SARS-CoV-2 Triggering Severe Acute Respiratory Distress Syndrome and Secondary Hemophagocytic Lymphohistiocytosis in a 3-Year-Old Child With Down SyndromeSARS-CoV-2는 다운 증후군이 있는 3세 아동의 중증 급성 호흡곤란 증후군 및 이차성 혈구탐식성 림프조직구증을 유발합니다Case Reports Published on 2021-04-302022-09-11 Journal: Journal of the Pediatric Infectious Diseases Socie [Category] MERS, SARS, 진단, 치료제, [키워드] acute respiratory distress acute respiratory distress syndrome acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 Admission Child Complication coronavirus disease Coronavirus disease 2019 Coronavirus-2 COVID-19 Down syndrome genetic susceptibility hemophagocytic lymphohistiocytosis hyperinflammation Hyperinflammatory syndrome Immunoglobulin intensive care Intravenous immunoglobulin investigation Patient pediatric pediatrics Remdesivir respiratory respiratory distress SARS-CoV-2 secondary secondary hemophagocytic lymphohistiocytosis secondary to severe acute respiratory distress syndrome Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 sHLH sHLH. Steroids syndrome Treatment triggers [DOI] 10.1093/jpids/piaa148 PMC 바로가기 [Article Type] Case Reports
Primary varicella-zoster virus infection of the immunocompromised associated with acute pancreatitis and hemophagocytic lymphohistiocytosis A case reportArticle Published on 2021-04-232023-05-31 Journal: Medicine [Category] Fulltext, 두창, 수두, 홍역, [키워드] hemophagocytic lymphohistiocytosis Pancreatitis Varicella zoster virus infection [DOI] 10.1097/MD.0000000000025351 PMC 바로가기
Case Report: Leishmania and HIV Co-Diagnosis: How to Understand Medical History?Article Published on 2021-04-212023-08-30 Journal: Frontiers in Immunology [Category] E형 간염, [키워드] bone marrow aspirate hemophagocytic lymphohistiocytosis HIV Pancytopenia visceral leishmaniasis [DOI] 10.3389/fimmu.2021.669723 PMC 바로가기
Germline variants in UNC13D and AP3B1 are enriched in COVID-19 patients experiencing severe cytokine stormsUNC13D 및 AP3B1의 생식선 변이체는 심각한 사이토카인 폭풍을 경험하는 COVID-19 환자에서 풍부합니다Brief Communication Published on 2021-04-192022-09-10 Journal: European Journal of Human Genetics [Category] MERS, 변종, 유전자 메커니즘, [키워드] analyzed AP3B1 association characterized conducted coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient cytokine Cytokine storm Cytokine storms DHX58 Factor Genes germline help hemophagocytic lymphohistiocytosis HLH hospitalized COVID-19 patient host inflammatory response host inflammatory responses Hyperinflammatory Immunogenetics individual Infection management outcome outcomes PID Primary Immunodeficiency RNF168 significantly susceptibility UNC13D variant variants viral infection whole-exome sequencing [DOI] 10.1038/s41431-021-00886-x PMC 바로가기 [Article Type] Brief Communication
Do COVID-19 Infections Result in a Different Form of Secondary Hemophagocytic LymphohistiocytosisCOVID-19 감염은 다른 형태의 2차 혈구탐식성 림프조직구증을 초래합니까?Review Published on 2021-03-152022-09-10 Journal: International Journal of Molecular Sciences [Category] 바이오마커, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 benefit biochemical Biomarker caused CD163 coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 criteria cytokine Cytokine storm Diagnosis Diagnostic Criteria effective feature form hemophagocytic lymphohistiocytosis HLH identify Immunosuppression macrophage activation syndrome morbidity and mortality Natural killer cells NK cell pandemic question raising recent respiratory Result SARS-CoV-2 secondary severe acute respiratory syndrome Coronavirus severe COVID-19 severe COVID-19 patients Treatment [DOI] 10.3390/ijms22062967 PMC 바로가기 [Article Type] Review
A network-informed analysis of SARS-CoV-2 and hemophagocytic lymphohistiocytosis genes’ interactions points to Neutrophil extracellular traps as mediators of thrombosis in COVID-19SARS-CoV-2와 hemophagocytic lymphohistiocytosis 유전자의 상호 작용에 대한 네트워크 기반 분석은 COVID-19의 혈전증 매개체로서 호중구 세포외 트랩을 가리킵니다.Research Article Published on 2021-03-082022-09-10 Journal: PLoS Computational Biology [Category] SARS, 유전자 메커니즘, [키워드] abnormal coagulation acting Adults Algorithm Algorithms Analysis approach children circulating co-morbidities co-morbidity Coagulation concert condition consequence COVID-19 described disease Diseases Endothelium environmental condition environmental conditions Epidemic extracellular trap extracellular traps favor feature Genetic genetic information H1N1 H1N1 influenza hematologic hemophagocytic lymphohistiocytosis HLH Host host gene hyperinflammation Hypothesis identify Immune cell immune cells increase increased risk individual inflammatory condition inflammatory conditions inflammatory process inflammatory signal inflammatory signals Influenza information Interaction life-threatening likelihood manuscript mechanism mediators Metabolic disorders morbidities NET NETs network neutrophil Neutrophils Pathogenesis pathogenic pathway Pathways potential mechanism potential molecular predict presenting problem Pulmonary thromboembolism regulate responsible risk SARS-CoV-2 serious complication severe COVID-19 severely ill patient severely ill patients similarities similarity tested Thromboembolism thrombosis thrombotic thrombotic complication Thrombotic complications trajectory underlying condition underlying conditions vascular thrombosis Viral protein Viral proteins [DOI] 10.1371/journal.pcbi.1008810 PMC 바로가기 [Article Type] Research Article
