COVID-19-related end stage lung disease: two distinct phenotypesArticle Commentary Published on 2022-02-162022-10-28 Journal: Annals of Medicine [Category] Coronavirus, COVID19(2023년), Fulltext, SARS, [키워드] acute respiratory distress ARDS Biomarker classical Clinical features COVID-19 DAD defined Diagnosis Diffuse alveolar damage drug Follow-up histopathological Hypothesis information lung Lung disease lung transplantation pathophysiology phenotype Phenotypes Prognosis pulmonary fibrosis radiological Risk factors syndrome Treatment worse prognosis [DOI] 10.1080/07853890.2022.2039954 PMC 바로가기 [Article Type] Article Commentary
An In Vivo Observational Histological Study of Peripheral Arterial Damage in Patients with Acute Limb Ischemia in SARS-CoV-2 InfectionArticle Published on 2022-02-142022-10-31 Journal: Diagnostics [Category] COVID-19, [키워드] active smokers Acute limb ischemia Analysis analyzed arterial Arterial hypertension CD45 CD68 change damage Diabetes Mellitus endothelial Endothelial dysfunction events Evidence histologic histological histopathological immunohistochemistry in vivo Inflammation intraarterial investigated Ischemia lack limb mechanism obese Patient patients patients with COVID-19 performed peripheral prothrombotic Reactions reported Research risk factor SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 patients skeletal muscles structures suffered Thrombus thrombus formation tissue [DOI] 10.3390/diagnostics12020488 PMC 바로가기 [Article Type] Article
The omicron (B.1.1.529) SARS-CoV-2 variant of concern does not readily infect Syrian hamstersArticle Published on 2022-02-012022-10-27 Journal: Antiviral Research [Category] COVID-19, [키워드] B.1.1.529 bronchopneumonia COVID-19 COVID-19 pandemic D614G demonstrated detectable End exacerbated hamster hamsters histopathological infect Infectious virus Infectivity Inflammation log lung Lungs mutated new SARS-CoV-2 omicron Omicron variant organ pathology replicate SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 VoC the lungs a the spike protein variant viral RNA load WHO [DOI] 10.1016/j.antiviral.2022.105253 PMC 바로가기 [Article Type] Article
The omicron (B.1.1.529) SARS-CoV-2 variant of concern does not readily infect Syrian hamstersArticle Published on 2022-02-012022-10-27 Journal: Antiviral Research [Category] Coronavirus, COVID-19, COVID19(2023년), Fulltext, MERS, SARS, [키워드] B.1.1.529 bronchopneumonia COVID-19 COVID-19 pandemic D614G demonstrated detectable End exacerbated hamster hamsters histopathological infect Infectious virus Infectivity Inflammation log lung Lungs mutated new SARS-CoV-2 omicron Omicron variant organ pathology replicate SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 VoC the lungs a the spike protein variant viral RNA load WHO [DOI] 10.1016/j.antiviral.2022.105253 PMC 바로가기 [Article Type] Article
The omicron (B.1.1.529) SARS-CoV-2 variant of concern does not readily infect Syrian hamstersOmicron (B.1.1.529) SARS-COV-2 우려 변형은 시리아 햄스터를 쉽게 감염시키지 않습니다.Article Published on 2022-02-012022-09-01 Journal: Antiviral Research [Category] 변종, 진단, 치료기술, [키워드] animals B.1.1.529 bronchopneumonia COVID-19 COVID-19 pandemic D614G demonstrated detectable End exacerbated hamster hamsters Highlights histopathological histopathological examination infect Infectious virus Infectivity Inflammation log lung Lungs mutated new SARS-CoV-2 omicron Omicron variant organ pathology replicate SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants SARS-CoV-2 VoC Spike protein the lungs a the spike protein variant Viral Viral RNA viral RNA load VOCs WHO [DOI] 10.1016/j.antiviral.2022.105253 PMC 바로가기 [Article Type] Article
RNA SARS-CoV-2 Persistence in the Lung of Severe COVID-19 Patients: A Case Series of AutopsiesMicrobiology Published on 2022-01-312022-10-31 Journal: Frontiers in Microbiology [Category] COVID-19, [키워드] addition Analysis Autopsy BK virus bronchopneumonia contribute contributing to Course COVID-19 COVID-19 patient death died disease Disease progression expected genomic RNA gRNA histopathological illness duration Immunocompromised immunohistochemistry immunomodulatory therapy immunosuprression include Infection lung lung cell lung lesions median mRNA onset of symptom onset of symptoms Patient pediatric persistence populations Protein Pulmonary infection replicative RNA RT-PCR SARS-CoV-2 secondary Sery severe COVID-19 sgRNA the disease viral persistance Viral protein viral replication virus [DOI] 10.3389/fmicb.2022.824967 PMC 바로가기 [Article Type] Microbiology
