Sero-survey on long-term care facility residents reveals increased risk of sub-optimal antibody response to BNT162b2: implications for breakthrough preventionResearch Published on 2022-03-102022-10-27 Journal: BMC Geriatrics [Category] Coronavirus, COVID-19, MERS, SARS, [키워드] administration advanced age Antibody Response Antibody titer association BNT162b2 Cancer Care caused Comorbidities Comorbidity Complete confidence coronavirus 2 coronavirus disease Corticosteroid corticosteroid therapy COVID-19 death Diabetes Mellitus diagnosis of COVID-19 dose evaluate Factor Health care worker humoral humoral responses IgG implication increased risk individual investigated Italian Long term care facilities Measures medium multivariate logistic regression Older age positive serology predictor reduced risk Reinfection resident respiratory response to vaccination Result reveal S-IgG antibodies SARS-CoV-2 SARS-CoV-2 specific antibody serological response severe disease supplementary material vaccination Vaccine [DOI] 10.1186/s12877-022-02884-0 PMC 바로가기 [Article Type] Research
Protective and pathogenic role of humoral responses in COVID-19COVID-19에서 체액 반응의 보호 및 병원성 역할Review Published on 2022-03-012022-09-11 Journal: Journal of microbiology (Seoul, Korea) [Category] MERS, SARS, 변종, 진단, [키워드] accumulating addition advent antibody Antibody Response antibody-escaping variants COVID-19 develop driving dysregulated effective help humoral immune response humoral immune responses Humoral immunity Humoral response humoral responses identify immune pressure immune responses individuals Infection knowledge measure mechanism mutations Neutralizing activity pandemic pathogenic progression Protective Regulatory SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike-specific specific antibodies spike-specific antibodies understanding vaccination Viral viral pathogen [DOI] 10.1007/s12275-022-2037-8 PMC 바로가기 [Article Type] Review
Immunogenicity and tolerability of COVID-19 messenger RNA vaccines in primary immunodeficiency patients with functional B-cell defects기능적 B 세포 결함이 있는 원발성 면역결핍 환자에서 코로나19 메신저 RNA 백신의 면역원성과 내약성Multicenter Study Published on 2022-03-012022-09-11 Journal: The Journal of Allergy and Clinical Immunology [Category] MERS, SARS, 진단, 치료기술, [키워드] ACE2 ACE2 blocking antibody ACE2 receptor acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 antibody Antibody deficiency Antibody Response Antibody responses B-cell blocking activity blocking antibody BNT162b2 BNT162b2 vaccine cellular immunity Clinical management cohort of patient common variable immunodeficiency coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 mRNA Vaccination COVID-19 vaccine trials detectable dose effective Efficacy enzyme evaluated functional Good Good syndrome help humoral Humoral response humoral responses IFN-γ IgG antibody IgG responses immune responses immunodeficiency immunogenicity information less mAb Messenger RNA Moderna mRNA mRNA vaccine mRNA vaccines mRNA-1273 neutralization not effective Patient patients Pfizer-BioNTech PID PIDs positive Primary immunodeficiencies Primary Immunodeficiency RBD RBD binding RBD-specific IgG responses Reactions reactogenicity Receptor binding domain referred to respiratory retrospective retrospective review Safe SARS-CoV-2 SARS-CoV-2 IFN-γ release assay SARS-CoV-2 spike protein SARS-CoV-2 spike protein antibody SARS-CoV-2 spike protein receptor binding domain SARS-CoV-2 vaccination severe acute respiratory syndrome Coronavirus Spike protein spike protein RBD stimulated subject subjects T-cell immune response T-cell Response the spike protein Tolerability vaccination Vaccine was performed were excluded with COVID-19 [DOI] 10.1016/j.jaci.2021.11.022 PMC 바로가기 [Article Type] Multicenter Study
