Sequential Appearance and Isolation of a SARS-CoV-2 Recombinant between Two Major SARS-CoV-2 Variants in a Chronically Infected Immunocompromised Patient만성 감염 면역저하 환자에서 두 가지 주요 SARS-CoV-2 변이체 간의 SARS-CoV-2 재조합체의 순차적인 출현 및 분리Article Published on 2022-06-102022-09-11 Journal: Viruses [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] Alpha variant Analysis analyzed appearance backbone chronic infection Combination combinations concurrent infection Coronaviruses Follow-up genetic recombination Genome genomes genomic Genomic surveillance humans Immunosuppression infecting Infection initial lymphoma Major mechanism mutant Mutation Next-generation sequencing parental Patient PCR predominant recombinant Recombination reported RNA viruses SARS-CoV-2 SARS-CoV-2 variants Seven spike gene Surveillance the patient variant variants virus viruses was obtained [DOI] 10.3390/v14061266 PMC 바로가기 [Article Type] Article
SARS-CoV-2 Continuous Genetic Divergence and Changes in Multiplex RT-PCR Detection Pattern on Positive Retesting Median 150 Days after Initial InfectionSARS-CoV-2 지속적인 유전적 분화 및 초기 감염 후 150일의 양성 재검사 중앙값에 대한 다중 RT-PCR 검출 패턴의 변화Article Published on 2022-06-022022-09-11 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료기술, 치료법, 치료제, [키워드] accumulate amplification Amplification assay analyzed being Chain Reaction change Clinical diagnosis Continuous COVID-19 COVID-19 pandemic Day detection diagnostic Divergence envelope gene epicenter Epidemiology evaluated Evolution Frequency gene amplification Genetic genetic divergence genomes highlight hotspot identify in viral independent Infection initial isolate isolates lab molecular molecular evolution multiplex Multiplex RT-PCR Mutation next generation sequencing NGS Nucleocapsid gene Patient pattern performed polymerase chain polymerase chain reaction positive primer probe Region Reinfection reverse transcription reverse transcription polymerase chain reaction RT-PCR SARS-CoV-2 SARS-CoV-2 RNA specimen Spectrum target tested utility Viral viral genome viral genomes Viral variants virus WGA whole genome [DOI] 10.3390/ijms23116254 PMC 바로가기 [Article Type] Article
A conserved subunit vaccine designed against SARS-CoV-2 variants showed evidence in neutralizing the virusSARS-CoV-2 변이체에 대해 설계된 보존 소단위 백신은 바이러스를 중화하는 증거를 보여주었습니다Article Published on 2022-06-012022-09-11 Journal: Applied Microbiology and Biotechnology [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] addition affinity analyzed antibody approach B-cell response conserved coronavirus coronavirus disease country Coverage COVID-19 Cytopathic effect docking domain Efficiency elicit envelope envelope protein epitope Epitope-based vaccine Epitopes Evidence FIVE genomes glycoprotein highest IgG immunogenic immunoinformatics IMPROVE induce linker lung tissue membrane membrane glycoprotein MHC MHC class MHC class I MHC class II mice molecular molecular docking Multi-epitope vaccine Mutation neutralize Neutralizing Neutralizing antibodies neutralizing antibody novel Novel coronavirus omicron outbreak pandemic peptide peptides Proteins recognize reported required S1 and S2 S2 domain SARS-CoV-2 SARS-CoV-2 genomes SARS-CoV-2 variant SARS-CoV-2 variants selected sequence sequences spike Spike surface glycoprotein, Immunogenic, Neutralizing antibody. Spread step subunit Subunit vaccine Surface glycoprotein surface protein surface proteins T-cell T-cell epitope T-cell epitopes the vaccine Vaccine vaccine construct variant variants variants of SARS-CoV-2 Vero Cell viral surface virus virus replication wild type wild-type virus [DOI] 10.1007/s00253-022-11988-x PMC 바로가기 [Article Type] Article
