive Analysis of the Cellular Landscapes of Lung and Blood Specimens From Patients With COVID-19SARS-CoV-2, 미토콘드리아 품질을 파괴하여 면역 탈출 달성: COVID-19 환자의 폐 및 혈액 표본의 세포 환경에 대한 종합 분석Article Published on 2022-07-012022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 치료제, [키워드] activated activating alveolar alveolar epithelial cell alveolar epithelial cells alveolar macrophage Alveolar macrophages analyzed antiviral immunity B cell B cells blocked Blood calcium cell count Comprehensive coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patients crossfire cytokine Cytokine storm dataset Defense Degradation energy metabolism epithelial epithelial cell epithelial cells escape exacerbated excessive inflammation explain expression Gene Expression HIF1a Host IFI27 immune immune cells Immune escape Inflammation inhibited Interaction interferon landscape lung tissue Lungs Macrophage macrophages manifestation MCU metabolic pathway metabolism Mitochondria mitochondrial mitochondrial fission mitochondrial functions mitochondrial quality. pathway patients with COVID-19 Perspective plasma pro-inflammatory Regulatory T cell regulatory T cells released Replication respiratory capacity resulting RNA-sequencing SARS-CoV-2 significant changes in Single-cell RNA-sequencing T cells target transformation Tregs type I viral infection [DOI] 10.3389/fimmu.2022.946731 PMC 바로가기 [Article Type] Article
Natural killer cell homing and trafficking in tissues and tumors: from biology to application Reviews Published on 2022-06-292022-10-05 Journal: Signal Transduction and Targeted Therapy [Category] 바이오마커, [키워드] Affect Allogeneic Alter blood circulation Bone marrow Cancer Cancer immunotherapy cancer treatment cancers CAR cells cellular chemokine chemokine receptors chimeric antigen receptor clinical utility cytokine Cytokines Defense develop Evidence Ex vivo expansion Factor Factors homing Immunotherapy IMPROVE infiltration Innate lymphoid cells Integrins limit lymphoid organs lymphoid tissues mechanism microenvironment natural natural killer cell NK cell peripheral tissues profile receptors solid tumors Steady state subset tissue transcriptional transfer transferred Treatment [DOI] 10.1038/s41392-022-01058-z [Article Type] Reviews