degrade – Page 5 – Communicable Diseases Research

Carboxypeptidase B blocks ex vivo activation of the anaphylatoxin-neutrophil extracellular trap axis in neutrophils from COVID-19 patients

Research

Published on 2021-02-082022-11-01
Journal: Critical Care [Category] COVID-19, MERS,

Single-cell RNA sequencing reveals SARS-CoV-2 infection dynamics in lungs of African green monkeys

단일 세포 RNA 시퀀싱은 아프리카 녹색 원숭이의 폐에서 SARS-CoV-2 감염 역학을 보여줍니다

Research Article

Published on 2021-01-272022-09-10
Journal: Science Translational Medicine [Category] 유전자 메커니즘, 치료기술, 치료제,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 African green monkey African green monkeys Alveolar macrophages Analysis animal model animal models animals best Cell cellular debris clearance contribute coronavirus coronavirus disease Coronavirus disease 2019 Course COVID-19 dataset degrade determine Factor genomic RNA green monkeys Host Host immune response host response host responses identify immune cell population immune cell populations immune responses in vivo inactivated Indicator infected cell infected cells Infection infiltrating Inflammatory response information inoculated knowledge lung Lungs Lymph node Macrophage macrophages mediastinal lymph nodes Mild mild to moderate moderate monocyte Monocyte-derived macrophages occur Pathogenesis phagocytosis pneumocyte Pneumocytes provide recruited replicate Replication respiratory respiratory tract responsible reveal RNA RNA sequencing SARS-CoV-2 SARS-COV-2 infection Sequencing sequencing data severe acute respiratory syndrome Coronavirus Single-cell RNA sequencing switching therapeutic targets valuable resource Viral viral genome viral replication virus virus replication while
[DOI] 10.1126/scitranslmed.abe8146 PMC 바로가기 [Article Type] Research Article

An update on ACE2 amplification and its therapeutic potential

ACE2 증폭 및 치료 가능성에 대한 업데이트

Review

Published on 2021-01-012022-09-11
Journal: Acta physiologica (Oxford, England) [Category] SARS, 변종, 치료제,

COVID-19 global pandemic planning: Performance and electret charge of N95 respirators after recommended decontamination methods

COVID-19 글로벌 전염병 계획: 권장되는 오염 제거 방법 후 N95 호흡기의 성능 및 일렉트릿 충전

Original Research

Published on 2020-12-162022-09-11
Journal: Experimental Biology and Medicine [Category] MERS, SARS, 치료기술,

Fine-tuning autophagy maximises lifespan and is associated with changes in mitochondrial gene expression in Drosophila

미세 조정 autophagy는 수명을 최대화하고 초파리의 미토콘드리아 유전자 발현 변화와 관련이 있습니다

Research Article

Published on 2020-11-302022-09-06
Journal: PLoS Genetics [Category] Communicable Disease,

[키워드] abrogated Amino acid applied approach Atg1 Atg5 autophagy block cellular cellular pathway changes in characteristic conditions conserved Critical damaged Degradation degrade Deletion detrimental disease down-regulated down-regulation downregulation Drosophila Effect energy expression extension feature Glucose Health healthy help highlight immune system IMPROVE in vivo increase in Increased insulin insulin receptor Intervention leads Longevity metabolism metabolomic Mild mitochondrial mitochondrial gene mitochondrial genes mitochondrial metabolism moderate Moderation organelle over-expressing overexpression pathway Pathways phenotype Phenotypes profile proteasomal Protein Rapamycin receptor reduced Research short-lived signature transcriptional profile Transcriptional upregulation triacylglycerol up-regulated up-regulation upregulated upregulation
[DOI] 10.1371/journal.pgen.1009083 PMC 바로가기 [Article Type] Research Article

Single-Cell Sequencing of Glioblastoma Reveals Central Nervous System Susceptibility to SARS-CoV-2

Oncology

Published on 2020-11-162022-10-31
Journal: Frontiers in Oncology [Category] COVID-19,

[키워드] ACE2 ACE2 expression acute respiratory syndrome Analysis Angiotensin converting enzyme-2 Bone marrow brain tissue cathepsin caused CD31 CD73 Cell cell cluster cells Central nervous system CNS coronavirus COVID-19 outbreak degrade dependent on Endothelial cell enzyme expressed Glioblastoma glioblastoma multiform human cell human host immunofluorescence staining Invasion mechanism microenvironment nervous nervous system precursor public health emergency receptor Result S protein SARS-CoV SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2–infected patient severe acute respiratory syndrome coronavirus 2 single-cell single-cell transcriptome analysis specimens stem cell suffered susceptibility Symptoms System the spike protein Transcriptome viral nucleic acid
[DOI] 10.3389/fonc.2020.566599 PMC 바로가기 [Article Type] Oncology