A systematic review and meta-analysis of the accuracy of SARS-COV-2 IGM and IGG tests in individuals with COVID-19COVID-19 환자를 대상으로 한 SARS-COV-2 IGM 및 IGG 검사의 정확도에 대한 체계적인 검토 및 메타 분석Review Published on 2022-03-012022-09-11 Journal: Journal of Clinical Virology [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, [키워드] Accuracy antibody AUC Chain Reaction Cochrane Library complementary confirmation contribute database databases diagnostic Diagnostic meta-analysis diagnostic testing eligible evaluate exposure to high accuracy Humoral response humoral responses IgG antibodies IgM and IgG Immunoglobulin immunoglobulins immunosurveillance index individuals with COVID-19 Infection literature Meta-analysis nucleic acid Nursing observational studies observational study polymerase chain polymerase chain reaction Research reverse transcriptase Reverse transcriptase polymerase chain reaction RT-PCR SARS-CoV-2 SARS-COV-2 infection sensitivity Sensitivity and specificity serology specificity systematic review the disease transcriptase utility Viral viral nucleic acid virus was performed Web of Science [DOI] 10.1016/j.jcv.2022.105121 PMC 바로가기 [Article Type] Review
Safety and immunogenicity of the SARS-CoV-2 ARCoV mRNA vaccine in Chinese adults: a randomised, double-blind, placebo-controlled, phase 1 trial중국 성인을 대상으로 한 SARS-CoV-2 ARCoV mRNA 백신의 안전성 및 면역원성: 무작위 배정, 이중 맹검, 위약 대조, 1상 시험Clinical Trial Published on 2022-03-012022-09-11 Journal: The Lancet. Microbe [Category] MERS, SARS, 임상, 진단, 치료기술, [키워드] abnormal change abnormal changes Academy administration adverse event adverse events Adverse reaction Adverse reactions All participant All participants analyses Analysis Anti-RBD IgG anti-SARS-CoV-2 Antibody titre assigned baseline block Block randomisation caused cellular immune responses China Chinese clinical testing conducted convalescent patient Convalescent patients COVID-19 pandemic development domain dose dose-escalation doses double-blind effective vaccine Effective vaccines eligible participant ELISA ELISPOT ENCODE enrolled enzyme enzyme-linked immunospot expected exploratory Fever first vaccination FIVE foundation grade 3 group groups highest hospital humoral humoral immune responses Humoral response humoral responses IFN-γ IL-2 immune immune response immune responses immunogenicity incidence individual Intramuscular injection investigators Laboratory laboratory analyses Laboratory test Laboratory tests live SARS-CoV-2 lowest majority Medical Science Medical Sciences Mild moderate mRNA vaccine natural neutralisation assays Neutralising Antibodies neutralising antibody observation outcome participant Participants peaked Phase 1 phase 1 trial Placebo placebo group placebo-controlled Primary outcome pseudovirus randomised Randomly RBD RBD IgG RBD-specific IgG receive Registered reported research and development resolved Safe Safety safety analyses safety profile SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2-specific T-cell response SARS-CoV-2-specific T-cell responses Science screened second dose second vaccination secondary outcome Serious Adverse Event Serious Adverse Events Seven significantly Specific Specific T-cell response Spike protein Support systemic adverse event T-cell Response T-cell responses the placebo group the SARS-CoV-2 titre titres Tolerability treatment allocation Trial vaccination Vaccine vaccine dose vaccine doses were assessed were given with COVID-19 Zhejiang [DOI] 10.1016/S2666-5247(21)00280-9 PMC 바로가기 [Article Type] Clinical Trial
SARS-CoV-2 Omicron Spike recognition by plasma from individuals receiving BNT162b2 mRNA vaccination with a 16-week interval between dosesComparative Study Published on 2022-03-012023-07-08 Journal: Cell Reports [Category] COVID19(2023년), [키워드] coronavirus COVID-19 delayed mRNA vaccine regimen humoral responses neutralization omicron SARS-CoV-2 spike glycoproteins variants of concern [DOI] 10.1016/j.celrep.2022.110429 PMC 바로가기 [Article Type] Comparative Study
