Inhibition of cytokine signaling by ruxolitinib and implications for COVID-19 treatmentReview article Published on 2020-09-012022-10-05 Journal: Clinical immunology (Orlando, Fla.) [Category] SARS, 치료법, [키워드] alveolar damage Antiviral treatment Clinical data coronavirus coronavirus disease COVID-19 Critical cytokine cytokine level cytokine signaling Cytokine storm death effective elevated Hyperinflammatory Immune cell infiltration implication IMPROVE inhibition Janus kinase lung Lung function mitigate other disease outcomes pathway Patient patients with COVID-19 plasma pro-inflammatory cytokines progression reduce reduce mortality ruxolitinib severe COVID-19 severe disease shown Support supported Treatment Vaccine [DOI] 10.1016/j.clim.2020.108517 [Article Type] Review article
The Effects of Type 2 Diabetes Mellitus on Organ Metabolism and the Immune SystemImmunology Published on 2020-07-222022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS, [키워드] abnormality acute respiratory syndrome affecting bidirectional cause circulatory system coronavirus diabetic patient disease Diseases Effect explain Fatty liver gut microbiota hyperinsulinemia immune cell functions Immune cell infiltration immune system immunization immunological immunometabolism impairment increase inducer Infectious diseases Inflammation insulin resistance intestinal permeability mechanisms metabolic Metabolic abnormality metabolic factors metabolism obesity occur organ Organ failure oxidative stress pathogenic agent Patient Premature progression promote protocol regulate SARS-CoV-2 subsequent susceptibility susceptible System systemic low-level inflammation tissue turn Type type 2 diabete Type 2 diabetes mellitus [DOI] 10.3389/fimmu.2020.01582 PMC 바로가기 [Article Type] Immunology
Bioinformatic Analysis of Correlation between Immune Infiltration and COVID-19 in Cancer PatientsResearch Paper Published on 2020-07-062022-10-29 Journal: International Journal of Biological Sciences [Category] COVID-19, MERS, SARS, [키워드] ACE2 ACE2 expression acute respiratory syndrome addition Bioinformatic Cancer cancer patient caused cell line Colon coronavirus coronavirus disease correlated correlation COVID-19 digestive enrichment analysis estimation expressed fetal GSEA healthy Immune cell infiltration immune infiltration Infection investigated male maternal-fetal transmission pathway performed Profiling reproductive SARS-CoV-2 SARS-COV-2 infection severity signaling pathways significantly suggested susceptibility tissue tissues Tumor Urinary tract [DOI] 10.7150/ijbs.48639 PMC 바로가기 [Article Type] Research Paper
Complement Activation Contributes to Severe Acute Respiratory Syndrome Coronavirus PathogenesisResearch Article Published on 2018-10-092022-10-29 Journal: mBio [Category] Coronavirus, [키워드] absence Activation acute respiratory syndrome Adaptive immune response animal models ARDS Bacterial cascade chemokine chemokines complement contributed controls coronavirus Coronavirus infection Critical cytokine Defense disease distress dysfunction effective exhibited fungal infections high-titer virus Host human infection identify immune Immune cell infiltration Infection Inflammatory cytokine inflammatory monocyte inhibiting intranasal investigated less lung Lung pathology mice mouse-adapted SARS-CoV neutrophil observation outbreak outcome outcomes Pathogenesis pathologic pathology pattern recognition receptor Proinflammatory response Protective reduced regulate relative Replication respiratory Respiratory disease respiratory viruses SARS-CoV SARS-CoV infection sera Severe case Signaling significantly stimulate subsequent syndrome systemic inflammation therapeutic These data Treatment Viral load weight loss [DOI] 10.1128/mBio.01753-18 PMC 바로가기 [Article Type] Research Article
Tertiary lymphoid structures are associated with higher tumor grade in primary operable breast cancer patientsResearch Article Published on 2015-03-062023-08-29 Journal: BMC Cancer [Category] E형 간염, [키워드] Adaptive immune response Breast cancer Immune cell infiltration Tertiary lymphoid structures Tumor [DOI] 10.1186/s12885-015-1116-1 PMC 바로가기 [Article Type] Research Article