Case report: Understanding the impact of persistent tissue-localization of SARS-CoV-2 on immune response activity via spatial transcriptomic analysis of two cancer patients with COVID-19 co-morbidityArticle Published on 2022-09-122022-11-15 Journal: Frontiers in Immunology [Category] SARS, 유전자 메커니즘, 진단, [키워드] acute respiratory syndrome addition Analysis association B cell cancer patient Cancer patients cancer treatment Case report co-morbidity Colorectal cancer Comorbidity coronavirus correlation COVID-19 demonstrated Effect evaluated Evidence Ex vivo examined exclusion experiment HCC Hepatocellular carcinoma heterogeneity highest Immune checkpoint blockade immune dysfunction immune response immune responses Immunity immunohistochemistry immunological effect Immunological memory Immunotherapy Inflammation intra-tumor heterogeneity long-term immune memory lymphocyte Macrophage infiltration memory B cell modulate multiplex nasopharyngeal swab test Patient persistence Population positive predicted profile Reinfection response SARS-CoV-2 significantly Single-cell RNA sequencing spatial localization spatial transcriptomics Support T cell T cell dysfunction tissue tissue-localized immunity. tissues transcriptomic transcriptomic analysis Tumor tumor microenvironment understanding virus while with COVID-19 [DOI] 10.3389/fimmu.2022.978760 PMC 바로가기
The complexity of examining laboratory-based biological markers associated with mortality in hospitalized patients during early phase of the COVID-19 pandemic: A systematic review and evidence mapArticle Published on 2022-09-092022-11-15 Journal: PLoS ONE [Category] 바이오마커, 진단, [키워드] 95% CI appraisal association biological marker Biomarker Biomarkers Blood urea nitrogen China Clustering conducted country COVID-19 Critical early phase effect sizes Evidence glomerular filtration rate heterogeneity hospital hospitalized patient hospitalized patients IL-6 include Inflammatory Joanna Briggs Institute laboratory biomarker limit methodology Mortality multiple study overlapping pandemic Patient patients hospitalized patients with COVID-19 Quality renal screened searched Sery SMD standardized mean difference systematic review Web of Science were used with COVID-19 [DOI] 10.1371/journal.pone.0273578 PMC 바로가기
Single-cell transcriptomics reveals common epithelial response patterns in human acute kidney injuryArticle Published on 2022-09-092022-11-15 Journal: Genome Medicine [Category] 유전자 메커니즘, 진단, [키워드] Acute kidney injury adverse outcomes affected AKI Cell cell type changes in characterized Control COVID-19 criteria Critical Critical illness Critically ill patient diagnosed with COVID-19 disease disease-associated distal epithelial Gene Expression heterogeneity highlighting histology human kidney humans hypoxia Improving individual Injury inter-individual interferon response KDIGO kidney Kidney injury kidney tissue limbs mechanism molecular molecular responses occur oxidative stress performed Post-mortem provide proximal resource respiratory infections response reveal Sequencing single-cell sequencing Single-cell transcriptomics subtype Therapies Transcriptome transcriptomic transcriptomics [DOI] 10.1186/s13073-022-01108-9 PMC 바로가기
COVID-19 infection and transmission includes complex sequence diversityArticle Published on 2022-09-082022-11-15 Journal: PLoS Genetics [Category] SARS, 변종, 진단, [키워드] allele approach biallelic complex consensus sequence COVID-19 infection COVID-19 pandemic Delta Donor Evolution heterogeneity heterogeneous include Infection infections investigator Lineage majority microbial nucleotide change Occurrence omicron pandemic pathogen Patient polymorphism recipients reported SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 sequence sequence sequence variation Sequencing significantly SNP tested Transmission Transmission dynamics transmitted variant variants variants of concern viral genome whole genome [DOI] 10.1371/journal.pgen.1010200 PMC 바로가기
HLA alleles, disease severity, and age associate with T-cell responses following infection with SARS-CoV-2Article Published on 2022-09-062022-11-16 Journal: Communications Biology [Category] SARS, 치료기술, [키워드] age antibodies CD4 CD8 contributing to controls convalescent disease severity eight Factor functional heterogeneity HLA HLA alleles Humoral response Icelanders induce infection with SARS-CoV-2 investigated Protein reactive SARS-CoV-2 SARS-COV-2 infection Symptom T-cell immunity T-cell Response T-cell responses the N protein uninfected [DOI] 10.1038/s42003-022-03893-w PMC 바로가기