Trajectories of humoral and cellular immunity and responses to a third dose of mRNA vaccines against SARS-CoV-2 in patients with a history of anti-CD20 therapy항-CD20 치료 이력이 있는 환자에서 체액성 및 세포성 면역의 궤적과 SARS-CoV-2에 대한 3차 mRNA 백신에 대한 반응Article Published on 2022-03-012022-09-11 Journal: RMD Open [Category] MERS, SARS, 임상, 진단, 치료기술, [키워드] Analysis anti-CD20 anti-CD20 therapy anti-CD20 treatment anti-SARS-CoV-2 immune response anti-SARS-CoV-2 immune responses antibody concentration Antibody concentrations cell-mediated immune Cell-mediated immunity cellular immunity CMI comparable Concentration Control covariance COVID-19 decay dose elicited healthy volunteer healthy volunteers humoral humoral and cell-mediated immunity Humoral response humoral responses IgG immune responses Immunity immunogenicity inefficient interferon interferon-γ investigated Linear regression majority mRNA vaccine non-responder non-responders outcome Participants Patient patients registration number Responder responders response reveal rituximab RNA SARS-CoV-2 SARS-CoV-2 vaccine second vaccination systemic vasculitis Therapies therapy Trajectories trajectory Trial Registration Number vaccination Vaccination strategy Vaccine vaccine dose Vasculitis [DOI] 10.1136/rmdopen-2021-002166 PMC 바로가기 [Article Type] Article
An analysis of antibody responses and clinical sequalae of the Sinopharm HB02 COVID19 vaccine in dialysis patients in the United Arab Emirates아랍에미리트의 투석 환자에서 Sinopharm HB02 COVID19 백신의 항체 반응 및 임상 후유증 분석Article Published on 2022-03-012022-09-11 Journal: Nephrology (Carlton, Vic.) [Category] SARS, 변종, [키워드] adverse events Analysis anti-spike antibodies anti-spike antibody antibodies antibody Antibody Response Antibody responses appear baseline booster dose Case fatality rate Clinical effect Cohort Course COVID COVID-19 COVID-19 vaccination COVID19 dialysis dose examined Fatality rate General population Haemodialysis haemodialysis patients humoral immune response humoral immune responses Humoral response humoral responses immune responses individuals Infection occur Patient patients positive PROTECT reduction in response Side-effects Sinopharm Standard survival the antibody response the vaccine to define United Arab Emirate vaccination vaccination schedule Vaccine were given [DOI] 10.1111/nep.13980 PMC 바로가기 [Article Type] Article
Cellular and humoral responses to SARS-CoV-2 vaccination in immunosuppressed patients면역 억제 환자에서 SARS-CoV-2 백신 접종에 대한 세포 및 체액 반응Article Published on 2022-03-012022-09-11 Journal: Cellular immunology [Category] SARS, 치료기술, [키워드] Activation anti-spike antibodies B-cell BNT162b2 BNT162b2 mRNA CD8 ChAdOx1 ChAdOx1 nCoV-19 cohorts comparable COVID-19 cytokine Cytokines demonstrated depleting detectable difference Efficacy elicited haematological malignancies haematological malignancy healthy healthy volunteers highest Humoral response humoral responses immunodominance immunogenic immunological responses Immunophenotyping Immunosuppressed immunosuppressed patient immunosuppressed patients Immunosuppression immunosuppressive immunosuppressive therapy less Longevity Lower memory naïve no significant differences non-responder participant Participants Patient patients treated phenotype preserved protective immunity receiving renal responders response SARS-CoV-2 SARS-CoV-2 vaccination SARS-CoV-2 vaccine SARS-CoV-2 vaccines seroconvert serological seropositive Seropositivity significant difference T-cell T-cell ELISpot T-cell Response T-cell responses Th1 cytokine therapy Transplant Vaccinations vaccine immunogenicity vaccine response vaccine responses were used [DOI] 10.1016/j.cellimm.2022.104501 PMC 바로가기 [Article Type] Article
Performance Evaluation of Lateral Flow Assays for Coronavirus Disease-19 Serology코로나바이러스 질병-19 혈청학에 대한 측면 흐름 분석의 성능 평가Review Published on 2022-03-012022-09-11 Journal: Clinics in laboratory medicine [Category] MERS, SARS, 진단, 치료기술, 치료제, [키워드] 2019 Accuracy acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 anti-SARS-CoV-2 antibodies anti-SARS-CoV-2 antibody antibody caused containment measures coronavirus coronavirus disease Coronavirus-2 COVID-19 detect determine diagnostics Evolution Flow globe herd immunity Humoral response humoral responses Immunity implementation individual level Infection Lateral lateral flow LFAs Longevity MONITOR morbidities mortalities natural infection pandemic performance population surveillance populations respiratory SARS-CoV-2 SARS-CoV-2 virus serologic serologic assay serologic assays serology Seroprevalence Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus Surveillance target populations the SARS-CoV-2 virus Transmission dynamics use cases vaccination Vaccine virus [DOI] 10.1016/j.cll.2021.10.005 PMC 바로가기 [Article Type] Review