P. falciparum msp1 and msp2 genetic diversity in P. falciparum single and mixed infection with P. malariae among the asymptomatic population in Southern Beninarticle Published on 2022-08-312024-09-01 Journal: Parasitology International [Category] 말라리아, [키워드] Asymptomatic genetic diversity Merozoite surface protein P. falciparum P. malariae [Article Type] article
Historical Evolutionary Dynamics and Phylogeography Analysis of Transmissible Gastroenteritis Virus and Porcine Deltacoronavirus: Findings from 59 Suspected Swine Viral Samples from ChinaArticle Published on 2022-08-292022-11-16 Journal: International Journal of Molecular Sciences [Category] 유전자 메커니즘, [키워드] adaptive addition America Analysis analyzed Asia Bayesian Bayesian inference caused Characteristics China coronavirus COVID-19 epidemic Cross-species transmission distribution Dynamics event Evolution evolutionary dynamics finding genetic diversity Genome sequence data genotypes highlighting Human humans infect likelihood lineages maximum measure membrane fusion Migration Pandemics PDCoV phylogeography Porcine deltacoronavirus Positive selection recent Sample spatiotemporal Spike protein Surveillance Suspected TGEV transmissible gastroenteritis virus Transmission transmission rate transmitted [DOI] 10.3390/ijms23179786 PMC 바로가기
High activity of an affinity-matured ACE2 decoy against Omicron SARS-CoV-2 and pre-emergent coronavirusesOmicron SARS-CoV-2 및 사전 출현 코로나바이러스에 대한 친화성 성숙 ACE2 유인물의 높은 활성Article Published on 2022-08-252022-09-11 Journal: PLoS ONE [Category] SARS, 변종, [키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adeno-associated virus affinity airway angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 antigenic antigenic drift binding can not clade complicate coronavirus coronavirus disease Coronavirus disease 2019 Coronaviruses COVID-19 COVID-19 pandemic decoy develop drug Efficacy Evolution exceptional genetic diversity human ACE2 inhibitor intranasal intrinsic mitigate monoclonal antibody mutant nanomolar affinity Neutralizing omicron pandemic populations preparation Prophylaxis receptor Receptor-binding domain sarbecovirus Sarbecoviruses SARS-CoV-1 SARS-CoV-2 SARS-CoV-2 spike protein SARS-CoV-2 variant SARS-CoV-2 variants severe acute respiratory syndrome Coronavirus Spike protein the SARS-CoV-2 the spike protein therapeutic Threats Treatment Vaccine variant variants viral evolution viral genome viral spike viral strain viral strains virus widespread zoonotic [DOI] 10.1371/journal.pone.0271359 PMC 바로가기 [Article Type] Article
Genetic Diversity of Plasmodium falciparum and Distribution of Antimalarial Drug Resistance Mutations in Symptomatic and Asymptomatic InfectionsArticle Published on 2022-08-162024-08-29 Journal: Med Instrum [Category] 말라리아, [키워드] antimalarial drug resistance Cameroon genetic diversity Molecular genotyping Plasmodium falciparum symptomatic and asymptomatic carriers.
Strategies for HIV-1 vaccines that induce broadly neutralizing antibodies Reviews Published on 2022-08-122022-10-05 Journal: Nature reviews. Immunology [Category] 변종, 유전자 메커니즘, 임상, [키워드] acquisition activate B cell complex mechanism Critical effective expand genetic diversity glycoprotein HIV-1 HIV-1 infection immune evasion immune system induce Interaction Lineage mutations neutralizing antibody Research Safe Strategy vaccination Vaccine Vaccine development [DOI] 10.1038/s41577-022-00753-w [Article Type] Reviews
Molecular Epidemiology and Evolutionary Analysis of Avian Influenza A(H5) Viruses Circulating in Egypt, 2019-2021Article Published on 2022-08-112023-06-22 Journal: Viruses [Category] 조류인플루엔자, [키워드] Avian Influenza Egypt genetic diversity H5N8 poultry Virus evolution [DOI] 10.3390/v14081758 PMC 바로가기
