Cell surface detection of vimentin, ACE2 and SARS-CoV-2 Spike proteins reveals selective colocalization at primary ciliavimentin, ACE2 및 SARS-CoV-2 스파이크 단백질의 세포 표면 검출은 일차 섬모에서 선택적 공동 국소화를 나타냅니다Article Published on 2022-04-292022-09-11 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 치료기술, [키워드] ACE2 acetylated tubulin Arl13b binding Cell cell surface cell types cells cellular receptor cellular receptors ciliated cytoplasm docking Extracellular facilitate filament protein immunoreactivity Incubation Interaction Intermediate filament marker moderate occur Particle plasma membrane platform positive Protein receptor reported reveal S1 subunit SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 spike protein selective spike Spike protein Spike proteins structures tubulin vimentin viral invasion virus [DOI] 10.1038/s41598-022-11248-y PMC 바로가기 [Article Type] Article
Molecular Cross-Talk between Integrins and Cadherins Leads to a Loss of Vascular Barrier Integrity during SARS-CoV-2 InfectionSARS-CoV-2 감염 시 인테그린과 캐드헤린 간의 분자 상호작용으로 혈관 장벽 무결성 상실Article Published on 2022-04-252022-09-11 Journal: Viruses [Category] COVID19(2023년), SARS, 변종, [키워드] abnormal coagulation barrier cadherin candidate cilengitide complex Complication contribute COVID-19 Cytokine storms dysregulation Effects elicit endothelial endothelial cells Endothelial dysfunction Endotheliitis event events expressed Extracellular homeostasis Hypoxemia inhibitor integrin integrin αVβ3 Integrins integrity internalization intracellular signaling life-threatening Loss mechanism motif multiple organ failure Pathways peptide phenotype phlogistic prevented Protein receptor redistribution RGD motif SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant SARS-CoV-2 variants SARS-CoV-2 variants of concern Spike protein Support the spike protein thrombotic Thrombotic complications Trigger Vascular vascular dysfunction vascular leakage [DOI] 10.3390/v14050891 PMC 바로가기 [Article Type] Article
Progress in Assays of HMGB1 Levels in Human Plasma-The Potential Prognostic Value in COVID-19인간 혈장의 HMGB1 수준 분석 진행 - COVID-19의 잠재적 예후 가치Review Published on 2022-04-052022-09-11 Journal: Biomolecules [Category] COVID19(2023년), SARS, 치료기술, [키워드] acute respiratory syndrome approach Autoimmune Autoimmune disorders Cancer Cell cells COVID-19 disease severity Diseases ELISA EMSA explain Extracellular Extracellular HMGB1 Health HMGB1 Human Human plasma immunosensor induce Inflammatory response Inflammatory responses inflammatory storm Level Occurrence outbreak Patient plasma/serum. Potential Progress Protein Rapid recent release of HMGB1 released respiratory SARS-CoV-2 virus Sepsis Severe acute respiratory syndrome survival the SARS-CoV-2 virus therapeutic window Treatment value [DOI] 10.3390/biom12040544 PMC 바로가기 [Article Type] Review
Unraveling the antiviral activity of plitidepsin against SARS-CoV-2 by subcellular and morphological analysis세포내 및 형태학적 분석을 통한 SARS-CoV-2에 대한 플리티뎁신의 항바이러스 활성 규명Article Published on 2022-04-012022-09-11 Journal: Antiviral Research [Category] Coronavirus, COVID19(2023년), SARS, 치료기술, 치료법, 치료제, [키워드] absence Affect Alpha Analysis antitumor agent Antiviral antiviral activity antiviral drugs Antiviral treatment approach biogenesis block caused Cell Complete coronavirus COVID-19 double-stranded RNA dsRNA Efficacy electron electron microscopy elongation factor eukaryotic translation evaluate the effect Extracellular genome replication group host protein infected Vero E6 cells Interaction labeling mechanism mechanism of action Microscopy morphogenesis Morphological morphological analysis New coronavirus new coronavirus SARS-CoV-2 offer organelle pandemic plasma membrane Plitidepsin Post-infection progeny Protein provided SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 nucleocapsid shown Structure subcellular Support target TEM transmission electron microscopy treated unique Vero E6 Vero E6 cell VERO E6 cells Vesicle viral infection Viral particles viral replication virion virus viruses [DOI] 10.1016/j.antiviral.2022.105270 PMC 바로가기 [Article Type] Article
Whole Exome Sequencing Identifies a Rare Mutation in NACAD as a Possible Cause of COVID orchitis in BrothersConference abstract Published on 2022-04-012022-10-05 Journal: The journal of sexual medicine [Category] 변종, [키워드] ACE2 ACE2 pathway Affect affected age amino acid change antigens average Blood body aches Brother cause cellular cellular entry chromosome 7 circulating controls cough COVID COVID-19 COVID-19 patient Critical current Cytokine storm DNA extraction Evidence examined Exome Extracellular Fever FIVE frameshift Frequency Genetic genetic susceptibility Genotype Human hypothese IgG Inflammation involved kidneys less liver Lungs men Mutation NACAD nonsynonymous objective organ Pain pathogenicity Patient patients PCR PCR positive performed plasma samples polymerase chain population prevalence Prevalence PROTECT R&D Systems report Result SARS CoV-2 SARS-CoV2 Sequencing Serum level soluble ACE2 sore throat subject susceptibility Symptom syndrome testicular pain Transport USA variant variants Vascular endothelium WES while with COVID-19 [DOI] 10.1016/j.jsxm.2022.01.068 [Article Type] Conference abstract
