Opposite Outcomes of the Within-Host Competition between High- and Low-Pathogenic H5N8 Avian Influenza Viruses in Chickens Compared to DucksArticle Published on 2022-01-122023-06-02 Journal: Journal of Virology [Category] 조류인플루엔자, [키워드] avian viruses emergence Evolution highly pathogenic Influenza low pathogenic. [DOI] 10.1128/JVI.01366-21 PMC 바로가기
COVID-19 Impact on Public Health, Environment, Human Psychology, Global Socioeconomy, and EducationReview Article Published on 2022-01-112022-10-29 Journal: The Scientific World Journal [Category] COVID-19, SARS, [키워드] addition boost China confirmed case coronavirus COVID-19 described disadvantage education Environment global pandemic Health highly pathogenic Human immune systems Impact infected patient management manuscript MERS-CoV pandemic pandemic of COVID-19 provided Psychology Public SARS-CoV WHO World Health Organization Wuhan [DOI] 10.1155/2022/5578284 PMC 바로가기 [Article Type] Review Article
Exploring COVID-19 pathogenesis on command-line: A bioinformatics pipeline for handling and integrating omics data명령줄에서 COVID-19 발병 기전 탐색: omics 데이터를 처리하고 통합하기 위한 생물정보학 파이프라인Article Published on 2022-01-012022-09-11 Journal: Advances in protein chemistry and structural biolo [Category] SARS, 유전자 메커니즘, [키워드] Activation acute respiratory syndrome acute respiratory syndrome coronavirus Bioconductor bioinformatics cholesterol cholesterol metabolism cohort of patients comprehensive view coronavirus COVID-19 COVID-19 pathogenesis Data integration Differentially expressed genes ECM experiment global public health handling healthy highly pathogenic immune system activity infected individuals infected patients information knowledge leukocyte lung mapped marker mechanism metabolism molecules offer Open Access pathway Pathways plasma proteasomal degradation Protein Proteins proteome proteomics Quantitative raw data regulated robust robustness SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 transcript Transcriptome transcriptomics transcriptomics data transcripts virus Wuhan Wuhan, China [DOI] 10.1016/bs.apcsb.2022.04.002 PMC 바로가기 [Article Type] Article
A genome-wide CRISPR screen identifies interactors of the autophagy pathway as conserved coronavirus targetsShort Reports Published on 2021-12-282022-10-28 Journal: PLoS Biology [Category] COVID-19, SARS, [키워드] approved approved drugs autophagy cell cultures cell line clinically Compound conducted conserved coronavirus coronavirus 2 Coronavirus replication coronavirus target CoV CoV replication CoVs demonstrated dependent on dose-dependent inhibition effective effective therapy epithelial Factor FKBP8 Genes genome-wide CRISPR screen HCoV-229E Health highlighting highly pathogenic Host Huh7 human coronavirus identify independent Infection inhibitor MERS-CoV Middle East MINAR1 nasal over pathway Protein Replication required respiratory SARS-CoV SARS-COV-2 infection Support survival target therapeutic intervention Tmem41b Treatment virus replication viruses [DOI] 10.1371/journal.pbio.3001490 PMC 바로가기 [Article Type] Short Reports
Spatiotemporal Associations and Molecular Evolution of Highly Pathogenic Avian Influenza A H7N9 Virus in China from 2017 to 2021Article Published on 2021-12-152023-05-31 Journal: Viruses [Category] Fulltext, 조류인플루엔자, [키워드] Avian influenza virus Epidemiology Evolution H7N9 hemagglutinin highly pathogenic phylogeography [DOI] 10.3390/v13122524 PMC 바로가기 [Article Type] Article
Antiviral Immunity in SARS-CoV-2 Infection: From Protective to Deleterious ResponsesReview Published on 2021-12-132022-10-29 Journal: Microorganisms [Category] COVID-19, [키워드] antibodies Antiviral caused cellular cellular and molecular coronavirus COVID-19 pandemic Diagnosis effective highly pathogenic Human immune response Immunity immunopathology Inflammation intrinsically involved Lymphocytes MERS produced question Respiratory illness response SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variants the SARS-CoV-2 therapeutic approaches zoonotic origin [DOI] 10.3390/microorganisms9122578 PMC 바로가기 [Article Type] Review