An improved Fuzzy based GWO algorithm for predicting the potential host receptor of COVID-19 infectionResearch article Published on 2022-08-012022-10-05 Journal: Computers in biology and medicine [Category] COVID19(2023년), SARS, 변종, [키워드] ACE2 ACE2 protein acute respiratory syndrome ADAM17 Affect affected Algorithm analyzed ASGR1 Asialoglycoprotein Basigin Bone marrow Brain caused CD147 Cell CLEC4M Cluster Clustering Coronavirus-2 COVID-19 COVID-19 infection cytoplasm Differential evolution algorithm disease disintegrin domain drug effective Effectiveness eliminating entry of SARS-CoV-2 enzyme Evolution population dynamics exploratory expresse expression profile EXT1 EXT2 EXT3 Factor fusing Fuzzy clustering G protein-coupled receptor genetic diversity GLCE Glucuronic acid GPR78 Grey Grey wolf optimizer help Host host cell host cell membrane host receptor humans hybridizing I, II identify identifying IHC immunohistochemistry individual Infection inhibiting Interaction intestine kidney KREMEN1 Kringle liver lung mechanism membrane protein Membrane proteins Mutation NDST2 neuropilin NRP1 operator pathogenesis of COVID-19 pathogenesis of SARS-CoV-2 pathogenicity protease Protein PVR receptor replication of SARS-CoV-2 SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike protein SARS-CoV-2 virus serine protease Seurat shown Single cell RNA sequencing data single-cell Spike protein spleen Spread therapeutic target TMPRSS2 toolkit transcriptionally transcriptomics transmembrane protein Transmission virus XYLT1 XYLT2 [DOI] 10.1016/j.compbiomed.2022.106050 [Article Type] Research article
A comprehensive genomic study, mutation screening, phylogenetic and statistical analysis of SARS-CoV-2 and its variant omicron among different countries국가별 SARS-CoV-2 및 그 변이체 오미크론에 대한 포괄적인 게놈 연구, 돌연변이 스크리닝, 계통 발생 및 통계 분석Article Published on 2022-08-012022-09-11 Journal: Journal of infection and public health [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus addition Analysis anticipated approach assist average B.1.1.529 B.1.617.2 bioinformatics Brazil changes in Complete confidence conserved Corona coronavirus country COVID-19 Delta determined by domain domains Drug discovery Effect evaluate Evolution full-length genome Genes genetic diversity Genome genome sequence Genome sequences genomic genomic sequence help heterozygosity highest identify in viral in-silico information isolates Japan MSN Mutation mutation analysis offer omicron Omicron variant Omicron variants ORF1 ORF10 ORF1ab ORF7a Phylogenetic Phylogenetic tree Phylogeny polymorphism Population predict prevalent Protein provide resource SARS-CoV-2 selected sequence severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 shape Spike protein standard error statistical analysis strain the Spike the vaccine these viruses TRS unique Vaccine variant variants Variation variations viral genome viral genome sequence viruses was determined was used were used Wuhan-Hu-1 [DOI] 10.1016/j.jiph.2022.07.002 PMC 바로가기 [Article Type] Article
SARS-CoV-2 lineage dynamics in England from September to November 2021: high diversity of Delta sub-lineages and increased transmissibility of AY.4.22021년 9월부터 11월까지 영국의 SARS-CoV-2 계보 역학: Delta 하위 계통의 높은 다양성과 AY.4.2의 전파 가능성 증가Article Published on 2022-07-272022-09-11 Journal: BMC Infectious Diseases [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] 95% CI assessment Clustering Community community transmission country COVID-19 COVID-19 symptom Delta delta variant endemicity England exhibiting genetic diversity genomic data Genomic surveillance greater immune Immune escape Immunity increases in individual introduced less Lineage lineages Mutation mutation rate natural infection no symptom no symptoms nose swab Phylogenetic relationship positive individuals Predictive prevalent lineage proportion provided random reduced reduction in Region reported Reproduction number RT-PCR testing SARS-CoV-2 SARS-CoV-2 lineage South study period surveillance data symptom status symptomatic individuals Transmissibility Transmission advantage unique vaccination variant virus [DOI] 10.1186/s12879-022-07628-4 PMC 바로가기 [Article Type] Article
Viral variant-resolved wastewater surveillance of SARS-CoV-2 at national scale Research Published on 2022-07-182022-10-05 Journal: Nature biotechnology [Category] COVID19(2023년), SARS, 변종, 임상, 치료기술, [키워드] approach complementary complex country de novo delta variant elevated epidemiological Epidemiology genetic diversity National predict public health quantification representing Reproduction number reproductive robust SARS-CoV-2 SARS-CoV-2 surveillance sequenced Sequencing spatiotemporal Support Surveillance variant variants of concern [DOI] 10.1038/s41587-022-01387-y [Article Type] Research