human body – Page 5 – Communicable Diseases Research

Reverse vaccinology approach towards the in-silico multiepitope vaccine development against SARS-CoV-2

SARS-CoV-2에 대한 in-silico 다중 에피토프 백신 개발을 위한 역백신학 접근법

Research Article

Published on 2021-01-232022-09-11
Journal: F1000Research
[Category] 치료법,

H2V: a database of human genes and proteins that respond to SARS-CoV-2, SARS-CoV, and MERS-CoV infection

H2V: SARS-CoV-2, SARS-CoV, MERS-CoV 감염에 반응하는 인간 유전자 및 단백질 데이터베이스

Database

Published on 2021-01-072022-09-01
Journal: BMC Bioinformatics
[Category] 유전자 메커니즘, 진단,

[키워드] accelerate analysis Antiviral antiviral agent approved article caused cellular and molecular cellular pathway cellular pathways collected confirmed case coronavirus Coronavirus infection Coronavirus infections country CoV infection COVID-19 pandemic database death develop Economy expected Gene highly pathogenic human body human gene human genes identify Impact impair Infection information measure MERS MERS-CoV MERS-CoV infection molecular Novel coronavirus powerful tool Protein proteomic provide public health respond response Result SARS-CoV SARS-CoV-2 Society targets these viruses transcriptomic Treatment Vaccine Viral viral infection viral infections viral pathogenesis viruses WHO
[DOI] 10.1186/s12859-020-03935-2 PMC 바로가기 [Article Type] Database

Identification and characterization of a silent mutation in RNA binding domain of N protein coding gene from SARS-CoV-2

SARS-CoV-2의 N 단백질 코딩 유전자의 RNA 결합 도메인에서 침묵 돌연변이의 식별 및 특성화

Comparative Study

Published on 2021-01-062022-09-10
Journal: BMC Research Notes
[Category] 변종, 유전자 메커니즘, 치료기술, 치료법,

[키워드] acute respiratory syndrome addition affinity Base excision repair binding domain changed China Chinese coding gene coding sequence COVID-19 cytosine DNA DNA sequence DNA sequences human body human immunity human-to-human transmission identification IMPROVE Iran leucine Missense mutation mutated Mutation N protein nucleocapsid nucleotide objective Occurrence pathogenicity proline repair mechanism respiratory Result resulting risk RNA RNA binding domain RNA sequence RNA sequences SARS-CoV-2 Severe acute respiratory syndrome silent single nucleotide TDG thymine Thymine DNA glycosylase (TDG) Transcription uracil Viral Viral RNA Zinc
[DOI] 10.1186/s13104-020-05439-x PMC 바로가기 [Article Type] Comparative Study

Genomic RNA Elements Drive Phase Separation of the SARS-CoV-2 Nucleocapsid

게놈 RNA 요소가 SARS-CoV-2 뉴클레오캡시드의 상 분리를 유도합니다

Article

Published on 2020-12-172022-09-11
Journal: Molecular Cell
[Category] SARS, 신약개발, 치료법, 치료제,

[키워드] aggregation Antiviral compound Antiviral compounds binding site body temperature buffer characterized concentrations condensation condition coronavirus crosslink drive effective element feature Genome genomic genomic region human body liquid location mammalian cell mammalian cells N-protein nucleocapsid nucleocapsid protein phase physiological promote reduced Region regulate RNA RNA sequence room temperature SARS-CoV-2 SARS-CoV-2, Condensation, phase separation, packaging, RNP-MaP, RNA structure, nucleocapsid, coronavirus. separation single-stranded Small molecules strength temperature the SARS-CoV-2 valency Viral Viral RNA
[DOI] 10.1016/j.molcel.2020.11.041 PMC 바로가기 [Article Type] Article

Update on COVID-19 Myocarditis

COVID-19 심근염에 대한 업데이트

Review

Published on 2020-12-092022-09-10
Journal: Medicina
[Category] MERS, SARS, 치료제,

[키워드] Acute coronary syndrome acute respiratory syndrome addition Affect arrhythmia Arrhythmias cardiac Cardiac complications Cardiogenic shock Complication convalescent plasma coronary syndrome coronavirus coronavirus 2 COVID-19 COVID-19 disease current Diagnosis Endomyocardial biopsy etiologies Evidence expected heart failure Host immune response human body imaging modality include increasingly Injury Intervention key factor Laboratory laboratory findings life life threatening life-threatening management manifestation morbidity morbidity and mortality MRI myocarditis Non-invasive organ system organ systems performed reducing refractory remains uncertain Remdesivir respiratory respiratory distress Respiratory distress syndrome Respiratory system SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severe COVID-19 disease Severe respiratory distress Shock Steroids Support syndrome therapy Viral while
[DOI] 10.3390/medicina56120678 PMC 바로가기 [Article Type] Review

Bone biology and COVID-19 infection: Is ACE2 a potential influence factor?

뼈 생물학과 COVID-19 감염: ACE2가 잠재적인 영향 요인입니까?