Pathogenicity of the Canadian Delmarva (DMV/1639) Infectious Bronchitis Virus (IBV) on Female Reproductive Tract of ChickensArticle Published on 2021-12-112022-10-28 Journal: Viruses [Category] Coronavirus, [키워드] age bronchitis cause characteristic chicken circulating consequence cystic oviduct Delmarva (DMV)/1639 strain demonstrated determine distribution experiment false layer syndrome female reproductive tract Genome highly pathogenic histopathological IBV incidence Infection Infectious bronchitis virus (IBV) kidney lesion observation over oviduct Prevalence provide respiratory tract SPF syndrome tissue tonsils tract viral shedding virus were infected white leghorn chicken [DOI] 10.3390/v13122488 PMC 바로가기 [Article Type] Article
Propagation of SARS-CoV-2 in Calu-3 Cells to Eliminate Mutations in the Furin Cleavage Site of SpikeArticle Published on 2021-12-042022-10-28 Journal: Viruses [Category] COVID-19, SARS, [키워드] accumulate accumulated accumulated mutation animal model animal models arising B.1.351 Calu-3 Calu-3 cell Care Cell culture cell cultures cell lines cleavage Deletion eliminated evaluate furin furin cleavage site generate hamsters highly pathogenic in vivo independent infect lung epithelial Mutation nucleotide position pathogenic Polymorphisms Population produced Propagation remained SARS-CoV-2 SARS-CoV-2 isolate SARS-CoV-2 pathogenesis SARS-CoV-2 variant Site spike stock preparation therapeutic Vaccine variant Vero Cell virus virus stock was used wild-type [DOI] 10.3390/v13122434 PMC 바로가기 [Article Type] Article
TMPRSS2 promotes SARS-CoV-2 evasion from NCOA7-mediated restrictionTMPRSS2는 NCOA7 매개 제한으로부터 SARS-CoV-2 회피를 촉진합니다Research Article Published on 2021-11-222022-09-10 Journal: PLoS Pathogens [Category] MERS, SARS, 유전자 메커니즘, [키워드] acquisition Activation Antiviral Antiviral effect antiviral effects ATPase biological significance Cell cell surface characterized cleavage coactivator concomitant use consequence coronavirus Critical cytoplasmic dysregulation ectopic expression Effect effector endocytic Endosomal acidification epithelial cells evade furin furin cleavage furin cleavage site gene knockout HCoV HCoV-229E HCoV-NL63 highly pathogenic Host immune response host immune responses IFN IFN treatment IFNs immune responses Inborn errors Infection infections inhibit inhibit SARS-CoV-2 inhibited inhibitor innate immune response innate immune responses interact interferon interferons ISG ISGs isoform lentivirus less Lung epithelial cells lysosomal protease mechanism MERS MERS-CoV NCOA7 NL63 nuclear nuclear receptor option overexpression Particle pathway patients with COVID-19 plasma membrane polybasic promote protease Protein pseudotyped Pseudotyped viruses receptor removal repertoire Research RNA robust SARS-CoV-1 SARS-CoV-2 SARS-CoV-2 entry SARS-COV-2 infection SARS-CoV-2 spike seasonal severe COVID-19 spike Spike protein Support the interferon TMPRSS TMPRSS2 TMPRSS2 protease Trigger vacuolar Vesicle Viral viral spike protein virus virus entry virus infection virus infections viruses [DOI] 10.1371/journal.ppat.1009820 PMC 바로가기 [Article Type] Research Article
Molecular Analysis of the Avian H7 Influenza Viruses Circulating in South Korea during 2018–2019: Evolutionary Significance and Associated Zoonotic ThreatsBrief Report Published on 2021-11-112023-05-31 Journal: Viruses [Category] Fulltext, 조류인플루엔자, [키워드] Avian Influenza H7 highly pathogenic [DOI] 10.3390/v13112260 PMC 바로가기 [Article Type] Brief Report