The Myotis chiloensis Guano Virome: Viral Nucleic Acid Enrichments for High-Resolution Virome Elucidation and Full Alphacoronavirus Genome AssemblyArticle Published on 2022-01-202022-10-28 Journal: Viruses [Category] Coronavirus, [키워드] acid alphacoronavirus assembly bat characterized Chilean Community complicate coronavirus ecological ecosystem emerging viruses ENhance enrichment epidemiological favor Guano high mortality rate High-resolution highlight Human identify include knowledge mammal Myotis PEDV persistence Population secure severe disease Spread Surveillance turn unique variety viral pathogen viral reads virome virome and bats viruses widespread zoonosis zoonotic zoonotic pathogens [DOI] 10.3390/v14020202 PMC 바로가기 [Article Type] Article
Competing endogenous RNA network mediated by circ_3205 in SARS-CoV-2 infected cellsOriginal Article Published on 2022-01-172022-10-31 Journal: Cellular and Molecular Life Sciences [Category] COVID-19, [키워드] biological processe Blood coagulation Cell circRNA Cohort common contributing to coronavirus 2 Coronavirus disease 2019 correlated COVID-19 enrichment event expressed expression Gene expression regulatory network host cell Human immune response Infection Interaction KCNMB4 microRNA miRNA miRNA sponge miRNA target molecular mRNA mRNAs Nasopharyngeal swab outbreak pandemic positive positive sample positively correlated predicted Predictive PRKCE Real-time PCR respiratory responsible retrieved RNA SARS-CoV-2 SARS-CoV-2 infected cell Spearman’s correlation spike Student’s t test supplementary material target targets uninfected upregulated upregulation validation cohort Viral load [DOI] 10.1007/s00018-021-04119-8 PMC 바로가기 [Article Type] Original Article
Persistent Oxidative Stress and Inflammasome Activation in CD14 high CD16 − Monocytes From COVID-19 PatientsCOVID-19 환자의 CD14 높은 CD16- 단핵구에서 지속적인 산화 스트레스 및 염증 활성화Immunology Published on 2022-01-142022-08-31 Journal: Frontiers in Immunology [Category] 바이오마커, [키워드] addition caspase caspase-1 caused CD14 CD14highCD16− monocytes CD16 Cell contribute coronavirus coronavirus disease correlated COVID-19 dependent on disease severity displaying enrichment evidenced hallmark healthy controls hyperinflammation Hyperinflammatory IL-1β immunopathology implicated in vitro Inflammasome inflammasome activation lipid peroxidation Mild mitigate mitochondrial monocyte Monocytes NLRP3 NLRP3 inflammasome outcome outcomes oxidative oxidative stress oxidative stress response pathway Patient persistent response SARS-CoV-2 secretion severe COVID-19 patient severe COVID-19 patients signaling pathway Stress stress response stress responses Superoxide therapy [DOI] 10.3389/fimmu.2021.799558 PMC 바로가기 [Article Type] Immunology
Identifying potential novel insights for COVID-19 pathogenesis and therapeutics using an integrated bioinformatics analysis of host transcriptome숙주 전사체의 통합 생물정보학 분석을 사용하여 COVID-19 병인 및 치료법에 대한 잠재적인 새로운 통찰력 식별Article Published on 2022-01-012022-09-11 Journal: International journal of biological macromolecules [Category] SARS, 신약개발, 유전자 메커니즘, 치료제, [키워드] Analysis analyzed axon guidance Bioinformatics analysis clinical trials combating COVID-19 COVID-19 pathogenesis database DEGs differentially expressed gene Differentially expressed genes DNA drug drug candidate drug candidates Drug repurposing drug target dysfunction enrichment enrichment analysis entrectinib exacerbate Exemestane expressed fibrosis Functional module analysis gene expression profile help hidden host transcriptome Host transcriptome and drug repurposing hub genes hypercytokinemia identify identifying IMPROVE induce Interaction kinase kinases Lung fibrosis mechanism molecular mechanism molecular mechanisms omeprazole overexpression overlapping Pathogenesis pathogenesis of COVID-19 pathogenic pathway Pathway analysis Pathways performed PPI predicted protein-protein interaction Protein-protein interaction network selected Sema7A System Systems biology target targets TINF2 transcription factor transcription factors transcriptional profile transcriptional profiles Transcriptome Treatment was performed was used [DOI] 10.1016/j.ijbiomac.2021.11.124 PMC 바로가기 [Article Type] Article
Omicron N501Y mutation among SARS-CoV-2 lineages: Insilico analysis of potent binding to tyrosine kinase and hypothetical repurposed medicineSARS-CoV-2 계통 중 Omicron N501Y 돌연변이: 티로신 키나아제 및 가상의 용도 변경 의약품에 대한 강력한 결합의 인실리코 분석Article Published on 2022-01-012022-09-11 Journal: Travel medicine and infectious disease [Category] SARS, 변종, 신약개발, [키워드] Analysis analyzed applied B.1.1.7 B.1.351 binding Cancer Cancer patients Care EGFR elevated ENhance enrichment Factor host cell host cells hypothetical Interaction kinase kinases Lineage lineages management molecular docking analysis Mutation N501Y N501Y mutation network network pharmacology omicron pandemic pathogenic Pathways Phosphorylation PI3K polar Precision predicted Receptor binding domain SARS-CoV-2 SARS-CoV-2 entry SARS-CoV-2 lineage Signaling Spike receptor binding domain therapy tyrosine variants [DOI] 10.1016/j.tmaid.2021.102242 PMC 바로가기 [Article Type] Article