Catwalk: identifying closely related sequences in large microbial sequence databasesArticle Published on 2022-06-012022-11-16 Journal: Microbial Genomics [Category] COVID19(2023년), SARS, 치료기술, [키워드] approach Bacterial Bacterial genomics bottleneck bypasse clinically coded comparison Comparisons cut-offs database develop faster Genome genomes identify implementation large sample microbial microbial relatedness Mycobacterium tuberculosis National Nim outbreak outbreak detection. SARS-CoV-2 SARS-CoV-2 genomes searched sequence Sequence analysis Sequencing similarity tested Transmission Tuberculosis viral sequences [DOI] 10.1099/mgen.0.000850 PMC 바로가기
Clinical data mining reveals Gancao-Banxia as a potential herbal pair against moderate COVID-19 by dual binding to IL-6/STAT3임상 데이터 마이닝은 IL-6/STAT3에 대한 이중 결합에 의해 중간 정도의 CovID-19에 대한 잠재적 인 허브 쌍으로 간카오-밴 내증을 밝혀냅니다.Article Published on 2022-06-012022-08-31 Journal: Computers in biology and medicine [Category] COVID19(2023년), SARS, 유전자 메커니즘, 임상, 치료제, [키워드] activator Analysis applied association benzyl binding Bioinformatic Chinese Chinese medicines (CMs) clinical clinical records Commission coniferin coronavirus disease Coronavirus disease 2019 COVID-19 Critical cytokine Cytokine storm Data mining Defense demonstrated dual FIVE Frequency Gancao-Banxia Gene ontology genomes group highest IL-6 immune response immune responses indicated Inflammatory response ingredient inhibit interleukin interleukin-6 Interleukin-6 (IL-6) KEGG Kyoto licochalcone a Medicine Moderate COVID-19 moderate COVID-19 patients molecular docking multisite network network pharmacology Pathways patients piperazine potential mechanisms PPI protein-protein interaction provided quercetin quinone Radix reveal SARS-CoV-2 signal Signal transducer and activator of transcription Signal transducer and activator of transcription 3 (STAT3). signaling pathways STAT3 Support target targets the cytokine storm therapeutic efficacy therapy Transcription Viral were used [DOI] 10.1016/j.compbiomed.2022.105457 PMC 바로가기 [Article Type] Article
Clinical and genomic data of sars-cov-2 detected in maternal-fetal interface during the first wave of infection in Brazil브라질의 첫 번째 감염 파동 동안 산모-태아 경계면에서 검출된 sars-cov-2의 임상 및 게놈 데이터Article Published on 2022-06-012022-09-11 Journal: Microbes and infection [Category] COVID19(2023년), SARS, 유전자 메커니즘, 치료기술, [키워드] abortion Americas Apoptosis B.1.1.28 B.1.1.33 Brazil circulating clinical Clinical virology contribute coronavirus fetal Fetal placenta First wave FIVE genomes genomic data gestation Ground-glass opacities ground-glass opacity highest hospital hospital discharge IgM Illumina Miseq in viral indicate induction of apoptosis Infection interferon involved Lineage Lungs Maternal Mild molecular virology mother Mutation Neonatal infection Newborn nonsynonymous mutation Nonsynonymous mutations Nsp12 Nsp3 ORF3 ORF7b outcome Pathways Phylogeny Placenta pregnant women Preterm birth preterm births Protein qPCR Replication reported RT-qPCR SARS-CoV-2 SARS-COV-2 infection secretion Sequencing South spontaneous abortion state stillborn symptomatic symptomatic cases tested treated umbilical Umbilical cord vertical transmission viral replication Virological virus women [DOI] 10.1016/j.micinf.2022.104949 PMC 바로가기 [Article Type] Article
Target and drug predictions for SARS-CoV-2 infection in hepatocellular carcinoma patients간세포암 환자에서 SARS-CoV-2 감염에 대한 표적 및 약물 예측Article Published on 2022-05-312022-09-11 Journal: PLoS ONE [Category] COVID19(2023년), SARS, 치료기술, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus Analysis Cell clinician Complication coronavirus coronavirus disease COVID-19 COVID-19 patient COVID-19 patients Critical dataset datasets differentially expressed differentially expressed gene drug drugs effective effective drug effective drugs epithelial cell functional genomes HCC HCC patient HCC patients Hepatocellular carcinoma hub genes Human identify Ilomastat infected with SARS-CoV-2 Interaction Kyoto lung epithelial microRNA MicroRNAs miRNA molecular Ontology pandemic pathway Patient patients Protein protein-protein interaction provide Research reveal SARS-CoV-2 SARS-COV-2 infection selected severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 synergistic synergistic effect target terminology therapeutic transcription factor transcriptomic analysis Treatment was performed with COVID-19 [DOI] 10.1371/journal.pone.0269249 PMC 바로가기 [Article Type] Article