Role of the renin-angiotensin system in NETosis in the coronavirus disease 2019 (COVID-19)코로나바이러스 질병 2019(COVID-19)의 NETosis에서 레닌-안지오텐신 시스템의 역할Review Published on 2022-04-012022-09-11 Journal: Biomedicine & pharmacotherapy = Biomédecine & phar [Category] COVID19(2023년), SARS, 치료기술, [키워드] ACEi angiotensin Angiotensin II angiotensin II type 1 receptor blockers Angiotensin system angiotensin-converting enzyme inhibitor angiotensin-converting enzyme inhibitors antagonist ARBs blocker Blood blood pressure Brain cause Complication contribute coronavirus disease COVID-19 death endocytosis Evidence explain Extracellular help hypertension induce Infarction involved kidney Low-density granulocytes lung mechanism Myocardial infarction NET NETosis NETs neutrophil neutrophil activation Neutrophil extracellular trap Neutrophil extracellular traps neutrophil recruitment Numerous organ Patient patients with COVID-19 procoagulant promote recent recent findings receptor reduce regulate Renin renin-angiotensin system risk role severe COVID-19 stroke thrombosis Treatment Trigger virus [DOI] 10.1016/j.biopha.2022.112718 PMC 바로가기 [Article Type] Review
Ultrastructural insight into SARS-CoV-2 entry and budding in human airway epithelium사람의 기도 상피에서 SARS-CoV-2 진입 및 발아에 대한 미세구조적 통찰력Article Published on 2022-03-252022-09-11 Journal: Nature Communications [Category] MERS, SARS, 변종, 진단, 치료법, [키워드] ACE2 airway epithelium B.1.1.7 B.1.1.7 variant budding cilia ciliary ciliated ciliated cell ciliated cells Concentration direct fusion envelope epithelial cells examined excluded explain Extracellular Genome goblet host cells Human airway epithelium Intact isolate isolates mechanism membrane membranes microvilli nucleocapsid nucleocapsids periphery plasma membrane profile profiles S glycoprotein SARS-CoV-2 SARS-CoV-2 entry SARS-CoV-2 infected cell SARS-CoV-2 infected cells TMPRSS2 tomography transmission electron microscopy Viral viral entry viral membrane virion virions virus [DOI] 10.1038/s41467-022-29255-y PMC 바로가기 [Article Type] Article
Preclinical Studies on Convalescent Human Immune Plasma-Derived Exosome: Omics and Antiviral Properties to SARS-CoV-2회복기 인간 면역 혈장 유래 엑소좀에 대한 전임상 연구: SARS-CoV-2에 대한 오믹스 및 항바이러스 특성Article Published on 2022-03-242022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 진단, 치료제, [키워드] biochemical convalescence plasma convalescent convalescent plasma COVID-19 COVID-19 pandemic Efficacy Exosome Exosomes Extracellular extracellular vehicles (EVs) Extracellular vesicles Gene ontology Good good manufacturing practice Human immune measure Ministry of Health passive immunity Practice Preclinical property SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections Society Support Treatment Turkish Red Crescent Viral viral treatment. [DOI] 10.3389/fimmu.2022.824378 PMC 바로가기 [Article Type] Article
Inhaled Placental Mesenchymal Stromal Cell Secretome from Two- and Three-Dimensional Cell Cultures Promotes Survival and Regeneration in Acute Lung Injury Model in Mice2차원 및 3차원 세포 배양에서 흡입된 태반 중간엽 간질 세포 Secretome은 마우스의 급성 폐 손상 모델에서 생존 및 재생을 촉진합니다Article Published on 2022-03-222022-09-11 Journal: International Journal of Molecular Sciences [Category] SARS, 유전자 메커니즘, [키워드] acute lung injury acute respiratory distress acute respiratory distress syndrome acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 administration adult stem cells ALI model ARDS Cell cell spheroids cell-free therapy content coronavirus COVID-19 COVID-19 pandemic cultivation damaged death effective Effectiveness exhibited Extracellular Extracellular vesicles FIBRIN fibroblast healthcare histological immunomodulating in some Inflammatory Inflammatory diseases inhalation Inhaled investigated lung Lung inflammation Lung injury lung surfactant lung tissue Lungs management Measures mice Model morbidity and mortality Mortality Patient placental potential therapy problem proteomic regeneration regenerative respiratory distress Respiratory distress syndrome restored SARS-CoV-2 Secretome severe acute respiratory syndrome Coronavirus severe pneumonia stromal cell surfactant survival syndrome Taking therapeutic tissue regeneration [DOI] 10.3390/ijms23073417 PMC 바로가기 [Article Type] Article
LCOR mediates interferon-independent tumor immunogenicity and responsiveness to immune-checkpoint blockade in triple-negative breast cancer Research Published on 2022-03-172022-10-05 Journal: Nature cancer [Category] 변종, 유전자 메커니즘, [키워드] Antigen binding blockade Breast cancer Cancer stem cell cell differentiation clinical response Combination driving Efficacy element expression Extracellular generate Genetic heterogeneity IFN Immune escape Immunotherapy ISREs LCOR Metastasis Modification modulation phenotypic reduced RNA Support therapy These data transcriptional Vesicle [DOI] 10.1038/s43018-022-00339-4 [Article Type] Research