Article

Published on 2020-11-012022-09-11
Journal: Medical Hypotheses
[Category] SARS, 치료기술, 치료제,

On the whereabouts of SARS-CoV-2 in the human body: A systematic review

인체 내 SARS-CoV-2의 행방: 체계적인 검토

Research Article

Published on 2020-10-302022-08-13
Journal: PLoS Pathogens
[Category] Biology and Life Sciences, COVID-19, MERS, SARS,

[키워드] ACE2 ACE2 entry-receptor ACE2 receptor addition aligned Blood body fluid body fluids Brain breast milk caused cerebrospinal fluid complex interplay component concerning consequence Containment correlated COVID-19 patients detect infectious virus Diagnosis distribution entry receptor Evidence expressed expression data expression level expression levels focus foundation heart highlight Host human body human host human population human tissue human tissues Impact implicates the presence improve diagnostics Infectious virus information intestines kidneys knowledge lung Lungs male genital male genitals Mucus multiple organ multiple organs multiple tissue multiple tissues observé organotropism of SARS-CoV-2 pandemic pandemic virus performed pharynx Proteins provide researcher RNA Saliva SARS-CoV-2 SARS-CoV-2 detection SARS-CoV-2 entry receptor SARS-CoV-2 pathogenesis SARS-CoV-2 patients Scientific community Semen Single Cell Spread Stool systematic review These data Trachea Treatment treatment of COVID-19 patients Urine vessels Viral viral presence viral shedding viral shedding in body fluids virus
[DOI] 10.1371/journal.ppat.1009037 PMC 바로가기 [Article Type] Research Article

Coordinate genomic association of transcription factors controlled by an imported quorum sensing peptide in Cryptococcus neoformans

Cryptococcus neoformans에서 가져온 쿼럼 센싱 펩타이드에 의해 제어되는 전사 인자의 게놈 연관성을 조정합니다.

Research Article

Published on 2020-09-212022-09-06
Journal: PLoS Genetics
[Category] Communicable Disease,

[키워드] acting Affect association binding Cell Cell density cell surface receptor cell wall change chromatin immunoprecipitation Control control cell Coordinate Cryptococcus Cryptococcus neoforman Cryptococcus neoformans Deletion eukaryotic expression form function functions fungal fungal pathogens Gene Expression Genes Genetic genomic genomic studies genomic study human body Hypothesis identify Impact infect Macrophage macrophages mating mechanism Meningitis microbe modulate modulating pathogen pathogenic Pathogens peptide predicted promote promoters proximal quorum regulated required reveal secreted surface receptor target transcription factor transcription factors virulence whole-genome
[DOI] 10.1371/journal.pgen.1008744 PMC 바로가기 [Article Type] Research Article

A Guide to COVID-19: a global pandemic caused by the novel coronavirus SARS-CoV-2

COVID-19 가이드: 신종 코로나바이러스 SARS-CoV-2로 인한 세계적 대유행

Review

Published on 2020-09-012022-09-11
Journal: The Febs Journal
[Category] SARS, 치료제,

[키워드] ACE2 candidate vaccine cause caused Characteristics characterized contaminated surfaces coronavirus Coronaviruses COVID-19 CRISPR disease droplet droplets drug Epidemiology Fever genomic global pandemic guide human body Human coronavirus human coronaviruses individuals inhalation Interaction Laboratory Like MERS MERS-CoV novel coronavirus SARS-CoV-2 pandemic Pneumonia Prophylaxis SARS SARS-CoV SARS-CoV-2 SARS-CoV-2 strain Shortness of breath similarity the disease the SARS-CoV-2 the United State Transmission transmitted Treatment United Kingdom United States Vaccine vaccine trial vaccine. Vaccines virus
[DOI] 10.1111/febs.15375 PMC 바로가기 [Article Type] Review

Tripartite Combination of Candidate Pandemic Mitigation Agents: Vitamin D, Quercetin, and Estradiol Manifest Properties of Medicinal Agents for Targeted Mitigation of the COVID-19 Pandemic Defined by Genomics-Guided Tracing of SARS-CoV-2 Targets in Human Cells

대유행 완화제 후보의 삼자 조합: 인간 세포에서 SARS-CoV-2 표적의 게놈 유도 추적으로 정의된 COVID-19 대유행의 표적 완화를 위한 약제의 비타민 D, 케르세틴 및 에스트라디올 매니페스트 특성

Article

Published on 2020-05-212022-09-10
Journal: Biomedicines
[Category] 비임상,

[키워드] 2019 coronavirus disease ACE2 activity Affect agent Alter analyses analysis breath build candidate cell types cellular clinical trial clinical trials Combination condition contribute coronavirus coronavirus disease Coronavirus infection COVID-19 COVID-19 pandemic deficiency disease drug drugs drugs and medicinal substance repurposing Effect elements enrichment eriodictyol estradiol experiment expression expression profiling facilitate Follow-up function functions furin FURIN expression FURIN gene GATA5 gene expression profile Gene expression profiles gene expression signature Gene Set Enrichment Analyses gene silencing Genomics GSEA HIF1a high mortality HMGA2 HNF4A Human human body human cell human cells human gene human genes hypothetical identify Immediate Immune cell immune cells Immunosuppression Impact infect Infection Inference inhibitor inhibitors of SARS-CoV-2 INSIG1 interfere Intervention intrinsically Luteolin majority male Mitigation mitigation approaches molecular Mortality observation observational study observations Older overexpression pandemic Panel Patient persistence present property Protein Protein target protein targets Proteins quercetin Randomized randomized clinical trial Regulatory reported repressor required RUNX1 SARS-CoV-2 SARS-CoV-2 coronavirus SARS-CoV-2 entry SARS-COV-2 infection SARS-CoV-2 protein SARS-CoV-2 proteins SARS-CoV-2 viral selective severity SFTPC smoking Spread SUMMIT drug-docking screen target targets Testosterone the SARS-CoV-2 tissues tracing Transgenic mouse Treatment upstream utility Viral Viral protein Viral proteins virus Vitamin D vitamin D deficiency website
[DOI] 10.3390/biomedicines8050129 PMC 바로가기 [Article Type] Article