COVID-19-associated cytokine storm syndrome and diagnostic principles: an old and new IssueCOVID-19 관련 사이토카인 폭풍 증후군 및 진단 원칙: 오래된 문제와 새로운 문제Review Published on 2021-02-182022-09-10 Journal: Emerging Microbes & Infections [Category] SARS, 유전자 메커니즘, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition Antigen Autoimmune disease Autoimmune diseases autologous benefit Bone marrow CAR-T Characteristics chimeric chimeric antigen receptor claimed clinical experience Clinical sign Clinical signs clinician coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient CRS CSS cytokine cytokine release Cytokine release syndrome Cytokine storm Cytokine storm syndrome Cytokines Deterioration diagnosed diagnoses diagnosing Diagnosis diagnostic Diagnostic Criteria disease early stage early stages Evolution familial/primary hemophagocytic lymphohistiocytosis hemophagocyte hemophagocytic lymphohistiocytosis hemophagocytic syndrome HLH include issue less limitation Macrophage macrophage activation macrophage activation syndrome malignancy mechanisms non-specific paper Pathogenesis Patient Research respiratory SARS-CoV-2 secondary hemophagocytic lymphohistiocytosis sensitivity severe acute respiratory syndrome Coronavirus sHLH Signs and symptoms Symptoms T-cell T-cell receptor therapy [DOI] 10.1080/22221751.2021.1884503 PMC 바로가기 [Article Type] Review
Coronavirus disease 2019: investigational therapies in the prevention and treatment of hyperinflammationArticle Published on 2021-01-192023-06-14 Journal: Expert review of clinical immunology [Category] MERS, SARS, [키워드] Coronavirus disease 2019 (COVID-19) Cytokine release syndrome Cytokine storm syndrome hemophagocytic lymphohistiocytosis hyperinflammation [DOI] 10.1080/1744666X.2021.1847084 PMC 바로가기 [Article Type] Article
Fatal outcome of anti-MDA5 juvenile dermatomyositis in a paediatric COVID-19 patient: a case report소아 코로나19 환자에서 발생한 항MDA5 소아 피부근염의 치명적 결과: 증례 보고Case Reports Published on 2021-01-012022-09-11 Journal: Modern rheumatology case reports [Category] 진단, 치료제, [키워드] addition Admission Anti-MDA5 BAL BAS Bronchoalveolar lavage Case report children COVID-19 Cyclophosphamide dermatomyositis diagnosed died disease drug emphysema health condition hemophagocytic lymphohistiocytosis high mortality rate high risk hospital hypoxemic Hypoxemic respiratory failure Immunoglobulin immunosuppressive immunosuppressive therapy Infection initiated Intensive Interstitial lung disease interstitial lung disease (ILD) intravenous Intravenous immunoglobulin juvenile dermatomyositis Lung disease MDA5 Methylprednisolone outcome Patient performed Pneumomediastinum Pneumothorax poor prognosis positive Real-time PCR real-time RT-PCR referred to Respiratory failure risk risk for disease SARS-CoV-2 SARS-COV-2 infection secondary hemophagocytic lymphohistiocytosis Septic shock severe complications subcutaneous emphysema sulfamethoxazole therapy Tofacitinib Treatment worsening [DOI] 10.1080/24725625.2020.1832755 PMC 바로가기 [Article Type] Case Reports
Weathering the COVID-19 storm: Lessons from hematologic cytokine syndromesCOVID-19 폭풍우를 이겨내기: 혈액학적 사이토카인 증후군의 교훈Review Published on 2021-01-012022-09-11 Journal: Blood reviews [Category] MERS, SARS, 바이오마커, 임상, 진단, [키워드] acute respiratory syndrome attenuation blockade CAR-T CAR-T cell therapy Cell Cell signaling Cell therapy Clinical features clinical trial clinical trials coronavirus COVID-19 CRS CSS cytokine cytokine level cytokine levels Cytokine release syndrome Cytokine storm syndrome cytokine syndrome Cytokines develop Diagnosis Diagnostic Criteria disease Evidence foundation hematologic hematological hemophagocytic lymphohistiocytosis idiopathic Idiopathic multicentric Castleman disease Inflammation inhibiting lesson marker multi-organ dysfunction novel Pathogenesis Patient Release respiratory SARS-CoV-2 secondary hemophagocytic lymphohistiocytosis severe acute respiratory syndrome Coronavirus Severe acute respiratory syndrome coronavirus −2 (SARS-CoV-2). severe COVID-19 sHLH signaling pathway storm subset Treatment [DOI] 10.1016/j.blre.2020.100707 PMC 바로가기 [Article Type] Review