Associations of Guillain-Barré syndrome with coronavirus disease 2019 vaccination: Disproportionality analysis using the World Health Organization pharmacovigilance databaseArticle Published on 2022-09-012022-11-16 Journal: Journal of the peripheral nervous system : JPNS [Category] 변종, [키워드] acute respiratory syndrome Administered Analysis association AstraZeneca Cambridge cause ChAdOx1 nCoV-19 coronavirus coronavirus disease COVID-19 COVID-19 vaccination COVID-19 vaccine database demonstrated Encephalitis Epidemiological study greater Guillain-barrè syndrome Guillain-Barré syndrome variants heterogeneity higher risk Influenza influenza vaccine influenza vaccines information median time Moderna mRNA-based vaccine Occurrence Odds ratio Pfizer reported risk SARS-CoV-2 syndrome the WHO vaccination Vaccines variant World Health Organization [DOI] 10.1111/jns.12507 PMC 바로가기
Geographical distribution of cystic fibrosis carriers as population genetic determinant of COVID-19 spread and fatality in 37 countries37개국에서 COVID-19 확산 및 사망률의 인구 유전적 결정인자인 낭포성 섬유증 보균자의 지리적 분포Article Published on 2022-09-012022-09-11 Journal: The Journal of Infection [Category] Fulltext, MERS, 변종, 유전자 메커니즘, 진단, [키워드] affected Cancer carrier carriers Case fatality rate CF carriers CFR CFTR Conductance conducted correlated country COVID-19 Cystic cystic fibrosis determine distribution ecological Ecological study Factor fatality fibrosis Genetic genetics geographical distribution heterogeneity higher risk Host Indicator Mortality multivariate Older pandemic pathogenic variant pathogenicity performed Population genetics positively correlated Prevalence Rate Regression model regulator respiratory tract infection Respiratory tract infections SARS-CoV-2 severe COVID-19 shown significantly Spread subject susceptible undergo Variability Weighting [DOI] 10.1016/j.jinf.2022.06.006 PMC 바로가기 [Article Type] Article
Predictors of poor serologic response to COVID-19 vaccine in patients with cancer: a systematic review and meta-analysisResearch article Published on 2022-09-012022-10-05 Journal: European journal of cancer (Oxford, England : 1990 [Category] 변종, [키워드] 95% confidence interval advanced age anti-CD20 therapy article Cancer Cancer patients cancer treatment Chemotherapy China cohort study Complete Concentration correlated Course COVID-19 vaccination COVID-19 vaccine database Endocrine Factor heterogeneity Immunotherapy inclusion criteria Infrastructure item male Meta-analysis metastatic disease Mutation no significant difference Odds ratio outcome Patient patients Patients with cancer predict predictor predictors Probability receiving Registered Relating reported Reporting Result review searched Seroconversion Serologic response statistical systematic review Treatment vaccination Vaccination strategy was used [DOI] 10.1016/j.ejca.2022.05.031 [Article Type] Research article
Assessing severe acute respiratory syndrome coronavirus 2 infectivity by reverse-transcription polymerase chain reaction: A systematic review and meta-analysisArticle Published on 2022-09-012022-11-15 Journal: Reviews in Medical Virology [Category] COVID19(2023년), SARS, 치료기술, [키워드] 95% confidence interval Accuracy acute respiratory syndrome Assessing Cell Cell culture cell culture system clinical heterogeneity coronavirus cycle threshold determine diagnostic estimate Evidence Genome heterogeneity indicate infectivity Infectivity limitation log Logistic regression Major Meta-analysis performed polymerase chain Positive predictive value PPV Probability protocol ranged real-time polymerase chain reaction reference test respiratory sample Respiratory samples RT-PCR SARS-CoV-2 SARS-CoV-2 RNA detection searched specificity statistical subgroup symptom onset systematic review Viral RNA virus isolation [DOI] 10.1002/rmv.2342 PMC 바로가기
Estimation of the COVID-19 mean incubation time: Systematic review, meta-analysis, and sensitivity analysisMeta-Analysis Published on 2022-09-012023-06-20 Journal: Journal of medical virology [Category] Fulltext, MERS, [키워드] COVID-19 heterogeneity mean incubation time Meta-analysis publication bias sensitivity analysis [DOI] 10.1002/jmv.27841 PMC 바로가기 [Article Type] Meta-Analysis