Exploratory analysis – Page 5 – Communicable Diseases Research

Immunogenicity of COVID-19 mRNA Vaccines in Pregnant and Lactating Women

임산부와 수유부에서 코로나19 mRNA 백신의 면역원성

Article

Published on 2021-06-152022-09-11
Journal: JAMA [Category] MERS, SARS, 변종, 진단,

ABO phenotype and clinical correlates of COVID-19 severity in hospitalized patients

Research Article

Published on 2021-06-122022-10-31
Journal: Future Science OA [Category] COVID-19,

[키워드] ABO ABO blood type Abstract Admission Analysis Anemia association Blood Blood Group blood phenotype clinical disease confounding variables COVID-19 COVID-19 disease COVID-19 severity death diagnosed with COVID-19 Diagnosis Diego Disease progression Evidence Exploratory analyses Exploratory analysis FIVE help Hispanic hospital Hospitalization Hospitalized hospitalized patient imperative increased risk intensive care intubation male Male sex Manifestations material morbidity and mortality outcome Patient phenotype predictor San Diego severity Support suppress susceptibility total patients with COVID-19
[DOI] 10.2144/fsoa-2021-0045 PMC 바로가기 [Article Type] Research Article

Correlation of Population SARS-CoV-2 Cycle Threshold Values to Local Disease Dynamics: Exploratory Observational Study

인구 SARS-CoV-2 주기 임계값과 지역 질병 역학의 상관관계: 탐색적 관찰 연구

Observational Study

Published on 2021-06-032022-09-10
Journal: JMIR Public Health and Surveillance [Category] Coronavirus, MERS, SARS, 임상, 진단, 치료기술,

[키워드] association average changes in collected Community correlated correlation COVID-19 COVID-19 hospitalization Ct value Ct values cycle cycle threshold Daily determine disease disease dynamic distribution Epidemiology evaluate exploratory Exploratory analysis feature geographical area greater hospitalizations limitation Linear regression local outbreaks measure Measures median objective outbreak Patient care Population population distribution population distributions processed Research Result reverse transcription polymerase chain reaction Rt SARS-CoV-2 scatterplot specimen statistically significant Testing threshold Transmission transmission rate value were used
[DOI] 10.2196/28265 PMC 바로가기 [Article Type] Observational Study

The immune modulatory effects of umbilical cord-derived mesenchymal stromal cells in severe COVID-19 pneumonia

Short Report

Published on 2021-06-022022-10-29
Journal: Stem Cell Research & Therapy [Category] COVID-19, MERS, SARS,

[키워드] accompanied addition assays baseline bronchoalveolar cellular chemokine circulating circulating monocyte Coronavirus disease 2019 COVID-19 Cytokines decrease effective ELISA Exploratory analysis flow cytometry functional immune modulatory effect immune reaction immunological immunomodulatory property immunosuppressive Infection Inflammatory inflammatory neutrophils Inflammatory response intensive care unit interleukin-6 life-threatening low-density Mesenchymal stromal cells MSC MSCs myeloid cells neutrophil neutrophil recruitment Patient Peripheral blood plasma Pneumonia pro-inflammatory cytokines pro-thrombotic reduction renal scRNA-seq Serum level severe COVID-19 Severe COVID-19 pneumonia Single-cell RNA sequencing stromal cell supplementary material T lymphocyte treated Treatment Trial tumor necrosis factor-α umbilical were assessed
[DOI] 10.1186/s13287-021-02376-9 PMC 바로가기 [Article Type] Short Report

The socio-spatial determinants of COVID-19 diffusion: the impact of globalisation, settlement characteristics and population

Research

Published on 2021-05-202022-11-01
Journal: Globalization and Health [Category] COVID-19,

[키워드] absence anticipated Characteristics coronavirus country COVID-19 COVID-19 case COVID-19 diffusion COVID-19 transmission Defense determinant diffusion disease driver epidemiological explain Exploratory analysis global pandemic Globalisation greater Hierarchical household size Human Development Impact Infectious disease Interaction Johns Hopkins University knowledge limitations Model Older outcome population density populations predict predictor quantile regression regions Regression model replicated reported Repository Research Result Spatial diffusion Spread supplementary material sustained total population urbanisation vaccination variable Virological while widespread
[DOI] 10.1186/s12992-021-00707-2 PMC 바로가기 [Article Type] Research

Convalescent plasma therapy and mortality in COVID-19 patients admitted to the ICU: a prospective observational study

Research

Published on 2021-05-122022-10-28
Journal: Annals of Intensive Care [Category] COVID-19,

[키워드] 95% CI acute respiratory distress syndrome Admission association benefit convalescent plasma Convalescent plasma therapy coronavirus COVID-19 COVID-19 patient criteria Critically ill patient Exploratory analysis female hazard Horowitz ICU identify index intensive care invasive ventilation median median age Mortality non-invasive ventilation Patient plasma Probability prognostic variable prospective observational cohort prospective observational study receiving required Respiratory failure Result single-center supplementary material survival survival rates susceptible therapy Treatment treatment groups ventilatory support
[DOI] 10.1186/s13613-021-00867-9 PMC 바로가기 [Article Type] Research

Is lung ultrasound score a useful tool to monitoring and handling moderate and severe COVID-19 patients in the general ward? An observational pilot study

