Gene ontology – Page 5 – Communicable Diseases Research

Material Basis and Mechanism of Chansu Injection for COVID-19 Treatment Based on Network Pharmacology and Molecular Docking Technology

Research Article

Published on 2021-10-112022-10-31
Journal: Evidence-based Complementary and Alternative Medicine : eCAM [Category] COVID-19,

Network Pharmacology Reveals That Resveratrol Can Alleviate COVID-19-Related Hyperinflammation

네트워크 약리학, 레스베라트롤이 COVID-19 관련 과염증을 완화할 수 있음을 밝혀냄

Research Article

Published on 2021-09-222022-09-10
Journal: Disease Markers [Category] SARS, 유전자 메커니즘,

[키워드] Analysis Anti-inflammatory Antiviral antiviral agent approach benefit bioinformatic analysis Can COVID-19 COVID-19 patients COVID-19 therapy dataset DEGs differentially expressed gene enrichment analysis followed by gene analysis Gene Expression Omnibus Gene ontology GEO GO term GO terms GSE147507 hyperinflammation IL-17 involved KEGG KEGG pathway Kyoto location network notable overlap pathway pathway enrichment Pathways pharmacological pharmacological mechanism Pharmacology Potential protein-protein interaction resveratrol SARS-CoV-2 screened signaling pathway target targets therapeutic therapy TNF signaling
[DOI] 10.1155/2021/4129993 PMC 바로가기 [Article Type] Research Article

Bioinformatics and system biology approach to identify the influences of SARS-CoV-2 infections to idiopathic pulmonary fibrosis and chronic obstructive pulmonary disease patients

특발성 폐섬유증 및 만성 폐쇄성 폐질환 환자에 대한 SARS-CoV-2 감염의 영향을 확인하기 위한 생물정보학 및 시스템 생물학 접근

Article

Published on 2021-09-022022-09-11
Journal: Briefings in Bioinformatics [Category] SARS, 유전자 메커니즘, 치료기술,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Analysis approach bioinformatics Biomarker build candidate drug candidate drugs chronic obstructive chronic obstructive pulmonary disease confirmed COVID-19 case COPD coronavirus COVID-19 COVID-19 infection dataset datasets DEGs detect differentially expressed differentially expressed gene Differentially expressed genes drug molecule effective fibrosis functional Gene Expression Omnibus Gene ontology GEO GSE147507 help hub gene hub genes identify Idiopathic pulmonary fibrosis influence Interaction interactions IPF linkage molecular molecular mechanism molecular mechanisms obstructive pulmonary disease Ontology pathway Pathway analysis Patient patients performed PPI PPI network progression protein-protein interaction Protein–protein interaction protein–protein interaction (PPI). pulmonary disease pulmonary fibrosis risk factor Risk factors RNA-seq dataset SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 virus second wave severe acute respiratory syndrome Coronavirus shared pathway shared pathways statistical System biology the epidemic the SARS-CoV-2 virus therapeutic transcription factors transcriptomic analysis underlie were used
[DOI] 10.1093/bib/bbab115 PMC 바로가기 [Article Type] Article

Comparative study of predicted miRNA between Indonesia and China (Wuhan) SARS-CoV-2: a bioinformatics analysis

인도네시아와 중국(우한) SARS-CoV-2 간의 예측 miRNA 비교 연구: 생물정보학 분석

Article

Published on 2021-09-012022-09-11
Journal: Genes & genomics [Category] Coronavirus, SARS, 치료기술, 치료제,

[키워드] Analysis analyzed association binding bioinformatics Bioinformatics analysis both groups center Characteristics chi-square test China Comparative contribute COVID-19 case Data center detect DIANA-miRPath dysregulation enhancement FIVE Gene ontology Gene ontology analysis Genetic genetic regulation Genome data mining genomic Genomics GISAID host miRNA host miRNAs host mRNA https://www.gisaid.org/ immune system in both group indicate Indonesia Inflammation less majority mature miRNAs microRNA miRNA miRNA target miRNA targets miRNAs NCBI ORF1ab gene pandemic predict predicted Regulation Research SARS-CoV-2 SARS-CoV-2 mutation SARS-CoV-2 mutations SARS-CoV-2 sequence SARS-CoV-2 sequences significant difference statistical statistical analysis Variation variations Viral RNA was used Wuhan Wuhan, China
[DOI] 10.1007/s13258-021-01119-7 PMC 바로가기 [Article Type] Article

Computational analysis of TMPRSS2 expression in normal and SARS-CoV-2-infected human tissues

정상 및 SARS-CoV-2에 감염된 인간 조직에서 TMPRSS2 발현의 전산 분석

Article

Published on 2021-09-012022-09-11
Journal: Chemico-biological interactions [Category] 유전자 메커니즘,

[키워드] acute respiratory illnesses Analysis analyzed B cells Cancer CD8 Cell cell growth co-expression correlated correlation cytokine datasets epididymis expression female G-CSF gene co-expression network Gene expression profiles Gene ontology growth healthy individuals high expression level highest human host cells human tissue human tissues IFN-α IL-1 IL-12 IL-18 IL-2 IL-4 IL-7 IL-8 immune immune signature Immune signatures in healthy individual interferon interferon response investigated involved IP-10 kidneys Lungs male MCP-1 mechanism metabolism Nasopharyngeal swab nasopharyngeal swabs NK cells no significant difference normal lung tissue not significantly different Older older patients older population other diseases pancreas parathyroid Parathyroid gland pathway Pathway and gene ontology Pathways Patient performed Population positive positively correlated potential mechanism proliferation Prostate salivary salivary gland SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2-infected patient SARS-CoV-2-infected patients seminal vesicle Serine serine protease significantly lower small intestine stomach T cells tissue tissues TMPRSS2 TMPRSS2 expression TMPRSS2 expression level TMPRSS2 expression levels TMPRSS2 protein TNF-α transmembrane serine protease transmembrane serine protease 2 Vesicle
[DOI] 10.1016/j.cbi.2021.109583 PMC 바로가기 [Article Type] Article

