Associations between Allelic Variants of the Human IgH 3′ Regulatory Region 1 and the Immune Response to BNT162b2 mRNA VaccineArticle Published on 2021-10-192022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] acute respiratory syndrome analyses antibody production Antigen-specific B cells approach B cell response BNT162b2 BNT162b2 mRNA cells coronavirus Coronavirus disease 2019 COVID-19 COVID-19 patient effective response effective vaccine Escalation flow cytometry Genetic genetic background HS1.2 Human human immunoglobulin IgH locus Immune profile individuals injection levels of antibodies locus NK cell Pfizer–BioNTech progression Protein Region regulatory region required response Safe SARS-CoV-2 SARS-CoV-2 spike serological significant increase single-nucleotide SNP subject subjects subset Support the disease vaccination Vaccine variant [DOI] 10.3390/vaccines9101207 PMC 바로가기 [Article Type] Article
Albumin as a Prognostic Indicator in Pre-Intubated Patients With SARS-CoV-2: A Retrospective, Multi-Institutional StudyInternal Medicine Published on 2021-10-062022-10-31 Journal: Cureus [Category] COVID-19, [키워드] 24 hour acute respiratory syndrome age association Biomarker Cohort collected Coronavirus-2 Corporation determine effort endotracheal Escalation evaluated FIVE higher risk Indicator Infection initiated intubation lab likelihood Linear regression marker Mortality multivariate New York City nippv Non-invasive oxygen Patient patients patients with SARS-CoV-2 positive airway pressure positive pressure ventilation Pre-intubation predict Prognosis required Result Retrospective study SARS-CoV-2 SARS-CoV-2 patient serological serological marker serological test serum serum albumin utility while worsening [DOI] 10.7759/cureus.18532 PMC 바로가기 [Article Type] Internal Medicine
Comparative molecular investigation of the potential inhibitors against SARS-CoV-2 main protease: a molecular docking studyComparative Study Published on 2021-10-012022-10-04 Journal: Journal of biomolecular structure & dynamics [Category] SARS, 신약개발, [키워드] Anti-viral Anti-viral drugs Assessing binding affinity Comparative complex COVID-19 docked drug drug candidate Drug discovery effective epirubicin Escalation Evidence exhibited filtered In-vitro indicated inhibit inhibitor inhibitors Interaction less literature review molecular molecular docking molecular docking studies Molecular dynamics simulation Novel coronavirus outbreak pandemic pathogen recent reduce mortality saquinavir SARS-CoV-2 SARS-CoV-2 virus synergistic Vaccine vapreotida. [DOI] 10.1080/07391102.2020.1796813 PMC 바로가기 [Article Type] Comparative Study
Rationale and design of the Prone Position and Respiratory Outcomes in Non-intubated COVID-19 PatiEnts: The “PRONE” StudyRandomized Controlled Trial Published on 2021-10-012022-10-05 Journal: Contemporary clinical trials [Category] SARS, 임상, [키워드] Awake benefit Care conducted coronavirus disease COVID-19 defined determine discharge Effect Escalation fraction Hospitalized hospitalized patient Invasive mechanical ventilation multicenter Non-intubated outcome oxygen oxyhemoglobin saturation Patient Pneumonia position prone Prone position prone positioning Randomized rationale respiratory respiratory parameter respiratory rate Respiratory Support Secondary objective supplemental oxygen Trial while [DOI] 10.1016/j.cct.2021.106541 PMC 바로가기 [Article Type] Randomized Controlled Trial
Evaluation of superinfection, antimicrobial usage, and airway microbiome with metagenomic sequencing in COVID-19 patients: A cohort study in ShanghaiCOVID-19 환자의 메타게놈 염기서열 분석을 통한 중복 감염, 항균 사용 및 기도 미생물군집 평가: 상하이 코호트 연구Article Published on 2021-10-012022-09-11 Journal: Journal of microbiology, immunology, and infection [Category] SARS, 유전자 메커니즘, 치료기술, 치료제, [키워드] accounted airway Analysis analyzed antimicrobial Antimicrobials Bacteremia carbapenem center clinical clinical benefit Co-infection Cohort cohort study COVID-19 COVID-19 patient COVID-19 patients Critically ill critically ill COVID-19 patients detect develop Escalation Fungal infection help high risk information Intensive intubation investigated laboratory-confirmed management mechanical ventilation metagenomic sequencing Microbiome microbiota Mild Mortality mortality rate Non-COVID-19 Patient Precision Public Retrospective study semi-quantitative severe COVID-19 severe COVID-19 patient severe patients Shanghai Shanghai Public Health Clinical Center significantly subgroups suggested superinfection Surveillance targeted therapy therapy total population virus [DOI] 10.1016/j.jmii.2021.03.015 PMC 바로가기 [Article Type] Article
