Randomised controlled trial of intravenous nafamostat mesylate in COVID pneumonitis: Phase 1b/2a experimental study to investigate safety, Pharmacokinetics and PharmacodynamicsCOVID 폐렴에서 정맥내 나파모스타트 메실레이트의 무작위 대조 시험: 안전성, 약동학 및 약력학을 조사하기 위한 1b/2a상 실험 연구Clinical Trial Published on 2022-02-012022-09-11 Journal: EBioMedicine [Category] COVID19(2023년), MERS, SARS, 바이오마커, 신약개발, 임상, 치료제, [키워드] 95% CI Administered adverse events Analysis Anti-inflammatory Anticoagulant anticoagulant effect anticoagulant effects antiviral activity assigned average characterisation Controlled trial COVID COVID-19 COVID19 creatinine credible interval demonstrated dose Edinburgh Endpoint endpoints Evidence evidence of Hospital stay hospitalised hospitalised patient Hospitalised patients inactive independent Infectious diseases intravenous intravenous infusion manuscript maximum mean difference mesylate metabolites nafamostat Nafamostat mesylate observé Odds ratio open open label Oxford oxygen Patient patients Pharmacodynamics pharmacokinetics phase Phase 2 PK data plasma platform Pneumonitis Primary outcome Primary outcomes progressed randomised randomised controlled trial Randomly rate ratio receive reported Repurposed drug Research respiratory Respiratory medicine response SARS-CoV-2/COVID-19 Seven significantly higher significantly more SOC Standard of care statistically significant difference therapy Tolerability Total Total manuscript word count. Trial university with COVID-19 [DOI] 10.1016/j.ebiom.2022.103856 PMC 바로가기 [Article Type] Clinical Trial
The binding of heparin to spike glycoprotein inhibits SARS-CoV-2 infection by three mechanisms스파이크 당단백질에 대한 헤파린의 결합은 세 가지 메커니즘에 의해 SARS-CoV-2 감염을 억제합니다Article Published on 2022-02-012022-09-11 Journal: The Journal of Biological Chemistry [Category] COVID19(2023년), SARS, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Antiviral antiviral activity antiviral agent antiviral therapy assays bind binding biochemical cleavage competing conformation conformations coronavirus COVID-19 derivative docking experiment facilitate furin glycoprotein glycosaminoglycan heparan sulfate heparin hinge region homotrimer Host host cell host cell receptor inactive induce Infection inhibit inhibit SARS-CoV-2 investigated mechanism molecular molecular dynamics molecular dynamics simulations motion multifunctional N-terminal domain opening Proteoglycan RBD Receptor-binding domain residue responsible S1/S2 site SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike glycoprotein SARS-CoV-2 virus SARS-CoV-2 virus spike (S) severe acute respiratory syndrome Coronavirus spike glycoprotein subunit sulfate the RBD the receptor-binding domain the SARS-CoV-2 viral infection virus [DOI] 10.1016/j.jbc.2021.101507 PMC 바로가기 [Article Type] Article
Real-World Use and Adverse Events of SARS-CoV-2 Vaccination in Greek Patients with Inflammatory Bowel DiseaseArticle Published on 2022-01-272022-10-30 Journal: Journal of Clinical Medicine [Category] COVID-19, [키워드] abdominal pain Adverse adverse event AEs age Analysis Clinical characteristics concerning COVID-19 COVID-19 vaccination COVID-19 vaccine Crohn’s disease demographics demonstrated diarrhea disease dose doses Effect female gender Hospitalization IBD inactive Inflammatory bowel disease information injection knowledge Occurrence Patient patients reaction reported safety profile SARS-CoV-2 SARS-CoV-2 vaccination serious AE Symptom systemic Total Treatment ulcerative colitis vaccination Vaccine were excluded [DOI] 10.3390/jcm11030641 PMC 바로가기 [Article Type] Article
The COVID-19 Conundrum: Keeping safe while becoming inactive. A rapid review of physical activity, sedentary behaviour, and exercise in adults by gender and ageResearch Article Published on 2022-01-272022-10-28 Journal: PLoS ONE [Category] COVID-19, SARS, [키워드] age APA articles build CINAHL consequence COVID-19 database Decline decrease Effect Effects eligibility criteria Evidence Factor Gender groups impacted impacts implication inactive initial intensity Keeping Older age participant physical activity promote public health Reflecting remained reported response Result Safe Seven Universal was performed [DOI] 10.1371/journal.pone.0263053 PMC 바로가기 [Article Type] Research Article
Efficacy and safety profile of COVID-19 vaccine in cancer patients: a prospective, multicenter cohort study암 환자에 대한 COVID-19 백신의 효능 및 안전성 프로파일: 전향적, 다기관 코호트 연구Multicenter Study Published on 2022-01-272022-09-12 Journal: Future Oncology [Category] MERS, SARS, 진단, [키워드] affecting antibody Blood blood sample Cancer cancer patient Cancer patients cancer treatment Chemotherapy Control control group CoronaVac COVID-19 COVID-19 vaccine COVID-19 vaccines defined disease disrupting dose effective Efficacy and safety evaluate evaluated Factor high risk highlight IgG IgG antibody immune response Immunotherapy inactivated Inactivated vaccine inactive infection with SARS-CoV-2 levels of antibodies malignancy marker multicenter cohort study Older Patient PROTECT receiving safety profile SARS-CoV-2 SARS-CoV-2 vaccination seropositive significantly lower spike the patient the vaccine vaccination Vaccine virus volunteers were measured [DOI] 10.2217/fon-2021-1248 PMC 바로가기 [Article Type] Multicenter Study