TopHap: rapid inference of key phylogenetic structures from common haplotypes in large genome collections with limited diversityTopHap: 다양성이 제한된 대규모 게놈 컬렉션의 공통 일배체형에서 주요 계통 발생 구조의 신속한 추론Article Published on 2022-05-132022-09-11 Journal: Bioinformatics [Category] COVID19(2023년), SARS, 변종, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 analyses approach bioinformatics bootstrap build building co-occurrence common variants coronavirus datasets determine develop evaluated evolutionary relationship evolutionary relationships Features fraction Genome genomes genomic global effort Haplotype haplotypes IMPROVE interfere massive Mutation pandemic Phylogenetic phylogenetic inference Phylogenetic relationship Phylogenetic tree phylogenetically Phylogeny produced provided reconstructed SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 genomes SARS-CoV-2 phylogeny sequence sequences Sequencing sequencing error sequencing errors severe acute respiratory syndrome Coronavirus signal signal-to-noise ratio strain Strains Structure the SARS-CoV-2 traditional methods variant variants variants of concern [DOI] 10.1093/bioinformatics/btac186 PMC 바로가기 [Article Type] Article
Global mapping of RNA homodimers in living cells살아있는 세포에서 RNA 동종이량체의 전역 매핑Article Published on 2022-05-012022-09-11 Journal: Genome research [Category] COVID19(2023년), SARS, 치료기술, 치료제, [키워드] antiviral therapies assembly chimeric conserved data sets detect disrupt domain effective genomes homodimer human transcriptome in vitro in vivo infected cells involved lack living cell N gene Paris physiological Region reveal RNA SARS-CoV-2 sequence snoRNA snRNA subcellular localization subset target Transcriptome transcriptome-wide transcripts tRNAs viral genome viral genomes virus-infected cell virus-infected cells zebrafish Zika [DOI] 10.1101/gr.275900.121 PMC 바로가기 [Article Type] Article
Ubiquitous Micro-Modular Homologies among Genomes from Viruses to Bacteria to Human Mitochondrial DNA: Platforms for Recombination during Evolution?바이러스에서 박테리아, 인간 미토콘드리아 DNA에 이르기까지 게놈 간의 유비쿼터스 마이크로 모듈식 상동성: 진화 중 재조합을 위한 플랫폼?Article Published on 2022-04-242022-09-11 Journal: Viruses [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, 치료기술, [키워드] acute respiratory syndrome annealing appear Bacterial Biology Cluster coding comparison computer Control DNA DNA sequence domain Escherichia Escherichia coli Evolution four letter genetic encoding system Genetic Genome genome segment genomes Human identity investigated mechanism micro-modular identities in 1000 randomized SARS-CoV-2 genomes micro-modular sequence identities mitochondrial mitochondrial DNA nucleotide nucleotide sequence nucleotides Numerous patch type sequence similarities platform question raised Randomized Randomly Recombination respiratory SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 genomes SARS-CoV-2 RNA SARS-CoV-2 RNA compared to genomes of many viruses, protobacteria, Escherichia coli SARS-CoV-2 sequence sequence sequence identity Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 signals for evolution, annealing and integrative recombination the 4,641,652 nt DNA sequence of Escherichia coli K12. variant variants viruses Wuhan [DOI] 10.3390/v14050885 PMC 바로가기 [Article Type] Article