The Pivotal Role of Adipocyte-Na K peptide in Reversing Systemic Inflammation in Obesity and COVID-19 in the Development of Heart Failure

Review

Published on 2020-11-142022-10-28
Journal: The Cochrane database of systematic reviews [Category] COVID-19,

[키워드] ACE-2 ACE-2 receptor Activation acute respiratory syndrome adipocyte adipocytes administration adverse outcome amplification amplify antioxidant Cell complex Concentration coronavirus coronavirus disease COVID COVID-19 Cytokine storm Cytokines Cytokines storm death degrade demonstrated development drug enzyme exacerbate Express expression failure fat form global pandemic group heart heart failure heme oxygenase increase infected with COVID-19 Infection Inflammatory cytokine Inflammatory mediators Laboratory Modification Na/K-ATPase obese obese patients obesity pandemic Patient peptide Proteins reactive oxygen species reactive oxygen specy receptor reduction regulate renal responsible risk RNA role ROS ROS production SARS-CoV-2 selective shown Signaling subjects subunit susceptibility systemic systemic cytokine systemic inflammation tissue virus white with COVID-19
[DOI] 10.3390/antiox9111129 PMC 바로가기 [Article Type] Review

The COVID-19 pandemic: a global health crisis

COVID-19 팬데믹: 글로벌 보건 위기

Review

Published on 2020-11-012022-09-10
Journal: Physiological Genomics [Category] SARS, 유전자 메커니즘, 치료제,

[키워드] ACE2 ACE2 receptors acute respiratory distress acute respiratory distress syndrome age amplify angiotensin angiotensin converting enzyme Angiotensin converting enzyme-2 ARDS Atypical cardiovascular disease causative agent cause Comorbidities Comorbidity Complication COVID-19 COVID-19 infection crown Cytokine storm degrade destruction diabetes disease Disease progression envelope protein epithelial cells Ethnicity event Extracellular fibrosis genetics geographic location GTPases Health Health Organization Host Hypercoagulation hypertension include induce Infection inflammatory immune response lead Lung epithelial cells mechanism membrane morbidity Novel coronavirus novel coronavirus SARS-CoV-2 pandemic Pathogenesis pathophysiology patients positive-sense prevalent Prevent pulmonary fibrosis receptor reduce respiratory Respiratory disease respiratory diseases respiratory distress Respiratory distress syndrome risk factor RNA genome route SARS-CoV-2 Sepsis severe cases Severity of infection single-stranded spike glycoprotein spike glycoproteins subsequent Symptom syndrome The United States Therapeutic approach thrombosis Transmission understanding United States upregulation Vaccine Vascular Viral viral envelope proteins World Health Organization Wuhan Wuhan, China
[DOI] 10.1152/physiolgenomics.00089.2020 PMC 바로가기 [Article Type] Review

Short‐term inhibition of SARS‐CoV‐2 by hydrogen peroxide in persistent nasopharyngeal carriers

지속적인 비인두 운반체에서 과산화수소에 의한 SARS-CoV-2의 단기 억제

Short Communication

Published on 2020-09-242022-09-10
Journal: Journal of medical virology [Category] SARS, 치료제,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 assistance baseline burning sensation carrier convalescent coronavirus coronavirus disease Coronavirus disease 2019 Course COVID‐19 COVID‐19 degrade effective eight excluded hydrogen hydrogen peroxide hypertonic solution Incubation period investigated measure median time mucosal surfaces nasopharingeal nasopharyngeal negative swab one patient Patient persistent physician positive prevention prevention service Prevention Service) PROTECT quarantine respiratory SARS‐CoV‐2 SARS‐CoV‐2 service severe acute respiratory syndrome Coronavirus Side effect subject subjects suppressed Swab swabs symptom onset tested threshold Tolerability upper respiratory Viral viral shedding virus
[DOI] 10.1002/jmv.26485 PMC 바로가기 [Article Type] Short Communication

Obesity, Diabetes and COVID-19: An Infectious Disease Spreading From the East Collides With the Consequences of an Unhealthy Western Lifestyle

Endocrinology

Published on 2020-09-172022-10-31
Journal: Frontiers in Endocrinology [Category] COVID-19, MERS, SARS,

[키워드] activated acute respiratory distress caused Cell characterized clinical response condition consequence coronavirus COVID−19 cytokine response degrade diabete diabetes East facilitate feature immune response increase in individual Infectious disease Inflammatory response inflammatory state mechanism metabolic activity metabolic disease morbidity and mortality multi-organ failure obesity pandemic pandemic (COVID-19) pandemic of COVID-19 physical activity progression resulting SARS-CoV-2 Septic shock severe COVID-19 Spread spreading sustained syndrome the cytokine storm tissue tissue damage Trigger viral infection virus
[DOI] 10.3389/fendo.2020.582870 PMC 바로가기 [Article Type] Endocrinology