Genes – Page 5 – Communicable Diseases Research

Collection and detection of SARS-CoV-2 in exhaled breath using face mask

안면 마스크를 사용하여 호기에서 SARS-CoV-2 수집 및 감지

Article

Published on 2022-08-182022-09-11
Journal: PLoS ONE [Category] SARS, 치료기술, 치료제,

Multiomic analysis reveals cell-type-specific molecular determinants of COVID-19 severity

다중체 분석은 COVID-19 중증도의 세포 유형별 분자 결정 요인을 나타냅니다.

Article

Published on 2022-08-172022-10-30
Journal: Cell Systems [Category] COVID-19, MERS, 바이오마커, 변종, 유전자 메커니즘,

[키워드] Analysis CD56 Cell cell types COVID-19 COVID-19 severity cytokine determinant determinants dysfunction enrichment functions gene discovery Genes Genetic genetic risk Genetic variation genome-wide association Genome-wide association study genomic GWAS healthy human lung innate immune response Intervention limit machine learning mendelian randomization molecular natural killer network analysis NK cell NK cells NK-cell Pathogenesis potential therapeutic targets provide rare variant analysis reveal risk severe COVID-19 severe disease single-cell single-cell multiomic profiling. Support T cells these cell These cells upstream variant
[DOI] 10.1016/j.cels.2022.05.007 PMC 바로가기 [Article Type] Article

SEMgsa: topology-based pathway enrichment analysis with structural equation models

SEMgsa: 구조 방정식 모델을 사용한 토폴로지 기반 경로 강화 분석

Article

Published on 2022-08-172022-09-11
Journal: BMC Bioinformatics [Category] 유전자 메커니즘,

Bioinformatics analysis of potential pathogenesis and risk genes of immunoinflammation-promoted renal injury in severe COVID-19

Article

Published on 2022-08-162022-11-15
Journal: Frontiers in Immunology [Category] 바이오마커,

[키워드] activated addition Algorithm ALOX5 Analysis bioinformatics caused CD38 Cell characterized clinical utility correlated COVID-19 COVID-19 patient COVID-19 patients cytokine cytokine receptor dataset dendritic cells enrichment analysis expression expression pattern gene co-expression network Genes glomerular filtration rate HCK identify immune Immune cell Immune cell infiltration Including independent data set indicated Inflammation Inflammatory Injury Interaction involved ischemia-reperfusion injury ITGAX KEGG LYN macrophages MAPK3 Mild Miner moderate NCF4 necroptosis network analysis Neutrophils nomogram Pathogenesis pathway Pathways performed Peripheral blood poor prognosis PPI progression promoted protein-protein interaction random renal renal injury risk screened SELP Sequencing analysis severe COVID-19 SPI1 STEM TLR2 TLR4 toll-like receptor signaling transcriptomic Viral protein WGCNA
[DOI] 10.3389/fimmu.2022.950076 PMC 바로가기

SARS-CoV-2 Brain Regional Detection, Histopathology, Gene Expression, and Immunomodulatory Changes in Decedents with COVID-19

코로나19 사망자의 SARS-CoV-2 뇌 부위 검출, 조직병리학, 유전자 발현 및 면역조절 변화

Article

Published on 2022-08-162022-09-11
Journal: Journal of neuropathology and experimental neurolo [Category] SARS, 유전자 메커니즘, 치료기술,

[키워드] Amygdala arising Autopsies Autopsy Blood Brain brains cerebellar cortex change Control COVID-19 COVID-19 cases cytokine Deafferentation detection Differentially expressed genes downregulation Encephalitis fraction Gene Expression Genes Hemorrhagic hemorrhagic encephalitis Histopathology immune immune response indicated involved marker microglia mucosa neuronal Non-COVID-19 olfactory olfactory bulb portal receptor reduced reduction Region Regional RNA polymerase RNA sequence RNA sequences RNA-dependent RNA polymerase RNAseq RT-PCR S gene SARS-CoV-2 SARS-CoV-2 E gene sequence serum Significant subject upregulation viral sequence virus with COVID-19
[DOI] 10.1093/jnen/nlac056 PMC 바로가기 [Article Type] Article

Circulating microRNA signatures associated with disease severity and outcome in COVID-19 patients

Article

Published on 2022-08-112022-11-15
Journal: Frontiers in Immunology [Category] SARS, 치료제,

[키워드] 95% CI adaptive immune responses Angiogenesis antiviral response antiviral responses asymptomatic infection AUROC Biomarker Biomarkers chemokines circulating miRNA clinical condition collected Combination COVID-19 COVID-19 pathogenesis COVID-19 patient DE miRNA death differentially expressed disease disease severity downregulation driven by experiment Genes healthy control heart failure highlighting Hospital admission human cell impairment in vitro induce Inflammation inhibit Innate immunity interferon involved leukocyte life threatening Lung disease Lung epithelial cells Lung fibrosis microRNA Mild miR-4433b-5p miRNA miRNA signature miRNAs moderate modulated Mortality organ damage outcome Patient predicted pro-inflammatory cytokine pro-inflammatory factors provided RNA-sequencing SARS-CoV-2 SARS-COV-2 infection Sensitivity and specificity serum serum sample severe COVID-19 severe disease severity Stress subset the cytokine storm upregulation Vascular damage was performed with COVID-19
[DOI] 10.3389/fimmu.2022.968991 PMC 바로가기

Germline rare variants of lectin pathway genes predispose to asymptomatic SARS-CoV-2 infection in elderly individuals

렉틴 경로 유전자의 생식선 희귀 변이체는 노인에서 무증상 SARS-CoV-2 감염을 일으키기 쉽습니다.