Identification of Differentially Expressed Genes in COVID-19 and Integrated Bioinformatics Analysis of Signaling PathwaysCOVID-19에서 차별적으로 발현되는 유전자의 식별 및 신호 전달 경로의 통합 생물정보학 분석Research Article Published on 2021-12-242022-09-10 Journal: Genetics Research [Category] MERS, SARS, 유전자 메커니즘, [키워드] Analysis analyzed annotation bioinformatics cause CD69 cellular response chromosome complications coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 Cutoff CXCR4 cytokine cytokine production DAVID DEGs Diabetic diabetic complications Diagnosis Differentially expressed genes downregulated enrichment FN1 FoxO FOXP3 gene expression profile Gene ontology GO terms group GSEA help HLA-G hub genes identification IL-17 immune response involved ISG15 KEGG Kyoto leukocyte lung tissue mechanism MMP9 myeloid leukocyte necrotic necrotic cell death nuclear other disease pathway Pathways Pneumonia positive potential mechanisms potential molecular PPI protein-protein interaction RAGE Regulation Research screened selected signaling pathway target Treatment type I interferon upregulated Visualization [DOI] 10.1155/2021/2728757 PMC 바로가기 [Article Type] Research Article
Exploring the diversity of coronavirus in sewage during COVID-19 pandemic: Don’t miss the forest for the treesCOVID-19 전염병 동안 하수에서 코로나바이러스의 다양성 탐구: 나무를 위한 숲을 놓치지 마세요Article Published on 2021-12-152022-09-11 Journal: The Science of the total environment [Category] SARS, 유전자 메커니즘, 치료기술, 치료제, [키워드] analyzed animal coronavirus Animal host applied approach Characteristics circulation clinical samples contig Coronaviridae Coronaviridae family coronavirus CoV COVID-19 COVID-19 pandemic CoVs detect enrichment Genetic HCoV HCoV-OC43 infecting next generation sequencing NGS OC43 Occurrence pandemic protocol rodents SARS-CoV-2 sequenced Sequencing sewage Sewage virome specimen target Target enrichment sequencing typing Viral metagenomics. virus wake was obtained wastewater [DOI] 10.1016/j.scitotenv.2021.149562 PMC 바로가기 [Article Type] Article
A 3D structural SARS-CoV-2-human interactome to explore genetic and drug perturbations유전 및 약물 교란을 탐색하기 위한 3D 구조 SARS-CoV-2-인간 상호작용체Article Published on 2021-12-012022-09-11 Journal: Nature methods [Category] SARS, 변종, 신약개발, 유전자 메커니즘, [키워드] binding affinity candidate carried changes in COVID-19 pandemic downstream driven by emergence enrichment etiology Evolution facilitate followed by Genetic Host human population hypothese Interaction interface Meta-analysis molecular docking new viral agent new viral agents performed Perturbation predict predicted receptor ACE2 resource SARS-CoV-1 SARS-CoV-2 sequence Spike protein targets the spike protein Transmission variant Viral protein Viral proteins virulence [DOI] 10.1038/s41592-021-01318-w PMC 바로가기 [Article Type] Article
Single-Cell RNA Sequencing of Urinary Cells Reveals Distinct Cellular Diversity in COVID-19-Associated AKI비뇨기 세포의 단일 세포 RNA 시퀀싱으로 COVID-19 관련 AKI에서 뚜렷한 세포 다양성을 보여줍니다Article Published on 2021-11-052022-09-11 Journal: Kidney360 [Category] SARS, 치료기술, [키워드] ACE2 acute kidney Acute kidney injury acute kidney injury and ICU nephrology AKI alteration Analysis Anti-inflammatory Antiviral Basic science bladder Cell cell type cell types cells cellular collected contribute COVID-19 dataset direct infection Diversity eight enrichment Evidence evidence of Gene Expression highest hospitalized patient hospitalized patients Hypothesis ICU immune cells include infection with SARS-CoV-2 information kidney Kidney diseases Mortality Non-COVID-19 occur one patient pathophysiology pathway Pathway analysis Pathways Patient patients with AKI performed preliminary evidence resource RNA SARS-CoV-2 SARS-CoV-2 viral RNA scRNAseq severity single-cell Single-cell RNA sequencing tested TMPRSS2 TMPRSS2 expression transcript transcripts tubular cell uninjured urinary Urinary bladder urinary sediment Urine with COVID-19 [DOI] 10.34067/KID.0005522021 PMC 바로가기 [Article Type] Article
Development of a rapid viability RT-PCR (RV-RT-PCR) method to detect infectious SARS-CoV-2 from swabs면봉에서 감염성 SARS-CoV-2를 검출하는 신속한 생존력 RT-PCR(RV-RT-PCR) 방법 개발Article Published on 2021-11-012022-09-11 Journal: Journal of virological methods [Category] SARS, 치료기술, [키워드] 96-well plate acute respiratory syndrome coronavirus Algorithm Analysis antiviral drug COVID-19 COVID-19 pandemic Culture cycle threshold detect determine development enrichment epidemiological include increase in Incubation period Infectious SARS-CoV-2 Infectious virus PCR method Post-infection potential surface Rapid Rapid viability representing required respiratory resulting reverse transcriptase reverse transcriptase PCR RT-PCR SARS-CoV-2 SARS-CoV-2 RNA SARS-CoV-2 virion SARS-CoV-2 virions Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 Spread Swab swab sample swab samples swabs Transmission Ultrafiltration viability Viral detection viral infection virions virus [DOI] 10.1016/j.jviromet.2021.114251 PMC 바로가기 [Article Type] Article