A robust high-throughput fluorescence polarization assay for rapid screening of SARS-CoV-2 papain-like protease inhibitorsSARS-CoV-2 파파인 유사 프로테아제 억제제의 신속한 스크리닝을 위한 강력한 고처리량 형광 편광 분석Article Published on 2022-09-012022-09-11 Journal: Virology [Category] COVID19(2023년), SARS, 치료제, [키워드] Anacardic acid antiviral agent Antiviral agents cleavage competitive inhibitor COVID-19 develop disease effective therapy Fluorescence Fluorescence polarization functional High-throughput screening immune evasion in vitro inhibitor inhibitors lifecycle Papain Papain-like protease Papain-like protease inhibitors pathogen PLPro polyprotein protease protease inhibitors public health responsible robust SARS-CoV-2 Vaccines [DOI] 10.1016/j.virol.2022.07.006 PMC 바로가기 [Article Type] Article
Discovery of compounds that inhibit SARS-CoV-2 Mac1-ADP-ribose binding by high-throughput screeningArticle Published on 2022-07-012023-07-09 Journal: Antiviral Research [Category] COVID19(2023년), [키워드] ADP-ribose ADP-ribosylation coronavirus High-throughput screening macrodomain SARS-CoV-2 [DOI] 10.1016/j.antiviral.2022.105344 PMC 바로가기
Repurposing drugs as COVID-19 therapies: A toxicity evaluationCOVID-19 치료제로 약물 용도 변경: 독성 평가Review Published on 2022-07-012022-09-11 Journal: Drug discovery today [Category] COVID19(2023년), SARS, 신약개발, 치료제, [키워드] analyzed anti-SARS-CoV-2 Anti-SARS-CoV-2 Activity approved autophagy blockers chemical structures clinical trials contributed correlated COVID-19 CPE Cytopathic effect cytotoxicity database drug drug candidate drug candidates Drug interactions Drug repurposing Efficiency enrolled ether hERG High-throughput screening highlight house identify In vitro assay induce nonspecific pandemic Phospholipidosis profile repurposing SARS-CoV-2 Severe acute respiratory syndrome significantly Structure Toxicity [DOI] 10.1016/j.drudis.2022.04.001 PMC 바로가기 [Article Type] Review
[Discovery of SARS-CoV-2 main protease inhibitors using an optimized FRET-based high-throughput screening assay]Article Published on 2022-06-252023-07-09 Journal: Sheng wu gong cheng xue bao = Chinese journal of biotechnology [Category] COVID19(2023년), [키워드] fluorescence resonance energy transfer (FRET) ginkgolic acid High-throughput screening Main protease inhibitor plumbagin. SARS-CoV-2 [DOI] 10.13345/j.cjb.210657
[Identifying SARS-CoV-2 main protease inhibitors by a novel sandwich-like fluorescence polarization screening assay]Article Published on 2022-06-252023-07-09 Journal: Sheng wu gong cheng xue bao = Chinese journal of biotechnology [Category] COVID19(2023년), [키워드] Anacardic acid Fluorescence polarization High-throughput screening Main protease inhibitor pentagalloylglucose. SARS-CoV-2 [DOI] 10.13345/j.cjb.210949
Discovery of small molecule inhibitors of Plasmodium falciparum apicoplast DNA polymerase플라스모디움 팔시파룸 아피코플라스트 DNA 중합효소의 소분자 억제제 발견Article Published on 2022-05-052024-08-01 Journal: Journal of Enzyme Inhibition and Medicinal Chemistry [Category] 말라리아, [키워드] Apicoplast DNA polymerase High-throughput screening malaria [DOI] 10.1080/14756366.2022.2070909 PMC 바로가기
Improved SARS-CoV-2 main protease high-throughput screening assay using a 5-carboxyfluorescein substrateArticle Published on 2022-04-012023-07-08 Journal: The Journal of Biological Chemistry [Category] COVID19(2023년), [키워드] 3CL protease (3CL(pro)) coronavirus enzyme kinetics FRET High-throughput screening main protease (M(pro)) protease substrate SARS-CoV-2 viral protease [DOI] 10.1016/j.jbc.2022.101739 PMC 바로가기
Label-free duplex SAMDI-MS screen reveals novel SARS-CoV-2 3CLpro inhibitors라벨이 없는 이중 SAMDI-MS 화면은 새로운 SARS-CoV-2 3CLpro 억제제를 보여줍니다Article Published on 2022-04-012022-09-11 Journal: Antiviral Research [Category] COVID19(2023년), SARS, 치료제, [키워드] 3CLpro activities acute respiratory syndrome Analysis Anti-viral Antiviral compound Antiviral compounds assays biochemical assay cathepsin cathepsin L cellular cytotoxicity chymotrypsin completion coronavirus COVID-19 cysteine cysteine protease described dose response evaluated feature gold High-throughput screening Human rhinovirus inhibitor mass mass spectrometry matrix monolayer optimization protease Protease inhibitor Proteases required reveal rhinovirus rhinoviruses SARS-CoV-2 selective selectivity Severe acute respiratory syndrome small molecule specific inhibitor structure activity relationship therapeutic target [DOI] 10.1016/j.antiviral.2022.105279 PMC 바로가기 [Article Type] Article
A highly sensitive cell-based luciferase assay for high-throughput automated screening of SARS-CoV-2 nsp5/3CLpro inhibitorsArticle Published on 2022-03-092023-07-01 Journal: Antiviral Research [Category] COVID19(2023년), SARS, [키워드] 3CLpro cell-based assay High-throughput screening nsp5 SARS-CoV-2 Small molecule inhibitors [DOI] 10.1016/j.antiviral.2022.105272 PMC 바로가기 [Article Type] Article
Mass COVID-19 patient screening using UvsX and UvsY mediated DNA recombination and high throughput parallel sequencingUVSX 및 UVSY 매개 DNA 재조합 및 높은 처리량 병렬 시퀀싱을 사용한 질량 COVID-19 환자 스크리닝Article Published on 2022-03-082022-09-10 Journal: Scientific Reports [Category] MERS, SARS, 유전자 메커니즘, 치료기술, [키워드] 2019 novel coronavirus 2019-nCoV Amplicon amplicons amplification approach Bioinformatics analysis Community Containment coronavirus disease Coronavirus disease 2019 cough COVID-19 COVID-19 patient detect develop DNA downstream fatigue Fever foundation Generation Genome High-throughput screening Illumina include individuals Infection Isolation isothermal life-threatening mass Mediated Medical conditions Molecular assay molecular assays non-infectious Novel coronavirus Patient per day platform protocol REcombinase Recombination REMBRANDT respiratory respiratory symptom RNA virus SARS-CoV-2 Sequencing Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 Shortness of breath Symptom Symptomatic patients [DOI] 10.1038/s41598-022-08034-1 PMC 바로가기 [Article Type] Article