Article

Published on 2022-08-012022-09-11
Journal: Genetics in medicine : official journal of the Ame [Category] COVID19(2023년), SARS, 변종,

[키워드] allelic variant allelic variants Asymptomatic Asymptomatic COVID-19 asymptomatic individual Asymptomatic individuals asymptomatic subject Cohort COLEC10 COLEC11 Collapsing complement complement system COVID-19 decreased activity decreased expression enrichment ES European Evidence exome sequencing data Genes Genetic genetic data Genome Aggregation Database germline Hospitalized hospitalized patient Hyperactivation individual individuals investigated lectin lectin pathway lung tissue MASP1 outcome performed phenotype predicted PROTECT prothrombin rare variant replicated SARS-CoV-2 SARS-COV-2 infection serum severe COVID-19 severe disease susceptible variant with COVID-19
[DOI] 10.1016/j.gim.2022.04.007 PMC 바로가기 [Article Type] Article

A comprehensive genomic study, mutation screening, phylogenetic and statistical analysis of SARS-CoV-2 and its variant omicron among different countries

국가별 SARS-CoV-2 및 그 변이체 오미크론에 대한 포괄적인 게놈 연구, 돌연변이 스크리닝, 계통 발생 및 통계 분석

Article

Published on 2022-08-012022-09-11
Journal: Journal of infection and public health [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus addition Analysis anticipated approach assist average B.1.1.529 B.1.617.2 bioinformatics Brazil changes in Complete confidence conserved Corona coronavirus country COVID-19 Delta determined by domain domains Drug discovery Effect evaluate Evolution full-length genome Genes genetic diversity Genome genome sequence Genome sequences genomic genomic sequence help heterozygosity highest identify in viral in-silico information isolates Japan MSN Mutation mutation analysis offer omicron Omicron variant Omicron variants ORF1 ORF10 ORF1ab ORF7a Phylogenetic Phylogenetic tree Phylogeny polymorphism Population predict prevalent Protein provide resource SARS-CoV-2 selected sequence severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 shape Spike protein standard error statistical analysis strain the Spike the vaccine these viruses TRS unique Vaccine variant variants Variation variations viral genome viral genome sequence viruses was determined was used were used Wuhan-Hu-1
[DOI] 10.1016/j.jiph.2022.07.002 PMC 바로가기 [Article Type] Article

Epigenetic mechanisms regulate sex-specific bias in disease manifestations

후성 유전적 메커니즘은 질병 발현에서 성별에 따른 편향을 조절합니다

Review

Published on 2022-08-012022-09-11
Journal: Journal of Molecular Medicine (Berlin, Germany) [Category] 유전자 메커니즘,

[키워드] affecting Anatomy Autoimmune disorders Cancer change chromosome Clinical outcome clinical study COVID-19 COVID-19 infection differential expression disease disease manifestation disease onset Diseases Effect Epigenetic epigenetic modification epigenetics exhibit explained expression fibrosis Genes Genetic Genetic and epigenetic changes Hormones immune response immune responses immune system implicated inactivation infections input involved Liver fibrosis mechanism Neuropsychiatric Neuropsychiatric diseases progression recent regulate Respiratory disease respiratory diseases response to therapy responsible Sex Sex bias Sex chromosome sex hormone Sex hormones susceptibility therapeutic targets therapy underlying disease X chromosome X-inactivation X-linked X-linked gene X-linked genes.
[DOI] 10.1007/s00109-022-02227-x PMC 바로가기 [Article Type] Review

SARS-CoV-2 infection impairs the insulin/IGF signaling pathway in the lung, liver, adipose tissue, and pancreatic cells via IRF1

SARS-CoV-2 감염은 IRF1을 통해 폐, 간, 지방 조직 및 췌장 세포의 인슐린/IGF 신호 전달 경로를 손상시킵니다

Article

Published on 2022-08-012022-09-11
Journal: Metabolism: clinical and experimental [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘,

[키워드] Activation adeno-associated virus adipose Adipose tissue AKT ameliorated analyzed association Autopsy Calu3 Calu3 cell CaLu3 cells Cell cell survival cells condition contribute COVID-19 COVID-19 pathology COVID-19 patient COVID-19 patients COVID-19 severity Critical critical patient critical patients cytokine determine Dexamethasone diabetes Diabetic diabetic patients Dihydrotestosterone Endocrine energy metabolism European population evaluate Evidence exacerbated exhibited Gain Gene Expression Genes GFP HEK293T Hospitalized Host human ACE2 human cells hyperglycemia impair impairment infected with SARS-CoV-2 insulin insulin resistance Insulin signaling Insulin/IGF signaling pathway interferon regulatory factor Interferone intron IRF1 liver lung Lungs male Male sex MAPK metabolic metabolic abnormalities Metabolic abnormality metabolism mouse model mTOR Multiorgan dysfunction Multiple organ damage Non-COVID-19 Non-COVID-19 patients obese obesity Older Older age Organoid overexpressing pancreatic Pancreatic cell pancreatic islets pathology patients patients with COVID-19 PI3K potential mechanism Prevalence provide Regulation reported Repository risk factor Risk factors SARS-CoV-2 SARS-CoV-2 infected cell SARS-CoV-2 infected cells SARS-COV-2 infection serotype severe COVID-19 severity Signaling signaling pathway significantly stem cell survival tissue tissue damage Tissue damage. tissues Transcriptome transcriptome dataset transcriptome datasets Transgenic mouse variant Whole blood whole blood transcriptome with COVID-19
[DOI] 10.1016/j.metabol.2022.155236 PMC 바로가기 [Article Type] Article