Integrated histopathological, lipidomic, and metabolomic profiles reveal mink is a useful animal model to mimic the pathogenicity of severe COVID-19 patients통합된 조직병리학, 지질학 및 대사체 프로필은 밍크가 심각한 COVID-19 환자의 병원성을 모방하는 유용한 동물 모델임을 보여줍니다Article Published on 2022-01-282022-09-10 Journal: Signal Transduction and Targeted Therapy [Category] Fulltext, SARS, 바이오마커, 진단, 치료법, 치료제, [키워드] Absorption accompanied activated Activation acute respiratory syndrome acute respiratory syndrome coronavirus alteration alveolar damage amino acids Analysis animal model Anti-inflammatory characterized cholesterol contributed coronavirus correlated COVID-19 patients demonstrated Diffuse alveolar damage digestion digestive distribution downregulated dysregulation effective Effects Endocrine fatal COVID-19 feature fetal hepatic dysfunction highlight histological histopathological Human immune dysregulation immune systems immunomodulating Infection Infectious diseases Inflammatory response inoculation Kynurenine Kynurenine pathway lesion Lipid lipids Macrophage macrophage activation macrophages melatonin metabolic pathways metabolite metabolites metabolomic observation pathogenicity pathophysiological feature Patient post inoculation potential biomarkers profile Proteins reported Research respiratory SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severe COVID-19 patient significantly Steroids transmitted Treatment strategies Vaccine Viral Viral protein vitamins was related widespread [DOI] 10.1038/s41392-022-00891-6 PMC 바로가기 [Article Type] Article
A Single Dose of an MVA Vaccine Expressing a Prefusion-Stabilized SARS-CoV-2 Spike Protein Neutralizes Variants of Concern and Protects Mice From a Lethal SARS-CoV-2 Infection사전 융합 안정화 SARS-CoV-2 스파이크 단백질을 발현하는 MVA 백신의 단일 용량은 우려의 변종을 중화하고 치명적인 SARS-CoV-2 감염으로부터 마우스를 보호합니다Immunology Published on 2022-01-272022-09-11 Journal: Frontiers in Immunology [Category] 변종, 진단, [키워드] administration animal models Antibody titers C57BL/6 caused Cell clinical trials concern COVID-19 vaccine Cytokines demonstrated dose Efficacy expressed expressing expression full-length hACE2 histopathological IgG immune responses immunized immunogenicity K18-hACE2 mice lesions lethal Lungs mice modified vaccinia virus morbidity morbidity and mortality mouse model MVA vector Neutralizing antibody titer neutralizing antibody titers parental poxvirus prefusion-stabilized S protein pro-inflammatory cytokine pro-inflammatory cytokines protective efficacy Protein reducing S protein SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 S protein SARS-CoV-2 spike SARS-CoV-2 vaccine SARS-CoV-2 viral loads single dose spike T-cell immune responses transgenic vaccine candidate variants variants of concern Viral viral loads viruses wild-type [DOI] 10.3389/fimmu.2021.824728 PMC 바로가기 [Article Type] Immunology
Studying the clinical, radiological, histological, microbiological, and immunological evolution during the different COVID-19 disease stages using minimal invasive autopsy최소 침습성 부검을 사용하여 상이한 COVID-19 질병 단계 동안 임상, 방사선 학적, 조직 학적, 미생물 학적 및 면역 학적 진화 연구Clinical Trial Published on 2022-01-252022-09-01 Journal: Scientific Reports [Category] 임상, 진단, 치료법, [키워드] alveolar damage America Autopsy change Characteristics clinical microbiology Cohort COVID-19 COVID-19 disease COVID-19 patients diffuse Diffuse alveolar damage disease evaluated Evolution had no heart histological histopathological IgG immunological immunological characteristics Immunopathogenesis Infection Inflammation interferon interferon-γ invasive liver organ Other other organs Pathogenesis pathophysiological mechanism pathophysiological mechanisms Patient PCR-confirmed COVID-19 patient positive radiological Significant significant differences significantly higher Society Stage stages Treatment viral infection WHO with COVID-19 [DOI] 10.1038/s41598-022-05186-y PMC 바로가기 [Article Type] Clinical Trial
Liver injury with COVID-19: laboratory and histopathological outcome—systematic review and meta-analysisReview Published on 2022-01-212022-11-01 Journal: Egyptian Liver Journal [Category] COVID-19, [키워드] 95% CI Abnormal liver function acute respiratory syndrome article authors Autopsy change Cohort studies coronavirus correlation COVID-19 database Direct distress eligibility criteria exclusion FIVE flow diagram hepatic injury higher odd histopathological Histopathology in vitro in vivo independent Infection Injury Laboratory Laboratory test liver Liver function liver function tests Liver injury liver tissue mechanism Meta-analysis Novel coronavirus outcome pathology Patient patients peer-reviewed reported Result retrospective SARS-CoV-2 SARS-COV-2 infection Science searched severe COVID-19 severity of COVID-19 statistically significant syndrome systematic review was done Web of Science with COVID-19 [DOI] 10.1186/s43066-022-00171-6 PMC 바로가기 [Article Type] Review