Observational Study

Published on 2021-05-042022-10-04
Journal: Journal of clinical monitoring and computing [Category] MERS, 임상,

[키워드] Admission BMI Body Characteristics Chest computed tomography Computed tomography correlated COVID-19 CT scan CT scans cutoff value Diagnosis diagnostic died disease Exploratory analysis females Follow-up Forward handling index initial invasive ventilation Italy lung Lung ultrasound male management mass median moderate moderate-severe moderate-to-severe COVID-19 pneumonia Non invasive ventilation Noninvasive ventilation PaO Patient performed pilot study positive Predictive prognostic progression receiving Respiratory failure severe COVID-19 patient shown significantly significantly higher team the disease university
[DOI] 10.1007/s10877-021-00709-w PMC 바로가기 [Article Type] Observational Study

Protocol for the Implementation and Assessment of “MoodUP”: A Stepped Care Model Assisted by a Digital Platform to Accelerate Access to Mental Health Care for Cancer Patients Amid the COVID-19 Pandemic

Study Protocol

Published on 2021-04-272022-10-29
Journal: International Journal of Environmental Research an [Category] Coronavirus, MERS, SARS,

[키워드] accelerate access activate Algorithm Anxiety assessment Cancer cancer treatment Care characterized clinically Collaborative healthcare collected Complete conducted consequence Consequences COVID-19 COVID-19 pandemic Depression Depressive symptoms Digital expected Exploratory analysis facilitator feasibility Health Service healthcare High-risk patients implementation Implementation study IMPROVE Intervention management Mental mental health Model oncology outcomes pathway Patient patients platform poor mental health populations Portugal proportion questionnaire Research protocol risk scale screened severity subgroups Symptom Treatment Variation
[DOI] 10.3390/ijerph18094629 PMC 바로가기 [Article Type] Study Protocol

Efficacy of ChAdOx1 nCoV-19 (AZD1222) vaccine against SARS-CoV-2 variant of concern 202012/01 (B.1.1.7): an exploratory analysis of a randomised controlled trial

우려되는 SARS-CoV-2 변이체에 대한 ChAdOx1 nCoV-19(AZD1222) 백신의 효능 202012/01(B.1.1.7): 무작위 대조 시험의 탐색적 분석

Clinical Trial

Published on 2021-04-102022-08-13
Journal: Lancet (London, England) [Category] MERS, SARS, 변종, 임상, 진단,

[키워드] 1:1 95% CI adenoviral vector vaccine Ageusia analysed Anosmia assigned AstraZeneca AZD1222 B.1.1.7 B.1.1.7 lineage B.1.1.7 variant booster dose booster doses calculated canonical ChAdOx1 ChAdOx1 nCoV-19 Clinical research Clinical vaccine efficacy Coalition collected cough COVID-19 COVID-19 disease disease dominant Efficacy efficacy analysis efficacy cohort enrolled Exploratory analysis female Fever finding funding Genomics geometric mean geometric mean ratio groups in vitro Infection Innovation ISRCTN Lineage lineages MenACWY microneutralisation assay NAAT NAAT positive NAAT positive swab network neutralisation activity neutralising antibody response Neutralising antibody responses NIHR NIHR Oxford Biomedical Research Centre non-B.1.1.7 variant nose and throat nucleic acid nucleic acid amplification nucleic acid amplification test Oxford participant phase 2/3 Poisson regression model positive sample post-hoc analysis provided randomised controlled trial Randomly receive recruited reduced Registered Relative risk risk robust SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant second dose second dose of vaccine sequenced seronegative participant seronegative participants Shortness of breath South Swab swabs symptomatic symptomatic COVID-19 symptoms of COVID-19 tested the vaccine throat swabs Trial upper airway upper airway swab Vaccine vaccine efficacy vaccine-induced antibodies vaccine-induced antibody Valley variant variant of SARS-CoV-2 Victoria Victoria lineage virus neutralisation activity were measured
[DOI] 10.1016/S0140-6736(21)00628-0 PMC 바로가기 [Article Type] Clinical Trial

Patient factors and temporal trends associated with COVID-19 in-hospital mortality in England: an observational study using administrative data

Observational Study

Published on 2021-04-012022-10-05
Journal: The Lancet. Respiratory Medicine [Category] Fulltext, MERS, 유전자 메커니즘, 임상,

[키워드] accounted adjusted Admission age Analysis Asian changes in Charlson Comorbidity Index Comorbidities Complete COVID-19 COVID-19 patient cubic splines dataset death Deceased Deprivation diagnosis of COVID-19 died discharge discharged early phase England Exploratory analysis Factor Final frailty greater group hospital Hospital Episode Statistics Hospital stay hospitalised patient identify improvement In-hospital death in-hospital mortality index infection rate investigated linear Logistic regression logistic regression model Male sex moderate Mortality mortality rate Multiple occurred Older Older age Outbreaks pandemic Patient patients with COVID-19 predictor presence of comorbidity Primary outcome Probability reduction reported retrospective risk score severe liver disease Sex significantly study period variables was used white with COVID-19
[DOI] 10.1016/S2213-2600(20)30579-8 PMC 바로가기 [Article Type] Observational Study