Effects of long-term social isolation on central, behavioural and metabolic parameters in middle-aged miceArticle Published on 2022-01-242022-10-05 Journal: Behavioural brain research [Category] 임상, [키워드] affected age alteration BDNF Behaviour behavioural CA3 contribute COVID-19 pandemic decrease Effect Evidence Food Intake Future groups hippocampus inactive Isolated Isolation male memory metabolic parameter metabolic parameters mice parameter performed physical activity randomly divided social group social isolation Trial was measured were assessed [DOI] 10.1016/j.bbr.2021.113630 PMC 바로가기 [Article Type] Article
The Broad-Spectrum Antiviral Potential of the Amphibian Peptide AR-23Article Published on 2022-01-142022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, SARS, [키워드] activity Amphibian antimicrobial peptide antimicrobial peptides antiviral activity antiviral agent Antiviral agents antiviral drug antiviral drugs antiviral molecule antiviral therapy contrary coronavirus DNA DNA and RNA drugs early stage effective evaluated exhibited greater HCoV-229E HSV-1 identify inactive indicated Infection inhibitory activity investigated peptide peptides performed Potential reported RNA SARS-CoV-2 secretion strain therapeutic effect therapeutic options variety viral infections virus viruses [DOI] 10.3390/ijms23020883 PMC 바로가기 [Article Type] Article
Effectiveness of Live Health Professional–Led Group eHealth Interventions for Adult Mental Health: Systematic Review of Randomized Controlled Trials성인 정신 건강을 위한 Live Health Professional-Led Group eHealth 중재의 효과: 무작위 대조 시험의 체계적인 검토Review Published on 2022-01-112022-09-10 Journal: Journal of Medical Internet Research [Category] SARS, 임상, [키워드] Adult Adults adverse impact Anxiety article bereavement calculate CBT CINAHL Cochrane Library collaboration Contact Controlled controlled trials coping COVID-19 pandemic database Depression distress e-therapy Effect effect size effect sizes effective effective intervention Effectiveness eHealth eligible Evidence examined experimental evidence foster group Guidance had more Health heterogeneity Identifier implication improvement inactive inclusion criteria intensity Internet Intervention medium Mental mental health mHealth mobile interventions moderate objective offer offset outcome participant physical activity platform positive Primary outcomes problems professional provided psychotherapy PsycINFO Randomized controlled trial RCT RCTs reducing Registration report reported representing Result resulting review robust Sample size searched selected Substance use synchronous synthesis systematic review systematic reviews teleconference Telemedicine videoconference were used [DOI] 10.2196/27939 PMC 바로가기 [Article Type] Review
Inactive SARS-CoV-2 vaccine generates high antibody responses in healthcare workers with and without prior infection비활성 SARS-CoV-2 백신은 감염 여부에 관계없이 의료 종사자에게 높은 항체 반응을 생성합니다.Article Published on 2022-01-032022-09-11 Journal: Vaccine [Category] MERS, SARS, 변종, 진단, 치료기술, [키워드] 95% CI Abbott age Anti-spike antibody Antibody Response Antibody titers approach benefit cellular immune responses Chemiluminescent microparticle immunoassay China CMIA CoronaVac COVID-19 Dilution dose effective faculty female first dose generate group HCW HCWs healthcare worker Healthcare workers humoral Humoral and cellular immune responses Humoral immunity hypertension IgG IgG level IgG levels immune responses immunoassay inactive Infection İstanbul life male material Microparticle monitoring neutralization test Participants Patient plaque reduction neutralization Plaque reduction neutralization test PRNT required SARS-CoV-2 vaccine second dose significantly higher significantly lower Sinovac Life Sciences Spread study group the anti-spike/RBD antibody. Turkey USA vaccination Vaccine variants was used were measured [DOI] 10.1016/j.vaccine.2021.11.051 PMC 바로가기 [Article Type] Article
The impact of COVID-19 movement restrictions on physical activity in a low-income semi-rural population in Malaysia: A longitudinal studyResearch Theme 1: COVID-19 Pandemic Published on 2021-12-252022-10-31 Journal: Journal of Global Health [Category] Coronavirus, MERS, SARS, [키워드] 95% confidence interval affected Asia asked changes in Cohort Community Control country COVID-19 COVID-19 pandemic detrimental East employment Future Health Implications inactive investigated less Malaysia movement Non-communicable disease Observatory participant physical activity provided random reduced reduction reductions in replaced Result risk risk factor South translate Travel with COVID-19 [DOI] 10.7189/jogh.11.05029 PMC 바로가기 [Article Type] Research Theme 1: COVID-19 Pandemic