How the scientific community responded to the COVID-19 pandemic: A subject-level time-trend bibliometric analysisResearch Article Published on 2021-09-302022-10-28 Journal: PLoS ONE [Category] COVID-19, SARS, [키워드] Analysis association Bank country COVID-19 determine domain Escalation Health highest incidence indicated Infectious disease International National physical public health Research Result retrieved Scientific community subject triggered with COVID-19 [DOI] 10.1371/journal.pone.0258064 PMC 바로가기 [Article Type] Research Article
Epidural morphine in COVID ARDS patients with high respiratory drive: a structured summary of a study protocol for a randomised controlled trial높은 호흡 드라이브가 있는 COVID ARDS 환자의 경막외 모르핀: 무작위 대조 시험을 위한 연구 프로토콜의 구조화된 요약Letter Published on 2021-09-162022-09-10 Journal: Trials [Category] SARS, 임상, [키워드] 1:1 28-day mortality Abnormalities acceptance administer Administered Admission Adult patient Adult patients allocation ARDS patient aseptic technique assistant average blind Blinding both group both groups catheterization Coagulation comparator Patients control group COVID COVID 19 patient COVID 19 patients COVID-19 criteria CTRI death discharge dissemination dose doses double blind Dyspnoea element Endotracheal intubation Epidural epidural catheter Epidural morphine epidural space Escalation exclusion criteria fixed fraction greater Group allocation HCO hypoventilation Hypoxemia ICU ICU patient inclusion criteria India injection Intervention intervention group intubation involved list Local maximum mechanical ventilation Medical Science Medical Sciences Metabolic acidosis minimum morphine morphine sulphate Mortality NIV non-invasive ventilation number Nurse objective outcome Pain parameters participant Patient Patient self-induced lung injury patients with COVID19 physician Placebo protocol random randomisation randomised randomised controlled trial recruited reduce Registered registry Research respiratory respiratory acidosis Respiratory drive respiratory parameters resulting Sample size sealed second dose secondary Secondary outcomes Sedation Sepsis severe hypoxemia sitting position skin Source Study protocol sulphate supplementary material team the patient Trial ventilator parameters website with COVID-19 [DOI] 10.1186/s13063-021-05570-5 PMC 바로가기 [Article Type] Letter
De-escalation strategies for non-pharmaceutical interventions following infectious disease outbreaks: a rapid review and a proposed dynamic de-escalation framework전염병 발생 후 비약물적 개입을 위한 단계적 축소 전략: 신속한 검토 및 제안된 동적 단계적 축소 프레임워크Review Published on 2021-09-162022-09-11 Journal: Globalization and Health [Category] 변종, [키워드] Analysis build changes in concept confirmed case confirmed cases Contact tracing country COVID-19 criteria De-escalation De-escalation strategies disease outbreaks Epidemiology Escalation Final final analysis Government Grey literature guide Health policy Health surveillance health system health systems impacts Infection Infectious disease Intervention lead measure MONITOR Non-pharmaceutical interventions NPI Outbreaks over Pandemics Patient Prevent provide public health reported Result resurgence retrieved robust severity of COVID-19 speed Spread supplementary material Surveillance thematic analysis timeline Transmission treat Vaccine variants variants of concern [DOI] 10.1186/s12992-021-00743-y PMC 바로가기 [Article Type] Review
Virus-induced senescence is a driver and therapeutic target in COVID-19 Research Published on 2021-09-132022-10-05 Journal: Nature [Category] SARS, 유전자 메커니즘, 임상, 치료기술, 치료법, 치료제, [키워드] accompanied activation of platelet affected airway cascade cells cellular senescence Clinical severity Combination complement COVID-19 cytokine demonstrated eliminated endothelial cells endothelial damage Escalation Factor Factors feature form hallmark Immune cell infected cells Inflammation lung Lung disease Macrophage macrophage activation marker mice mucosa Neutrophil extracellular trap neutrophil infiltration organ damage pathogenic phenotype pro-inflammatory cytokines quercetin reduced SARS-CoV-2 SARS-CoV-2-infected hamster SASP secretion Serum level Stress supernatant therapeutic target thrombosis Treatment viral infections virus-infected cell viruses widespread with COVID-19 [DOI] 10.1038/s41586-021-03995-1 [Article Type] Research
Relationship between the Severity of Anxiety Symptoms, Aggression and Alcohol Consumption during the COVID-19 Pandemic PeriodArticle Published on 2021-09-112022-10-30 Journal: Medicina [Category] COVID-19, SARS, [키워드] affected aggression alcohol alcohol drinking Anxiety conducted Consumption correlation COVID-19 COVID-19 pandemic determine element Escalation excessive alcohol consumption Gender Health increase in indicated intensity Interaction material men mental health pandemic parameter Period physical Psychiatric psychoeducational Psychological reducing relationship Research Result severity socio-demographic study group Treatment verbal women [DOI] 10.3390/medicina57090959 PMC 바로가기 [Article Type] Article