Differential host circRNA expression profiles in human lung epithelial cells infected with SARS-CoV-2

SARS-CoV-2에 감염된 인간 폐 상피 세포의 차등 숙주 circRNA 발현 프로필

Article

Published on 2021-09-012022-09-11
Journal: Infection, genetics and evolution : journal of mol [Category] 유전자 메커니즘,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus Analysis binding cause cell death Circular circular RNA coronavirus coronavirus disease COVID-19 death down-regulated dysregulated enrichment analysis epithelial epithelial cell epithelial cells expression pattern expression profile function functions Gene Expression Gene ontology genomic highly pathogenic Host host immune responses human lung human lung epithelial cells immune immune responses Immunity implicated in viral indicated infected with SARS-CoV-2 Infection Inflammatory responses involved KEGG Lung epithelial cells miRNAs mRNA stability network analysis Ontology parental Pathogenesis performed Proteins regulate regulated RNA RNA binding protein RNA-Seq RNAs SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 significantly up-regulated viral pathogenesis Virus-host interactions
[DOI] 10.1016/j.meegid.2021.104923 PMC 바로가기 [Article Type] Article

The Molecular Mechanism of Multiple Organ Dysfunction and Targeted Intervention of COVID-19 Based on Time-Order Transcriptomic Analysis

시간 순서 Transcriptomic 분석을 기반으로 한 다발성 장기 기능 장애의 분자 메커니즘 및 COVID-19의 표적 개입

Immunology

Published on 2021-08-242022-09-11
Journal: Frontiers in Immunology [Category] MERS, SARS, 유전자 메커니즘, 치료제,

[키워드] acetaminophen Activation addition Algorithm Angiogenesis B2M BFS algorithm Bioinformatics analysis biological process biological processe biological processes Brain caused CD40 CD40LG cell-mediated immune cell-mediated immune response changes in Comparative Compound Coronavirus disease 2019 COVID-19 CSF1 Curcumin CXCL10 cytokine Cytokine storm database defined determine Dexamethasone DNA downloaded drug energy metabolism enrichment analysis FCER1G FIVE gene co-expression network Gene Expression gene expression profile Gene expression profiles Gene ontology Genes heterogeneous high mortality hub genes ICAM1 identify immune gene immune response Immunity initial gene IRF7 LAT Lcn2 lead leukocyte lung metabolism molecular mechanism morphology Multiple multiple organ dysfunction multiple organ heterogeneity myeloid leukocyte neuronal Novel coronavirus olfactory organ organs other compound PageRank pandemic pattern PLAU predicted protein metabolism Protein–protein interaction Regulation Research response resveratrol RHOA rRNA second Spread SRC statins Stress stress response targeted intervention the cytokine storm TNFRSF1A TO-GCN Toxicogenomics Trachea tracheal Transmission Treatment unique was performed was used
[DOI] 10.3389/fimmu.2021.729776 PMC 바로가기 [Article Type] Immunology

A signaling pathway-driven bioinformatics pipeline for predicting therapeutics against emerging infectious diseases

Meta-Analysis

Published on 2021-08-202022-10-04
Journal: F1000Research [Category] MERS, SARS, 신약개발,

[키워드] acute respiratory syndrome Analysis Baricitinib bioinformatics can be used caused Cell clinical trial coronavirus Coronavirus-2 COVID-19 determine Differentially expressed genes disease Diseases drug drugs dysregulated Effect etiological agent food Gene ontology highlight human protein identify infected cells Infection Infectious disease influenza A virus MERS Meta-analysis Middle East pathogen pathway Pathways predict predicted Prophylactic reduce reported repurposing respiratory syncytial virus respiratory syndrome coronavirus RNA-seq data RNA-sequencing sarilumab SARS-CoV-2 SARS-COV-2 infection Signaling Spread Symptoms target therapeutic Therapeutic treatment Tocilizumab treat Treatment virus while worldwide pandemic Wuhan, China
[DOI] 10.12688/f1000research.52412.2 PMC 바로가기 [Article Type] Meta-Analysis

A protein interactions map of multiple organ systems associated with COVID-19 disease

Original Article

Published on 2021-06-302022-11-01
Journal: Genomics & Informatics [Category] COVID-19,

Protective Effect of Zinc Oxide and Its Association with Neutrophil Degranulation in Piglets Infected with Porcine Epidemic Diarrhea Virus

Research Article

Published on 2021-06-232022-10-29
Journal: Oxidative Medicine and Cellular Longevity [Category] Coronavirus,

[키워드] Administered administration affected analyses Analysis anti-inflammatory effect Antiviral average biological process caused Colon Concentration Culture determine diarrhea differentially expressed gene dismutase dose drug Effect epidemic diarrhea Gene ontology growth histologic IL-1 β IL-6 IL-8 implication IMPROVE indicated Infection infectious dose Inflammation inhibit inoculated intestinal intestine lesions mechanism metabolism Microarray morphology neutrophil degranulation oxidative stress Oxide pathway PEDV peroxidase plasma Prevent Protein proteomic randomly divided redox status reduce reduction Replication rescued Result shown significantly increased small intestine TCID three group tissue treat Treatment villus Viral load virus were recorded Zinc zinc oxide
[DOI] 10.1155/2021/3055810 PMC 바로가기 [Article Type] Research Article